Yu go dɔn yɛri wi mama, papa, grani, ɛn granpa dɛn se, "O, mi bɔdi wik naw," ɛn "Mi bon dɛn dɔn brok." Infakt, as wi de ol, di trɛnk we wi bɔdi gɛt de go dɔŋ, ɛn di trɛnk we wi bon dɛn gɛt de go dɔŋ smɔl smɔl. Sɔntɛnde, we dis sik kin tranga, ivin if yu fɔdɔm smɔl ɔ ivin grap na bed, dat kin mek yu gɛt bɔku prɔblɛm fɔ brok yu an ɔ yu leg. Dis kכndyushכn we di bon dεm kin wik εn brit dεn kכl am כstioporosis . So, tide wi go tɔk bɔt wan rili impɔtant klas ɔf drɔgs we dɔktɔ dɛn kin yuz fɔ kɔntrol dis kayn bon wiknɛs.
Fɔ tɔk am simpul wan, wetin na dɛn bisfosfɔnat ya?
Bisfosfonayt na wan klas ɔf mɛrɛsin we dɛn kin yuz fɔ trit sik dɛn lɛk ɔstioporosis we kin mek di bon dɛn nɔ bɔku ɛn i nɔ kin gɛt trɛnk. Dis min se nɔto wan drɔgs de we gɛt dis nem, bɔt na wan kɔmbaynshɔn fɔ sɔm drɔgs. Apat frɔm di ɔstioporosis, dɔktɔ dɛn kin gi dis mɛrɛsin bak fɔ sɔm pipul dɛn we gɛt bɔku bɔku kalsiɔm na dɛn blɔd we denja (hypercalcemia).
Lɛ wi luk di men kayn mɛrɛsin dɛn we de ɔnda dis kategori. Dɛn tin ya kin kam insay tu men we dɛn. Wan na ɔral (pils we dɛn kin tek wit mɔt), ɛn di ɔda wan na intravenous (IV) (likwid we dɛn kin gi insay vein).
| Aw fɔ gi mɛrɛsin | Ɛgzampul dɛn bɔt mɛrɛsin (we dɛn kin yuz bɔku tɛm na Sri Lanka) . |
|---|---|
| Bisfosfonat dɛn we dɛn kin tek bay mɔt | Alendronate, Risedronate, Ibandronate, ɛn ɔda pipul dɛn |
| Fluid we dɛn kin put insay di bɛlɛ (IV Bisphosphonates) . | Zoledronic asid, Pamidronate, we dɛn kɔl Pamidronate |
Aw dis mɛrɛsin kin afɛkt di bɔdi?
Fɔ ɔndastand dis, wi fɔ ɔndastand smɔl fɔs bɔt aw wi bon dɛn de wok. Tink bɔt wi bon dɛn lɛk bildin we dɛn de mek ɔltɛm. Wi bɔdi kin brok ɛn pul ol bon we wik. dis prכsεs dεn kכl am bon rεsכpshכn.Na di sem tɛm, nyu bon we strɔng kin mek na di say dɛn we dɛn pul am. As lɔng as dɛn tu tin ya balans, wi bon dɛn kin stil strɔng.
Bɔt as wi de ol, mɔ afta uman dɛn dɔn lɛf fɔ gɛt bɛlɛ, dis balans kin lɔs. Wetin kin apin na dat ol bon kin brok kwik kwik wan pas aw nyu bon kin fɔm. Di rizin na dat smɔl smɔl di bon dɛn kin tan lɛk tin, dɛn kin gɛt mɔ porous, ɛn wik.
so, wetin dεn bisfosfכnat dεm ya de du na fכ kכntro εn ridyus di rεt fכ di bon rεsכpshכn bכku bכku wan. afta dat, biכs di ol bon strכng we nyu bon de fכm, di כvala density εn trεnk fכ di bon dεm de go כp. Fɔ tɔk am simpul wan, dɛn kin stɔp di bon dɛn we de lɔs.
Us kɔndishɔn dɛn dɛn kin yuz bisfɔsfɔnat fɔ?
Dɔktɔ dɛn kin tɔk mɔ bɔt dis mɛrɛsin fɔ dɛn sik ya:
- Ɔstioporosis na wan sik we kin apin to uman dɛn afta dɛn dɔn lɛf fɔ gɛt bɛlɛ.
- Ɔstioporosis na man dɛn.
- Fɔ mek di ɔstioporosis nɔ apin.
- Ɔstioporosis we kin kam bikɔs dɛn kɔntinyu fɔ yuz mɛrɛsin lɛk stɛroyd (glucocorticoids).
- Paget’s disease of the bone na sik wae de bon dεm de divεlכp abnכmal wan.
- kכntrol di komplikashכn dεm we de apin wit sכm kayn kεnsar (e.g. Multiple Myeloma) εn we di kεnsar sεl dεm de spre to di bon dεm (Bכn Mεtastasis).
- Fɔ kɔntrol di haypa kalsiɔm we gɛt fɔ du wit kansa (di kalsiɔm lɛvɛl we de go ɔp na di blɔd bikɔs ɔf kansa).
Aw a fɔ yuz dis mɛrɛsin? Dis rili impɔtant!
I impɔtant fɔ fala dɛn instrɔkshɔn ya gud gud wan fɔ gɛt di ful bɛnifit fɔ di mɛrɛsin ɛn fɔ mek yu nɔ gɛt bɔku sayd ɛfɛkt dɛn.
Medikeshɔn dɛn we dɛn kin yuz fɔ it
Di we aw fɔ tek dɛn pils ya rili spɛshal. Yu fɔ fala di dɔktɔ in instrɔkshɔn dɛn di rayt we.
- Yu fɔ tek di pil na mɔnin, bifo yu it ɔ drink ɛnitin (we yu ɛmti bɛlɛ) .
- Di pil fɔ jɔs tek wit wan ful glas wata (plɛn wata) . I nɔ fɔ tek dis mɛrɛsin wit tin dɛn lɛk ti, kɔfi, milk, ɔ frut drink.
- Di tin we impɔtant pas ɔl: Afta yu dɔn tek di mɛrɛsin, yu fɔ sidɔm ɔ tinap fɔ at le 30 to 60 minit . Nɔ ledɔm, ledɔm, ɔ slip fɔ ɛni rizin.
- Di rizin fɔ dis na bikɔs dis mɛrɛsin kin pwɛl di εsophagus. Dat risk kin dɔn we yu tinap bikɔs di mɛrɛsin kin pas kwik kwik wan na di bɛlɛ.
- I nɔ fayn fɔ it ɔ drink ɛni ɔda tin insay dis 30-60 minit tɛm. Afta da tɛm de dɔn, yu kin it brɛf lɛk aw yu kin it.
IV Mɛrɛsin dɛn
Yu nɔ go ebul fɔ du dis na os. Dɛn kin gi dis tritmɛnt na ɔspitul ɔ klinik. Dipen pan yu kɔndishɔn, dɛn kin gi dis injɛkshɔn (infushɔn) wan tɛm insay di ia ɔ ɛvri sɔm mɔnt.
We yu de tek dis mɛrɛsin, bɔku tɛm yu dɔktɔ go tɛl yu fɔ it tin dɛn we gɛt bɔku kalsiɔm (milk, yogɔt, chiz, smɔl fish) ɛn tek wan vaytamɛn D sɔpɔtmɛnt , bikɔs dɛn tu tin ya impɔtant fɔ mek yu bon dɛn strɔng.
Wetin na di sayd ɛfɛkt dɛm we bisphosphonates kin gɛt?
Jɔs lɛk ɛni ɔda mɛrɛsin, sɔm bad bad tin dɛn kin apin. Bɔt nɔ wɔri, bɔku pan dɛn na smɔl smɔl tin dɛn.
| Tayp fɔ mɛrɛsin | Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt |
|---|---|
| Mɛrɛsin we dɛn kin tek bay mɔt | Prɔblɛm dɛn we de na di bɛlɛ lɛk at bɔn, GERD, ɛsophagitis, bɛlɛ pen, ɛn ɔlsa. (Dɛn kin avɔyd dɛn tin ya bɔku tɛm if yu fala di kɔrɛkt we fɔ tek yu mɛrɛsin.) |
| Medikeshɔn we dɛn kin put insay di bɛlɛ (IV). | Di sayn dɛm we fiba di wan dɛm wae gɛt kol ɔr flu, lɛk fiva, bɔdi we de at, ed we de at, ɛn joyn ɛn mɔsul pen, kin apin fɔ wan ɔ tu dez afta yu dɔn tek di mɛrɛsin. Bɔku tɛm, dɛn tin ya kin go insay sɔm dez. |
Sayd ɛfɛkt dɛm wae nɔr kin bɔrku bɔt wae fayn fɔ no bɔt
Pan ɔl we dɛn tin ya nɔ kin bɔku , i impɔtant fɔ no bɔt dɛn.
- Osteonecrosis of the jaw: Dis risk kin rili smɔl, mɔ afta dɛn dɔn du ɔpreshɔn lɛk fɔ pul di tut. So if yu de tek dis mɛrɛsin, tɛl yu dɛntist ɛvri tɛm we yu si am.
- Atypical femur fractures: Dis na tin we nɔ kin apin so ɔltɛm pan pipul dɛn we de tek dis mɛrɛsin fɔ lɔng tɛm (mɔ pas 3-5 ia).
- Prɔblɛm na di yay: Inflameshɔn (uveitis, scleritis) na difrɛn pat dɛn na di yay kin apin.
Di tin we impɔtant pas ɔl na dat di risk fɔ brok bon bikɔs ɔf ɔstioporosis if yu nɔ tek dis mɛrɛsin na tawzin tɛm pas di rili smɔl risk fɔ dɛn sayd ɛfɛkt ya. So, i rili impɔtant fɔ fala wetin yu dɔktɔ tɛl yu fɔ du.
Ustɛm yu want fɔ si di dɔktɔ bak?
If yu de tek dis mɛrɛsin, i impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ chɛk if di mɛrɛsin de wok ɛn if ɛni sayd ɛfɛkt de. Dɛn kin sɛn yu bak to bon spɛshal dɔktɔ (Endocrinologist ɔ Rheumatologist).
Yu dɔktɔ kin tɛl yu bak fɔ mek yu du DXA skan fɔ si aw yu bon dɛn tan.
Speshal Notis: If yu dɔn de yuz dis mɛrɛsin fɔ pas tri ia ɛn yu gɛt nyu pen na yu shɔl ɔ yu groin, nɔ ignore am ɛn tɛl yu dɔktɔ wantɛm wantɛm.
Mɛsej we dɛn kin kɛr go na os
- Bisphosphonates na wan mɛrɛsin we rili wok we de ɛp fɔ mek di bon dɛn we wik bikɔs ɔf ɔstioporosis strɔng.
- Dɛn mɛrɛsin ya kin wok bay we dɛn kin slo di rit we di bon dɛn kin lɔs.
- We yu de tek mɛrɛsin we yu de it, i impɔtant fɔ drink am ɛmti bɛlɛ, wit wata nɔmɔ, ɛn fɔ tinap ɔ sidɔm fɔ 30-60 minit afta yu tek di mɛrɛsin.
- Pan ɔl we smɔl smɔl sayd ɛfɛkt dɛn kin apin, siriɔs sayd ɛfɛkt dɛn nɔ kin apin so ɔltɛm. Di bɛnifit dɛn we di mɛrɛsin de gi pas di prɔblɛm dɛn fa fawe.
- If yu gɛt ɛni kwɛstyɔn, wɔri, ɔ dawt bɔt dis mɛrɛsin, tɔk to yu dɔktɔ bɔt am opin wan. Nɔ ɛva stɔp fɔ tek yu mɛrɛsin if yu nɔ gɛt dɔktɔ advays.
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