Sɔntɛnde, yu kin fil lɛk se yu nɔ gɛt trɛnk, yu kin taya ɔltɛm, ɛn yu kin sik ɔltɛm? Sɔntɛnde, dɛn sik ya we tan lɛk se dɛn nɔ gɛt natin fɔ du wit dɛnsɛf kin kam bikɔs ɔf prɔblɛm we de na wan pan di smɔl smɔl pat dɛn na wi bɔdi. Tide, wi go tɔk bɔt wan kɔndishɔn we kɔmplikt smɔl, bɔt we rili impɔtant fɔ no bɔt. Dat na di Maytochondrial Diseases.
Fɔs, lɛ wi si, wetin na maytokɔndria?
fכ simpul wan, maytochכndria na sכm sכm "pawa haus" dεm insay εvri sεl na wi bכdi. Jɔs lɛk aw wi gɛt pawa plant fɔ gi pawa to wi os, na so wi sɛl dɛn de yuz dɛn maytokɔndria ya fɔ mek di ɛnaji we dɛn nid fɔ wok. We wi yuz di it we wi de it ɛn di ɔksijɛn we wi de blo, dɛn smɔl smɔl faktri ya de mek lɛk 90% pan di ɛnaji we wi bɔdi nid. So imajin us prɔblɛm dɛn go kam if dɛn pawa plant ya nɔ bin de wok fayn.
Mitochondrial sik nɔto wan sik. Dɛn na jɛnɛral wɔd fɔ wan grup ɔf kɔndishɔn dɛn we kin kɔmɔt frɔm di disfɔkshɔn fɔ dɛn pawa haus ya.
We dɛn pawa plant ya nɔ de wok fayn, di sɛl dɛn nɔ de gɛt di ɛnaji we dɛn nid. Dɔn di ɔgan dɛn we gɛt dɛn sɛl dɛn de nɔ kin wok fayn. Dis kin afɛkt ɛni pat na wi bɔdi.
- Bren
- Nɛvɔ sistɛm
- Mɔsul dɛn
- Kidni dɛn
- At
- Liva
- Yay
- Yes
- Pankrias we de na di bɔdi
Dis kin afɛkt ɛnitin.
Wetin na di men kayn sik dɛm we de na di maytochondrial?
Bɔrku kayn dis sik de, bɔt sɔm pan de sik wae kin kam pan pɔrsin na:
- MELAS sεndrכm (Maytochondrial εnεsεfalopati, laktik asidכsis εn εpisod dεm we lεk strכk)
- Leber hεriditi optik nyuropati (LHON) .
- Sindrom we gɛt di sik we dɛn kɔl Leigh syndrome
- Di sik we dɛn kɔl Kearns-Sayre (KSS) .
- Mayoklɔnik ɛpilepsi ɛn ragged-rɛd fayba sik (MERRF) .
dis kin tan sכmtεm sכmtεm, bכt mεmba se dis na kכndishכn dεm we de mek difrεn simptom dεm εn na di chenj dεm we de apin na di maytochכndrial fכnshכn.
Wetin kin bi di sayn dɛm fɔ dɛn sik ya?
Dis na de pat wae de pasmak pan de sik. Bikɔs di sayn dɛn kin difrɛn bad bad wan frɔm wan pɔsin to ɔda pɔsin, i kin dipen pan di kayn sɛl dɛn we dɛn afɛkt ɛn usay dɛn de na di bɔdi. Sɔm pipul kin gɛt sɔm kayn sik wae nɔr kin pasmak, wae ɔda wan kin gɛt bɔrku sayn dɛm wae nɔr kin pasmak. Di sayn dɛm kin difrɛn ivin insay di sem famili.
Di tebul we de dɔŋ ya de sho sɔm pan di kɔmɔn sayn dɛm we dɛn kin si pan dɛn sik ya.
| Kategori fɔ di simptom dɛn | Di sayn dɛn we pɔsin kin si |
|---|---|
| Rilat to growth ɛn trɛnk | Nɔ grow fɔ di ej, di mɔsul dɛn wik, di mɔsul dɛn de pen, ɛn bɔdi we nɔ gɛt layf. |
| Rilat to kɔgnishɔn ɛn lanin | I nɔ de si fayn ɛn/ɔ i nɔ de yɛri fayn, i nɔ de ebul fɔ lan, ɔ i nɔ de divɛlɔp igen. |
| Rilayt to di dijestiv sistɛm | Vɔmit we yu nɔ ɛksplen, dayarɛa ɔ kɔnstipɛshɔn, i nɔ izi fɔ pis, asid riflɔks. |
| Nɛvɔ sistɛm we gɛt fɔ du wit am | Sizhɔ, maygren, fɔdɔm. |
| Ɔda tin dɛn we de apin | I nɔ izi fɔ blo, di aylid we de drɔp (ptosis). |
Dɛn sayn ya kin bigin wae dɛn bɔn am ɔr kin kam pan ɛni ej na layf. Dɔktɔ kin sɔprayz dis we di sayn dɛn kin apia wan tɛm na sɔm ɔgan sistɛm dɛn we nɔ gɛt natin fɔ du wit dɛnsɛf.
Wetin mek dis kayn sik kin apin?
Di men rizin fɔ dis na di tin dɛn we nɔ fayn na di bɔdi .
Fɔ tɔk am simpul wan, di maytochondria dɛn we de insay wi sɛl dɛn kin gɛt dɛn instrɔkshɔn fɔ mek ɛnaji frɔm wi DNA. if chenj כ mכtεshכn de na dis DNA, di maytochכndria dεm nכ de gεt di instrכkshכn dεm rayt. Dɔn dɛn nɔ kin ebul fɔ mek ɛnaji fayn fayn wan. Dis kin pwɛl di sɛl dɛn ɔ mek dɛn day bifo tɛm.
Aw pɔsin kin gɛt dis sik?
Dis na sik dɛm we pɔsin kin gɛt we i kam pan jɛnɛtiks, we min se dɛn kin pas frɔm mama ɛn papa to pikin dɛm. Sɔntɛnde, ivin if nɔbɔdi na di famili nɔr gɛt dis sik, sɔmbɔdi kin gɛt dis sik bikɔs ɔf wan random genetic mutation.
wan spεshal fכs na dat di maytochכndria dεm gεt dεn yon yכnik DNA. di sik dεm we de kכz fכ difεkt dεm na dis maytochכndrial DNA de kכmכt nכmכ frכm di mama to di pikin dεm.
Ɔda sik dɛn kin mek di maytochondrial wok fayn?
Yɛs. dεn kכl am sεkכnd maytochכndrial disfכnkshכn. Dat min se yu nɔ gɛt jenɛtik maytokɔndria sik, bɔt wan ɔda mɛrɛsin we de mek yu maytokɔndria nɔ de wok fayn. Fɔ ɛgzampul:
- Dis sik we dɛn kɔl Alzaima
- Distrofi we de na di mɔsul dɛn
- Tayp 1 dayabitis
- Mɔltipɛl sklɛrosis (MS) .
- Sɔm kayn kansa dɛn
di maytochכndria kin afekt wit sik dεm lεk:
Aw fɔ no bɔt dis sik?
Fɔ no dis sik kin tranga smɔl bikɔs di sayn dɛm kin difrɛn. Nɔr kin ebul fɔ no am wit jɔs wan tɛst. Yu dɔktɔ kin du sɔm tɛst dɛn.
- Wan gud rivyu fɔ yu ɛn yu famili in mɛdikal istri .
- Fɔ du wan kɔmplit ɛgzam fɔ yu bɔdi .
- Wan tɛst we gɛt fɔ du wit di nervɔs sistɛm .
- Blɔd ɛn urine tɛst . Sɔntɛnde dɛn kin du spɛshal tap bak.
- DNA tɛst we dɛn de du .
- dipכnt pan di simptom dεm, dεn kin du tεst dεm lεk MRI skan, EKG כ Echocardiogram fכ di at, yay εgzam, yεri tεst, εn EEG tεst fכ mכnitor di bren aktiviti .
- Sɔntɛnde i kin nid fɔ tek smɔl pat pan di skin ɔ di mɔsul (bayopsi) ɛn chɛk am ɔnda maykroskɔp.
So, i rili impɔtant fɔ go to dɔktɔ ɔ ɔspitul we spɛshal pan dɛn kayn sik ya fɔ no if yu gɛt am.
Wetin na di tritmɛnt dɛn?
כnכfכs, nכ mכrεshכn de fכ mitochondrial sik yet. Bɔt difrɛn tritmɛnt dɛn de fɔ ɛp fɔ kɔntrol di sik dɛn ɛn fɔ mek dɛn nɔ gɛt prɔblɛm dɛn we go mek pɔsin in layf de pan denja .
- Mɛrɛsin dɛm wae de ridyus di sayn dɛm:Fɔ ɛgzampul, mɛrɛsin we de mek pɔsin nɔ gɛt ɛpilepshɔn.
- Vitamin ɛn sɔpɔtmɛnt: Tin dɛn lɛk riboflavin, kɔɛnzym Q10, ɛn carnitine kin ɛp fɔ sɔm pipul dɛn.
- Chenj fɔ it ɛn ɛksesaiz: Yu dɔktɔ go tɛl yu fɔ du dɛn tin ya bay aw yu sik.
- Fizik tɛrapi, ɔkupeshɔn tɛrapi, ɔ tɔk tɛrapi tritmɛnt.
- We yu wɛr tin dɛn we de ɛp yu lɛk tin fɔ ɛp yu fɔ yɛri .
Wetin kin woke fɔ wan pɔrsin nɔr kin woke fɔ ɔda pɔrsin, so i bɛtɛ fɔ tɔk to yu dɔktɔ ɛn kam wit tritmɛnt plan we go fayn fɔ yu.
Yu tink se dɛn go ebul fɔ mek di sik nɔ wɔs?
Pan ɔl we no we nɔ de fɔ mek dis sik nɔ kam, yu kin de fa frɔm sɔm tin dɛn we kin mek di sik wɔs.
- Nɔ put am na say we kol ɔ wam pasmak .
- Nɔ skip fɔ it.
- Gɛt gud slip na nɛt.
- Stay away frɔm strɛs as yu ebul.
Yu dɔktɔ go advays yu fɔ kip yu trɛnk pas fɔ spɛn ɔl yu bɔdi in trɛnk wan tɛm.
Ustɛm a fɔ go to dɔktɔ?
If yu gɛt sayn dɛm fɔ di maytochondrial sik ɛn yu gɛt prɔblɛm fɔ du di tin dɛm we yu de du ɛvride, mek shɔ se yu go to dɔktɔ.
If yu gɛt sik ɔ yu gɛt siriɔs prɔblɛm fɔ blo, go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
Fɔ no se yu ɔ pɔsin we yu lɛk gɛt dis sik kin tranga. Bɔt mɛmba se yu famili, yu padi dɛn, ɛn yu dɔktɔ dɛn, de fɔ ɛp yu fɔ liv fayn fayn wan wit dɛn sik ya.
Mɛsej we dɛn kin kɛr go na os
- di maytochכndrial sik dεm na wan grup fכ jεnεtik sik dεm we di "pawa plant" dεm we de prodyuz enεji fכ wi sεl dεm nכ de wok fayn.
- Di sayn dɛm kin rili difrɛn ɛn kin inklud fɔ gɛt mɔsul dɛm we wik, we yu nɔ de si/yɛri fayn, we yu nɔ de lan fayn, ɛn we yu gɛt ɛpilepshi.
- Fɔ no dis sik na tin we at fɔ du ɛn dɛn nid fɔ du sɔm tɛst dɛn we dɛn kin du wit mɛrɛsin. I impɔtant fɔ go to spɛshal pɔsin fɔ dis.
- Pan ɔl we dɛn nɔ kin ebul fɔ mɛn di sik ɔltogɛda, difrɛn tritmɛnt dɛn de fɔ kɔntrol di sayn dɛm ɛn fɔ mek in layf bɛtɛ.
- Yu kin kɔntrol di sik wae de kam pan pɔrsin wae gɛt dis sik bay wae yu nɔr de du tin lɛk strɛs, nɔr de slip fayn, ɛn wae yu nɔr de fil fayn.
- If yu ɔ pɔrsin wae yu sabi gɛt dɛn kayn sik ya, nɔr shem fɔ go to dɔktɔ.
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