Wetin na HNPCC (Hɛridit Nɔnpɔlipɔsis Kɔlɔrektal Kansa)? Yu tink se i dɔn gɛt kansa na yu famili?

Sɔntɛnde, wi kin si se sɔm pipul dɛn na wan famili kin gɛt di sem kayn kansa. Ɔ dɛn kin se pipul dɛn we de na di sem famili kin gɛt dis sik pasmak. Na dat wi go tɔk bɔt tide. Pan ɔl we dis na tɔpik we kɔmplikt smɔl, lɛ wi tray fɔ ɔndastand am simpul wan.

Wetin na HNPCC ɛn Lynch Syndrome?

Fɔ tɔk am simpul wan, HNPCC (Hereditary Nonpolyposis Colorectal Cancer) na wan kayn kɔlorektal kansa we kin kam bikɔs ɔf di jɛnɛtik muteshon. Dis na bikɔs sɔm jin dɛn we wi kin gɛt frɔm wi mama ɛn papa kin mek wi gɛt kansa sɛl dɛn.

Sɔntɛm yu dɔn yɛri bɔt Lynch syndrome, we dɛn kin kɔl bak Lynch syndrome . HNPCC ɛn Lynch syndrome rili gɛt fɔ du wit dɛnsɛf, bɔt dɛn nɔr rili di sem. Wi kin kɔl HNPCC spɛshal wan as kansa we gɛt fɔ du wit Lynch sindrom we dɛn dɔn no bifo i ol 50. Dis kin inklud nɔto jɔs kansa na di kɔlon, bɔt i kin inklud bak kansa na di layn na di uterus (ɛndometrium), smɔl intestinal, ureter, ɛn rεnal pelvis. Insay HNPCC, di kansa kin bɔku pas ɔl na di rayt say na di kɔlon.

Aw kɔmɔn tin fɔ HNPCC?

HNPCC de mek bitwin 2% εn 4% pan כl di kכlכrektal kεnsar dεm. I kin apin pan ɛni ej, bɔt bɔku tɛm di sayn dɛm kin sho ɛn dɛn kin no di sik bifo i ol 50 ia.

Wetin na di sayn dɛm fɔ HNPCC?

Insay di fɔs stej, HNPCC nɔ kin kɔz ɛni sayn. Dis min se di kansa kin gro insay yu bɔdi we yu nɔ fil natin. Bɔt as di kansa de gro, yu kin gɛt sɔm sayn dɛn lɛk:

• Bɛlɛ de pen ɔ blo.
• Di it nɔ de te.
• Blɔd we de na di stɔl. (Dis na sayn we rili impɔtant, nɔ ignore am!)
• Fɔ fil taya ɔltɛm (Fatigue).
• We yu de lɔs yu wet we yu nɔ gɛt klia rizin.

Wetin na di tin dɛn we kin mek pɔsin gɛt HNPCC?

As wi bin se, HNPCC de kכz fכ di jin mכtεshכn we wi mama εn papa gεt. We dɛn kin pas dɛn jɛnɛreshɔn ya we nɔ fayn frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn, di risk fɔ gɛt kansa kin bɔku na da famili de. Wi kin kɔl dis ‘famili kansa sindrom’.

Di men famili kansa sindrom we de mek HNPCC na Lynch sindrom . i de kכz fכ di mכtεshכn dεm na di jin dεm MLH1, MSH2, MSH6, PMS2, εn EPCAM . di wok we dεn jin dεm ya de du na fכ kכrekt mistek dεm we de apin we di DNA de rεplik we wi sεl dεm de sheb. Imajin, if dɛn jin ya nɔ de wok fayn, dɛn nɔ go kɔrɛkt dɛn mistek dɛn de. Dɔn di chans fɔ mek di nɔmal sɛl dɛn bi kansa sɛl dɛn kin bɔku pasmak.

Yu tink se HNPCC kin pas?

Nɔ, HNPCC nɔto sik we pɔsin kin pas. Dis min se i nɔ de skata frɔm wan pɔsin to ɔda pɔsin bay we i tɔch ɔ sniz. כltu, di jin mכtεshכn we de mek HNPCC de pas dכn frכm jεnereshכn to jεnereshכn . So, sɔm pipul dɛm na di famili dɛm we gɛt dis jin muteshon kin gɛt kɔlon kansa ɔ ɔda kansa dɛm we gɛt fɔ du wit Lynch syndrome.

di impɔtant tin na dat dis jin we nɔ fayn ɛn di risk fɔ gɛt HNPCC kin kɔmɔt frɔm mama ɛn papa to pikin dɛn.

Aw dɔktɔ dɛn kin no se pɔsin gɛt kansa na in kɔlon?

Bɔku tɛm, dɔktɔ dɛn kin du wan ɛgzam fɔ di bɔdi fɔ chɛk if i gɛt kansa na di bɔdi. Dɔn dɛn kin se yu fɔ du kɔlon skɔpi , we min se yu fɔ put smɔl tiub we gɛt layt tru yu an fɔ chɛk di insay pat na yu kɔlon.

If ɛnibɔdi na yu famili gɛt HNPCC, yu fɔ rili tɛl yu dɔktɔ . I rili impɔtant.

Us tɛst dɛn kin du fɔ kɔnfɔm HNPCC?

Yu dɔktɔ kin se yu fɔ tɛst yu jɛnɛtiks fɔ no if yu gɛt di jin we gɛt fɔ du wit di sik we dɛn kɔl Lynch syndrome. Yu dɔktɔ go aks bak bɔt:

• Ɛnibɔdi na yu fambul we de nia yu (mama, papa, brɔda ɛn sista dɛn) dɔn ɛva gɛt kansa na yu kɔlon? Ɛspɛshali if dɛn bin no se i gɛt am bifo i ol 50 ia.
• I de mek shɔ bak se yu nɔ gɛt ɔda kɔlon kansa we yu kin gɛt frɔm yu mama ɛn papa we dɛn kɔl Familial Adenomatous Polyposis (FAP) , we kin kɔmɔt frɔm difrɛn jɛnɛtik muteshon pas HNPCC.

Yu tink se ɔpreshɔn nid fɔ de fɔ HNPCC?

Yɛs, bɔku tɛm dɛn kin trit HNPCC wit ɔpreshɔn. Dɛn kɔl dis ɔpreshɔn kɔlektɔmi . I min fɔ pul wan pat ɔ ɔl di big intestinal. Bɔku kayn ɔpreshɔn dɛn de:

• pat pan di kכlekכmi כ sεgmεnt kכlektomi: insay dis, na di pat pan di kכlon we gεt kεnsar nכmכ dεn kin pul.
• Procterctomy: Dis involv fɔ pul di kɔlon ɛn di rεktum.
• Tכtal kolεktomi: insay dis, dεn de pul di כl kכlon.

Us ɔda tritmɛnt dɛn de fɔ HNPCC?

If kɔlon kansa dɔn skata (metastasized) to ɔda pat dɛn na di bɔdi, yu dɔktɔ kin tɛl yu fɔ du tritmɛnt dɛn lɛk:

• Kimotɛrapi: Dis kin min fɔ gi mɛrɛsin fɔ pwɛl di kansa sɛl dɛn.
• Immunotherapy: Dis kin min fɔ mek wi yon bɔdi in imyun sistɛm ebul fɔ fɛt di kansa sɛl dɛn.

Bɔku tɛm, dɔktɔ dɛn kin lɛk fɔ yuz imyunotɛrapi bikɔs bɔku tɛm i kin wok fayn ɛn i nɔ kin gɛt bɔku sayd ɛfɛkt dɛn.

Yu tink se dɛn kin ebul fɔ stɔp HNPCC?

Dɛn famili kansa sindrom ya kin kam bikɔs ɔf di chenj dɛn we dɛn kin gɛt frɔm di jɛnɛtiks. So, no we nɔ de fɔ mek dɛn chenj dɛn ya we de na di jɛnɛtiks nɔ apin . Bɔt if pɔsin na yu famili gɛt Lynch syndrome ɔ HNPCC, i rili impɔtant fɔ tɔk to yu dɔktɔ bɔt if yu fɔ du yu jenɛtik tɛst bak.

Fɔ chɛk ɔltɛm ɛn if nid de, fɔ du ɔpreshɔn fɔ mek dɛn nɔ gɛt di sik kin ridyus di risk fɔ day pan pipul dɛn we gɛt HNPCC.

Aw a go no if a de pan denja fɔ gɛt HNPCC?

If yu jenɛtik tɛst sho se yu gɛt wan jin muteshon we gɛt fɔ du wit Lynch syndrome, yu dɔktɔ kin se yu fɔ chɛk fɔ kɔlorektal kansa frɔm yu 20 ia . If dɛn no se kansa kwik kwik wan, di chans fɔ mek dɛn gɛt di tritmɛnt we go wok fayn kin bɔku.

If a gɛt HNPCC, wetin ɔda tin a fɔ ɛkspɛkt?

If yu gɛt HNPCC, yu kin gɛt mɔ risk fɔ gɛt ɔda kansa dɛn we gɛt fɔ du wit HNPCC. So yu dɔktɔ kin chɛk yu ɔltɛm bak fɔ dɛn kayn kansa ya:

• Bren kansa
• Kidni kansa
• Kansa na di liva
• Kansa na ovarian
• Bɛlɛ kansa
• Kansa na di skin
• Kansa we de na di uterin/Endometrial

Yu tink se HNPCC kin mɛn?

Lynch syndrome nɔr kin wɛl ɔl bikɔs na wan sik wae de kam pan pɔrsin in jɛnɛtiks. Bɔt ɔpreshɔn fɔ pul di wan ol kɔlon (tɔtal kɔlektɔmi) kin trit HNPCC ɛn mek di kɔlon kansa nɔ kam .

Wetin na di prɔgnosis fɔ pipul dɛm wae gɛt HNPCC?

Na lɛk 60% pan di pipul dɛn we dɛn no se gɛt HNPCC stil de alayv afta fayv ia . Dat min se 60 pan 100 pasɛnt dɛn stil de alayv fayv ia afta dɛn dɔn no se dɛn gɛt HNPCC. Di ɔvala 10 ia sɔvayv rɛt fɔ pipul dɛm wae gɛt Lynch syndrome de bitwin 70% ɛn 88%. Dɛn statystik ya kin tan lɛk se i de mek pɔsin fred, bɔt mɛmba se if dɛn no am kwik ɛn trit am fayn, dɛn kin ebul fɔ kɔntrol dis sik bɔku tɛm .

Aw a go tek kia ɔf misɛf if a gɛt HNPCC?

If yu gɛt ɛni nyu sayn fɔ kansa na yu kɔlon, tɛl yu dɔktɔ wantɛm wantɛm . Fɔ ɛp fɔ mek yu nɔ gɛt kansa na yu kɔlon, yu kin du dɛn tin ya:

• Nɔ smok.
• It tin dɛn we go mek yu gɛt wɛlbɔdi.
• Ɛksesaiz ɔltɛm.
• Gɛt ɔl di kansa skrinin dɛn we yu dɔktɔ tɛl yu fɔ du.
• Limit fɔ drink rɔm.
• Mek yu gɛt wɛlbɔdi wet.

Mi pikin de pan denja fɔ gɛt HNPCC?

If yu gɛt Lynch syndrome, yu pikin gɛt 50% chans fɔ gɛt di jin muteshon we de mek i gɛt am. Dis min se if yu gɛt tu pikin dɛn, wan kin gɛt di jin ɛn di ɔda wan nɔ kin gɛt am. if dεn gεt dis kayn jin mכtεshכn, da pikin de gεt hכy risk fכ divεlכp HNPCC.

FAP ɛn HNPCC kɔlon kansa na di sem?

HNPCC εn FAP (Familial Adenomatous Polyposis) na dεn tu jεnεtik kכlon kεnsar, bכt dεn kin kכz fכ m כtεshכn insay difrεn jin dεm .

Pipul wae gɛt FAP kin gɛt bɔrku polyp na dɛn kɔlon. Sɔntɛnde, bɔku bɔku pan dɛn smɔl smɔl tin ya kin de we dɛn kɔl pɔlip. Bɔt pipul dɛm wae gɛt HNPCC nɔr kin gɛt bɔrku pɔlip, ɛn sɔmtɛm kansa kin kam wae nɔr gɛt ɛni pɔlip. di polip dεm we de divεlכp na HNPCC kin bi flat.

di polip dεm we de divεlכp pan dεn tu kכndyushכn ya dεn kin tek dεm lεk prεkansa , we min se dεn kin tכn to kεnsar insay sכm tεm.

Di tin dɛn we impɔtant pas ɔl we wi nid fɔ mɛmba frɔm dis stori na

HNPCC (Hereditary Nonpolyposis Colorectal Cancer) na wan kayn kכlכrektal kεnsar we de kכz fכ wan jεnεtik dεfεkt we de pas dכn tru jεnereshכn. I gɛt fɔ du bak wit di sik we dɛn kɔl Lynch syndrome.

• If na famili histri bɔt kansa, i rili impɔtant fɔ tɔk to yu dɔktɔ bɔt am.
• Ivin if yu nɔr gɛt di sayn dɛm, if yu de pan denja , go gɛt skrinin ɔltɛm.
• If dɛn no am kwik, i go mɔs bi se di tritmɛnt go wok fayn.
• HNPCC nɔto sik we pɔsin kin gɛt, bɔt i kin kɔmɔt frɔm in jɛnɛtiks.
• I rili impɔtant fɔ liv fayn layf ɛn fala di advays we dɔktɔ gi yu.

If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, nɔ fred fɔ aks yu dɔktɔ. Dɛn go ɛp yu.

` HNPCC, Lynch sindrom, kolorektal kansa, kכlon kεnsar, rεktal kεnsar, jεnεtik mכtεshכn, hεridita kεnsar, kεnsar skrεnin, kכlonskכpi, כpεrayshכn, kεmothεrapi, imyuno tεrapi