Yu gɛt hATTR (hereditary transthyretin-mediated amyloidosis), we na wan jenɛtik kɔndishɔn we nɔ kin apin so ɔltɛm? Yu taya wit di pen we yu de fil ɔltɛm, yu nɔ de fil fayn, ɔ yu nɔ de fil fayn na yu an ɛn fut? If na so, yu dɔktɔ go dɔn tɛl yu bɔt wan vaysin we dɛn kɔl Inotersen. Tide, lɛ wi tɔk smɔl bɔt wetin na dis mɛrɛsin, wetin i de du, ɛn wetin yu nid fɔ tek tɛm we yu de yuz am.
Us kayn mɛrɛsin na Inotersen?
Fɔ tɔk am simpul wan, Inotersen na vaysin we dɛn kin gi fɔ trit di prɔblɛm dɛn we kin mit pipul dɛn we gɛt wan sik we dɛn kɔl hATTR . insay dis hATTR sik, wan protin we dεn prodyuz na wi bכdi de kכmכt mכr pas aw i nid εn i de pwεl di nεv dεm. Dis mɛrɛsin de wok bay we i de ridyus da prɔtin de we de gɛda na di bɔdi . Dɔn di sayn dɛm wae yu kin fil lɛk pen, yu bɔdi nɔr kin fil fayn, ɛn yu nɔr kin fil fayn na yu an ɛn fut, kin bigin fɔ stɔp smɔl smɔl. Yu kin fɛn dis mɛrɛsin na makit ɔnda di nem `(Tegsedi)`.
Tin dɛm wae yu fɔ tɛl yu dɔktɔ bifo yu tek dis mɛrɛsin
Bifo yu bigin fɔ tek dis mɛrɛsin, sɔm tin dɛn de we yu fɔ rili tɔk to yu dɔktɔ. Dis infɔmeshɔn rili impɔtant fɔ yu sef.
- If yu gɛt kidni sik: Tɛl wi bɔt ɛni kidni prɔblɛm.
- If yu blɔd sɛl nɔ bɔku: Fɔ ɛgzampul, if dɛn bin dɔn no se yu gɛt smɔl wayt blɔd sɛl, rɛd blɔd sɛl, ɔ pletlɛt, mek yu dɔktɔ no.
- If yu gɛt ɛni alɛji: Tɛl wi if yu gɛt alɛji to ɛni ɔda mɛrɛsin, it, ɔ day, nɔto jɔs to Inotersen.
- If yu gɛt bɛlɛ ɔ yu de plan fɔ gɛt bɛlɛ: I impɔtant fɔ tɛl yu dɔktɔ bɔt dis, bikɔs yu fɔ tek spɛshal kia wit mɛrɛsin dɛn insay dis tɛm.
- If yu na mama we de gi pikin in bɛlɛ: I impɔtant fɔ no bɔt dis ivin we yu de gi pikin in bɛlɛ.
Aw fɔ yuz di vaysin?
Dis na injɛkshɔn we dɛn kin put ɔnda di bɔdi . Nɔ wɔri, yu dɔktɔ ɔ nɔs go sho yu ɛksaktɔli aw fɔ injekt yusɛf. I rili impɔtant fɔ tek di injɛkshɔn jɔs lɛk aw yu dɔktɔ tɛl yu, di rayt de, ɛn di rayt amɔnt. Kɔntinyu fɔ yuz am te i tɛl yu fɔ stɔp.
I rili impɔtant: Nɔ ɛva trowe nidul ɛn sirinj dɛn we yu dɔn yuz na di dɔti. Dɛn fɔ put dɛn na spɛshal kɔntena we gɛt shap tin dɛn. If yu nɔ gɛt wan, aks yu dɔktɔ bɔt aw fɔ gɛt wan.
Yu go gɛt spɛshal instrɔkshɔn liflet ``(MedGuide)`` wit dis mɛrɛsin. Mɛmba fɔ tek tɛm rid am ɔltɛm.
Wetin fɔ du if yu tek bɔku mɛrɛsin?
If yu tink se yu dɔn tek bɔku mɛrɛsin, go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu wantɛm wantɛm . Ɔ kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital .
Wetin a go du if a mis wan doz fɔ tek mɛrɛsin?
Tek di doz we yu mis as yu mɛmba. Bɔt if yu nɛks doz nɔ rich tu dez, skip di doz we yu mis ɛn tek yu nɛks doz di tɛm we yu dɔn sɛtul. Nɔ ɛva tek tu doz wan tɛm, dat na, tu doz.
Ɔda tin dɛm wae kin miks wit dis mɛrɛsin
Yu fɔ tek tɛm bad bad wan if yu de tek ɔda mɛrɛsin dɛn we yu de tek dis mɛrɛsin, bikɔs dɛn kin miks. Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn, vaytamɛn dɛn, ɛn ɛbul mɛrɛsin dɛn we yu de tek.
Dis dɔŋ ya na sɔm mɛrɛsin dɛm wae kin miks wit dis mɛrɛsin.
| Kategori fɔ drɔgs | Ɛgzampul dɛn |
|---|---|
| Di tin dɛn we de mek blɔd tan | Warfarin, Enoxaparin, Aspirin, Klɔpidogrɛl, Apixaban, Rivaroxaban |
| Di tin dɛn we dɛn kin yuz fɔ mɛn pen (NSAID) . | Mɛrɛsin dɛn lɛk Ibuprofen ɛn Naproxen |
| Antibayɔtik ɛn ɔda mɛrɛsin fɔ sɔm infɛkshɔn dɛn | Asiklɔvir, Jɛntamisin, Vankomaysin, Amfɔterisin B |
| Diuretiks we dɛn kin yuz fɔ pul wata | Mɛrɛsin dɛn lɛk Furosemide |
| Ɔda mɛrɛsin dɛn | Sisplatin, Sayklɔspɔrin, Zoledrɔnik asid, Pamidronɛt |
Dis list nɔr de ɔlsay, so i bɛtɛ fɔ tɛl yu dɔktɔ bɔt ɔltin we yu de tek.
Tin dɛn we yu fɔ tek tɛm wit we yu de tek mɛrɛsin
- Si yu dɔktɔ ɔltɛm: Chek in wit yu dɔktɔ ɔltɛm fɔ si aw yu de du ɛn if di mɛrɛsin de wok. Tɛl dɛm if yu sik de wɔs ɔr nɔr de wɔs.
- Tek tɛm wit vaytamɛn A: Yu dɔktɔ kin tɛl yu fɔ tek vaytamɛn A sɔpɔtmɛnt we yu de tek dis mɛrɛsin. Dis na bikɔs dis mɛrɛsin kin ridyus di lɛvɛl we di vaytamɛn A de na di bɔdi. Tek vaytamɛn A sɔpɔtmɛnt lɛk aw yu dɔktɔ tɛl yu. Dɔn bak, tɔk to am bɔt di it we yu de it.
Wetin na di bad tin dɛn we kin apin to pɔsin?
Lɛk ɛni mɛrɛsin, dis wan kin mek sɔm pipul dɛn gɛt sayd ɛfɛkt. Sɔm siriɔs, sɔm kɔmɔn. I impɔtant fɔ no bɔt dɛn tin ya.
| Sayd ɛfɛkt we pɔsin kin gɛt | Tɔk bɔt |
|---|---|
| Tin dɛn fɔ tɛl yu dɔktɔ wantɛm wantɛm | |
| Alɛji we pɔsin kin gɛt | Skin rash, it, swel na di fes, lip, tong ɔ trot. |
| Kidni injury | di urine we de kכmכt dכn, di ankכl, an, כ fut de swel. |
| Liva injuri | Pen na di rayt say na di bɛlɛ, yu nɔ kin want fɔ it, yu nɔ kin fil fayn, yu skin ɔ yu yay kin yɔlɔ, yu kin gɛt dak yɔlɔ/brawn urine. |
| Blɔd ɔ brus we nɔ kɔmɔn | Fɔ fil lɛk se yu skin de brus izi wan, blɔd de kɔmɔt na yu nos ɔ yu gɔm. |
| Strok | Wan say we yu fes, yu an, ɔ yu leg kin swɛ/sum wantɛm wantɛm, i nɔ kin izi fɔ tɔk, i nɔ kin izi fɔ waka, i kin at fɔ ed bad bad wan. |
| If i kɔntinyu ɔ i de mɔna yu, tɛl yu dɔktɔ. | |
| Pen ɛn rɛdnɛs na di say we dɛn injekt | Riakshכn na di sayt we di injεkshכn de gi |
| Ed de at | |
| Vɔmit | |
| Fiva | |
| Taya | |
Aw yu kin kip di mɛrɛsin?
I rili impɔtant fɔ kip dis mɛrɛsin fayn fayn wan.
- Di bɛst we: Kip am na frij. Bɔt nɔ ɛva friz. Kip insay di ɔrijinal pak te yu rɛdi fɔ yuz.
- Ɔda we fɔ du am: Yu kin kip dis mɛrɛsin na rum tɛmpracha (bitwin 20-25 sɛlshiɔs) fɔ te 6 wik. Bɔt if yu du dat, yu fɔ protɛkt am frɔm layt ɛn ɔt. Trowe ɛnitin we lɛf afta 6 wik.
- Mek shɔ se yu kip am usay pikin ɛn animal dɛn we yu lɛk nɔ go ebul fɔ rich.
Nɔ ɛva trowe mɛrɛsin dɛn we dɔn pas ɔ we yu nɔ yuz na dɔti ɔ dɔŋ di tɔylɛt. Aks yu dɔktɔ aw fɔ trowe dɛn fayn fayn wan.I go tɛl yu di bɛst we fɔ du am.
Mɛsej we dɛn kin kɛr go na os
- Inotersen na vaysin fɔ nyurolɔjik dizayd we wan kɔndishɔn we dɛn kɔl hATTR kin kɔz.
- Bifo yu bigin fɔ tek di mɛrɛsin, tɛl yu dɔktɔ bɔt ɛni ɔda sik we yu gɛt ɛn ɔl di mɛrɛsin dɛn we yu de tek.
- Lan aw fɔ injekt di vaysin fayn fayn wan. Trowe di nidul dɛn we yu dɔn yuz fayn fayn wan.
- If yu gɛt ɛni siriɔs sayd ɛfɛkt, lɛk alɛji, kidni ɔ liva prɔblɛm, ɔ paralayz, tɛl yu dɔktɔ wantɛm wantɛm.
- Stɔr di mɛrɛsin na frij ɔ lɛk aw yu dɔktɔ tɛl yu.
- If yu gɛt ɛni kwɛstyɔn bɔt dis mɛrɛsin, nɔ ɛva fred fɔ aks yu dɔktɔ.
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