Sɔntɛm yu bin gɛt blɔd tɛst fɔ sɔm ɔda sik. Ɔ sɔntɛm na bin dɔktɔ chɛk-ap we dɛn bin de du ɛvri ia. Da tɛm de, di dɔktɔ tɛl yu se, "Yu gɛt wan abnɔmal prɔtin na yu blɔd we dɛn kɔl 'M protin', ɛn wi kɔl dis kɔndishɔn MGUS." We ɛnibɔdi yɛri sɔntin lɛk dis, i kin shɔk ɛn fred smɔl. I rili nɔmal fɔ mek bɔku kwɛstyɔn dɛn kam na wi maynd, lɛk ‘Dis kansa?’, ‘Wetin go apin to mi naw?’, ‘Mɛda de fɔ dis?’ Bɔt nɔ wɔri. Tide, wi go tɔk bɔt wetin na MGUS, i rili denja, ɛn wetin wi fɔ du bɔt dis kɔndishɔn insay wan rili simpul we we yu go ɔndastand.
Wetin na MGUS rili?
Fɔ tɔk am simpul wan, MGUS (Monoclonal Gammopathy of Undetermined Significance) na wan sik we yu blɔd de mek wan prɔtin we nɔmal. Wi kin kɔl dis abnɔmal protin di M protin . Dɛn kin no dis bay we dɛn de du blɔd tɛst ɔ sɔntɛnde dɛn kin du urine test.
Okay, naw mek wi go dip smɔl ɛn si aw dis kin apin.
Imajin se wi gɛt difens ami insay wi bɔdi. Wan spɛshal kayn sojaman we de na dis ami na plasma sɛl dɛn . Dis na rili wan kayn wayt blɔd sɛl. Dɛn men wok na fɔ mek spɛshal prɔtin wɛpɔn dɛn we dɛn kɔl antibodi fɔ fɛt di jem dɛn we de mek wi gɛt sik (baktri, vayrɔs, ɛn ɔda tin dɛn) we de kam insay wi bɔdi. na dεn antibodi dεm ya de protεkt wi frכm sik bay we dεn de kech εn pwεl di jεm dεm.
Bɔt pan pɔsin we gɛt MGUS, sɔm pan dɛn plasma sɛl ya kin go ‘rɔng’ smɔl. Dat min se, insted fכ mek nכmal, hεlty antibodi dεm, dεn sεl dεm ya kin bigin fכ mek bכku bכku wan we fiba, yuslεs, abnכmal protin. Na dat wi kin kɔl di M protin.
Di impɔtant tin na dat MGUS nɔto kansa . Bɔt dɔktɔ dɛn kin si am se na bad tin we kin mek pɔsin gɛt kansa. Dat min se, i kin bi di biginin fɔ kansa. Bɔt nɔ fred dɛn wɔd ya. Bɔrku pipul dɛm wae gɛt MGUS nɔr go ɛva gɛt ɛni siriɔs sik na dɛn layf.
Yu tink se sɔm sayn dɛn de fɔ MGUS?
Na dis na di wɔndaful tin. Bɔrku pipul dɛm wae gɛt MGUS nɔr kin gɛt ɛni simptom . Na dat mek dɛn kin no bɔt dis sik bɔku tɛm, we dɛn de du blɔd tɛst fɔ ɔda rizin. Sɔntɛm yu nɔ go fil ɛni difrɛns. So na kɔmɔn tin fɔ tink se, "A fayn," we yu kam fɔ no se yu gɛt MGUS. dat na biכs dεn M protin dεm ya kin jכs de na di bכdi, we nכ de mek nכ bad tin to di bכdi.
Wetin mek MGUS de divɛlɔp? Wetin na di tin dɛn we kin mek pɔsin gɛt dis sik?
Infakt, dɔktɔ dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin mek dɛn plasma sɛl dɛn ya kin bigin fɔ biev dis kayn we we nɔmal wantɛm wantɛm. I stil na mistɛri. Bɔt risach dɔn sho se sɔm pipul dɛn kin gɛt dis sik smɔl.
Factor dεm wae de inkrεs di risk fכ divεlכp MGUS
- Ej: MGUS kin kam mɔr as yu de ol. E kin pasmak afta yu dɔn ol 50. We yu rich 70 ia, lɛk 5 pan ɔl 100 pipul dɛm kin gɛt dis sik.
- Jɛnda: Man dɛn kin gɛt MGUS pas uman dɛn.
- Ras: Dis sik kin apin mɔ pan sɔm rays, mɔ blak pipul dɛn .
- Famili histri: If yu fambul we de nia yu (mama, papa, brɔda ɛn sista) gɛt blɔd kansa lɛk MGUS ɔ multiple myeloma , yu kin gɛt dis sik smɔl.
- Di tin dɛn we de apin na di envayrɔmɛnt: Pipul dɛn we dɔn gɛt histri fɔ yuz insɛktisayd ɔ peshɛnt sayd kin gɛt mɔ prɔblɛm.
- Ɔda sik dɛm: Pipul dɛm wae gɛt sɔm ɔtoimyun sik dɛm kin de pan denja bak.
- If yu gɛt raytin: If yu gɛt bɔku raytin, dat kin mek yu gɛt prɔblɛm bak.
Wetin na di pɔsibul kɔmplikeshɔn dɛm fɔ MGUS?
Dis na di tin we ɔlman kin tink ɛn fred pas ɔl. As wi bin dɔn tɔk, MGUS nɔto kansa. Bɔt fɔ smɔl pipul dɛn, dis sik kin bigin fɔ bi wan sik we rili siriɔs as tɛm de go.
Na lɛk 20 to 25 pan ɔl 100 pipul dɛm wae gɛt MGUS go gɛt siriɔs sik wae gɛt fɔ du wit blɔd. Dat min se 75-80 pan 100 nɔ go gɛt ɛni prɔblɛm.
Di men sik dɛm wae kin kam as MGUS de go bifo na:
- Multiple Myeloma: Dis na di prɔblɛm we kin apin pas ɔl. Na kansa we de na di plasma sɛl dɛn.
- Amyloidosis: Na sik we di M protin dεm de put insay difrεn כgan dεm na di bכdi εn de pwεl dεm.
- Waldenstrom macroglobulinemia: Dis na wan kayn blɔd kansa bak we nɔ kin bɔku.
- Chronic lymphocytic leukemia: Na ɔda kayn blɔd kansa.
Di impɔtant tin na dat nɔto ɔlman we gɛt mɔltipɛl mayloma gɛt MGUS fɔs. Bɔt nɔto ɔlman we gɛt MGUS kin gɛt mɔltipɛl mayloma.
Apat frɔm dat, MGUS kin mek di risk fɔ ɔda wɛlbɔdi prɔblɛm dɛn bɔku smɔl:
- Blɔd we de klɔt
- Bon we de lɔs ɔ we brok
- Infekshɔn dɛn we kin kam bɔku tɛm
- Kidni prɔblɛm dɛn
- Nεv dεm we de pwεl (peripheral neuropathy): Dis kin mek di limb dεm sכmtεm sכmtεm εn sכmtεm sכmtεm.
Aw dɔktɔ kin no se i gɛt MGUS?
Yu dɔktɔ go du blɔd ɛn urine tɛst fɔ chɛk if M protin de. We dɛn dɔn kɔnfyus dat, dɛn go asɛs di risk fɔ mek dis kɔndishɔn tɔn to kansa. Dis go luk pan tri men tin dɛn:
1. di amoun fכ M protin na di bכdi: if di M protin lεvεl pas 1.5 g/dL (gram pan wan dεsilita), di risk go hכy sכm.
2. M protin tכp: difrεn tכp dεm de fכ M protin (dεn kכl am Immunoglobulin (Ig) tכp dεm). Sɔm kayn wae kin mek pɔrsin gɛt siriɔs sik pas ɔda wan dɛm.
3. di sεrum-fri layt chen (FLC) lεvεl dεm: dis na כda protin we di plasma sεl dεm de mek. Wan spɛshal blɔd tɛst ( Serum-free light chains (FLC) test ) kin no if dɛn tin ya nɔ fayn.
Pɔsin we gɛt ɔl dɛn tri tin ya kin gɛt bɔku kansa. Bɔt pɔrsin wae nɔr gɛt ɛni wan pan dɛn tin ya kin gɛt bɔrku risk. Yu dɔktɔ go ɛksplen to yu us risk grup yu de insay bay di rizɔlt fɔ dɛn tɛst ya.
Tritmɛnt de fɔ MGUS?
Na di gud nyus: Bɔrku pipul dɛm wae gɛt MGUS nɔr nid ɛni tritmɛnt.
So wetin yu de du? di dכkta de du wetin dεn kכl "watchful waiting" כ "active surveillance." Fɔ tɔk am simpul wan, "watchful waiting."
Dat min se, if dɛn nɔ gi yu mɛrɛsin, dɛn kin chɛk yu blɔd M prɔtin lɛvɛl ɛn ɔda tin dɛn ɔltɛm pan wan schedule we dɛn dɔn sɛt.
- Bɔku tɛm, dɛn kin ɔda fɔ mek dɛn du blɔd tɛst ɛvri 3 to 6 mɔnt fɔ di fɔs ia.
- Dɔn, if ɔltin stebul, yu kin aks fɔ mek dɛn chɛk yu ɛvri 6 mɔnt ɔ wan tɛm insay di ia .
Di men tin we mek dɛn de chɛk-ap ɔltɛm lɛk dis na fɔ no di fɔs sayn dɛn we de sho se MGUS de tɔn to siriɔs kɔndishɔn. If dɛn notis ɛni chenj, dɛn kin bigin fɔ trit am kwik kwik wan. Dat na big bɛnifit.
If yu gɛt ɔda prɔblɛm apat frɔm MGUS, lɛk we yu bon wik, yu dɔktɔ go gi yu sɛpret tritmɛnt fɔ dat.
Ustɛm a fɔ go to di dɔktɔ?
If yu gɛt MGUS, yu dɔktɔ go gi yu patikyula de fɔ yu chɛk-ap. Mek shɔ se yu go pan dɛn de dɛn de. Apat frɔm dat, if yu gɛt ɛnitin we nɔ kɔmɔn, go to yu dɔktɔ wantɛm wantɛm, pas fɔ wet fɔ yu nɛks klinik apɔntinmɛnt. Dɛn sayn ya kin bi sayn fɔ sho se yu sik de wɔs.
Pe atɛnshɔn mɔ to di sayn dɛn we de dɔŋ ya.
| Simptom dɛm fɔ wach fɔ | Diskripshɔn ɛn pɔsibul kɔz |
|---|---|
| Taya pasmak fɔ natin | Taya wae difrɛn frɔm nɔrmal taya ɛn nɔr de go ilɛksɛf yu slip. I kin bi bikɔs ɔf anemia (blɔd we nɔ de). |
| Bɔn pen | Pen, mɔ na di chɛst, bak, ɔ di rib. Dis na wan impɔtant sayn fɔ mek pɔsin gɛt mɔltipɛl mayloma. |
| We yu de lɔs yu wet we yu nɔ ɛksplen | If yu lɔs yu wet wantɛm wantɛm we yu nɔ tray. |
| Infekshɔn dɛn we kin kam bɔku tɛm | If yu kin gɛt kol ɛn flu bɔku tɛm bikɔs yu imyun sistɛm wik. |
| Rash ɔ izi brus | Blɔd we de kɔmɔt frɔm ivin smɔl injuri ɔ we de sho blu spat (bruis) ɔnda di skin. |
| Tingling ɔ numbness na di limb dɛm | Di nerve damej (peripheral neuropathy) kin mek yu gɛt sɔm kayn sik lɛk dis na di an ɛn fut. |
| Ɛd we de at, diziz, we yu de si chenj | di simptom dεm lεk dis kin apin bikoz fכ di bכdi tik we di M protin de mek. |
Di diagnosis fɔ MGUS kin mek yu at pwɛl smɔl. Di very wod dem "undetermined significance" insaid de tel yu se plenti tin stil de we wi no sabi abaut am. Risach stil de go bifo fɔ no wetin mek i siriɔs fɔ sɔm pipul dɛn ɛn nɔto fɔ ɔda pipul dɛn.
Bɔt di bɛst tin na dat, wit di tin dɛn we de apin na mɛdikal sayɛns tide, yu kin ebul fɔ no di prɔblɛm we yu gɛt bifo tɛm. Ɛn bikɔs dɛn de wach yu ɔltɛm, dɛn kin kech ɛni chenj kwik kwik wan. So di bɛst tin we yu go du na fɔ ridyus yu fred ɛn fala di dɔktɔ in instrɔkshɔn dɛn di rayt we.
Mɛsej we dɛn kin kɛr go na os
- MGUS nɔto kansa, bɔt na prɛkansa kɔndishɔn we gɛt di potenshal fɔ tɔn to kansa.
- Bɔrku pipul dɛm wae gɛt MGUS nɔr kin gɛt ɛni sayn ɛn nɔr kin gɛt ɛni siriɔs prɔblɛm ɔlsay na dɛn layf.
- Di tin we impɔtant pas ɔl na fɔ mek dɛn du yu blɔd ɛn urine tɛst di tɛm we dɛn dɔn plan, lɛk aw yu dɔktɔ se. Dɛn kɔl dis ‘watchful waiting’.
- If yu gɛt nyu tin dɛn we nɔ kɔmɔn (especially bon pen, extreme taya, weit loss), go to yu dɔktɔ wantɛm wantɛm, ɛn nɔ wet fɔ di nɛks klinik apɔntinmɛnt.
- Nɔ fred dis kayn tin we nɔ impɔtant. Di tin we impɔtant pas ɔl na fɔ de ɔnda di rayt dɔktɔ we de kia fɔ yu. Tɔk to yu dɔktɔ bɔt ɛni kwɛstyɔn ɔ tin we yu kin fred.
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