Imajin, i nɔ kin izi fɔ yu fɔ waka wantɛm wantɛm, yu nɔ kin balans, ɛn yu kin fil lɛk se yu ed de tɔn ɛn fɔdɔm we yu tinap we yu sidɔm. Na nɔmal tin fɔ mek yu fil bad bad wan we dɛn tin ya bigin fɔ apin wantɛm wantɛm. Pan ɔl we sɔntɛnde wi nɔ kin pe atɛnshɔn tumɔs to dɛn tin ya, dɛn kin bi di fɔs sayn fɔ sɔm sik dɛn we nɔ kin bɔku. Tide wi go tɔk bɔt wan pan dɛn kayn sik ya we nɔ kin bɔku, bɔt we rili siriɔs. Dat na Multiple System Atrophy , wan sik we wi dɔktɔ ɛn pasɛnt dɛn kin kɔl (MSA) fɔ shɔt tɛm. Pan ɔl we dis na tɔpik we kɔmplikt smɔl, wi go tɔk bɔt am rili simpul wan, di we we yu go ɔndastand.
Fɔ tɔk am simpul wan, wetin na dis MSA?
MSA na wan sik we nɔ kin apin so ɔltɛm na di nyurolɔjik we sɔm pat dɛn na wi bren kin wik smɔl smɔl ɛn day. As tɛm de go, di tin dɛn we di bɔdi kin ebul fɔ du ɛn di wok we dɛn pat dɛn ya we dɔn pwɛl na di bren kin kɔntrol kin dɔn smɔl smɔl. Fɔ tɔk tru, dis na tin we rili sɔri, bikɔs dis sik kin dɔn wit day.
Trade, dɔktɔ dɛn bin de kɔl dis kɔlekɛshɔn fɔ di sik dɛn wit tri nem. Dɛn bin de:
- Shy-Drager sindrom we gɛt di sik
- Sporadik ɔlivopontosɛribɛl atrofi
- Striatonigral dijεnεreshכn
Bɔt leta, sɔm pipul dɛn we de stɔdi bɔt dis bin kam fɔ no se dɛn tri sik ya gɛt bɔku tin dɛn we ɔlman kin si. So, dεn kכmbayn dεm כl εn gi dεm di nem "Multiple System Atrophy" (MSA). "Multiple System" min "sεvεra sistεm dεm." Dis min se dis sik kin afɛkt sɔm sistɛm dɛn na wi bɔdi. Di sayn dɛm kin dipen pan us pat dɛm na di bren dɔn pwɛl. Na dat mek ɔlman kin gɛt difrɛn kɔmbaynshɔn pan di sayn dɛm.
Leta, dɛn bin sheb di sik mɔ, mɔ bay di sayn dɛn we i de sho. Fɔ fala dis, tu kayn MSA de.
| MSA tayp | Diskripshɔn ɛn men tin dɛn |
|---|---|
| MSA-C | Di ‘C’ we de ya tinap fɔ ‘Cerebellar’. di sεribεl na di pat pan di bren we de kכdכn di muvmεnt dεm we wi de muv. Di men sayn dɛm fɔ dis kayn na we yu nɔ de balans (ataxia) . Dis min se wi nɔ kin ebul fɔ kɔntrol wi an ɛn fut dɛn fayn fayn wan, lɛk we wi de waka. pan tap dat, prכblεm de wit di bכdi in כtomatכk fכnshכn (autonomic dysfunction) εn fכ fכl fכ fכl. |
| MSA-P | Di ‘P’ we de ya tinap fɔ ‘Parkinsonism’. Dis kayn MSA-C gɛt sɔm kayn sayn dɛm wae rili fiba dis sik wae de kam wit Pakinson. Fɔ ɛgzampul, we pɔsin de shek shek, we i de muv sloslo, ɛn we i de rigid. Pan ɔl we dɛn sik ya we dɛn kɔl Parkinson ’s na di men wan dɛn we de bigin, as tɛm de go, di sayn dɛn we fiba ɔda MSA-C (we yu nɔ de balans, prɔblɛm wit ɔtomɛtik wok) kin apin bak. |
Udat de pan denja fɔ gɛt MSA?
MSA kin afɛkt big pipul dɛm, mɔr lɛk afta dɛn dɔn ol 30. Di sayn dɛm kin sho mɔs bitwin di ej dɛm fɔ 50 ɛn 59. Dis sik kin afɛkt ɛnibɔdi, ilɛksɛf na man ɔ uman.
Dis na sik we nɔ kin apin so ɔltɛm. Akɔdin to statɛstik, na 0.6 to 0.7 nyu kes nɔmɔ de pan ɛvri 100,000 pipul dɛn ɛvri ia. Dis min se dis nɔto kɔmɔn sik na wi sosayti.
Aw MSA sik kin afɛkt wi bɔdi?
MSA de mek di sεl dεm day na difrεn pat dεm na di bren. Di sayn dɛm kin dipen pan us pat na di bren dɔn pwɛl. di men pat dεm na di bren we de afekt na:
- Basal Ganglia: Dɛn wan ya de rayt na di midul pan di bren. Dɛn tan lɛk hab we de kɔnɛkt difrɛn pat dɛn na di bren to dɛnsɛf. Na tru dis pat we difrɛn pat dɛn na di bren kin kam togɛda ɛn wok togɛda.
- Brenstem: Dis na di say we dεn de kכntro di כtomatכk prכsεs dεm na wi bכdi we implεnt fכ liv. Fɔ ɛgzampul, tin dɛn lɛk aw yu de blo, aw yu at de bit, ɛn aw yu blɔd prɛshɔn. Dɛn tin ya kin apin ɔtomɛtik wan we wi nɔ tink bɔt dɛn, nɔto so? Dis na di kɔntrol sɛnta.
- Sεribεl: Dis de na di bak pat pan di ed, nia di bεs. Dis na di men pat na wi bren we de mek wi bɔdi muv fayn fayn wan ɛn mek wi balans. Apat frɔm dat, risach dɔn sho naw se dis pat de insay wi filin ɛn disayd bak.
So, we dɛn pat ya na di bren dɔn pwɛl, ɔl di tin dɛn we dɛn pat dɛn de kɔntrol kin bigin fɔ go haywire. fכ egzampl, we di `(brainstem)` dכn pwεl, siriכs prכblεm de wit כtomatכk prכsεs lεk bכdi prεshכn.
Wetin na di men sayn dɛm fɔ MSA?
Insay MSA, sɔm sayn dɛm kin kɔmɔn fɔ ɔl tu di kayn sik dɛm. Apat frɔm dat, tin dɛn de we gɛt fɔ du wit ɛni wan pan dɛn. di men tin we kכmכn fכ di tu tכp dεm na כt כnomik disfכnkshכn . Fɔ tɔk am simpul wan, di tin dɛn we kin apin ɔtomɛtik wan na wi bɔdi nɔ kin wok fayn.
Awtonɔmik Disfɔkshɔn Simptom dɛn
- Orthostatic Hypotension: Dis na di fɔs sayn wae bɔrku pipul kin gɛt. We yu tinap wantɛm wantɛm we yu sidɔm ɔ ledɔm , yu blɔd prɛshɔn kin go dɔŋ wantɛm wantɛm . Dis kin mek yu ed de tɔn, yu nɔ de si fayn, ɛn yu kin ivin fɔdɔm.
- Nɔ ebul fɔ kɔntrol yu urine ɛn stɔl: Urinary incontinence ɛn fecal incontinence kin apin we yu nɔr ɛkspɛkt am.
- Sεkswal disfכnkshכn: Prכblεm lεk εrectile dysfunction, spεshal wan pan man dεm, kin apin we dεn de du mami ɛn dadi biznɛs.
- Slip prכblεm: spεshal wan, dεn kin si wan kכndyushכn we dεn kכl ``(REM) slip bihayvya dizayd''. Insay dis, we yu de drim, yu de muv yu bɔdi, ala, ɛn flay yu an ɛn fut dɛn fɔ ansa yu drim dɛn.
- Di swet we de go dɔŋ (Anhidrosis): Di bɔdi in ebul fɔ swet kin ridyus bad bad wan.
- Sɔm sayn dɛm lɛk wae yu nɔr de si fayn, yu mɔt de dray, yu nɔr de fil fayn fɔ slip, ɛn yu gɛt kɔnstipɛshɔn bak.
imכtant, dεn כtonom disfכnkshכn dεm ya kin apin mכnt, כ ivin ia, bifo di mכtalman simptom dεm bigin (lεk di we aw yu de waka εn di trem). Dis kin apin bitwin 20% ɛn 75% pan di MSA pasɛnt dɛn.
Di kayn we aw pɔsin de tink ɛn di we aw i de fil
Na lɛk wan pat pan tri pan di wan dɛn we gɛt MSA kin gɛt prɔblɛm wit dɛn ebul fɔ tink ɛn pe atɛnshɔn. I nɔ kin izi fɔ dɛn bak fɔ kɔntrol aw dɛn de fil, ɛn dis kin mek dɛn gɛt difrɛn prɔblɛm dɛn wit dɛn maynd.
- Wɔri
- Pwɛl at
- Kray ɔ laf we nɔ fayn
- Panik atak dɛn
- Tin fɔ tink bɔt fɔ du bad ɔ kil yusɛf
Simptom dɛn we gɛt fɔ du wit muvmɛnt
Dɛn kwaliti ya kin difrɛn difrɛn wan bay di tu kayn MSA we wi bin dɔn tɔk bɔt.
| MSA-C (Sεribεl) kכntribyushכn dεm | MSA-P (Parkinsonism) simptom dɛm |
|---|---|
| Di men sayn na ataxia , we min se yu nɔ de wok togɛda igen. | De men sayn dɛm na Pakinson , wae min sayn dɛm wae fiba dis sik. |
| - di muvmεnt dεm we di limb dεm nכ de kכntro, we de chaotic. | - Muvmεnt dεm kin rili slo (bradykinesia) . |
| - di limb dεm de tret we yu de tray fכ du sכmtin (Action tremor). | - Fɔ fil tayt ɛn stif na di bɔdi, ɛn fɔ tinap we i tan lɛk se i bɛn fɔ go bifo. |
| - Fɔ waka wit di fut dɛn we nɔ kɔmɔn we de fa frɔm dɛnsɛf, lɛk we yu de waka we yu de shuffle. | - Fɔdɔm bɔku tɛm we yu de waka. |
| - di ay twit εn muvmεnt we dεn nכ de kכntro (nystagmus) . | - Slurring ɛn slurring fɔ wɔd dɛn we yu de tɔk. |
Wetin kin mek pɔsin gɛt MSA?
Wi nɔ stil no di rayt tin we kin mek pɔsin gɛt MSA . Bɔt sayɛnsman dɛn tink se na wan prɔtin we dɛn kɔl alfa-synuclein . Dɛn tink se dis prɔtin nɔ kin gɛda na difrɛn pat dɛn na di bren we nɔ kin de, ɛn dis kin mek di bren sɛl dɛn pwɛl. I sɔprayz fɔ no se dɛn tink bak se dis sem prɔtin de mek pɔsin gɛt di sik we dɛn kɔl Pakinsin.
Di prɔtin dɛn impɔtant fɔ mek wi bɔdi wok fayn. Bɔt we dɛn prɔtin ya gɛda na di rɔng ples, di rɔng we, dɛn kin pwɛl di sɛl dɛn. Na dat kin apin na MSA.
Risach stil de go bifo fɔ no wetin mek dis alfa-synuclein protin de gɛda na di bren. Dɛn kin sɔprayz se i kin bi bikɔs ɔf di chenj dɛn we de apin na di jɛnɛtiks. in patikyula, pruf de fכ se di MSA-C tכp kin transmit frכm jεnereshכn to jεnereshכn to sכm mak. כltu, dεn nכ fכnshכn dis kayn jεnεtik link yet fכ di MSA-P tכyp.
Impɔtant: MSA nɔto sik we pɔsin kin pas. I nɔ kin pas frɔm wan pɔsin to ɔda pɔsin ɛni we.
Aw dɛn kin no se pɔsin gɛt MSA?
Dis na de pat wae kin tranga pasmak pan de sik. Na di onli we fɔ kɔnfɔm MSA wit 100% shɔ.na fɔ chɛk di bren tisu afta pɔsin day. di rizin fכ dis na biכs naw nכ tεknכlכji nכ de fכ si if di alfa-synuclein protin de dכn na di bren fכ pכsin we de alayv.
Bɔt we di pɔsin we sik de alayv, dɔktɔ dɛn kin sɔprayz se i gɛt di sik. Dɛn kin yuse tin dɛm lɛk di sayn dɛm, di pɔrsin in mɛdikal histri, famili histri, ɛn aw pɔrsin kin du sɔm tritmɛnt dɛm. Bɔku tɛm, dɔktɔ dɛn kin no fɔs se i gɛt Pakinsin sik. Bɔt as ɔda sayn dɛm de kam as tɛm de go, ɔr we di mɛrɛsin fɔ Pakinsin dɔn stɔp fɔ wok, dɛn kin nid fɔ chenj di diagnosis to MSA.
Ki difrɛns bitwin MSA ɛn Pakinsin sik
| Di kwaliti we pɔsin gɛt | Mɔltipɛl Sistɛm Atrofi (MSA) . | Dis sik we dɛn kɔl Parkinson |
|---|---|---|
| Di spid we di sik de skata | Di sayn dɛm kin wɔs kwik kwik wan . | Di sik kin go bifo smɔl smɔl . |
| Wikɛd tin dɛn we kin apin ɔtomɛtik wan | Bɔrku tɛm, siriɔs kɔmplikɛshɔn (e.g., blɔd prɛshɔn prɔblɛm) kin apin insay di fɔs ia we di sik bigin. | I kin tek sɔm ia fɔ mek dɛn sayn ya kam. |
| Tremor | Di shek shek nɔ bɔku, sɔntɛm dɛn ivin nɔ de . | Trem we kin apin we yu rɛst na wan big sayn . |
| Rispɔns to Levodopa | Na smɔl pipul dɛn nɔmɔ kin ansa dis mɛrɛsin.Ɔ nɔto so atɔl. | I de ansa fayn fayn wan to dis mɛrɛsin. |
Test dɛn fɔ no if pɔsin gɛt di sik
Na smɔl tɛst dɛn nɔmɔ de we go ebul fɔ no MSA dairekt wan. Bɔku tɛm, dɛn kin du sɔm tɛst fɔ pul ɔda kɔndishɔn ɛn gɛda pruf fɔ sɔpɔt di saspek se MSA kin bi di kɔz.
- MRI (Magnetic Resonance Imaging) scan: Sɔntɛnde dis kin sho se sɔm pat dɛn na di bren dɔn pwɛl. insay MSA-C, spεshal wan, dεn kin si wan patεn we dεn kכl "hכt kכros bכn" sayn na wan pat pan di bren. I tan lɛk wan hot krɔs bɔn. Bɔt dɛn kin si dis sayn bak pan ɔda sik dɛn, so i nɔto difinitiv diagnosis fɔ MSA.
- jεnεtik tεst: dis kin chεk fכ jεnεtik mכtεshכn dεm we riliyt to di alfa-synuclein protin.
- Skin biopsy: Sɔm nyu risach dɔn sho se dis tɛst kin ɛp fɔ no if alfa-synuclein de na di nerve tissue na di skin. Bɔt dis stil de na di risach pat.
Yu dɔktɔ go ɛksplen to yu us tɛst dɛn we i tink se nid fɔ du, bay aw yu sik, ɛn wetin fɔ ɛkspɛkt frɔm dɛn.
Tritmɛnt de fɔ MSA?
Bɔt i sɔri fɔ no se naw, no mɛrɛsin nɔ de fɔ mɛn MSA . So, di men gol fɔ tritmɛnt na fɔ kɔntrol di sayn dɛm ɛn kip gud kwaliti layf fɔ as lɔng as i pɔsibul.
Di tritmɛnt we dɛn kin gi kin dipen pan di sikman in sik ɛn aw dɛn kin tranga. Fɔ ɛgzampul, dɛn kin gi blɔd prɛshɔn mɛrɛsin fɔ ɔrtɔstatik haypɔtɛnshɔn, fɔ rilaks mɔsul fɔ mek i stif, ɛn ɔda mɛrɛsin fɔ kɔntrol di urinary. Dɔn bak, tin dɛn lɛk fisiotɛrapi ɛn tɔk tɛrapi rili impɔtant.
If yu ɔr pɔrsin wae yu sabi gɛt dis sik, nɔr tray fɔ trit yusɛf ɔr de kɔntrol di sayn dɛm. Ɔltɛm, go to dɔktɔ we sabi du di wok ɛn fala dɛn advays.
Us kayn tumara bambay pɔrsin wae gɛt dis sik kin ɛkspɛkt?
MSA na sik we de go bifo. Na lɛk af pan di wan dɛn we gɛt di sik go nid ɛp fɔ waka (lɛk ken ɔ waka) insay 5 ia frɔm di tɛm we dɛn bigin fɔ gɛt di sik. Na lɛk 60% go nid wilchia insay 5 ia. Bay 6 to 8 ia, bɔku pan di sik pipul dɛn kin de na bed.
As di sik de go bifo, dɛn nid fɔ du difrɛn mɛrɛsin dɛn fɔ mek di bɔdi kɔntinyu fɔ wok.
- Tracheostomy na we dɛn kin mek smɔl ol na di trot ɛn put wan tiub fɔ ɛp fɔ mek i nɔ ebul fɔ blo fayn.
- Tiub fidin na we yu de gi it tru tiub we di sikman nɔ ebul fɔ swɛla.
- Tubing ɔ ɔda ɔpreshɔn fɔ kɔntrol di urine ɛn stɔl.
Tipikli, di avrej layf we pɔsin we gɛt MSA kin liv frɔm di tɛm we dɛn no di sik na bitwin 6 ɛn 10 ia. Sɔm kayn tin wae nɔr kin tranga pasmak, i kin pɔsibul fɔ liv fɔ 15 ia. Bɔt if di sik rili bad, di layf we pɔsin kin liv kin shɔt pasmak.
Di prɔblɛm dɛn we kin kam wit di sik kin mek pɔsin day mɔ. Fɔ ɛgzampul:
- Nyumonia.
- Sepsis (blɔd pɔyzin) bikɔs ɔf di urinary tract infection.
- Day wan wan we kin kam bikɔs ɔf prɔblɛm wit di we aw di bren kin kɔntrol aw i de blo we i de slip.
Aw wi kin kia fɔ di wan dɛn we wi lɛk?
As di sayn dɛm fɔ pɔrsin wae gɛt MSA de wɔs as tɛm de go, dɛn kin teik tɛm nɔr kin ebul fɔ liv fɔ dɛnsɛf. Sɔntɛm bak dɛn nɔ kin ebul fɔ tink, tɔk, ɛn disayd fɔ dɛnsɛf.
So, e fayn fɔ tɔk bɔt di tumara bambay wit di wan dɛm wae yu lɛk kwik kwik wan pan de sik, wae de pɔrsin stil de mɛmba. If yu de na say we yu nɔ ebul fɔ disayd fɔ du sɔntin, i go fayn fɔ ɔlman if yu ebul fɔ tɔk bifo tɛm bɔt wetin fɔ disayd bɔt yu mɛrɛsin ɛn pripia di ligal dɔkyumɛnt dɛn.
Ustɛm yu fɔ go to dɔktɔ?
Bɔrku pan de fɔs sayn dɛm fɔ MSA na tin dɛm wae yu fɔ rili tɔk bɔt wit dɔktɔ.
- Mami ɛn dadi biznɛs di we aw Gɔd nɔ want.
- Kɔntinyu fɔ diziz ɛn nɔ kin no natin we yu tinap.
- Prɔblɛm dɛn we yu kin gɛt we yu de slip, mɔ we yu nɔ kin ebul fɔ blo fayn we yu de slip.
If yu dɔktɔ dɔn tɛl yu se yu gɛt wan sik we de mek yu muv lɛk Pakinsin, i impɔtant fɔ tɔk bɔt ɛni chenj we yu gɛt pan yu sik. Ɛspɛshali if di mɛrɛsin (levodopa) fɔ Pakinsin nɔr de woke, dat na big tin fɔ sho se yu kin gɛt MSA.
MSA na siriɔs sik we kin kil pɔsin. Na tru se no mɛrɛsin nɔ de fɔ am. Bɔt, dɛn kin trit bɔku pan di sayn dɛm. Tru da tritmɛnt de, dɛn kin kip di pɔsin in kwaliti layf na gud lɛvɛl fɔ bɔku ia. Da tɛm de na fayn chans fɔ spɛnd gladi at wit di wan dɛn we dɛn lɛk ɛn ɛnjɔy layf ful wan.
Mɛsej we dɛn kin kɛr go na os
- MSA na wan sik we nɔ kin apin so ɔltɛm ɛn we kin kil pɔsin ɛn we kin pwɛl sɔm pat dɛn na di bren smɔl smɔl.
- tu men tכp dεm de: MSA-C (balans lכs de bכku) εn MSA-P (Parkinsonism fכm dεm de bכku).
- di כtonom disfכnkshכn, lεk we di bכdi prεshכn de dכn we i tinap εn we i nכ de kכntrכl di urinary, de apin kwik kwik wan.
- MSA kin go bifo kwik kwik wan pas di sik we dɛn kɔl Pakinsin ɛn i nɔ kin gri fɔ tek di mɛrɛsin dɛn we dɛn kin tek pan Pakinson.
- Pan ɔl we no mɛrɛsin nɔ de fɔ dis sik, tritmɛnt dɛn de fɔ kɔntrol di sayn dɛm ɛn fɔ mek in layf bɛtɛ.
- I rili impɔtant fɔ no di sayn dɛm kwik kwik wan, go to dɔktɔ, ɛn plan fɔ tumara bambay.
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