Yu kin dɔn si sɔmbɔdi na yu famili, yu fambul ɔr yu padi de du tritmɛnt fɔ kansa. Yu fɔ dɔn yɛri bɔt di tritmɛnt we dɛn kɔl "Kemotherapy" we yu de du dis kayn tritmɛnt. Yu go mɔs no bak se we dɛn de du dis kemo tritmɛnt, di nɔmba fɔ di wayt blɔd sɛl dɛn we de fɛt sik dɛn na di bɔdi kin go dɔŋ. Insay dis kayn tin, insay dis atikul, wi go tɔk bɔt wan spɛshal mɛrɛsin we dɔktɔ dɛn kin yuz fɔ ɛp wi bɔdi in difɛns sistɛm. Dat na G-CSF.
Wetin na G-CSF rili?
Fɔ tɔk am simpul wan, G-CSF na wan mɛrɛsin we de ɛp wi bɔdi fɔ mek mɔ wayt blɔd sɛl dɛn , mɔ wan kayn we dɛn kɔl "nyutrofil."
Imajin se wi bɔdi tan lɛk kɔntri. Dɔn dɛn nyutrofil ya tan lɛk di sojaman dɛn na da kɔntri de. Na dɛn sojaman ya we dɛn kɔl nyutrofil de fɛt agens di jem dɛn we de na do, dat na, ɛnimi dɛn lɛk baktri ɛn vayrɔs, ɛn protɛkt wi frɔm sik ɛn infɛkshɔn. So wetin go apin if dɛn sojaman dɛn ya go dɔŋ? Wi kɔntri, dat na wi bɔdi, kin izi fɔ gɛt sik.
Pan ɔl we di nem G-CSF kin tan lɛk se i kɔmplikt smɔl, if wi brok di minin we i min, i rili simpul.
- Granulocyte: Dis na di nem we dɛn kin gi wan kayn wayt blɔd sɛl. Nyutrofil dεm na wan kayn granulosayt dεm bak.
- Koloni-Stimulating Factor: dis na sכmtin we de "כda" כ "stimulate" sεl dεm. lεk fכktri manija we de gi wok to wokman dεm, dis protin de go na wi bon mכro εn se, "Okay, stat fכ mek nyutrofil naw."
So wetin dis dכg we dεn kכl G-CSF de du na we i de go na di bon mכro , we na di pat we lεk sכpכn insay wi bon dεm, εn i de tεl di stεm sεl dεm we de de, "Una fכ bi nyutrofil kwik kwik wan, εn di nyutrofil dεm we de de fכ divayd εn mכltiply." Dɔn dɛn nyutrofil sojaman dɛn ya we dɛn jɔs dɔn mek kin jɔyn di blɔd ɛn bigin fɔ wok fɔ protɛkt wi.
di impɔtant tin na dat, pan ɔl we G-CSF na sɛntetik drɔg, i de falamakata di prɔses we wan prɔtin we dɛn kin mek na wi bɔdi na wi bɔdi.
Insay us sityueshɔn dɛn dɛn kin yuz G-CSF?
G-CSF na dεn kin yus mεntal wan fכ trit εn prεvεnt wan kכndyushכn we dεn kכl "nyutropenia." Nyutropenia na jɔs wan nɔmba we smɔl pas di nɔmal nyutrofil dɛn we de na di blɔd.
Na tritmɛnt fɔ kansa (Kɛmotɛrapi) .
Dɛn mek di kemotɛrapi mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn kansa fɔ kil di kansa sɛl dɛn we de sheb kwik kwik wan. Bɔt dɛn mɛrɛsin ya nɔ kin ebul fɔ no di kansa sɛl dɛn nɔmɔ, bɔt dɛn nɔ kin ebul fɔ no di sɛl dɛn we gɛt wɛlbɔdi ɛn we kin sheb kwik kwik wan na wi bɔdi. So, bikɔs nyutrofil dɛn we dɛn kin mek na di bon mɛro, dɛnsɛf na wan kayn sɛl we kin sheb kwik kwik wan, dɛn kin pwɛl dɛn bak bikɔs ɔf kemo drɔgs.
Dis tan lɛk fɔ sprɛy ɛbisayd fɔ pul gras, bɔt i kin pwɛl gud plant dɛn bak.
Dis na di rizin we mek nyutropenia kin rili kɔmɔn afta dɛn dɔn tek kimotɛrapi. If dis sik kam tranga, ivin smɔl infekshɔn kin mek pɔsin in layf de pan denja. If dɛn kayn tin ya apin, dɔktɔ dɛn kin se G-CSF fɔ mek i nɔ gɛt di sik ɛn fɔ mek di bɔdi ebul fɔ protɛkt insɛf bak.
Insay wan stem sɛl transplant
Insay sɔm kayn kansa ɛn blɔd dizayd, dɛn kin nid fɔ transplant stem sɛl. Dɛn kin yuz G-CSF bifo ɛn afta dis prɔsidyu.
- Bifo di transplant: We dɛn gi di pɔsin G-CSF, di bon mɛro kin mek bɔku bɔku stem sɛl dɛn ɛn pul dɛn insay di blɔd. Dɔn dɔktɔ dɛn kin gɛda dɛn wɛlbɔdi stem sɛl dɛn de frɔm di blɔd.
- We dɛn de transplant am: Dɔn, di kemotɛrapi ɔ redyushɔn tɛrapi we dɛn kin tek bɔku mɔni kin pwɛl ɛni sɛl we lɛf na di bɔdi we nɔ fayn.
- afta di transplant: fכ finish, di hεlty stεm sεl dεm we dεn bin dכn kכlekt bifo dεn de introdכks bak insay di bכdi. Leta dɛn sɛl dɛn ya go bi nyu blɔd sɛl dɛn we gɛt wɛlbɔdi.
If yu na stem sel dona, yu kin nid bak fɔ gɛt G-CSF injɛkshɔn bifo di prɔsidyu.
Ɔda kɔndishɔn dɛn we kin mek nyutrofil dɛn smɔl
di nyutrofil lεvεl dεm kin lכw bak bikoz fכ sכm kכndishכn dεm we de we dεn bכn am (sivεri kכnεjital nyutropenia) כ insay kes dεm we dεn nכ no di kכz (idiopathic neutropenia). insay dεn kayn kes dεm ya, dεn de yuz G-CSF fכ inkrεs di nyutrofil lεvεl dεm.
Di kayn G-CSF ɛn aw dɛn kin gi dɛn
G-CSF de na di makit ɔnda difrɛn nem dɛn. Di tu kayn dɛn we dɛn kin yuz mɔ na:
1. Filgrastim: Dis na wan kayn we we de akt fɔ shɔt tɛm. Bɔku tɛm, dɛn nid fɔ gi am as injɛkshɔn ɛvride.
2. Pegfilgrastim: Dis na wan we fɔ di mɛrɛsin we de wok fɔ lɔng tɛm, so bɔku tɛm i kin du fɔ gɛt jɔs wan injɛkshɔn bitwin tu rawnd kemotɛrapi.
Dɛn mɛrɛsin ya de ɔnda difrɛn brand nem ɛn biosimilars. Fɔ ɛgzampul, yu dɔktɔ kin ebul fɔ tɛl yu bɔt nem dɛn lɛk Neupogen®, Neulasta®, Nivestym®, ɛn Zarxio®.
| Tayp fɔ G-CSF | Nɔmba fɔ di tɛm dɛn we dɛn gi (bɔku tɛm) . |
|---|---|
| Filgrastim (fɔ shɔt tɛm) . | Ɛvride (fɔ sɔm dez ɔ wik) . |
| Pegfilgrastim (we kin tek lɔng tɛm) . | Wan tɛm pan ɛni kemo saykl |
Aw dɛn kin gi dis mɛrɛsin to di bɔdi?
Dɛn kin gi G-CSF as injɛkshɔn we de ɔnda di bɔdi , bɔt insay sɔm kes dɛn dɛn kin gi am bak as IV infushɔn .
- Yu kin gɛt fɔ go na di klinik ɛvride fɔ gɛt di vaysin.
- Ɔ, nɔs go tich yu ɔ yu fambul klia wan aw fɔ injekt di vaysin na os. I nɔ at so.
Yu tink se ɔlman nid G-CSF?
Nɔ, dɛn nɔ kin gi G-CSF to ɔlman we de du kemotɛrapi ɔ we gɛt smɔl nyutrofil. Lɛk ɛni mɛrɛsin, G-CSF gɛt bɛnifit dɛn ɛn sɔm risk dɛn bak fɔ gɛt sayd ɛfɛkt dɛn. Yu dɔktɔ go tink bɔt sɔm tin dɛn bifo yu gi yu dis mɛrɛsin.
- yu ej
- Yu ɔvalayn wɛlbɔdi stetmɛnt
- Di kayn kansa we yu gɛt
- Di kayn kemotɛrapi we yu de gɛt
- If yu dɔn ɔlrɛdi gɛt sayn dɛn fɔ nyutropenia (lɛk fiva) .
So, na di dɔktɔ we de trit yu de disayd if dɛn nid G-CSF ɔ nɔ nid am. Yu nɔ nid fɔ wɔri bɔt am.
Benefit ɛn poshubul sayd ɛfɛkt dɛm fɔ G-CSF
If dɛn se yu fɔ yuz G-CSF, mɛmba se di bɛnifit dɛn pas di prɔblɛm dɛn fa fawe.
Di men bɛnifit dɛn we yu kin gɛt:
- Di risk fɔ gɛt siriɔs infɛkshɔn we kin mek pɔsin in layf de pan denja kin ridyus bad bad wan.
- If nyutrofil lɛvɛl smɔl, dat kin mek di kemotɛrapi nɔ delay ɔ ridyus di doz , we kin mek dɛn kɔntinyu fɔ gɛt kansa tritmɛnt lɛk aw dɛn bin dɔn plan.
Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt
Mɔs pan di sayd ɛfɛkt dɛn na fɔ shɔt tɛm nɔmɔ ɛn dɛn kin go afta dɛn dɔn stɔp G-CSF.
| Sayd ɛfɛkt we pɔsin kin gɛt | Diskripshɔn ɛn manejmɛnt |
|---|---|
| Kɔmɔn sayd ɛfɛkt dɛn | |
| Pen na di bon ɛn mɔsul dɛn | Dis na di sayd ɛfɛkt we dɛn kin gɛt mɔ. i tan lεk "growing pains" biכs di bon mכro de mek tu mכch sεl dεm wan wan. Yu kin aks yu dɔktɔ bɔt aw fɔ tek wan mɛrɛsin we de mek yu fil pen lɛk paracetamol. |
| Taya | Yu kin fil taya bikɔs yu bɔdi de yuz mɔ ɛnaji fɔ mek nyu sɛl dɛn. Gɛt bɔku rɛst. |
| Ɛd pen, nɔs, dayarɛa | Bɔku tɛm, dɛn tin ya nɔ kin at fɔ du. Di dɔktɔ go gi yu di rayt mɛrɛsin fɔ dɛn tin ya. |
| Rɛd, it, ɔ pen na di say we dɛn injekt | Bɔku tɛm, dis kin go insay wan ɔ tu dez. |
| Siriv (bɔt nɔ kin apin so ɔltɛm) simptom dɛm wae fɔ ripɔt to dɔktɔ kwik kwik wan | |
| Sayn dɛn we de sho se pɔsin gɛt infekshɔn | Fiva, kol, trot we de at, kɔf. Dɛn tin ya kin bi sayn fɔ se yu gɛt infekshɔn. Tɛl yu dɔktɔ wantɛm wantɛm. |
| Simptom dɛm fɔ wan alɛji riakshɔn | Skin rash, it, swel na yu fes ɔ lip, i nɔ izi fɔ blo. Dis na imejensi. Go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm. |
| Shap pen na di ɔp lɛft pat na di bɛlɛ | Dis kin bi sayn fɔ wan prɔblɛm we nɔ kin apin so ɔltɛm wit di splin. |
| Di an ɛn fut dɛn kin swel wantɛm wantɛm, i nɔ kin izi fɔ blo | dis kin bi sayn dεm fכ rili rare bכt siriכs kכndyushכn lεk kapilari lik sεndrכm כ ARDS. Go to dɔktɔ wantɛm wantɛm. |
Tin dɛn fɔ mɛmba we yu de tek G-CSF
- Tɛl yu dɔktɔ yu kɔmplit mɛdikal istri. Mek shɔ se yu tɛl am bɔt ɛni ɔda sik we yu gɛt ɛn ɛni ɔda mɛrɛsin we yu de tek (inklud vaytamɛn).
- I nɔ fayn fɔ tek G-CSF if yu gɛt bɛlɛ, yu de tray fɔ gɛt bɛlɛ, ɔ yu de gi pikin in bɛlɛ . Tɔk to yu dɔktɔ bɔt dis.
- Nɔ wɔri bɔt di sayd ɛfɛkt dɛn. If yu gɛt ɛni sayd ɛfɛkt, tɛl yu dɔktɔ ɔ nɔs. Dɛn go ɛp yu fɔ manej dɛn.
- Mek dɛn du yu blɔd tɛst di rayt tɛm. Yu dɔktɔ go chɛk yu nyutrofil lɛvɛl ɛn no aw lɔng yu nid fɔ gɛt tritmɛnt.
G-CSF na wan rili impɔtant adjɔnt na di kansa tritmɛnt prɔses. I de gi big bɔst fɔ mek di tritmɛnt dɛn we dɛn kin gi di kemotɛrapi sef ɛn gɛt mɔ sakrifays. If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, duya nɔ shem fɔ aks yu dɔktɔ we de trit yu.
Mɛsej we dɛn kin kɛr go na os
- G-CSF na wan mɛrɛsin we de mek wan kayn wayt blɔd sɛl we dɛn kɔl nyutrofil na di bɔdi bɔku.
- Dis kin ridyus di risk fɔ gɛt siriɔs infɛkshɔn we kin apin we dɛn de trit di kemotɛrapi.
- Bɔn ɛn mɔsul pen na di sayd ɛfɛkt we kin apin pas ɔl ɛn bɔku tɛm dɛn kin ebul fɔ kɔntrol am.
- If yu gɛt fiva, i nɔ izi fɔ blo, ɔ yu gɛt siriɔs alɛji, tɛl yu dɔktɔ wantɛm wantɛm ɔ go na ɔspitul.
- If yu gɛt ɛnitin fɔ wɔri bɔt dis mɛrɛsin, nɔ ɛva shem fɔ tɔk bɔt am wit yu dɔktɔ.
💬 Comments (0)
No kɔmɛnt nɔ de yet. Ad yu kɔmɛnt ya fɔ di fɔs tɛm.
Ad yu kɔmɛnt