Bɛlɛ pen, blɔd na di stɔl? I kin bi wan sik we dɛn kɔl Juvenile Polyposis Syndrome (JPS) .

Yu ɔ sɔmbɔdi na yu famili, mɔ pikin, kin gɛt bɛlɛ at ɔltɛm? Yu dɔn notis smɔl blɔd na yu stɔl? Ɔ yu de fil taya ɛn yu de fil taya? Bɔku tɛm wi kin dismis dɛn sayn ya as simpul bɛlɛ pen ɔr nɔr kin it fayn. Bɔt sɔmtɛm, dɛn kayn sik ya kin kam bikɔs ɔf wan sik wae wi nɔr dɔn yɛri bɔrku bɔt, bɔt wi fɔ rili no bɔt. Tide wi go tɔk bɔt wan pan dɛn kayn sik ya, we na Juvenile Polyposis Syndrome (JPS).

Wetin na JPS rili?

fכ simpul wan, Juvenile Polyposis Syndrome (JPS) na jεnεtik kכndishכn we abnכmal growth dεm de fכm na di insay wכl dεm na wi dijestiv sistεm (gastrointestinal - GI tract). Wi kin kɔl dɛn tin ya we de gro pan mɛrɛsin, polip . Imajin wan smɔl tin we tan lɛk grep we de hang pan wan tik we de insay wi intestin. Na so dɛn polip ya kin fɔm.

dis polip dεm kin fכm enisay na wi dijestiv sistεm.

• Bɛlɛ
• Na di smɔl intestinal
• Na di big intestinal (kɔlɔn) .
• Rɛktum na di rɛktɔm

Bɔt dɛn kin si dɛn mɔ na di big intestinal ɛn di rɛktum. Pɔsin we gɛt JPS kin gɛt ɛnisay frɔm sɔm to ɔndrɛd pan dɛn polyp ya.

Naw yu kin tink se bikɔs i gɛt di wɔd "juvenile" insay, dis na sik we kin jɔs afɛkt yɔŋ pikin dɛn. Nɔto fɔ tru. Di wɔd "juvenile" ya nɔr de tɔk bɔt di ej we di sik de divɛlɔp. i de tכk bכt di nεchכr fכ di sεl dεm we dεn de si we dεn tek di polip εn egzamin am כnda maykroskכp. Bɔt bɔku tɛm, di sayn dɛm fɔ dis sik kin bigin fɔ sho na pikin ɔr yɔŋ , bɔku tɛm bifo i ol 20 ia.

Yu tink se men kayn JPS dɛn de?

Yɛs, dɛn kin sheb JPS to tri men kayn dɛn. dis klasification dεm de bay di sayz fכ di polip dεm we de fכm εn usay dεn de.

Udat kin gɛt dis sik? Yu tink se na frɔm dɛn gret gret granpa dɛn?

JPS na bikɔs ɔf wan jenɛtik muteshɔn, so ɛnibɔdi kin gɛt am. Na wan sik we nɔ kin apin so ɔltɛm. Ɔlsay na di wɔl, di wan dɛn we kin gɛt dis sik na lɛk wan pan ɔl wan ɔndrɛd tawzin pipul dɛn .

Yɛs, pɔsin kin gɛt dis sik . JPS na wetin wi mεdikal kכl ``autosomal dominant`` kכndishכn. Dis jɔs min se ivin if pikin gɛt wan kɔpi fɔ di jin we dɔn chenj fɔ dis sik frɔm in mama ɔ in papa, i go du fɔ mek di pikin gɛt dis sik.

• Na lɛk 75% pan di wan dɛn we gɛt JPS kin gɛt di sik frɔm dɛn mama ɛn papa.
• insay di rεst 25% pan di kes dεm, di sik kin apin bikoz fכ wan spontan mכtεshכn na di pikin in bכdi, pan כl we di mama εn papa nכ gεt dis jin mכtεshכn.

Wetin na di sayn dɛm fɔ JPS?

di men sayn fכ dis sik na di fכmeshכn fכ polyp dεm, we wi bin tכk bכt, na di intestכn dεm. Bikɔs dɛn tin ya kin mek insay di bɔdi, wi nɔ kin si dɛn frɔm do. Bɔrku tɛm, pɔlip nɔr kin sho ɛni sayn te dɛn big smɔl ɔr dɛn nɔmba go ɔp. Bɔt we di sayn dɛn bigin fɔ sho, dɛn kin tan lɛk dis.

Ɔda kwaliti dɛn we pɔsin kin si we dɛn bɔn am

lεk 15% pan di JPS pasεn dεm gεt כda fכshal abnכmaliti dεm we dεn bכn dεm apat frכm di intestinal polyp dεm.

• Kleft lip ɛn palata
• Fɔ gɛt ɛkstra finga ɔ fut finga dɛn (Polydactyly) .
• divεlכpmεnt abnכmaliti dεm na di bren, at, כ urinary sistεm
• Twisting na di intestines (Malrotation) .

Yu tink se link de bitwin JPS ɛn di risk fɔ gɛt kansa?

Dis na de impɔtant tin fɔ no bɔt dis sik. di polip dεm we de divεlכp bikoz fכ JPS nכ de fכs kεnsar (benign). Dɛn na nɔmal tumbu dɛn. Bɔt as tɛm de go, i rili ay risk fɔ mek dɛn polip ya chenj to kansa.

So, pɔrsin wae gɛt JPS kin gɛt bɔrku risk fɔ gɛt dɛn kayn kansa ya:

• Kansa we de na di kɔlɔrɛkt
• Bɛlɛ kansa
• Smɔl intestinal kansa
• Kansa na di pankrias

Nɔ fred dis. Dis nɔ min se ɔlman go gɛt kansa. Bɔt i min se di prɔblɛm kin bɔku. Na dat mek i rili impɔtant fɔ no di sik di rayt tɛm ɛn gɛt skrinin di rayt tɛm lɛk aw yu dɔktɔ tɛl yu.

Wetin na di patikyula tin we kin mek pɔsin gɛt JPS?

As wi bin dɔn tɔk, dis na tin we pɔsin kin gɛt frɔm in jɛnɛtiks. JPS kin kכz mεntal bay mכtεshכn insay tu jin dεm na wi bכdi we dεn kכl BMPR1A εn SMAD4 .

Fɔ ɔndastand dis, lɛ wi yuz wan simpul ɛgzampul. Imajin se di sɛl dɛn na wi bɔdi tan lɛk motoka dɛn we de na rod. Tu jin dɛn we dɛn kɔl BMPR1A ɛn SMAD4 tan lɛk trafik polis ɔfisa dɛn. dεn de kכntro di sεl dεm we de gro εn divεlכpmεnt, we de gi di signal dεm "OK, divayd naw" εn "OK, stכp naw."

We dɛn tu jin ya chenj, lɛk we dɛn trafik kɔp dɛn de nɔ de igen, di sɛl dɛn nɔ kin ebul fɔ kɔntrol dɛnsɛf. Dɛn kin bigin fɔ sheb ɛni we we dɛn want, ɛn kwik kwik wan. na so dεn sεl dεm ya we de divayd we dεn nכ kכntrol de kam togεda εn fכm dεn tכmכro dεm ya we dεn kכl polip.

apat frכm JPS, pipul dεm we gεt mכtεshכn na di SMAD4 jin de pan risk fכ divεlכp כda jεnεtik kכndyushכn we dεn kכl hεridita hεmorrhagic telangiectasia (HHT).

Aw fɔ no bɔt dis sik?

We yu tɛl yu dɔktɔ bɔt yu sik, i go chɛk yu ɛn aks yu bɔt yu famili mɛdikal histri. Fɔ no if yu gɛt JPS, yu fɔ gɛt at le wan pan dɛn tin ya:

• fכ gεt fayv כ mכr polip dεm na di big intestin εn/כ rεktum.
• di prεsεns fכ polip dεm כdasay na di dijestiv sistεm.
• Fɔ gɛt at le wan polip ɛn famili histri fɔ JPS.

Tu men tɛst de fɔ no if dis sik dɔn kam.

. Dis kin ɛp fɔ si if pɔlip de, ɔmɔs de, ɛn usay dɛn de. We dɛn de du di ɛgzam, dɛn kin pul smɔl smɔl polip dɛn ɛn tek wan tisu sɛmpul (bayɔpsi) fɔ tɛst.

2. Jεnεtik bכdi tεst: dεn de tek bכdi sεmpl εn tεst fכ di BMPR1A כ SMAD4 jin mכtεshכn we de mek JPS. Dis kin kɔnfɔm di sik 100% pan di tɛm.

Wetin na di tritmɛnt dɛm fɔ JPS?

Di men gol fɔ trit JPS na fɔ pul di polip dɛn.Dis kin kɔntrol di sayn dɛm ɛn ridyus di risk fɔ gɛt kansa tumara bambay. Yu dɔktɔ go disayd di bɛst tritmɛnt fɔ yu bay yu ej, wɛlbɔdi, di nɔmba fɔ di pɔlip, ɛn usay dɛn de.

Bɔku we dɛn de fɔ trit pɔsin:

• fכ pul di polip dεm we dεn de du di kכlon sכkכpi: If di polip dεm nכ sכm εn sכm saiz, dεn kin kכt dεm εn pul dεm wit di sem instrכmεnt we dεn yuz fכ du di egzamin.
• Ɔpreshɔn fɔ pul di polip dɛn: If di polip dɛn big ɔ de na ples we at fɔ rich wit kɔlonɔskɔp, i kin nid fɔ du ɔpreshɔn.
• Ɔpreshɔn fɔ pul wan pat na di kɔlon: If bɔku bɔku polip dɛn de na wan say, dɔktɔ dɛn kin disayd fɔ ɔpreshɔn fɔ pul da wan ol pat de na di kɔlon.

If yɔŋ pikin dɛn gɛt wan polip nɔmɔ, dɛn kin pul am we dɛn de du kɔlon skɔpi. Dɛn nɔ kin du ɔpreshɔn pan pikin dɛn ɔltɛm.

Aw fɔ mɛn di sik afta dɛn dɔn no se i gɛt am?

JPS na kɔndishɔn we nid fɔ de manej fɔ lɔng tɛm. Afta dɛn dɔn trit wi ɛn pul di polip dɛn, wi nid fɔ de wach wi ɔltɛm fɔ si if dɛn de gro bak ɔ if nyu wan dɛn de fɔm. Na dat mek wi kin du skrinin .

Yu dɔktɔ go tɛl yu fɔ du dɛn tɛst ya pan di tɛm we dɛn dɔn plan fɔ du.

• Blɔd tɛst dɛn
• Kolonoskopi we dɛn kin du
• Ɛndoskopi we de ɔp

Dɛn kin du di fɔs tɛst jɔs lɛk aw di sik sho ɔ bifo yu ol 15. If di tɛst rizɔlt fayn, dɛn go aks yu fɔ ripit di tɛst ɛvri 3 ia. Bɔt if yu gɛt pɔlip ɛn dɛn dɔn pul am, yu go nid fɔ du tɛst ɛvri ia . if di polip dεm nכ kam bak, dεn kin inkrεs di intaval bitwin di tεst dεm to 3 ia.

Ustɛm yu nid fɔ go to dɔktɔ?

If yu gɛt ɛni wan pan di sayn dɛn we wi dɔn tɔk bɔt, mɔ blɔd na yu stɔl , nɔ ɛva ignore am. I kin bi simpul ɛmoroyd, ɔ i kin bi sayn fɔ wan sik we rili siriɔs lɛk JPS. So, go to yu dɔktɔ wantɛm wantɛm.

Dɔn bak, if pɔsin na yu famili dɔn gɛt JPS bifo, ɔ if yu dɔn gɛt kansa na yu bɔdi we yu yɔŋ, i go fayn fɔ mek yu tɔk to yu dɔktɔ bɔt am ɛn du yu jenɛtik tɛst if nid de, ilɛksɛf yu nɔ gɛt ɛni sayn.