We yu dɔktɔ tɛl yu se yu gɛt kansa, yu kin gɛt bɔku kwɛstyɔn dɛn na yu maynd, nɔto so? Wi dɔn yɛri bɔt ‘chemo’ ɛn ‘radiation’, bɔt yu dɔktɔ kin de tɔk bɔt wan nyu klas fɔ drɔgs we dɛn kɔl ‘Angiogenesis Inhibitors’. Wetin dɛn kɔl dis strenj drɔg? Wetin i rili de du? Nɔ wɔri, lɛ wi tɔk bɔt am simpul wan.
Fɔs, lɛ wi si, wetin na dɛn angiogenesis inhibitors ya?
Fɔ tɔk am simpul wan, dis na wan kayn mɛrɛsin we de stɔp nyu blɔd vesel dɛn fɔ gro, we na di blɔd vesel dɛn we de gi di tumbu dɛn. כda nem dεm fכ dis na anti-angiogenic, anti-angiogenic ejen, εn anti-angiogenic tεrapi.
Tink bɔt am, fɔ mek ɛnitin gro, i nid it, it, nɔto so? Kansa sɛl dɛn jɔs tan lɛk dat. Dɛn nid bak fɔ kɔntinyu fɔ gɛt blɔd we ful-ɔp wit tin dɛn we go mek dɛn gro ɛn skata. We kansa sɛl smɔl, i kin liv bay we i de sok sɔm blɔd frɔm di wɛlbɔdi tisu we de rawnd am. bכt we di sεl gro to lεk 1-2 milimita, i gεt fכ divεlכp in yon nyu bכdi vεsεl sistεm. If nɔto dat, i nɔ go ebul fɔ gro mɔ.
dis na di say we dεn dכn dεm we dεn kכl Angiogenesis Inhibitors de kam in. dεn dכg dεm ya de wok bay we dεn de blכk di prכsεs we di kεnsar sεl dεm de mek nyu bכdi vεsul dεm de gro. I tan lɛk se yu kɔt wata we de go na tik. Dis kin mek di kansa nɔ gro kwik kwik wan, ɛn sɔntɛnde di tumbu kin ivin smɔl. Dis tritmɛnt nɔ go mɛn di kansa kpatakpata, bɔt i kin kɔntrol aw di tumbu de gro ɛn alaw yu fɔ de wit di wan dɛn we yu lɛk fɔ smɔl tɛm.
Aw dis mɛrɛsin de wok insay di bɔdi?
Dɛn drɔgs ya kin ambɔg wan prɔses we dɛn kɔl angiogenesis . Dis na rili nɔmal tin we kin apin na wi bɔdi. Imajin if yu kɔt yu an, nyu blɔd vesel dɛn nid fɔ gro fɔ wɛl di wund ɛn briŋ blɔd to da say de. Dɛn kɔl dat angiogenesis. di sel dεm we inju de sεnd wan signal, lεk "Ep wi!" Dis signal de mek nyu blɔd vesel dɛn gro.
Bɔt di prɔblɛm na dat, di kansa sɛl dɛnsɛf kin yuz dis sem tin fɔ bɛnifit dɛn. Di kansa sɛl dɛn kin sɛn di sem kayn sayn dɛn bak ɛn gro nyu blɔd vesel dɛn fɔ dɛnsɛf. na dεn blכd vesel dεm ya de gi di tכmכro di tin dεm we i nid, we de mek i gro εn spre to כda pat dεm na di bכdi.
Angiogenesis Inhibitors de wok bay we dεn de disrupt dis signal sistεm frכm di kεnsar. Bɔku pan dɛn drɔgs ya kin wok bay we dɛn kin blok wan prɔtin we dɛn kɔl vaskul ɛndoteyl growth factor (VEGF) . tink bɔt VEGF as di men "ɛp" signal we di kansa sɛl dɛn de pul. we dis VEGF signal de tay to di VEGF risεptor dεm na di kεnsar sεl dεm, nyu bכdi vεsul dεm de bigin fכ fכm.
Naw lɛ wi si aw dis mɛrɛsin de stɔp dis signal.
- fכ blכk di VEGF signal fכ biεn di rεsεpכta: sכm dכg dεm (fכ egzampl, monoklonal antibodi dεm lεk Bevacizumab (Avastin®) de go dayrekt to di VEGF protin εn atak am. Dɔn i nכ kin go to da rεsεpכta de εn tay am. I tan lεk fכ intasept wan lεta bifo i rich di pɔsin we i want fכ tek am.
- blכk signal frכm VEGF rεsεpכta dεm: sכm כda dכg dεm (fכ egzampl, tyrosine kinase inhibito dεm lεk sorafenib (Nexavar®) εn sunitinib (Sutent®)) de blכk di rεsεpכta fכ sεnd di mεsej bak, ivin if i gεt di signal.
- blכk כda signal sistεm dεm: sכm כda mεdikeshכn dεm (fכ egzampl, immunomodulator dεm lεk thalidomide εn lenalidomide (Revlimid®)) de intafεr כda signal sistεm dεm we de involv insay dis prכsεs.
Us kayn kansa dɛn kin yuz dis mɛrɛsin fɔ?
Bɔku tɛm, dɔktɔ dɛn kin gi dɛn angiogenesis inhibitors ya fɔ di kansa dɛn we dɔn go bifo ɔ we kin kam bak . Sɔm pan di kayn kansa wae dɛn kin kɔmand fɔ dis tritmɛnt na:
- Bren kansa
- Brɔst kansa
- Kansa na di sɛvikal
- Kansa na di kɔlon
- Falopian tiub kansa
- Kidni kansa
- Kansa na di liva
- Kansa na di lɔng
- Limfoma we dɛn kɔl Limfoma
- Bɔku bɔku mayloma
- Kansa na di pankrias
- Kansa we de na di bɛlɛ
- Bɛlɛ kansa
- Tayrɔyd kansa
- uterin/εndometrial kεnsar
Apat frɔm dat, dɛn kin yuz dɛn mɛrɛsin ya (VEGF inhibitors) bak fɔ trit sɔm ay sik dɛn we di blɔd vesel dɛn kin gro nɔmal wan na di yay.
Wetin kin apin we dɛn de trit am?
Dɔktɔ dɛn nɔ kin gi dɛn mɛrɛsin ya nɔmɔ. Bɔku tɛm dɛn kin gi dɛn togɛda wit ɔda tritmɛnt dɛn fɔ kansa, lɛk imyunotɛrapi ɛn kemotɛrapi .
Tink bɔt am lɛk wɔ. Angiogenesis Inhibitors de kɔt di it ɛn amunishɔn (blɔd) we di ɛnimi (kansa) de gɛt. Ɔda tritmɛnt dɛn (lɛk kemotɛrapi) kin go stret to di ɛnimi (kansa sɛl dɛn) ɛn atak dɛn. We dɛn tu we ya wok togɛda, di tin dɛn we kin apin kin wok fayn.
Dipen pan di kayn mɛrɛsin we dɛn gi yu, yu kin nid fɔ tek am as pil wan ɔ tu tɛm insay di de, ɔ yu kin nid fɔ gɛt am as IV (lɛk saline ) insay wan vein pan wan schedule ɔltɛm.
Aw lɔng dis tritmɛnt kin tek?
Aw lɔng yu tritmɛnt de dipen pan bɔku tin, lɛk di kayn mɛrɛsin we dɛn de gi yu ɛn di kayn kansa we yu gɛt. Bɔku pipul dɛn kin kɔntinyu fɔ tek dɛn mɛrɛsin ya as lɔng as dɛn de wok. Sɔntɛnde, dɛn kin stɔp di tritmɛnt if di sayd ɛfɛkt dɛn tumɔs fɔ bia. Yu dɔktɔ go tɔk to yu bɔt di bɛnifit ɛn sayd ɛfɛkt dɛn we di tritmɛnt go gɛt ɛn disayd fɔ du di bɛst.
Wetin na di sayd ɛfɛkt ɛn risk dɛm?
Lɛk ɛni mɛrɛsin, dɛn tritmɛnt ya kin gɛt sayd ɛfɛkt ɛn risk. Bɔku pan dɛn tin ya na prɔblɛm wit blɔd (blɔd) ɛn blɔd we de klɔt. Sɔntɛm, dɛn sayd ɛfɛkt ya kin mek pɔsin in layf de pan denja. So i impɔtant fɔ no bɔt dɛn tin ya.
Yu dɔktɔ go de wach yu wɛlbɔdi ɔltɛm fɔ ridyus dɛn prɔblɛm ya.
| Posisibul sayd ɛfɛkt/risk | Simpul ɛksplen |
|---|---|
| Di ay blɔd prɛshɔn | Di ay blɔd prɛshɔn. Dɛn fɔ chɛk ɛn kɔntrol dis ɔltɛm. |
| Blɔd we de kɔmɔt insay pɔsin in bɔdi | Blɔd we de kɔmɔt insay di bɔdi. |
| Di wund we de wɛl sloslo | Bikɔs i de ambɔg di fɔmɛshɔn fɔ nyu blɔd vesel dɛn, i kin mek di tɛm we i kin tek fɔ mek wund dɛn wɛl mɔ ɛn mɔ. |
| Pɔrfɔreshɔn na di bɛlɛ | Na smɔl tɛm nɔmɔ, di risk de fɔ mek di bɛlɛ ɔ di intestinal dɛn pɔt. |
| Di tayroyd nɔ de wok fayn | Fɔ slo di tayroyd gland we de kɔntrol di ɔmon dɛn na di bɔdi. |
| Liva we dɔn pwɛl | Sɔntɛnde, di we aw di liva de wok kin afɛkt. |
| Blɔd we de klɔt | Risk de fɔ mek di blɔd we de mek di blɔd klɔt we de mek pɔsin denja fɔm na di blɔd vesel dɛn. Dɛn tin ya kin mek yu gɛt tin dɛn lɛk at atak ɔr strok. |
De impɔtant tin wae yu kin du na fɔ ɔndastand dɛn sayd ɛfɛkt ɛn risk ya bifo yu bigin tritmɛnt. We yu no wetin fɔ ɛkspɛkt, yu kin no mɔ bɔt di chenj dɛn we de apin na yu bɔdi. If yu notis ɛnitin we nɔ kɔmɔn, mek yu dɔktɔ no wantɛm wantɛm. Dɔn i kin tich yu aw fɔ kɔntrol di sayd ɛfɛkt dɛn ɔ ajɔst di we aw yu de tek di mɛrɛsin.
Tin dɛn de we kin stɔp dis prɔses bay insɛf?
Dis na kwɛstyɔn we bɔku pipul dɛn kin aks. sכm it dεm gεt kכmpawnd dεm we de blכk sכm signal dεm we de involv insay di prכsεs fכ angiojεnεsis. Bɔku pan dɛn it ya de na di Mɛditarenian it dɛn. Fɔ ɛgzampul:
- Asparagus we dɛn kɔl Asparagus
- Dandelion rut na di rut
- Grin ti
- Ɔliv ɔyl
- Pinat dɛn we dɛn kin yuz fɔ mek tin dɛn
- Rɛd wayn
- Rɛd greps dɛn
Di wan dɛn we de stɔdi bɔt mɛrɛsin de tray fɔ yuz dɛn kɔmpawnd ya fɔ mek nyu mɛrɛsin dɛn, bɔt da risach de stil bigin.
Bɔt di tin we impɔtant pas ɔl fɔ mɛmba na ya na dat, dɛn it ya nɔ go ɛva bi tin fɔ tek ples fɔ di mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn kansa. In ɔda wɔd, if yu it bɔku rɛd greps ɛn drink grɛn ti, dat nɔ go stɔp kansa fɔ mek i kam. Dat na tin we nɔ rayt atɔl.
Bɔt fɔ it tin dɛn we gɛt fayn fayn tin dɛn rili impɔtant fɔ mek yu bɔdi strɔng. I impɔtant fɔ gi gud it to di bɔdi we yu de trit kansa ɛn afta yu dɔn trit am.
Ustɛm yu nid fɔ tɔk to di dɔktɔ?
If yu gɛt ɛni sik we yu nɔ bin de ɛkspɛkt we yu de trit yu, go to yu dɔktɔ wantɛm wantɛm.
Ɛspɛshali if yu si sayn dɛn fɔ wan sik we go mek yu layf de pan denja, lɛk at atak ɔ strok, go to di Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
di angiogenesis inhibitors na wan rili imכtant tritmεnt we de blכk di abiliti fכ di kεnsar sεl dεm fכ hajεk wi bכdi in כwn hiling prכsεs. Dɛn nɔ kin mɛn di kansa ɔltogɛda, bɔt dɛn kin ɛp fɔ kɔntrol di we aw i de skata ɛn gi yu mɔ tɛm fɔ liv. If yu dɔktɔ tɛl yu fɔ tek dis mɛrɛsin, mek shɔ se yu tɔk to yu dɔktɔ bɔt di wok we i de du na yu ɔl tritmɛnt plan.
Mɛsej we dɛn kin kɛr go na os
- Angiogenesis Inhibitors na wan kayn dכg we de stכp di fכmeshכn fכ nyu bכdi vεsul dεm we de gi kεnsar sεl dεm wit bכdi. Dis kin mek di kansa sɛl dɛn nɔ gɛt di tin dɛn we dɛn nid ɛn i kin kɔntrol aw dɛn de gro.
- Pan ɔl we dis nɔ kin mɛn di kansa ɔltogɛda, i kin kɔntrol aw di sik de skata ɛn mek i liv lɔng.
- Bɔku tɛm, dɛn kin gi dis tritmɛnt wit ɔda tritmɛnt dɛn lɛk kemotɛrapi.
- I impɔtant fɔ no bɔt di bad tin dɛn we kin apin lɛk ay blɔd prɛshɔn, blɔd we kin rɔtin, ɛn we wund kin de te fɔ wɛl, ɛn fɔ tɛl yu dɔktɔ if yu si ɛnitin we nɔ fayn.
- Pan ɔl we sɔm natura it dɛn gɛt kɔmpawnd dɛn we de ambɔg dis prɔses, dɛn nɔ fɔ ɛva yuz dɛn fɔ tek ples fɔ mɛrɛsin.
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