Yu go dɔn yɛri bɔt strɔng pen kil lɛk Tramadol ɛn Morphine. Dɔktɔ dɛn kin yuz dɛn mɛrɛsin ya afta sɔm ɔpreshɔn dɛn ɔ if dɛn gɛt siriɔs pen lɛk kansa. Bɔt if dɛn nɔ yuz dɛn tin ya di rɔŋ we, dat min se if yu tek am pasmak, dɛn kin rili bad ɛn ivin mek yu layf de pan denja. Insay dis kayn denja, wan spɛshal kayn drɔgs de we kin stɔp di akshɔn fɔ dɛn drɔgs ya wantɛm wantɛm ɛn sev pipul dɛn layf. Na dat wi kin kɔl ‘Opioid Antagonist’.
Fɔs, lɛ wi si wetin na dis ‘opioid’?
Fɔ tɔk am simpul wan, opioid na wan grup ɔf kεmεkal dεm we de wok wit wi nεv sεl dεm fכ ridyus pen. Sɔm kin apin bay dɛnsɛf, ɛn ɔda wan dɛn kin apin na lɛbɔretri. Dɔktɔ dɛn kin yuz dɛn fɔ trit di pen we smɔl to we i kin fil bad. Bɔt, ilɛgal drɔgs dɛn de bak lɛk heroin we de na dis sem grup.
Pipul dɛn kin gɛt adikshɔn to dɛn opioid ya. Di rizin na dat dɛn nɔr kin jɔs pul pen, bɔt dɛn kin briŋ bak wan strenj filin fɔ gladi, wan filin fɔ flot (euphoria). As tɛm de go, di doz we dɛn tek bifo yu gɛt da gladi at de nɔ kin du. Wi de kɔl dis ‘tolerance’. Dɔn dɛn kin tɛmpt yu fɔ mek yu ad di doz. As tɛm de go, dis kin bi wan dizayd fɔ yuz opioid.
So aw dis opioid antagonist de wok?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. imajin se wi bכdi, spεshal wan na di bren εn spεnal kכd (sεntri nεv sεstem), gεt spεshal ‘rεsεptor’ dεm we de rεspכnd to opioid dεm. Lɛk di kihol dɛn. dεn kכl dεm mu, kappa, εn dεlta rεsεpכta dεm. di men tin we de wok na wit dεn mu rεsεp כta dεm ya .
- Opioid (painkillers) tan lεk di ‘rayt ki’ we fit insay dis kihol. We yu put da ki de insay ɛn tɔn am, dat min se we yu tek wan opioid, dɛn riseptɔ dɛn de kin wok ɛn di pen kin go, di briz kin slo, ɛn da gladi gladi filin we a bin dɔn tɔk bɔt kin kam.
- di opioid antagonist dεm lεk ‘fek ki’ we fit insay da kihol de, bכt dεn nכ kin tכn am. We dis drɔg go insay di bɔdi, i kin go kwik kwik wan to dɛn riseptɔ dɛn de, we na di kihol dɛn. Bɔt i nɔ de mek di riseptɔ aktiv. Bifo dat, i de blok di ki ol.
Naw yu ɔndastand? Bikɔs di fek ki dɔn stɔp na di kihol, no we nɔ de fɔ mek di ‘rayt ki’, di opioid, kam kɔnɛkt. So di ifɛkt we di opioid dɛn gɛt kin stɔp kpatakpata. We pɔsin dɔn ɔvados pan opioid ɛn i tan lɛk se i dɔn stɔp fɔ blo, na dat kin apin we yu gi am dis antagonist. I kin go insay wantɛm wantɛm ɛn stɔp di akshɔn we di opioid dɛn de du, ɛn alaw dɛn fɔ blo nɔmal wan bak.
Wetin na di men kayn opioid antagonist dɛm?
Bɔku kayn mɛrɛsin ya de. Dɛn kin yuz ɛni wan pan dɛn fɔ difrɛn tin dɛn. Lɛ wi tek tɛm luk dis tebul.
| Nem fɔ di drɔg | Men yus | Impɔtant pɔynt dɛn |
|---|---|---|
| Nalɔkson we dɛn kɔl | Mεdikeshכn we de sev layf fכ opioid ovados. | Dɛn kin gi am as injɛkshɔn ɔ as sprɛy na in nos. If pɔsin dɔn stɔp fɔ blo bikɔs ɔf di opioid ɔvados, i kin mek i blo bak insay 2-5 minit. Insay wi kɔntri, dɛn kin yuz am mɔ na di imejensi tritmɛnt yunit dɛn (ETU) na ɔspitul dɛn. |
| Naltrekson we gɛt di sik | As lɔng tɛm mentenɛns tritmɛnt fɔ opioid ɛn rɔm adikshɔn. | Dis kin ɛp fɔ lɛf fɔ gɛt adikshɔn. I de mek yu nɔ gɛt di gladi at we kin kam we yu tek opioid. Bɔt i nɔ de kɔntrol di sayn dɛn we pɔsin kin gɛt we i de lɛf fɔ drink ɔ di tin dɛn we i kin want fɔ du. I kin kam insay pils ɔ injɛkshɔn. |
| Methylnaltrexone we gɛt di sik | Fɔ kɔnstipɛshɔn we strɔng opioid pen kil dɛn kin mek. | Dis na tin we difrɛn smɔl. I nɔ de go na di bren. bifo dat, i de כnli blכk di opioid rεsεpכta dεm na di intestכn dεm. So i nɔ de ambɔg di akshɔn fɔ pen mɛrɛsin, i jɔs de ridyus kɔnstipɛshɔn. Dɛn kin gi am fɔ pipul dɛm wae dɛn de trit fɔ siriɔs pen wae nɔr de dɔn. |
| Nalmefene we dɛn kɔl | Fɔ opioid ɔvados. | Dis tan lɛk naloxone, bɔt i kin de wok na di bɔdi fɔ lɔng tɛm. Bɔt dɛn nɔ de yuz am bɔku bɔku wan lɛk nalɔkson. |
Wetin na di bad tin dɛn we dɛn mɛrɛsin ya kin du?
di men εn mכst imεdiεt ifekt fכ drog lεk Naloxone εn Naltrexone na di כkכrεshכn fכ ‘opioid witdrawal symptoms’ . Imajin, pɔrsin in bɔdi dɔn yus to opioid fɔ lɔng tɛm. dis na di bכdi in rεspכns we dεn gi wan antagonist wan wan εn dεn stכp in akshכn.
Wetin na dɛn sayn ya we pɔsin kin gɛt we i de lɛf fɔ it?
- Nɔs we de rɔn
- Di wata we de kɔmɔt na di yay pasmak
- Fɔ yawn bɔku tɛm
- Inkris rεt fכ brith (Hyperventilation) .
- Hyperthermia we pɔsin kin gɛt
- Di at rit we de go ɔp (Tachycardia) .
- Mɔsul dɛn kin pen
- Nɔs ɛn vɔmit
- Rɔnbɛlɛ
- Wɔri
Di kayn we aw dɛn sik ya kin tranga kin difrɛn frɔm wan pɔsin to ɔda pɔsin. I dipen pan aw lɔng ɛn us kayn opioid dɛn bin yuz. Insay ɔspitul, dɔktɔ dɛn kin manej dis sik fayn fayn wan. Dɛn kin gi salin (IV fluid) ɛn ɔda mɛrɛsin dɛn.
Di sayd ɛfɛkt dɛm fɔ Methylnaltrexone, we dɛn kin yuz fɔ kɔnstipɛshɔn, difrɛn. Dɛn na:
- Bɛlɛ de pen
- Fɔ ful-ɔp di bɛlɛ
- Nɔs ɔ vɔmit
- Ed de at
- Mɔsul dɛn we de rɔl
- Diziz we pɔsin kin gɛt
Wetin na di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi?
Pan ɔl di bad tin dɛn we kin apin to dɛn, di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi kin pas dɛn fa fawe.
Naloxone na wan mɛrɛsin we de sev pɔsin in layf . I kin mek pɔsin nɔ day bikɔs i tek di opioid ɔvados. Dat na di tin we impɔtant pas ɔl.
Naltrekson we gɛt di sikNa wan rili impɔtant pat fɔ trit kɔmpleks kɔndishɔn lɛk opioid ɔ alcohol adikshɔn. Bɔt i nɔ go du fɔ insɛf. Drug adikshɔn na sik we rili kɔmpleks. I nid tritmɛnt frɔm difrɛn aspek dɛm, lɛk saykotɛrapi ɛn rihabiliteshɔn. Naltrexone na mɛrɛsin we de gi big trɛnk to da joyn de.
If yu ɔ pɔsin we yu sabi gɛt dis prɔblɛm, duya tɔk to yu dɔktɔ bɔt am. Bɔrku dɔktɔ ɛn mɛrɛsin de wae kin ɛp fɔ gɛt dis sik.
Mɛsej we dɛn kin kɛr go na os
- Wan opioid antagonist na wan kayn mɛrɛsin we de blok di akshɔn fɔ opioid (strɔng pen kil ɛn drɔgs lɛk heroin) na di bɔdi.
- Naloxone na wan rili impɔtant, fast-aktin mɛrɛsin we dɛn kin gi fɔ sev di layf fɔ pɔsin we dɔn ɔvados pan opioid.
- Dɛn drɔgs ya, mɔ we dɛn gi am to pɔsin we in bɔdi dɔn yus to opioid, kin mek i gɛt siriɔs sayn fɔ lɛf fɔ tek am. So, dɛn fɔ yuz dɛn ɔltɛm ɔnda dɔktɔ in sɔpɔtishɔn.
- Drug adikshɔn nɔto wikɛd tin, na sik we pɔsin kin trit. If yu ɔ pɔsin we yu sabi nid ɛp, nɔ shem ɛn tɔk to dɔktɔ bɔt am.
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