Lɛ wi no bɔt Nyurolɛptik Malignant Sindrom, we na wan denja sik we nyurolɛptik drɔgs kin kam wit!

Yu ɔ pɔrsin wae yu sabi kin de tek wan kayn mɛrɛsin wae dɛn kɔl nyurolɛptik, wae dɛn kin yuse fɔ trit sɔm kayn mɛntɛl hεlth sik. Pan ɔl we dɛn mɛrɛsin ya kin rili ɛp bɔku pipul dɛn, i nɔ kin apin so ɔltɛm we dɛn mɛrɛsin ya kin mek pɔsin gɛt prɔblɛm we denja, ivin we kin mek pɔsin in layf de pan denja. Na dat wi kin kɔl Nyurolɛptik Malignant Sindrom (NMS). Na kɔmplikɛt nem, bɔt i impɔtant fɔ no bɔt am.

Wetin na Nyurolɛptik Malignant Sindrom (NMS)? Lɛ wi ɔndastand am simpul wan!

Fɔ tɔk am simpul wan, nyurolɛptik malignant sindrom (NMS) na wan tin we nɔ kin apin so ɔltɛm ɛn we kin mek pɔsin in layf de pan denja fɔ wan klas ɔf drɔgs we dɛn kɔl nyurolɛptik (dɛn kin kɔl am bak antisaykotik mɛrɛsin). Dɛn kin yuse dɛn mɛrɛsin ya fɔ mɛn ɛn trit di sayn dɛm fɔ bɔrku mɛntɛl hεlth kכndyushכn dεm.

Yu kin si sɔm men simptom dɛm na dis `NMS` kɔndishɔn:

• Fɔ gɛt ay fiva (haypatɛmia).
• di mכsul dεm na di bכdi kin tayt εn i kin fil pen (if dis kכntinyu, di mכsul dεm kin ivin brok).
• Chenj dεm na di mεntal stεtus (lεk kכnfyushכn, mεmכri lכs).
• di כtonomik nεv sεstem dεm we de wok fayn כ disautonomia.

di כtonom nεv sεstem we wi kin gεt lεk di כtomatik sistεm we de na wi bכdi. I de kɔntrol tin dɛn lɛk blɔd prɛshɔn ɛn di rit we pɔsin de blo. We i nɔ de wok fayn, blɔd prɛshɔn kin go ɔp ɛn dɔŋ wantɛm wantɛm, i kin mek pɔsin swet pasmak (sɛkɔndari haypa haydrosis), ɛn i kin mek i kɔmɔt na di blɔd pasmak.

NMS na mɛdikal imejensi we de mek pɔsin in layf de pan denja, ɛn i nid fɔ go to dɔktɔ wantɛm wantɛm. So, if yu gɛt dɛn sik ya, di bɛst tin fɔ du na fɔ go na ɔspitul wantɛm wantɛm.

Wetin na dɛn nyurolɛptik mɛrɛsin ya?

Nyurolɛptik mɛrɛsin, ɔ antisaykotik mɛrɛsin, dɛn kin sheb am to tu men kategori.

1. Fɔs-jɛnɛreshɔn ɔ "tipik" antisaykotik.

2. Sεkכn jεnereshכn כ "atypical" antisaykotik.

Dɔktɔ dɛn kin gi dɛn fɔs ɛn sɛkɔn jɛnɛreshɔn antisaykotik fɔ difrɛn kayn mɛntɛl ɛn nyurolɔjik kɔndishɔn dɛn. Na sɔm ɛgzampul dɛn ya:

• Prɔblɛm fɔ bihayvya wae kin kam pan dis maynia sik.
• Bipola muud disɔda.
• Pwɛl at.
• Di prɔblɛm dɛn we pɔsin kin gɛt we i de it.
• Jɛnɛralized anxiety disɔda.
• Geriatric agiteshɔn we pɔsin kin gɛt.
• Nɔ ebul slip.
• Obsesiv-kɔmpulsiv disɔda (OCD).
• Di prɔblɛm dɛn we kin apin to pɔsin in pasɔnaliti.
• Pɔst-traumatik strɛs disɔda (PTSD).
Schizoaffective disɔda we gɛt di sik. Skizofrenia ɛn sik dɛn we gɛt fɔ du wit am.

Us mɛrɛsin dɛn kin mek pɔsin gɛt nyurolɛptik malignant sindrom (NMS)?

difrεn kayn mεdikeshכn dεm de we kin mek yu gεt `NMS`. Lɛ wi tek wan luk pan wetin dɛn bi.

Tipik nyurolɛptik (antipsaykotik) drɔgs:

• Bromperidol we dɛn kɔl Bromperidol
• Klɔrpromazin `(Klɔrpromazin)`
• Klɔpɛntiksol we dɛn kɔl
• Flufenazin `(Flufenazin)`
• Haloperidol `(Haloperidol)`
• Loxapin we dɛn kɔl loxapin
• Promazin we dɛn kɔl Promazin
• Tioridazin `(Tioridazin)`
• Tiotiksin we dɛn kɔl Tiothixene
• Trifluoperazin `(Trifluoperayzin)`

Atypical nyurolɛptik (antipsaykotik) drɔgs:

• Amisulprayd we dɛn kɔl
• Aripiprazol we dɛn kɔl
• Klɔzapin we dɛn kɔl
• Olanzapin we dɛn kɔl
• Kwitiapin we dɛn kɔl
• Risperidone we dɛn kɔl
• Ziprasidone we gɛt di sik
• Zotepin we dɛn kɔl Zotepine

Sɔm mɛrɛsin dɛn we de mek pɔsin nɔ gɛt bɛlɛ:

• Domperidone we dɛn kɔl Domperidone
• Drɔpɛridɔl `(Drɔpɛridɔl)`
• Mɛtɔklɔpramid
• Proklɔrpɛrazin `(Proklɔrpɛrazin)`
• Prɔmɛtazin we dɛn kɔl Prɔmɛtazin

Dopaminergic (Parkinson’s) mεdikeshכn dεm (bay we yu stכp dεn wan ya wan wan):

• Amantadin we dɛn kɔl am
• Dopamin agonist dɛn
• Levodopa we dɛn kɔl Levodopa
• Tolkapone we dɛn kɔl

Nɔ mek yu fred wit dis list. Nɔto ɔlman we de tek dɛn mɛrɛsin ya go gɛt NMS. Dis na tin we nɔ kin apin so ɔltɛm . Bɔt if yu de tek dɛn mɛrɛsin ya, i impɔtant fɔ no bɔt dis.

Wetin na di difrɛns bitwin NMS ɛn malignant hyperthermia?

Yu go dɔn yɛri bak bɔt wan sik we dɛn kɔl malignant hyperthermia. Na wan rare, siriɔs riakshɔn bak. Bɔt na di mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn pipul dɛn ɛn di tin dɛn we kin mek di mɔsul dɛn rilaks .

I kin mek bak di mɔsul dɛn stif, di rεflεks dεm kin dכn (hyporeflexia), εn di skin kin chenj (blu, rεd). Dɛn sayn ya kin tan lɛk di wan dɛn we de na NMS. Bɔt dɔktɔ dɛn kin no difrɛns bitwin dɛn tu bay we dɛn de luk di pɔsin in mɛdikal istri. Dat min se, ilɛksɛf dɛn jɔs dɔn du anestesia ɔ dɛn tek wan mɛrɛsin we de mek dɛn nɔ gɛt nyurolɛpshɔn.

Wetin na di difrɛns bitwin NMS ɛn Serotonin Syndrome?

Serotonin syndrome na ɔda tin we kin mek pɔsin kɔnfyus. I kin kam wit mɛrɛsin dɛm wae de na di sɛrotonergic klas, lɛk sɔm antidipreshan, amphetamine, antihistamine, ɛn mood stabilizer. Fɔ tɔk am simpul wan, i kin apin we wan kemikal we dɛn kɔl sɛrotonin de na di bɔdi tumɔs.

Di sayn dɛm fɔ sɛrotonin sindrom na fɔ mek yu mɔsul dɛn strɔng, yu kin gɛt bɔku bɔku tin fɔ du, yu kin gɛt dayarɛa, yu kin swet, yu mɔsul dɛn kin twitch (myoclonus), ɛn yu maynd kin chenj. Bɔt , fiva ɛn mɔsul rigiditi nɔ kin bɔku pan sɛrotonin sindrom pas NMS.

Yu dɔktɔ go no difrɛns bitwin dɛn tu tin ya bay we i de lisin to yu sik ɛn di mɛrɛsin dɛn we yu de tek.

Udat kin gɛt nyurolɛptik malignant sindrom (NMS)?

NMS kin apin pan ɛnibɔdi we de tek nyurolɛptik (antipsychotic) mɛrɛsin.

Pan ɔl we dɛn tink se lɛk tu-tɛd pan di NMS kes dɛm kin apin insay di fɔs wik we dɛn bigin fɔ tek nyurolɛptik mɛrɛsin, i impɔtant fɔ mɛmba se dis sik kin apin ɛni tɛm we dɛn de trit am.

Aw kɔmɔn dis `NMS` kɔndishɔn?

Infakt, nyurolɛptik malign sindrom (NMS) na wan sik we nɔ kin apin so ɔltɛm. I kin apin bitwin 0.01% ɛn 3.2% pan pipul dɛm we de tek nyurolɛptik mɛrɛsin.

Bɔt di gud nyus na dat di nɔmba fɔ di ripɔt bɔt NMS de go dɔŋ bikɔs dɛn dɔn kam wit nyu mɛrɛsin dɛn we nɔ gɛt bɛtɛ risk fɔ mek dɛn gɛt NMS, ɛn di we aw dɔktɔ ɛn di wan dɛn we sik dɔn no bɔt dis sik.

Wetin na di sayn dɛm fɔ nyurolɛptik malignant sindrom (NMS)?

di simptom dεm fכ `NMS` kin bigin fכ apia insay wan to tri de . Di men sayn dɛm wae de sho se yu gɛt dis sik na:

• Fiva we rili ay (102 to 104 digri F - 38.9 to 40 digri sɛlshiɔs).
• At ritm irɛgyulariti (arithmia).
• Di at rit we de go ɔp (tachycardia).
• Inkrεs pan di rεspiretכri rεt (tachypnea).
• di mכsul dεm stiff/stiffnεs `(mכsul rigiditi)`.
• Chenj dεm na di mεntal stεtus (lεk kכnfyushכn, agitεshכn, lכs kכnsεns).
• Ay blɔd prɛshɔn ɔ lɔw blɔd prɛshɔn.
• We pɔsin de swet pasmak.

If yu gɛt wan ɔ mɔ pan dɛn sik ya, mɔ if yu de tek nyurolɛptik mɛrɛsin, duya kɔl 911 ɔ go na di ɔspitul we de nia yu wantɛm wantɛm. Dis na mɛdikal imejensi.

Aw nyuroleptik mεdikeshכn de mek `NMS`?

`NMS` kכndishכn na wan nyurolεptik (antipsaykotik) dכg de kכz am.I kin apin wit wan doz, wit inkris pan di doz, ɔ wit kɔntinyu fɔ yuz di sem doz. Pan ɔl we NMS kin gɛt fɔ du wit fɔs jɛnɛreshɔn antisaykotik, i kin apin bak, to smɔl smɔl, we dɛn kin pul sɛkɔn jɛnɛreshɔn antisaykotik wantɛm wantɛm, sɔm antiɛmɛtik, ɛn dopaminergic drɔgs we dɛn kin yuz fɔ Pakinsin sik.

Sayɛnsman dɛn stil de tray fɔ no di rayt tin we kin mek pɔsin gɛt NMS. di tiori we de naw na dat i de kכz f כ dopamin D2 rεsεpכta antagonism . Dopamin na nyurotransmitta na wi bren. Na kemikal we de kɛr mɛsej bitwin sɛl dɛn. nyuroleptik dכg dεm de wok bay we dεn de blכk dis dopamin mεsenja fכ go insay sεl dεm tru spεsifi k rεsεpכta dεm.

we di dopamin risεptor dεm na yu haypothalamus εn/כ spεnal kכd dεn blכk, di mכsul tεnshכn de inkrεs. כlso, di disrupshכn fכ di dopamin rεsεpכta dεm na di haypothalamus na in de mek di hכy fiva εn big fכlt na di bכdi prεshכn we dεn si na NMS.

Aw dɛn kin no se pɔsin gɛt nyurolɛptik malignant sindrom (NMS)?

Fɔ mek dɔktɔ dɛn no se yu gɛt NMS, yu fɔ gɛt ɔl dɛn sik ɔ kɔndishɔn ya :

• Yu de tek nyurolɛptik mɛrɛsin ɔ yu dɔn stɔp fɔ tek dopaminergic mɛrɛsin wantɛm wantɛm.
• Yu gɛt siriɔs mɔsul tayt/tayt (dis kin ivin mek di mɔsul dɛn brok).
• Yu gɛt ay fiva.
• Wan chenj de na yu maynd.

Apat frɔm dat, at le tu pan dɛn kwaliti dɛn ya fɔ de:

• Fɔ swet pasmak ɔ we nɔ kɔmɔn.
• I nɔ izi fɔ swɛla.
• Nɔ ebul fɔ kɔntrol di urine ɔ stɔl (incontinence).
• Di at rit we de go ɔp (tachycardia).
• Wantɛm wantɛm, i nɔ ebul fɔ tɔk.
• Di blɔd prɛshɔn we de go ɔp ɔ we i kin chenj ɔltɛm.
• di wayt blɔd sɛl dɛn we de bɔku (Leukocytosis).
• di lεvεl dεm fכ kriaytin fכsfokinεz (CPK) de inkrεs bikoz fכ di mכsul dεm we de brok.
• Slow ɔ limited rεflεks (hyporeflexia).

Us tɛst dɛn kin du fɔ no if pɔsin gɛt `NMS`?

If yu dɔktɔ sɔprayz se yu gɛt NMS, dɛn kin ɔda fɔ du tɛst lɛk:

• Komprehensiv mɛtabolik panɛl.
• Urinalysis we dɛn kin du.
• Atrial ɔ venɔs blɔd gas tɛst.
• Kriatin fosfokinase (CPK) blɔd tɛst.

Aw dɛn kin trit nyurolɛptik malignant sindrom (NMS)?

NMS na wan mɛdikal imejensi. So i impɔtant fɔ no di sik ɛn bigin fɔ trit am kwik kwik wan. If yu gɛt NMS, i go mɔs bi se yu go nid fɔ go na ɔspitul.Yu go nid fɔ gɛt tritmɛnt na wan say usay dɛn de kia fɔ pipul dɛn we sik bad bad wan (ICU).

pan ɔl di kes dɛm fɔ `NMS`, di dɔktɔ dɛm go stɔp di nyurolɛptik (antipsaykotik) mɛrɛsin wantɛm wantɛm we mek di `NMS`. Apat frɔm dat, dɛn go trit di simptom dɛm fɔ `NMS` ɛn tek step fɔ mek dɛn nɔ gɛt pɔsibul kɔmplikeshɔn. Dɛn tritmɛnt ya kin bi:

• Fɔ mek yu kɔntinyu fɔ gɛt di at ɛn di we aw yu de blo stebul bay we yu de yuz mɛkanikal ventileshɔn, antiarithmic mɛrɛsin, ɛn/ɔ pesmɛka.
• fכ mεnten εlektrolayt bεlε na di bכdi bay we yu de gi intravenכs fכluid (IV fכluid).
• Fɔ mek di bɔdi in tɛmpracha go dɔŋ bay we yu de yuz blankit we de mek yu kol, ays wata, ɛn/ɔ ays pak.
• If blɔd prɛshɔn ay, kɔntrol am wit mɛrɛsin.
• Fɔ gi mɛrɛsin lɛk ɛparin fɔ mek blɔd nɔ klɔt.
• Fɔ gi mɛrɛsin dɛn we kin mek di bɔdi gɛt smɔl dopamin lɛvɛl bak.
• Gi mɔsul ɔ skel rilaksant.

Wetin na di risk factor dɛm fɔ divɛlɔp `NMS`?

Bɔku tin dɛn de we kin mek pɔsin gɛt nyurolɛptik malignant sindrom (NMS):

• Fɔ stat nyu nyurolɛptik (antipsychotic) mɛrɛsin ɔ fɔ inkrisayz di doz.
• Yuz mɔ pas wan nyurolɛptik mɛrɛsin ɔ yuz di drɔg lithium.
• Wantɛm wantɛm we dɛn stɔp fɔ tek wan dopaminergic drɔg fɔ di sik we dɛn kɔl Pakinsin.

Aw lɔŋ i go tek fɔ mek yu wɛl frɔm `NMS`? (Prɔgnosis) .

If dɛn no bɔt NMS kwik ɛn trit am kwik ɛn fayn, bɔku pipul dɛn kin wɛl insay tu wik to 14 dez.

Bɔt if di tritmɛnt delay, siriɔs prɔblɛm kin apin we kin afɛkt di mɔsul dɛn, kidni dɛn, at, ɛn/ɔ di lɔng dɛn.

If dɛn nɔ trit am kwik, NMS kin kil pɔsin. di mכtalman rεt fכ NMS de frכm 5% to 20%. Bɔt di we aw pipul dɛn de no mɔ bɔt NMS ɛn di yus fɔ nyu antisaykotik mɛrɛsin dɔn ridyus dis nɔmba fɔ pipul dɛn we de day insay di las sɔm dikɛd ia.

Bɔrku pipul, ɔnda di gayd fɔ dɔktɔ, kin ebul fɔ sakrifays fɔ ristart nyurolɛptik (antipsychotic) mɛrɛsin.

Wetin na di kɔmplikɛshɔn dɛm wae de kam wit nyurolɛptik malignant sindrom (NMS)?

כnכfכs, komplikashכn dεm fכ NMS na kכmכn εn siriכs. Sɔm kɔmplikeshɔn dɛn kin kam bikɔs ɔf di kwaliti dɛn we de sho se di NMS ɛn di ɔtonomik nɛvɔ sistɛm nɔ de wok fayn, ɔda wan dɛn, mɔ di infɛkshɔn, kin kam bikɔs i de na di intensiv kia yunit (ICU) fɔ lɔng tɛm.

Sɔm pan di prɔblɛm dɛn we NMS kin gɛt na:

• Rhabdomyolysis (we di mכsul sεl dεm de brok - dis na di kכmכn kכmplikεshכn).
• Di wata we nɔ de na di bɔdi.
• Akyu kidni we nɔ de wok fayn.
• Akyu respiratory failure we de mek pɔsin nɔ ebul fɔ blo fayn.
• Epileptic kondishɔn/ sik dɛn we kin mek pɔsin sik .
• Mayokardial infarkshɔn we pɔsin kin gɛt.
• di bכdi de kכlכt ɔlsay na di bכdi (Disseminated intravascular coagulation).
• Akyu liva we nɔ de wok fayn.
• Nyumonia.
• Sepsis (jam dεm we de go insay di bכdi).
• Infεkshכn na di urinary tract (UTI).
• Pɔlmonari ɛmbolizm.

Bikɔs dɛn prɔblɛm ya rili bad ɛn dɛn kin mek yu layf de pan denja, i rili impɔtant fɔ kɔl 911 wantɛm wantɛm ɛn go na di ɔspitul we de nia yu fɔ gɛt mɛrɛsin if yu gɛt sayn dɛn fɔ NMS. Bak, NMS na imejensi we de mek pɔsin in layf de pan denja ɛn i kin nid fɔ gɛt tritmɛnt na di Intensiv Keya Yunit (ICU).

Ustɛm a fɔ go to mi dɔktɔ?

If yu de tek wan ɔr mɔr nyurolɛptik (antipsychotics), antiemetics, ɛn/ɔ dopaminergic (Parkinson’s) mɛrɛsin, i impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ mek shɔ se dɛn de wok fayn fɔ yu. Dɔn bak, aks yu dɔktɔ bɔt di sayd ɛfɛkt dɛn we di mɛrɛsin dɛn we yu de tek kin gɛt ɛn us sayn dɛn yu fɔ no bɔt.

A fɔ go na di Imejɛnsi Dipatmɛnt (ETU) if a gɛt simptom fɔ `NMS`?

If yu gɛt sɔm sayn dɛm fɔ nyurolɛptik malignant sindrom (NMS), lɛk we yu gɛt bɔku bɔku fiva ɛn yu mɔsul dɛn stif, i impɔtant fɔ kɔl 911 ɔ go na di ɔspitul we de nia yu wantɛm wantɛm. NMS nid fɔ go to dɔktɔ wantɛm wantɛm. If dɛn nɔ trit am kwik ɛn fayn, i kin ivin mek pɔsin day.

Nyurolɛptik malignant sindrom (NMS) na siriɔs sik we kin mek pɔsin in layf de pan denja. So if yu gɛt sɔm sayn dɛn, i rili impɔtant fɔ go to dɔktɔ kwik kwik wan. NMS kin izi fɔ trit if dɛn kech am kwik. Pan ɔl we NMS nɔ kin bɔku, if yu de tek nyurolɛptik (antipsychotic) mɛrɛsin, tɔk to yu dɔktɔ ɔ fama bɔt di sayd ɛfɛkt ɛn di sayn dɛm we yu fɔ wach fɔ. Dɛn de de fɔ ɛp yu.

Di impɔtant tin dɛn we wi lan frɔm dis atikul (Take-Home Message) .

Okay, so lɛ wi mɛmba yu bɔt sɔm pan di impɔtant tin dɛn we yu fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt na dis `NMS`:

• NMS na wan sik we nɔ kin apin so ɔltɛm, bɔt we kin mek pɔsin in layf de pan denja we dɛn kin yuz nyurolɛptik mɛrɛsin dɛn.
• Ay fiva, mɔsul dɛn we de at, ɛn kɔnfyushɔn na yu maynd na di men sayn dɛm.
• If yu notis ɛni wan pan dɛn sayn ya, go to dɔktɔ wantɛm wantɛm. Nɔ delay.
• If yu de tek nyurolɛptik mɛrɛsin, tɔk to yu dɔktɔ bɔt di mɛrɛsin ɛn di bad tin dɛn we i kin du. Nɔ fred fɔ aks kwɛstyɔn.
• NMS kin wɛl ɔl if dɛn no bɔt am ɛn trit am kwik kwik wan.

Wi op se dɛn dɔn tɛl yu bɔt dis infɔmeshɔn. Stay wit wɛlbɔdi!

` Nyurolɛptik Malignant Sindrom, NMS, saykayatrik drɔgs, sayd ɛfɛkt, ay fiva, mɔsul stiffness