Yu kin gɛt maygren bak bɔku tɛm? Bikɔs yu nɔ ebul fɔ bia di bad bad pen we yu de fil, yu fɔ put ɔl di wok dɛn we yu de du na di de, sidɔm na dak rum ɛn lɔk yu yay? If na so i bi, nɔto yu wangren de. Bɔrku pipul kin sɔfa wit dis prɔblɛm wae dɛn kɔl maygren. So, tide wi go tɔk bɔt wan nyu klas fɔ drɔgs we de ɛp fɔ kɔntrol dis sik we dɛn kɔl maygren, ɛn dɛn spɛshal fɔ am.
Fɔ tɔk am simpul wan, wetin na dɛn CGRP Inhibitors ya?
CGRP inhibitors na spɛshal kayn mɛrɛsin we dɛn kin tek afta dɔktɔ in prɛskrishɔn. Dɛn kin yuz dɛn mɔ fɔ mɛn maygren ed we de at.
If yu gɛt maygren ɔltɛm, we kin rili bad, we na maygren we kin de fɔ lɔng tɛm , yu dɔktɔ kin gi yu dis mɛrɛsin. Sɔntɛnde dɛn kin yuz am bak fɔ trit di maygren we kin gɛt wan tɛm .
Aw dis mɛrɛsin de wok insay di bɔdi?
Dɛn kɔl dɛn mɛrɛsin ya CGRP inhibitor bikɔs ɔf di we aw dɛn de wok. Di wɔd "inhibit" min "fɔ stɔp" ɔ "fɔ kɔntrol."
Naw lɛ wi luk wetin na CGRP. CGRP na abbrevieshɔn fɔ Calcitonin Gene-Related Peptide . Na prɔtin we dɛn kin mek na wi bɔdi bay wilful. כnda nכmal kכndishכn, dis CGRP protin de εp wi bכku. Fɔ ɛgzampul, i de ɛp fɔ kɔntrol blɔd prɛshɔn bay we i de mek wi blɔd vesel dɛn big (vasodilation).
Bɔt pan pipul dɛn we gɛt maygren, di bɔdi de mek bɔku mɔ pan dis CGRP protin pas aw i nid. dis CGRP we pasmak de mek di nεv dεm na di bren, we de mek di pen signal dεm wכs. I kin mek bak di pen kin te.
so, wetin di CGRP inhibito dεm de du na fכ stכp di akshכn fכ di CGRP protin we dεn prodyuz pasmak, we de kכntro di biginin εn di siriכs pen.
Tu men kayn CGRP inhibito dεm de:
Dɛn kin sheb dis grup fɔ drɔgs to tu men kayn. Di we aw dɛn de wok difrɛn smɔl. Lɛ wi tek wan luk pan wetin dɛn bi.
| Tayp fɔ mɛrɛsin | Di we aw dɛn de du am | Ɛgzampul dɛn & Administreshɔn |
|---|---|---|
| CGRP monoklonal antibodi dεm (moAbs) . | Dis na spɛshal prɔtin dɛn we dɛn mek na di lab. Jɔs lɛk di antibodi dɛm we de fɛt di jem dɛm na wi bɔdi. bכt dεn ya nכ de fכt di jεm dεm, dεn de fכt di εksyכs CGRP protin dεm na di bכdi. We dis drɔg go insay di bɔdi, i de luk fɔ di CGRP we pasmak ɛn i de mek i nɔ wok. I tan lɛk sekyuriti gad dɛn we dɛn tren spɛshal wan. |
Yu kin gi yusɛf injɛkshɔn ɔnda di skin na os. Yu dɔktɔ go sho yu aw fɔ du am. |
| CGRP rεsεptכr antagonist dεm (gepants) . | Di bɛst we fɔ ɔndastand aw dis de wok na fɔ tink bɔt am lɛk gem we dɛn kin ple myuzik chia dɛn. imajin se di CGRP protin gεt spεshal ‘chairs’ (rεsεptor) dεm we i de atak pan pan nεv dεm na di bren. Wetin dis drɔg de du na fɔ rɔsh fɔ grap dɛn chia dɛn de bifo CGRP ebul fɔ rich to dɛn. So we CGRP dɔn dɔn wit chia fɔ sidɔm pan, i nɔ kin ebul fɔ atak di nɛv dɛn ɛn mek pɔsin fil pen. |
Sɔm pan dɛn kayn mɛrɛsin ya kin yuse bak fɔ kɔntrol di maygren simptom dɛm afta dɛn dɔn apin. |
Wetin na di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi?
CGRP inhibitors na di fɔs klas fɔ drɔgs we dɛn mek spɛshal fɔ protɛkt ɛn trit maygren. If yu yuz dɛn mɛrɛsin ya, dat go ɛp yu:
- Di frɛkuɛns we maygren kin gɛt kin go dɔŋ. Fɔ pɔsin we bin de gɛt lɛk tɛn maygren insay wan mɔnt, di nɔmba kin go dɔŋ to tu ɔ tri.
- Ivin if maygren apin, di kayn we aw i kin tranga ɛn di tɛm we i kin tek go stɔp. Di pen we bin de de fɔ tu ɔ tri dez kin stɔp insay sɔm awa.
- Sɔm maygren nɔ kin apin ɔltogɛda.
Ɛni bad bad tin dɛn de we kin apin to am?
Lɛk ɛni mɛrɛsin, dɛn mɛrɛsin ya kin mek sɔm pipul dɛn gɛt sayd ɛfɛkt. Bɔt bɔku tɛm, dɛn tin ya nɔ kin rili siriɔs.
Kɔmɔn sayd ɛfɛkt dɛn
- Bak pen
- Kɔnstipɛshɔn ɔ dayarɛa
- Dray mɔt
- Nɔmbɔdi (paresthesia) .
- Pen na di jɔyn dɛn
- Nɔs ɛn vɔmit
- Ɔda kɔmɔn ed pen we nɔto maygren
- Pen ɔ rɛd usai dɛn gi di injɛkshɔn ɔ usay dɛn gi di mɛrɛsin insay wan vein
Rare bɔt impɔtant kɔndishɔn dɛn fɔ wach fɔ
- di εlevεt liva εnzym lεvεl dεm (transaminitis) .
- Liva we dɔn pwɛl
- Di vishɔn we nɔ klia
Di tin we impɔtant pas ɔl na fɔ tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni wan pan dɛn bad bad tin ya . Nɔ fred fɔ tɔk bɔt am.
Aw kwik a go bigin fɔ fil fayn?
Yu nɔ go fil ɛni fridɔm wantɛm wantɛm afta yu dɔn bigin fɔ tek dis mɛrɛsin. Bɔku tɛm, i kin tek wan ɔ tu mɔnt fɔ mek yu bigin fɔ si di tin dɛn we kin apin. Aw yu kin fil fri kwik kwik wan kin dipen pan sɔm tin dɛn.
- Di kayn CGRP inhibitor we dɛn dɔn gi yu
- Aw ɔltɛm yu kin gɛt maygren?
- Di kayn we aw di maygren simptom dɛn kin siriɔs
- Yu ɔvalayn wɛlbɔdi stetmɛnt
Yu dɔktɔ go ɛksplen ɔl dis to yu, so i impɔtant fɔ peshɛnt te yu gɛt di rizɔlt.
Yu want fɔ si di dɔktɔ bak?
Yɛs, na fɔ tru. Afta yu bigin fɔ tek dis mɛrɛsin, yu fɔ fala yu dɔktɔ ɔltɛm lɛk aw dɛn tɛl yu. Dɔn yu dɔktɔ kin si aw dis mɛrɛsin de wok fɔ yu fayn fayn wan.
We yu go to yu dɔktɔ, mek shɔ se yu tɔk bɔt dɛn tin ya:
- Yu tink se di frɛkuɛns we pipul dɛn kin gɛt maygren dɔn go dɔŋ?
- Yu tink se di kayn pen we pɔsin kin fil dɔn go dɔŋ?
- Yu bin gɛt ɛni bad bad tin we apin to yu?
- Yu gɛt ɛni kwɛstyɔn bɔt aw fɔ gɛt vaysin na os?
Sɔntɛm yu dɔn yus to di filin fɔ maygren we tan lɛk se i go las sote go. Dis CGRP inhibitor mɛrɛsin kin ɛp yu fɔ pul da anɔynt, frustrate filin de ɛn kam bak to yu nɔmal layf. Yu kin stil gɛt maygren wan wan tɛm, bɔt i nɔ go tranga lɛk aw i bin de ɛn i nɔ go ambɔg di tin dɛn we yu de du ɛvride. Bifo yu bigin fɔ tek nyu mɛrɛsin, aks yu dɔktɔ ɛni kwɛstyɔn we yu gɛt bɔt am.
Mɛsej we dɛn kin kɛr go na os
- CGRP inhibitors na nyu, saksesful klas ɔf drɔgs we dɛn mek spɛshal fɔ trit maygren.
- Dɛn tin ya de wok bay we dɛn de blok wan prɔtin we dɛn kɔl CGRP, we de mek di maygren pen bɔku.
- Dɛn mɛrɛsin ya kin kam lɛk injɛkshɔn, mɛrɛsin we dɛn kin put insay dɛn bɛlɛ, tablɛt we dɛn kin tek bay mɔt, ɛn sprɛy na in nos.
- Dɛn mɛrɛsin ya kin rili ridyus di frɛkuɛns ɛn di kayn we aw pɔsin kin gɛt maygren.
- Tɛl yu dɔktɔ wantɛm wantɛm bɔt ɛni bad bad tin we go apin to yu.
- Dɛn mɛrɛsin ya na mɛrɛsin dɛn we dɛn kin gi pɔsin ɛn dɛn nɔ fɔ ɛva yuz dɛn if dɔktɔ nɔ gi dɛn advays.
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