Koj tus me nyuam puas feem ntau muaj kub taub hau uas tsis paub meej? Qhov no tej zaum yuav yog vim muaj SAIDs (Systemic Autoinflammatory Diseases)!

Koj tus me nyuam puas kub taub hau tas li? Qee zaum lawv kub taub hau ib lossis ob zaug hauv ib hlis, tab sis cov kws kho mob hais tias tsis muaj kev kis kab mob, uas yog, tsis muaj kab mob lossis cov kab mob hauv lub cev. Thaum lub sijhawm zoo li no, ua ib leej niam lossis leej txiv, koj tsim nyog heev uas yuav ntshai thiab ntxhov siab heev. "Vim li cas qhov no tshwm sim rau kuv tus menyuam?" Tej zaum koj tau xav ntau txhiab zaus. Tej zaum qhov laj thawj rau qhov no yog qee yam uas koj tsis tau hnov ​​​​dua. Hnub no, peb yuav tham txog SAIDs (Systemic Autoinflammatory Diseases), uas nyuaj rau nkag siab thiab tuaj yeem ua rau kub taub hau ntau zaus. Yav dhau los, cov no hu ua '(Periodic Fever Syndromes)' lossis '(Recurrent Fever Syndromes)'.

Cov SAIDs (Cov Kab Mob Autoinflammatory Systemic) no yog dab tsi?

Hais yooj yim xwb, SAIDs yog ib pawg kab mob uas tshwm sim vim muaj teeb meem tsis ua haujlwm lossis tswj hwm hauv peb lub cev tiv thaiv kab mob ntuj . Qhov tshwm sim yog tias, tsis muaj ib qho laj thawj sab nraud, uas yog, tus kab mob lossis cov kab mob me me, lub cev tsuas yog tsim kev o. Yog vim li cas qhov kub taub hau no tshwm sim.

Tam sim no koj yuav xav tias, "Auj, qhov no puas yog ib qho ntawm cov Kab Mob Autoimmune?" Tsis yog, ob qho no txawv me ntsis. Hauv cov Kab Mob Autoimmune, piv txwv li, hauv cov kab mob xws li Rheumatoid Arthritis lossis Lupus, peb lub cev tiv thaiv kab mob hloov pauv tsis raug tawm tsam nws cov hlwb noj qab haus huv. Tab sis hauv SAIDs, qhov teeb meem nyob nrog lub cev tiv thaiv kab mob uas yug los.

Cov kab mob SAIDs tsis tshua muaj ntau dua li cov kab mob Autoimmune. Feem ntau, cov no yog cov kab mob uas los ntawm noob caj noob ces , uas txhais tau tias lawv yog los ntawm kev hloov pauv lossis kev hloov pauv ntawm noob caj noob ces.

Cov kab mob SAIDs no feem ntau (tab sis tsis yog txhua lub sijhawm) pib thaum koj tus menyuam tseem yog menyuam mos lossis menyuam yaus . Tus menyuam yuav muaj cov kab mob no ntau zaus lossis tawm tsam qee lub sijhawm. Thaum lub sijhawm no, qhov kub taub hau thiab lwm yam tsos mob yuav tshwm sim. Txawm li cas los xij, ntawm cov "kev tawm tsam" no, tus menyuam yuav tsis muaj tsos mob. Tsis muaj kev kho rau SAIDs, tab sis feem ntau muaj kev kho mob zoo los tswj cov tsos mob.

Cov hom SAIDs tseem ceeb yog dab tsi?

Cov kws tshawb nrhiav tau txheeb xyuas txog li 60 hom kab mob SAIDs, thiab ntau hom kab mob no tab tom raug tshawb pom. Nov yog qee hom kab mob uas pom ntau dua:

• Kab mob ua npaws Mediterranean hauv tsev neeg (FMF): Qhov no yog cov kab mob ua npaws uas rov tshwm sim ntau tshaj plaws uas muaj los ntawm noob caj noob ces. Nws tuaj yeem ua rau mob o ntawm lub plab, hauv siab, thiab pob qij txha ntawm tus menyuam.
• Mob ua npaws tas li, mob aphthous-stomatitis, mob pharyngitis, mob adenitis (PFAPA): Qhov no feem ntau pib rau cov menyuam yaus, feem ntau ua ntej hnub nyoog 4 xyoos. Txawm li cas los xij, rau qee tus menyuam, qhov mob no yuav ploj mus tom qab hnub nyoog 10 xyoos.
• Kab mob qog nqaij hlav necrosis factor receptor-associated periodic fever syndrome (TRAPS): Qhov no tuaj yeem tshwm sim txij thaum yau mus txog rau thaum hluas, thiab qee zaum mus txog rau thaum laus.
• Mevalonate kinase deficiency (MKD): Yav tas los hu ua Hyper-IgD syndrome, qhov no feem ntau pib ua ntej tus menyuam muaj ib xyoos.
• Cov kab mob autoinflammatory cuam tshuam nrog NLRP3: Qhov no yav dhau los hu ua Cryopyrin-associated periodic syndromes (CAPS). Muaj peb hom kab mob me me hauv qhov no.
• Kab mob Still uas pib thaum laus (AOSD): Raws li lub npe qhia, kab mob no pib thaum laus. Nws yog hom kab mob uas tshwm sim rau cov neeg laus hu ua systemic juvenile idiopathic arthritis (JIA).
• Kab mob granulomatous cuam tshuam nrog NOD-2 (Blau syndrome): Qhov no feem ntau pib ua ntej hnub nyoog 4 xyoos. Nws feem ntau cuam tshuam rau daim tawv nqaij, qhov muag, thiab pob qij txha ntawm tus menyuam.

Cov tsos mob ntawm SAIDs yog dab tsi?

Cov tsos mob ntawm SAIDs feem ntau pib thaum yau. Cov tsos mob tseem ceeb thiab feem ntau yog kub taub hau tas li lossis kub taub hau ib ntus . Raws li tau hais ua ntej, tus menyuam yuav zoo thaum lub sijhawm uas tsis muaj kub taub hau. Txawm li cas los xij, muaj lwm cov tsos mob uas tshwj xeeb rau txhua hom SAID:

• Hauv FMF: Tus menyuam lub plab, hauv siab, thiab cov pob qij txha yuav mob heev thiab o. Qee zaum, yuav muaj pob khaus ntawm daim tawv nqaij ntawm ob txhais ceg qis lossis pob luj taws.
• Hauv PFAPA: Mob caj pas, mob qhov ncauj, o ntawm cov qog ntshav hauv caj dab. Cov no yog cov tsos mob tseem ceeb.
• Hauv KEV TXIAV TXIM: Lub cev yuav txias thiab kub taub hau. Tus menyuam yuav mob nqaij ntawm lub cev thiab caj npab. Tej zaum yuav muaj pob liab liab uas mob heev tshwm sim, uas yuav kis mus rau ntawm caj npab mus rau ceg thiab tom qab ntawd mus rau lub cev.
• Hauv MKD: Tej zaum koj yuav muaj cov tsos mob zoo li mob khaub thuas xws li mob khaub thuas txias, mob taub hau, mob plab, tsis xav noj mov, thiab lwm yam tsos mob.
• Hauv cov kab mob NLRP3: tej zaum yuav muaj pob khaus ntawm daim tawv nqaij, mob taub hau, mob nqaij, mob pob qij txha, thiab mob qhov muag (conjunctivitis).
• Hauv AOSD: mob tawv nqaij, mob pob qij txha, mob nqaij. Ib txhia neeg kuj yuav mob caj pas, mob plab, qaug zog, thiab xav tias tsis muaj zog.
• Hauv Blau syndrome: Tus menyuam yuav muaj cov qhov txhab ntawm daim tawv nqaij ntawm caj npab, ceg, lossis nruab nrab. Lawv kuj tseem yuav mob pob qij txha thiab mob qhov muag.

Xav txog seb, Nalini tus ntxhais me tau kub taub hau heev li peb txog plaub hnub txhua lub hlis rau ob peb lub hlis dhau los. Nrog rau qhov ntawd, nws kuj tseem muaj cov qhov me me hauv nws lub qhov ncauj thiab cov qog ntawm nws caj dab. Thaum nws coj mus rau kws kho mob, nws hais tias tej zaum nws yog PFAPA.

Cov ua rau muaj SAIDs yog dab tsi?

Feem ntau cov kab mob SAIDs yog cov kab mob caj ces . Qhov no txhais tau hais tias txhua yam ntawm cov kab mob no yog tshwm sim los ntawm kev hloov pauv hauv peb cov noob caj ces. Nov yog cov hom kab mob SAIDs feem ntau thiab cov noob caj ces uas cuam tshuam rau lawv:

• FMF: Tus gene hu ua `(MEFV)`. Tus gene no qhia kev tsim cov protein `(pyrin)`.
• PFAPA: Tus gene tseeb uas cuam tshuam rau qhov no tseem tsis tau raug txheeb xyuas.
• TRAPS: Tus noob hu ua `(TNFRSF1A)`. Qhov no yog qhov uas cov lus qhia rau kev ua cov protein `(tumor necrosis factor receptor - TNFR)` los ntawm.
• MKD: Tus gene `(MVK)`. Qhov no qhia kom muaj ib qho protein hu ua `(mevalonic kinase)`.
• Cov kab mob NLRP3: Tus noob hu ua `(NLRP3)`. Qhov no muab cov lus qhia rau kev ua cov protein hu ua `(cryopyrin)`.
• AOSD: Qhov laj thawj tseeb rau qhov no tseem tsis tau paub meej.
• Kab mob Blau: Tus gene `(NOD2)`. Qhov no qhia kom cov protein `(NOD2)` tsim tawm.

Cov ntsiab lus ntawm cov noob caj ces no yuav zoo li nyuaj me ntsis rau koj. Hais yooj yim xwb, cov noob caj ces no cuam tshuam rau kev tsim cov protein uas tswj kev o hauv peb lub cev. Yog vim li ntawd lub cev thiaj tsim cov mob o tsis muaj laj thawj.

Yog tias cov kab mob SAIDs tsis kho kom zoo, yuav muaj dab tsi tshwm sim?

Nws yog ib qho tseem ceeb heev uas yuav tsum tau kho kom zoo rau cov kab mob SAIDs no. Vim tias yog tias qhov mob hauv lub cev tseem txuas ntxiv mus, ib qho mob hu ua '(amyloidosis)' tuaj yeem tshwm sim. Qhov no txhais tau tias ib hom protein tau tso rau hauv peb lub raum, uas tuaj yeem ua rau lub raum puas tsuaj mus tas li . Yog li ntawd, yog tias muaj cov tsos mob, nws yog ib qho tseem ceeb heev uas yuav tsum nrhiav kev pab kho mob yam tsis quav ntsej lawv.

Cov kws kho mob kuaj mob SAIDs li cas?

Kev kuaj mob SAIDs yuav nyuaj vim tias cov tsos mob yuav zoo ib yam li lwm yam mob hnyav, xws li lupus lossis lymphoma. Yog li ntawd , nws yog qhov zoo tshaj plaws mus ntsib kws kho mob rheumatologist, tus kws kho mob uas tau kawm tshwj xeeb txog cov kab mob o , kom kuaj mob thiab tswj koj tus menyuam tus mob kom raug.

Koj tus menyuam tus kws kho mob pob qij txha yuav saib ntau yam los kuaj mob SAIDs. Nws yuav nug koj txog koj tus menyuam cov tsos mob thiab seb puas muaj leej twg hauv koj tsev neeg muaj keeb kwm mob khaub thuas ntau zaus. Tus kws kho mob yuav xav tias muaj tus mob no yog tias:

• Yog tias tus menyuam muaj mob kub taub hau ntau zaus .
• Yog tias leej twg hauv tsev neeg muaj keeb kwm ntawm kev kub taub hau ntau zaus .
• Yog tias tus me nyuam yog neeg ib haiv neeg ces yuav muaj feem kub taub hau ntau zaus.

Siv cov kev ntsuam xyuas twg?

Yuav kom paub tseeb tias koj tus menyuam mob pob qij txha, tus kws kho mob pob qij txha yuav pom zoo kom kuaj ntau yam. Qee qhov ntawm cov no suav nrog:

• Kev kuaj ntshav hauv chav kuaj: Kev kuaj ntshav xws li '(C-reactive protein - CRP)' thiab '(Complete blood count - CBC)' tuaj yeem kuaj xyuas seb puas muaj kev o ntawm lub cev. Cov kev kuaj no yog '(zoo)' thaum koj kub taub hau thiab rov qab mus rau qhov qub thaum kub taub hau ploj mus.
• Kuaj zis: Cov zis raug kuaj seb puas muaj cov protein ntau. Hauv cov neeg mob MKD, cov zis kuj raug kuaj seb puas muaj cov organic acid hu ua "mevalonic acid" ntau.
• Kev kuaj noob caj noob ces: Kev kuaj noob caj noob ces tuaj yeem kuaj xyuas seb puas muaj cov noob caj noob ces uas tau hais los saum toj no. Txawm li cas los xij, qee tus menyuam uas muaj SAIDs yuav tsis muaj cov noob caj noob ces uas pom, yog li cov txiaj ntsig ntawm kev kuaj yuav tsis muaj.

Cov kev kho mob rau SAIDs yog dab tsi?

Kev kho mob rau SAIDs nyob ntawm hom thiab qhov hnyav ntawm tus mob . Tsis muaj kev kho rau cov mob no, tab sis cov tshuaj tuaj yeem pab tswj koj tus menyuam cov tsos mob . Yog tias koj tus menyuam tsuas muaj ob peb zaug mob hauv ib xyoos, koj feem ntau tuaj yeem tswj cov tsos mob nrog cov tshuaj tua kab mob thiab cov tshuaj nonsteroidal anti-inflammatory (NSAIDs). Txawm li cas los xij, yog tias tus mob hnyav dua, koj tus kws kho mob yuav pom zoo lwm yam kev kho mob:

• FMF: Qhov no kho tau nrog tshuaj hu ua '(Colchicine)' kom txo qhov o. Yog tias muab '(Colchicine)' tsis tau rau tus menyuam, koj tuaj yeem sim siv hom tshuaj '(biologic)' hu ua '(Canakinumab)'.
• PFAPA: Cov tshuaj steroids xws li prednisone tuaj yeem ua rau lub sijhawm luv luv ntawm PFAPA "kev tawm tsam." Cimetidine, ib yam tshuaj uas muab rau qee tus menyuam rau cov mob plab, kuj tseem tuaj yeem pab txo cov tsos mob.
• TRAPS: Cov tshuaj '(Canakinumab)' zoo heev rau TRAPS. Tsis tas li ntawd, cov tsos mob tuaj yeem tswj tau nrog cov tshuaj tiv thaiv kev o xws li '(glucocorticoids)' uas tus kws kho mob tau sau tseg.
• MKD: `(Canakinumab)` kuj yog ib qho kev kho mob zoo rau MKD. `(NSAIDs)` lossis `(steroids)` tuaj yeem pab tau thaum muaj "kev tawm tsam".
• Cov kab mob NLRP3: Cov tshuaj immunomodulators xws li Canakinumab, Rilonacept, thiab Anakinra tau siv tau zoo los kho cov kab mob ntsig txog NLRP3.
• AOSD: Muaj ntau yam tshuaj tiv thaiv kev o xws li cov tshuaj steroids, cov tshuaj tiv thaiv kab mob rheumatic hloov kho (DMARDs), thiab cov tshuaj biologics siv los kho AOSD.
• Kab mob Blau: Nyob ntawm seb tus menyuam cov tsos mob li cas, tej zaum yuav sim siv cov tshuaj immunosuppressants, cov tshuaj tumor necrosis factor (TNF) inhibitors, thiab/lossis cov tshuaj pleev qhov muag.

Nyeem txog cov tshuaj no yuav ua rau koj ntshai me ntsis. Tab sis nco ntsoov, tag nrho cov tshuaj no yog muab rau hauv qab kev saib xyuas ntawm tus kws kho mob, hauv txoj kev uas zoo tshaj plaws rau tus menyuam. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum ua raws li kev kho mob raws li tus kws kho mob hais.

Puas yog SAIDs txoj cai yuav ploj mus?

Qee cov mob SAIDs yog cov mob uas yuav mob mus ib txhis . Lwm cov mob yuav kav ntev li ob peb xyoos thiab ploj mus thaum laus . Qee cov mob yuav mob mus ib txhis, tab sis dhau sij hawm, qhov zaus ntawm kev mob yuav txo qis thiab cov tsos mob yuav tsis hnyav zuj zus. Koj tus kws kho mob yuav piav qhia txog qhov tseeb ntawm koj tus menyuam tus mob rau koj.

Kev saib xyuas ib tug me nyuam uas muaj tus kab mob SAID yuav nyuaj heev. Yog tias koj tus kheej muaj tus kab mob SAID, koj siv tau koj qhov kev paub los pab saib xyuas koj tus me nyuam. Koj txoj kev nkag siab kuj tseem ceeb heev rau kev pab koj tus me nyuam nyob nrog tus mob no mus ib txhis.

Qhov tseem ceeb tshaj plaws yog nrhiav kev kho mob los ntawm cov kws kho mob uas muaj kev paub txog SAIDs. Lawv tuaj yeem pab tswj koj tus menyuam cov tsos mob thiab pab lawv muaj lub neej thaum yau zoo tshaj plaws.

Tej yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Zoo, yog li cia peb rov hais dua qee cov ntsiab lus tseem ceeb uas koj yuav tsum nco ntsoov los ntawm qhov peb tau tham txog:

• Yog tias koj tus menyuam kub taub hau ntau zaus, uas tsis paub meej , nws yuav yog ib qho cim ntawm SAID.
• Cov kab mob SAIDs tsis yog los ntawm kev kis kab mob , tab sis yog teeb meem nrog lub cev tiv thaiv kab mob.
• Cov no yog cov kab mob tsis tshua muaj uas feem ntau yog los ntawm cov caj ces .
• Cov tsos mob yuav txawv nyob ntawm hom SAID, tab sis kub taub hau ntau zaus yog qhov tsos mob tseem ceeb .
• Nws yog ib qho tseem ceeb uas yuav tsum mus ntsib kws kho mob Rheumatologist kom paub tseeb tias koj mob thiab kho tau zoo.
• Txawm hais tias kev kho mob tsis tuaj yeem kho tau tus kab mob tag nrho los xij, cov tsos mob tuaj yeem tswj tau zoo .
• Tsis txhob tsis quav ntsej cov tsos mob, vim tias lawv tuaj yeem ua rau lub raum puas tsuaj yog tias tsis kho.

Yog koj muaj lus nug ntxiv txog qhov no, tsis txhob yig nrog koj tus kws kho mob hauv tsev neeg lossis tus kws kho mob pob qij txha tham. Lawv yuav pab tau koj ntxiv.

SAIDs , cov tsos mob kub taub hau tas li, kub taub hau rov tshwm sim, cov kab mob autoinflammatory, kub taub hau, kub taub hau rau menyuam yaus, cov kab mob caj ces