Yu bɔdi de fil se yu nɔ gɛt layf? Na Myasthenia Gravis (MG) we yu tink se na di wɔl? Lɛ wi tɔk bɔt am!

Sɔntɛnde, yu kin fil se yu taya bad bad wan ɛn yu nɔ gɛt layf as di de de go? Ɛspɛshali we yu yay fil lɛk se i de lɔk, ɛn i nɔ kin izi fɔ tɔk, it, ɔ ivin es yu an ɔ yu leg? Dɛn tin ya nɔ kin jɔs taya. Tide wi go tɔk bɔt Myasthenia Gravis , ɔ (MG) fɔ shɔt, wan kɔndishɔn we kɔmplikt smɔl, bɔt dɛn kin manej am fayn if dɛn manej am fayn .

Wetin na Mayasthenia Gravis? Fɔ tɔk am simpul wan...

Myasthenia gravis na wan sik we pɔsin kin gɛt we i de fɛt insɛf . Wetin na dat? I rili simpul. Wi gɛt wan imyun sistɛm na wi bɔdi. I tan lɛk ami na wi bɔdi. I wok na fɔ protɛkt wi bay we i de fɛt di jem ɛn sik dɛn we de kɔmɔt na do. Bɔt, sɔntɛnde dis ami kin mek smɔl mistek. I de tink se ivin di sɛl dɛn we gɛt wɛlbɔdi na wi bɔdi na di ɛnimi. Dɔn i kin bigin fɔ atak dɛn wɛlbɔdi sɛl dɛn de. Na dat kin apin pan myasthenia gravis.

Dis kin afɛkt di mɔsul dɛn we de na di skel mɔ . Dat min se di mɔsul dɛn we de tay pan wi bon dɛn ɛn ɛp wi fɔ muv. Tink bɔt am, yu es yu an, blink yu yay, tɔk, laf, it, waka... Dɛn mɔsul ya de ɛp wit ɔl dis. Insay pɔsin we gɛt myasthenia gravis, dɛn mɔsul ya kin wik ɛn nɔ gɛt layf.

Di impɔtant tin na dat dis mɔsul wikɛdnɛs kin bɔku we yu de wok ɛn du tin, ɛn i kin stɔp we yu rɛst smɔl . Ivin if yu fayn we yu wek na mɔnin, as di de de go ɛn yu de du yu wok, smɔl smɔl yu kin taya ɛn yu mɔsul dɛn kin wik.

Dis na sik wae nɔr de te, dat min se e nɔr de go insay shɔt tɛm. Bɔt nɔ wɔri, gud tritmɛnt dɛn de fɔ ɛp yu fɔ kɔntrol yu sik dɛn ɛn liv nɔmal layf .

Wetin mek dis de apin? Wetin de apin insay wi bɔdi?

Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin se yu de wach kriket mats.

Wi nerves na di pitcha. Na dɛn kin sɛn mɛsej to di mɔsul dɛn.

Na wi mɔsul dɛn de kech. Na dɛn kin kech di mɛsej.

di ples we dεn tu de chenj mεsej dεm dεn kכl am di nyuromכskular jכnkshכn . Dat na di ple fild.

Naw, we wan nerve nid fɔ sɛn mɛsej to wan mɔsul, di nerve de pul wan kemikal we dɛn kɔl acetylcholine (dis na di bɔl). di mכsul dεm gεt spεshal ples fכ grap dis asetilkolin, we dεn k כl asetilkolin rεsεpכta dεm (dis na di kipa in gכlכv).

jכs lεk we di bכl hit di gכlכv, di mכsul de kכntrakt, dat min se i de aktibכt, we di asetilkolin de go εn tay pan dεn rεsεpכta dεm de. Dis kin apin kwik kwik wan, ɛn nɔr kin ambɔg am, na pɔrsin wae gɛt wɛl bɔdi in bɔdi.

bכt, wetin kin apin pan pכsin we gεt myasthenia gravis na dat di imyun sistεm we wi bin tכk bכt fכ mistek destroy כ blok dεn asetylcholine rεsεpכta dεm (catcher’s glove) . afta dat di mεsej (di bכl) we de kכmכt frכm di nεv nכ kin ebul fכ kech di mכsul (di kipa). Di mɛsej chenj kin apin rili sloslo, ɔ nɔ kin apin atɔl. Na dat mek di mɔsul dɛn kin wik. Yu ɔndastand?

Difrɛn kayn myasthenia gravis de?

Yɛs, mɔ difrɛn kayn dɛn de:

• Autoimmune myasthenia: Dis na di kayn we we dɛn kin gɛt mɔ. As wi bin dɔn tɔk, na bikɔs di imyun sistɛm nɔ de wok fayn. Pan ɔl we dɛn nɔ no di rayt tin we kin mek dis apin, dɛn biliv se na bikɔs dɛn kin mek sɔm kayn antibodi dɛn .
• Nyu bכbi maysthenia: Dis kin apin we di pikin gεt sכm antibodi dεm frכm mama we gεt myasthenia gravis we i bεlε. Afta di pikin bɔn, i kin kray smɔl ɛn i kin at fɔ mek i sok. Bɔt dis kin apin fɔ sɔm tɛm ɛn bɔku tɛm i kin bɛtɛ afta lɛk tri mɔnt so.
• Mayasthenia we dɛn bɔn wit: Dis nɔto ɔtoimyun kɔndishɔn. Na wan kayn we nɔ kin apin so ɔltɛm we pɔsin chenj in jɛnɛtiks .

tu men sכbtayp dεm de bak fכ כtoimyun myasthenia gravis:

1. Ocular myasthenia: Insay dis, di mכsul dεm we de muv di yay dεm εn rεs di aylid dεm de wik. Di aylid kin drɔp (ptosis) , ɔ i kin at fɔ kip di yay opin. Sɔm pipul kin si tu tin bak (dɔbul vishɔn). Bɔrku tɛm, di fɔs sayn wae de sho se yu gɛt mayasthenia na wae yu yay wik . Na lɛk af pan pipul dɛm wae gɛt dis kayn ocular myasthenia leta go gɛt di ɔda kayn.

2. Jɛnɛral myasthenia: pan dis, apat frɔm di mɔsul dɛm na di yay, di mɔsul dɛm na di fes, nɛk, an, leg, ɛn trot kin wik bak. I kin tranga fɔ tɔk, swɛla it, es yu an, grap na chia, waka lɔng, ɛn klaym stej.

Wetin na di sayn dɛm fɔ myasthenia gravis?

Pan ɔl we di sayn dɛn kin difrɛn, di wan dɛn we kin apin mɔ na:

• di mכsul dεm we de wik na di an, di finga dεm, di leg dεm, εn di nεk.
• Rili taya (taya) .
• Aylid we de drɔp (ptosis) .
• Blɔri ɔ dabl vishɔn .
• I nɔ izi fɔ sho aw yu de fil (lɛk fɔ nɔ ebul fɔ smayl fayn, fɔ mek yu fes).
• I nɔ kin izi fɔ tɔk, swɛla, ɔ it . Fɔ ɛgzampul, yu vɔys kin chenj smɔl smɔl we yu de tɔk, ɛn dis kin mek yu saund lɛk se yu de tɔk wit vɔys we nɔ de tɔk.
• I nɔ izi fɔ waka .

Di fɔs sayn dɛm fɔ myasthenia gravis kin apin ɔlmost wantɛm wantɛm. As wi bin dɔn tɔk, yu mɔsul dɛn kin wik we yu de du tin, ɛn dɛn kin gɛt trɛnk bak we yu rɛst . Di kayn we aw dis mɔsul wik kin difrɛn frɔm wan de to ɔda de. Bɔku pipul dɛn kin fil fayn we di de bigin ɛn dɛn kin wik pasmak we di de dɔn.

Na smɔl tɛm nɔmɔ, myasthenia gravis kin afɛkt di mɔsul dɛn bak na di respiratory system . Dis kin mek yu nɔr ebul fɔ blo fayn ɔr yu gɛt mɔr siriɔs prɔblɛm wit yu brith. If yu fil lɛk se yu gɛt prɔblɛm fɔ blo, na imejensi. Yu fɔ go na di ɔspitul we de nia yu wantɛm wantɛm. Bɔku tɛm, dis nɔ kin apin wan tɛm.

Udat de pan denja pas ɔl fɔ dis?

Pan ɔl we myasthenia gravis kin kam pan ɛni ej, i kin bɔku pan uman dɛn we nɔ rich 40 ia yet ɛn pan man dɛn we dɔn pas 60 ia .

Yu kin gɛt mɔ risk fɔ gɛt dis sik fɔ dɛn rizin ya:

• If yu gɛt ɔda ɔtoimyun kɔndishɔn (e.g. rεumatoid at, lupus).
• If yu gɛt tayroyd sik .

If yu dɔn ɔlrɛdi gɛt myasthenia gravis, sɔm tin dɛn kin mek yu sik dɛn wɔs:

• Sɔm mɛrɛsin fɔ malaria ɛn at ritm dizayd.
• Dɛn de du ɔpreshɔn pan am .
• Wan infɛkshɔn .

Wetin na di rilayshɔn bitwin di taymus gland ɛn di myasthenia gravis?

Bɔrku pipul dɛm wae gɛt myasthenia gravis kin gɛt prɔblɛm wit dɛn taymus gland . di taymus gland na wan sכmכl כgan na wi כp chεst, jכs dכn di brεstbon. Na pat pan wi limfatik sistɛm. Na di ɔgan we de mek wayt blɔd sɛl ɛn ɛp fɔ fɛt infɛkshɔn.

Na lɛk tu-tɛd pan di pipul dɛn we gɛt myasthenia gravis gɛt thymic hyperplasia , we na wan sik we di taymus gland kin wok pasmak. Apat frɔm dat, lɛk wan pan ɛvri tɛn pipul dɛn kin gɛt tumbu na di taymus gland we dɛn kɔl taymoma . Dɛn tin ya kin bi kansa ɔr nɔr gɛt ɛni prɔblɛm. dεn tink se dεn abnכmaliti dεm ya na di taymus gland de mek di imyun sistεm nכ de wok fayn.

Wetin na di prɔblɛm dɛn we kin apin we pɔsin gɛt myasthenia gravis?

Di men wan na wan sik we dɛn kɔl myasthenic crisis . Insay dis, di mɔsul dɛn we de ɛp yu fɔ blo kin rili wik. Dɔn, yu kin nid sɔntin lɛk mashin (respirator/mechanical ventilation) fɔ ɛp yu fɔ blo. Dis na mɛdikal imejensi we kin mek pɔsin in layf de pan denja.Dɛn kin se lɛk wan pan ɛvri fayv pipul dɛm wae gɛt myasthenia gravis go gɛt dis sik wan tɛm insay dɛn layf.

Apat frɔm dat, dis mɔsul dɛn we wik ɛn taya kin mek yu nɔ ebul fɔ tek pat pan di tin dɛn we yu lɛk. I kin mek bak yu gɛt strɛs ɛn pwɛl at . Bɔt stɔdi dɔn sho se bɔku pipul dɛn we gɛt myasthenia gravis kin du layt wok ɛn ɛksesaiz ɛvride.

Aw dɔktɔ dɛn kin no if pɔsin gɛt myasthenia gravis?

If yu dɔktɔ saspek dis afta i dɔn lisin to yu sayn dɛm ɛn du yu bɔdi ɛgzam, dɛn go du sɔm tɛst fɔ kɔnfirm am:

• Blɔd antibodi tɛst: Na lɛk 85% pan di pipul dɛm we gɛt myasthenia gravis gɛt abnɔmal ay lɛvɛl fɔ asɛtilkɔlin riseptɔ antibodi dɛm na dɛn blɔd. כda 6% gεt antibodi dεm to mכsul-spεsifi k kinaz (MuSK) .
• Imej skan: Dɛn kin du MRI (Magnetic Resonance Imaging) ɔ CT skan (Computed Tomography scan) fɔ chɛk fɔ si if i gɛt prɔblɛm lɛk tumor na di taymus gland.
• Elektromayografi (EMG): Dis tεst de mכsu di ilektrikal aktiviti fכ di mכsul dεm εn di nεv dεm. I kin no prɔblɛm wit di kɔmyunikeshɔn bitwin di nerv ɛn mɔsul dɛm.

Dɔktɔ dɛn kin klas myasthenia gravis akɔdin to aw di sik siriɔs. Jɛnɛral wan, fayv klas dɛn de (Klas I - V). Klas I na wan kayn sik we nɔ kin apin we kin afɛkt di yay nɔmɔ, we Klas V na wan bad bad sik we kin afɛkt di we aw pɔsin de blo, sɔntɛnde i kin nid fɔ put intubation ɔ mɛkanikal ventilation .

Wetin na di tritmɛnt fɔ myasthenia gravis?

Nɔr mɛrɛsin nɔr de fɔ myasthenia gravis, bɔt fayn tritmɛnt dɛn de wae kin ɛp yu fɔ kɔntrol yu sayn dɛm ɛn liv gud layf.

• Di mɛrɛsin dɛn we dɛn kin yuz:
• Cholinesterase inhibitors / anticholinesterase: dis mεdikeshכn dεm de wok bay we dεn de mek di kכmyunikeshn bitwin di nεv dεm εn di mכsul dεm bכku, we de mek di mכsul dεm trεnk bכku.
• Immunosuppressants: Mεdikeshכn dεm lεk k כtikostεroyd de wok bay we dεn de rεdכks di כva aktiviti fכ di imyun sistεm εn rεdכks di prodakshכn כf dεn rכng antibodi dεm.
• monoklonal antibodi dεm: Dis na bayoεnjinia protin dεm. Dɛn kin gi dɛn as injɛkshɔn we dɛn kin put insay di bɛlɛ (IV) ɔ as injɛkshɔn we dɛn kin put ɔnda di bɔdi (SQ) . Dɛn kin kɔntrol di ɔva aktiviti fɔ di imyun sistɛm.
• Plasma exchange / plasmapheresis: Na mashin de pul di plasma frɔm di blɔd, we gɛt antibodi dɛm we de ambɔg am, ɛn put plasma ɔ plasma sɔlvushɔn frɔm pɔsin we gi am.
• Imyunoglobulin we dɛn kin put insay di bɛlɛ ɔ we de ɔnda di bɔdi (IV ɔ SQ Immunoglobulin - IVIG ɔ SCIG): Dɛn kin gi antibodi dɛn frɔm di wan dɛn we gi dɛn bay we dɛn injɛkshɔn insay di bɛlɛ (IV) fɔ tu to fayv dez. Dis na tritmɛnt fɔ myasthenic kraysis ɛn bak fɔ generalized myasthenia gravis.
• Ɔpreshɔn: Taymɛktomi na di ɔpreshɔn we dɛn de du fɔ pul di taymus gland. Dɛn kin se dɛn fɔ du dis ɔpreshɔn fɔ pipul dɛn we gɛt tayma, ɛn fɔ pipul dɛn we nɔ gɛt taymus tumbu.

Ɔl dɛn tritmɛnt ya kin gɛt sɔm sayd ɛfɛkt, so tɔk to yu dɔktɔ bifo yu bigin ɛni nyu mɛrɛsin.

Wetin a kin du na os fɔ ridyus di sayn dɛm?

If yu gɛt myasthenia gravis, tray dɛn tin ya fɔ ridyus di taya we yu de fil ɛn fɔ mek yu mɔsul dɛn gɛt mɔ trɛnk:

• Ɛksesaiz ɔltɛm: Bɔt na afta yu dɔn go to yu dɔktɔ, na fɔ bigin ɛksesaiz program we sef we go fayn fɔ yu. We yu de du ɛksasaiz, i de mek yu mɔsul dɛn strɔng, i de mek yu fil fayn, ɛn i de mek yu bɔdi gɛt trɛnk.
• Nɔ go na do we di wɛda wam bad bad wan: Ɔt kin mek di sik dɛn wɔs. We yu fil se yu wam bad bad wan, put klos we yu sok insay kol wata na yu nɛk ɛn yu fɔrɛst.
• Put bɔku prɔtin ɛn kabɔhaydrɛt insay yu it: Dɛn kin gi yu bɔdi ɛkstra ɛnaji.
• Du di wok dɛm wae yu kin si se kin taya pasmak ali na di de: na da tɛm de yu kin gɛt mɔ ɛnaji.
• Tek shɔt slip ɔ rɛst insay di de: Dis go mek yu bɔdi rɛst smɔl.

Wetin na di fiuja fɔ myasthenia gravis? (Autluk) .

Myasthenia gravis na wan sik we dɛn kin mɛn . Di sayn dɛm kin kɔmɔt frɔm smɔl to siriɔs. Bɔrku tɛm, di sayn dɛm kin rich dɛn mak insay wan to tri ia afta dɛn dɔn no di sik fɔs.

Bɔrku pipul dɛn kin liv ful, aktif layf wit tritmɛnt.

Sɔntɛnde di sik kin go insay rɛmishɔn . Dis min se de sik kin dɔn fɔ sɔm tɛm. Dis kin bi fɔ shɔt tɛm ɔ fɔ ɔltɛm. If dis apin, yu dɔktɔ go chenj yu tritmɛnt plan.

Bɔrku pipul dɛm wae gɛt myasthenia gravis de liv nɔrmal layf . Di tin dɛm we kin mek pɔsin in layf de pan denja kin apin nɔmɔ we i afɛkt di we aw pɔsin de blo, lɛk di myasthenic crisis we wi bin tɔk bɔt.

Myasthenia gravis ɛn uman we gɛt bɛlɛ

Na sכm tεm we uman bεlε kin mek di myasthenia gravis simptom dεm fכ di fכs tεm. If yu dɔn gɛt dis sik, yu sik kin wɔs insay di fɔs tri mɔnt we yu gɛt bɛlɛ ɔ afta yu dɔn bɔn yu pikin. Bɔt sɔm tɛm dɛn de, di sayn dɛn we yu kin gɛt kin bɛtɛ we yu gɛt bɛlɛ.

Sɔm tritmɛnt dɛn nɔ kin sef we uman gɛt bɛlɛ ɛn we i de gi in mama in bɛlɛ. So i impɔtant fɔ mek yu go to yu dɔktɔ fɔ gayd yu insay dis tɛm fɔ mek shɔ se yu gɛt wɛlbɔdi bɛlɛ.

Ustɛm a fɔ go to dɔktɔ?

Si dɔktɔ if yu gɛt dɛn sayn ya:

• Blɔr vishɔn ɔ dabl vishɔn.
• I nɔ izi fɔ waka, tɔk, ɔ it.
• Di mɔsul dɛn kin taya ɔ wik bad bad wan.
• I nɔ kin izi fɔ yu fɔ blo.

Mɛmba se if yu gɛt prɔblɛm fɔ blo, na imejensi! Kɔl 911 (yu lokal imejensi nɔmba) wantɛm wantɛm ɔ go na di ɔspitul we de nia yu.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Yu kin aks di dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Wetin kin mek dɛn gɛt dɛn sik ya?
• Wetin na di bɛst tritmɛnt fɔ mi?
• Wetin na di sayd ɛfɛkt dɛm we di tritmɛnt dɛm kin gɛt?
• Us chenj dɛn we a nid fɔ chenj mi layf?
• Us simptom dɛn a fɔ luk fɔ bɔt di prɔblɛm dɛn we kin apin?
• A kin stat fɔ du ɛksɛsayz program sef wan?
• Yu tink se wan peshɛnt sɔpɔt grup de we a kin jɔyn?

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Myasthenia Gravis kin bi wan sik wae nɔr kin izi fɔ du. Pan ɔl we yu want fɔ kɔntinyu fɔ du sɔntin, sɔntɛnde yu kin fil taya ɛn wik. Dis kin afɛkt yu maynd ɛn bɔdi wɛl bɔdi as tɛm de go.

Bɔt mɛmba se pan ɔl we no mɛrɛsin nɔ de, wit tritmɛnt, bɔku pipul dɛn kin liv ful, aktif layf. Siriɔs disabiliti frɔm myasthenia gravis nɔ kin bɔku. Yu dɔktɔ kin tɔk bɔt aw fɔ kɔntrol yu sik so dat yu go ebul fɔ de wɛl. Nɔ panik, ɛn nɔ tray fɔ dil wit dis yu wan. Fɔ fala yu dɔktɔ in advays ɛn gɛt di ɛp we yu nid. A de wish yu fɔ wɛl kwik kwik wan!

` Myasthenia Gravis, Myasthenia Gravis, Mכsul wik, כtoimyun sik dεm, Asetilkolin, Taymus gland, Nyuromaskul jכnkshכn