Yu tink se ɛnibɔdi na yu famili, sɔntɛm yu mama, papa, ɔ grani, kin fɔgɛt smɔl smɔl tin dɛn? We yu nɔ ebul fɔ mɛmba ivin di smɔl smɔl tin dɛn, wi kin fil bad bak ɛn fred. De men rizin fɔ dis kin bi Alzaima sik. Infakt, no mɛrɛsin nɔ de yet fɔ dis sik. Bɔt nyu tritmɛnt dɛn de we go ɛp fɔ kɔntrol di sik we de prɛd kwik kwik wan ɛn mek i nɔ go bifo kwik kwik wan. Kisunla na wan pan dɛn kayn drɔgs ya we dɔn briŋ nyu op. Lɛ wi tɔk bɔt dis simpul ɛn klia wan tide.
Alzaima sik ɛn aw Kisunla de wok
Fɔ tɔk am simpul wan, Alzaima na wan sik na di bren we kin kam smɔl smɔl as tɛm de go. Sɔntɛm yu dɔn yɛri bɔt am as sik wae de mɛk pɔrsin nɔr de mɛmba ɔltɛm wae kin kam pan pipul dɛm wae dɔn ol. We dis sik bigin, di pat dɛm na wi bren we de kɔntrol impɔtant tin dɛm lɛk fɔ mɛmba, fɔ ɔndastand, fɔ tɔk, fɔ pe atɛnshɔn, ɛn fɔ tink kin pwɛl. di men rizin fכ dis na di akyumulεshכn fכ wan tכxik protin we dεn kכl amyloid bitwin di bren sεl dεm.
Jɔs lɛk aw wata paip na wi os kin lɔk wit dɔti ɛn stɔp di wata fɔ flɔ, we dis amyloid protin kin gɛda bitwin di bren sɛl dɛn, di bren sɛl dɛn nɔ kin ebul fɔ tɔk to dɛnsɛf ɛn wok fayn fayn wan.
Yu go dɔn yɛri se Alzaima sik na wan kayn dis maynia sik. Dimɛnshɔn na wan jɛnɛral wɔd fɔ kɔndishɔn wae kin mek yu nɔr kin ebul fɔ tink klia wan to de say wae yu nɔr kin ebul fɔ du ɛvride woke.
Bɔku tɛm, dɔktɔ dɛn kin sheb di sik to difrɛn stej dɛn. Insai di fɔs stej, fɔ shɔt tɛm mɛmori na di men sayn. As de sik de go bifo, ivin ɛvride wok lɛk fɔ pripia it, fɔ fɛn aw fɔ du tin, ɛn fɔ manej mɔni kin at. Leta, yu kin sho bak saykilɔjik sayn dɛm lɛk fɔ lɛf fɔ de wit ɔda pipul dɛm, fɔ nɔr gɛt intres pan ɛnitin, ɛn fɔ de agyu.
So, wetin dis nyu drɔg we dɛn kɔl Kisunla de du? I gɛt wan spɛshal antibodi we dɛn kɔl donanemab-azbt . wetin i de du na dat i de tכk di amyloid protin dεm we a bin tכk bכt we de kכmכt na di bren εn pul dεm na di bren. Dis we ya, Kisunla de ɛp fɔ ridyus di bren we de pwɛl ɛn slo di rit we di sik de wɔs.
Aw fɔ yuz Kisunla mɛrɛsin?
Kisunla nɔto pil. Dɛn kin gi am as infushɔn we dɛn kin put insay di bɛlɛ (IV) . Jɔs lɛk aw wi go gɛt salin, yu go gɛt fɔ gɛt dis tritmɛnt na ɔspitul ɔ klinik, we kin tek lɛk 30 minit.
We yu bigin fɔ trit yu, dɛn go gi yu tri dos dɛm we na 700 miligram (700 mg) ɛvri 4 wik. Afta dat, yu dɔktɔ go inkrisayz di doz to 1400 miligram (1400 mg) ɛvri 4 wik.
Bifo yu bigin dis tritmɛnt, yu dɔktɔ go ɔda fɔ mek dɛn du spɛshal skan na yu bren we dɛn kɔl tau positron emission tomography (PET) . Dis de chɛk aw bɔku amyloid dɔn de na yu bren. If di skan sho se di lɛvɛl we di amyloid de na yu bren dɔn go dɔŋ bad bad wan, yu dɔktɔ kin disayd fɔ stɔp di tritmɛnt.
Speshal pɔynt dɛn fɔ wach ɛn di sayd ɛfɛkt dɛn
Wan siriɔs sayd ɛfɛkt de we wi nid fɔ tek tɛm mɔ we wi de trit Kisunla. Dɛn kɔl am ARIA (amyloid-related imaging abnormalities) . Fɔ tɔk am simpul wan, dis drɔg kin mek dɛn si chenj dɛn we nɔmal we dɛn de du MRI skan na di bren. Nɔr kin ɔltɛm dis kin mek pɔrsin gɛt sɔm kayn sik.
Bɔt nɔr kin bɔrku, sɔm pipul dɛn kin gɛt sɔm kayn sik lɛk dis:
- Ed de at
- Kɔnfyus
- Fɔ vɔmit
- Vishɔn kin chenj
- Nɔ balans we yu de waka
Sɔntɛnde, di sayn dɛm fɔ ARIA kin rili fiba di wan dɛm wae gɛt strok. So, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek so dat i go no if na bikɔs ɔf ARIA ɔ ɔda tin.
Udat de pan ay risk fɔ gɛt ARIA?
Sɔm pipul dɛn kin gɛt ay risk fɔ gɛt ARIA dipen pan dɛn jenɛtik mek-ap. Pipul dεm we gεt tu kכpi fכ di jin we dεn kכl apolipoprotein E e4 (ApoE e4) kin gεt hכy risk fכ gεt siriכs sayd ifekt lεk bren swel כ bכdi bכn na dεn bren. So, yu dɔktɔ go mɔs ɔda fɔ mek dɛn du jenɛtik tɛst fɔ chɛk yu risk fɔ gɛt ARIA bifo yu bigin fɔ trit Kisunla. Yu go nid bak fɔ gɛt MRI skan ɔltɛm fɔ wach dis kɔndishɔn we yu de trit yu.
Aw dɛn bin stɔdi di sakrifays fɔ di Kisunla drɔg?
Dɛn dɔn du wan big klinik stɔdi fɔ si aw dis mɛrɛsin de wok fayn. Bɔrku pipul dɛm wae gɛt Alzaima sik wae dɔn bigin fɔ tek pat pan dis.
Di wan dɛn we du di risach bin sheb dɛn pipul ya to tu grup.
1. Dɛn bin gi wan grup: Kisunla mɛrɛsin.
2. Di ɔda grup: dɛn gi dɛn sɔntin we tan lɛk di mɛrɛsin, bɔt nɔ gɛt ɛni aktif ingridiɛnt (wi kɔl dis plesibo ).
Di tin dɛn we kin apin kin rili ɛnkɔrej wi. Lɛ wi ɔndastand dɛn rizɔlt dɛn de jɔs frɔm di tebul we de dɔŋ ya.
| Bɛnifit | Wetin di stɔdi bin fɛn |
|---|---|
| Fɔ slo di sik we de prɛd | Di rεt we di sik bin de go bifo pan di wan dεm we bin gεt Kisunla bin bכt 20% slo pas di wan dεm we bin gεt plasεbo. |
| Di simptom dɛm nɔ de wɔs | Fɔti sɛvin pasɛnt pan di wan dɛn we bin gɛt Kisunla nɔ bin gɛt ɛni wɔs pan dɛn sik insay wan ia, we yu kɔmpia am wit 29% nɔmɔ pan di wan dɛn we bin de na di plasɛbo grup. |
| Di amyloid we de dכn na di bren | We di stɔdi dɔn, 76% pan di wan dɛn we bin gɛt Kisunla bin gɛt rili lɔw lɛvɛl dɛn pan amyloid dipɔsit na dɛn bren. |
Dɛn rizɔlt ya sho se Kisunla kin slo fɔ mek di sik we dɛn kɔl Alzaima de go bifo bad bad wan.
Aw lɔŋ i kin tek fɔ mek di mɛrɛsin wok ɛn ɛni intarakshɔn de wit ɔda mɛrɛsin dɛn?
As yu gɛt yu fɔs doz fɔ Kisunla so, i kin bigin fɔ wok bay we i de tɔch di amyloid na di bren. Bɔt i kin tek sɔm mɔnt fɔ mek yu, di wan dɛn we de kia fɔ yu, ɛn yu dɔktɔ notis se yu sik dɛn de go dɔŋ ɛn di sik de go sloslo.
Intarakshɔn wit ɔda drɔgs
Bikɔs di risk fɔ mek yu bren blɔd wit ARIA, yu fɔ tek spɛshal kia we yu de yuz Kisunla wit tin dɛn we de mek yu blɔd tan . Pan ɔl we no klia pruf nɔ de yet, if yu de tek mɛrɛsin we de mek yu blɔd tan, yu fɔ rili tɔk bɔt dis wit yu dɔktɔ bifo yu bigin Kisunla tritmɛnt.
Di tin we impɔtant pas ɔl na fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek - ilɛksɛf na yu dɔktɔ gi yu, mɛrɛsin dɛn we yu kin bay na kɔt, vaytamɛn, Ayurveda ɔ Sinhala mɛrɛsin.
If yu gɛt ɛni sayn lɛk ed we de at we yu de trit yu, nɔ ignore am. I kin bi sayn fɔ ARIA, so tɛl yu dɔktɔ wantɛm wantɛm .
Mɛsej we dɛn kin kɛr go na os
- Kisunla na nyu mɛrɛsin wae dɛn kin yuse fɔ trit di fɔs stej dɛm fɔ Alzaima sik.
- dis de wok bay we i de pul di tכxik protin we dεn kכl amyloid we de kכmכt na di bren εn slo di rεt we di sik de bכku.
- Dis na tritmɛnt we dɛn kin put insay di bɛlɛ (IV) ɛn dɛn fɔ gɛt am na ɔspitul ɔ klinik.
- I rili impɔtant fɔ no bɔt di siriɔs sayd ɛfɛkt we dɛn kɔl ARIA. Dis nid fɔ gɛt MRI skan ɔltɛm bifo ɛn we dɛn de trit am.
- I impɔtant fɔ tɔk to yu dɔktɔ opin wan bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud di wan dɛn we de mek yu blɔd tan) ɛn ɛni nyu sayn we yu de gɛt.
- Pan ɔl we dis nɔto mɛrɛsin, i kin mek di sik slo bad bad wan ɛn i kin gi nyu op to di wan dɛn we sik ɛn dɛn famili.
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