Bɔku pipul dɛn sabi dis sik we dɛn kɔl "Gout", nɔto so? Jɔs imajin, we yu wek na mɔnin, yu big tɔ jɔyn kin fil lɛk se faya de bɔn, swel, ɛn rɛd. Yu nɔ ebul fɔ ivin tinap. E nɔr izi fɔ liv wit dis pen wae nɔr kin bia ɛn wae yu jɔyn dɛn kin swel. So, tide wi go tɔk bɔt wan spɛshal tritmɛnt fɔ kronik gaut , dat na, gaut we dɔn de fɔ lɔng tɛm ɛn sɔntɛnde i nɔ kin izi fɔ kɔntrol wit mɛrɛsin ɔltɛm. Dat na di Pegloticase vaysin.
Us kayn mɛrɛsin na Pegloticase?
Fɔ tɔk am simpul wan, Pegloticase na wan ɛnzaym . Naw yu go de wɔnda wetin na ɛnzaym. Enzym na spɛshal protin we de ɛp sɔm kemikal prɔses dɛn na wi bɔdi, lɛk fɔ digest, fɔ go bifo fayn fayn wan. So dɛn kin yuz dis ɛnzaym we dɛn kɔl Pegloticase, lɛk aw wi bin dɔn tɔk, fɔ trit krɛse gaut, we dɔn de fɔ lɔng tɛm ɛn sɔntɛnde i nɔ kin izi fɔ kɔntrol wit ɔda mɛrɛsin. Gaut kin apin we wan kemikal we dɛn kɔl yurik asid de bɔku na di bɔdi. Dis mɛrɛsin de wok bay we i de ridyus di lɛvɛl we yurik asid de.
Yu dɔktɔ kin gi yu dis mɛrɛsin ɔnda di brand nem ``Krystexxa.'' Dat na kɔmɔn nem fɔ dis mɛrɛsin.
Pan ɔl we dis na wan patikyula mɛrɛsin fɔ gaut, sɔntɛnde dɔktɔ dɛn kin yuz am fɔ ɔda mɛrɛsin dɛn. So, if yu gɛt ɛni kwɛstyɔn ɔ tin we de mɔna yu bɔt dis mɛrɛsin, i go fayn fɔ aks yu dɔktɔ ɔ fama we nɔ de ol ɛnitin. Dɛn go ɛksplen am to yu di rayt we.
Wetin na di tin dɛm we a nid fɔ tɛl di dɔktɔ bifo a bigin dis mɛrɛsin?
Bifo yu bigin fɔ trit yu wit Pegloticase, i rili impɔtant fɔ mek yu gi yu dɔktɔ wan kɔmplit ɛn ɔnɛs akɔdin to yu wɛlbɔdi. Dis na fɔ mek yu dɔktɔ disayd if dis tritmɛnt fayn fɔ yu ɔ if yu nid ɛni spɛshal kia. Dɛn go mɔs want fɔ no if yu gɛt ɛni wan pan dɛn tin ya:
- G6PD we nɔ de: Dis kin tan lɛk se na mɛrɛsin, bɔt fɔ tɔk am simpul wan, na we wan patikyula ɛnzaym nɔ de na wi rɛd blɔd sɛl dɛn. Fɔ gi pegloticase to pipul dɛm wae gɛt dis sik kin bi denja. So, if yu gɛt dis, yu fɔ rili tɛl dɛn.
- If yu gɛt at sik: If yu gɛt ɛni at sik, fɔ ɛgzampul, yu bin dɔn gɛt at atak bifo, ɔ if yu gɛt ɛni prɔblɛm wit aw yu at de wok, tɛl wi bɔt am.
- Alɛji dɛn:Mek shɔ se yu tɛl yu dɔktɔ if yu dɔn ɛva gɛt alɛji ɔ ɛnitin we nɔ kɔmɔn to Pegloticase, ɛni ɔda mɛrɛsin, it (e.g., sɔm pipul dɛn gɛt alɛji to tin dɛn lɛk pinat), day, ɔ tin dɛn we dɛn kin yuz fɔ mek tin nɔ pwɛl.
- Bɛlɛ: If yu gɛt bɛlɛ naw ɔ yu de plan fɔ gɛt bɛlɛ insay di nɛks tɛm, i rili impɔtant fɔ tɛl yu dɔktɔ, bikɔs sɔm mɛrɛsin dɛn kin afɛkt di pikin we i gɛt bɛlɛ.
- If yu na mama we de gi pikin in mama in bɛlɛ: If yu na mama we de gi pikin in bɛlɛ, yu fɔ tɔk bɔt dat bak, bikɔs sɔm mɛrɛsin dɛn kin pas to di pikin tru in mama in milk.
If yu tɔk dɛn tin ya kɔrɛkt wan, di dɔktɔ kin trit yu sef wan.
Aw dɛn kin gi yu dis Pegloticase mɛrɛsin?
Dis mɛrɛsin nɔto pil we yu de tek ɔ injɛkshɔn we yu kin tek go na os. Dɛn kin gi am as infushɔn insay wan vein . I tan lɛk se dɛn gi yu wan bɔtul we gɛt salin, ɛn dɛn kin put di mɛrɛsin na yu bɔdi smɔl smɔl. Bɔku tɛm , na pɔsin we tren fɔ mɛn wɛlbɔdi biznɛs, lɛk dɔktɔ ɔ nɔs, kin du dis na ɔspitul ɔ spɛshal klinik . Dis min se yu nɔ go ebul fɔ kɛr am go na os.
Bifo ɛni tritmɛnt sɛshɔn, dɛn go gi yu wan spɛshal infɔmeshɔn liflet (MedGuide) we de ɛksplen ɔltin bɔt dis mɛrɛsin, aw i de wok, ɛn di sayd ɛfɛkt dɛn we pɔsin kin gɛt. I rili impɔtant fɔ tek tɛm rid am ɛn nɔ jɔs tink bɔt am lɛk pepa. I gɛt bɔku tin dɛn we impɔtant fɔ mek yu sef.
Yu tink se dɛn kin gi dis mɛrɛsin to yɔŋ pikin dɛn?
Dɛn kin gi dis mɛrɛsin to big pipul dɛn. If yu de gi dis mɛrɛsin to yɔŋ pikin dɛn, yu fɔ tɔk to dɔktɔ we de mɛn pikin dɛn bɔt am ɛn tek spɛshal kia ɔnda in sɔpɔt ɛn advays. Nɔto ɔl di mɛrɛsin dɛn fayn fɔ yɔŋ pikin dɛn.
Wetin yu go du if yu aksidɛntli tek bɔku mɛrɛsin? (Ovadosage) .
Bikɔs dɛn kin gi dis na ɔspitul, ɔnda di sɔpɔtishɔn fɔ wɛlbɔdi biznɛs pipul dɛn, rili nid nɔ de fɔ wɔri bɔt fɔ gi yu tumɔs mɛrɛsin. Bɔt if yu tink se sɔntin dɔn apin to yu ɛni we, ɔ if yu fil se yu nɔ kin fil fayn, tɛl di dɔktɔ ɔ nɔs we bin de de da tɛm de wantɛm wantɛm. Dɛn go tek di tin dɛn we dɛn nid fɔ du.
Di tin we impɔtant pas ɔl: Dis mɛrɛsin na fɔ yu nɔmɔ. Nɔ gi am to ɔda pɔsin we gɛt yu sik, ɔ tɔk bɔt am, tink se i go wok fɔ dɛn. Di tin we de apin to ɔlman difrɛn.
Wetin yu kin du if yu nɔ ebul fɔ tek yu mɛrɛsin di rayt tɛm?
I rili impɔtant fɔ tek di mɛrɛsin di rayt de ɛn di rayt tɛm fɔ dis tritmɛnt. Dis na aw yu go gɛt di bɛst rizɔlt. If yu nɔ ebul fɔ go usay yu apɔntin, ivin di de we dɛn tɛl yu fɔ kam tek di mɛrɛsin, .Kɔl yu dɔktɔ ɔ klinik kwik kwik wan ɛn mek dɛn no. Dɛn go chenj di tɛm fɔ yu ɔ gi yu advays bɔt wetin fɔ du. Nɔ jɔs sidɔm rawnd.
Us ɔda tin dɛn kin miks wit dis mɛrɛsin?
Sɔm mɛrɛsin dɛn de we kin wok wit Pegloticase. Dis min se ɔl tu di wok we dis mɛrɛsin de du kin ridyus, ɔ di sayd ɛfɛkt dɛn kin bɔku, ɔ nyu prɔblɛm kin apin. Sɔm ɔda mɛrɛsin dɛn, mɔ di wan dɛn we dɛn kin yuz fɔ gaut, nɔ fɔ yuz wit Pegloticase. Fɔ ɛgzampul:
- `Allopurinol`
- `Fɛbuxostat`
- `Probenecid`
- `Sulfinpirazɔn`
Di list we de ɔp nɔ kin gɛt ɔl di tin dɛn we pɔsin kin du wit di mɛrɛsin. So, tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek – di mɛrɛsin dɛn we yu de tek, di mɛrɛsin dɛn we yu nɔ de gi yu, ɛbul mɛrɛsin dɛn, vaytamɛn dɛn, ɛn di tin dɛn we yu de yuz fɔ it. Dɔn bak, mek shɔ se yu tɛl yu dɔktɔ if yu de smok, drink rɔm, ɔ yuz ɔda drɔgs we nɔ rayt. Dɛn tin ya kin afɛkt aw yu mɛrɛsin de wok.
Wetin wi fɔ tek tɛm mɔ we wi de tek dis mɛrɛsin?
Bɔrku tin de wae yu ɛn de mɛdikal tim wae de trit yu fɔ tek tɛm pasmak wae yu de tek dis mɛrɛsin.
- Siriɔs Alɛji Riakshɔn: Dis na di men wan. Sɔntɛnde dis mɛrɛsin kin mek yu gɛt siriɔs alɛji (lɛk anafylaksis) . Bɔku tɛm dis kin apin di tɛm we dɛn de gi di injɛkshɔn insɛf. Fɔ ridyus dis risk, yu dɔktɔ kin tɛl yu fɔ tek ɔda mɛrɛsin (lɛk antihistamine ɔ kɔtikosterɔyd) bifo yu gɛt di Pegloticase injɛkshɔn. Dɛn kɔl dis ``pri-mɛdikeshɔn.'' I rili impɔtant fɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu, ɛn di rayt tɛm.
- Fɔ wach yu wɛl bɔdi: Wae yu de tek dis mɛrɛsin ɛn fɔ sɔm tɛm afta dat, pipul dɛm wae de du wɛl bɔdi biznɛs go de wach yu kɔndishɔn (e.g. at rit, blɔd prɛshɔn, brith) gud gud wan. So natin nɔ de fɔ wɔri bɔt. Dɛn go ebul fɔ no kwik kwik wan ɛni smɔl chenj.
- Pe atɛnshɔn to di sayn dɛm: Pe atɛnshɔn to if yu goiter simptom dɛm (e.g., joyn pen, swel) de bɛtɛ smɔl smɔl ɔ i tan lɛk se i de wɔs. If ɛni chenj de we tan lɛk dis, tɛl yu dɔktɔ ɔ pɔsin we de kia fɔ yu wɛlbɔdi biznɛs wantɛm wantɛm.
- Blɔd Tɛst:Yu go nid bak fɔ de chɛk yu ɔltɛm, lɛk fɔ du simpul blɔd tɛst , fɔ chɛk yu yurik asid lɛvɛl, if yu mɛrɛsin de wok, ɛn if ɛni ɔda prɔblɛm de. I impɔtant fɔ du dɛn tin ya ɔltɛm.
Wetin na di poshubul sayd effekt dɛm fɔ dis Pegloticase mɛrɛsin?
Lɛk ɛni mɛrɛsin, Pegloticase kin mek sɔm sayd ɛfɛkt. Bɔt dis nɔ min se ɔlman we de tek dis mɛrɛsin go gɛt dɛn. Sɔm pipul dɛn kin du wɛl if dɛn nɔ gɛt ɛni sayd ɛfɛkt. Bɔt i impɔtant fɔ no bɔt di bad tin dɛn we kin apin to yu. Sɔm sayd ɛfɛkt dɛn kin siriɔs, ɛn if yu notis ɛni wan pan dɛn, yu fɔ tɛl yu dɔktɔ wantɛm wantɛm.
Di sayd ɛfɛkt dɛm we yu fɔ ripɔt to yu dɔktɔ wantɛm wantɛm:
If yu gɛt ɛni wan pan dɛn tin ya, yu fɔ go to dɔktɔ wantɛm wantɛm.
- Alɛji: Skin rash, it lɛk ɛkzema ɔ hayv, swel na yu fes, lip, tɔŋ ɔ trot (dis kin mek i nɔ izi fɔ blo).
- Fɔ fil lɛk se yu skin de tɔn blu: If say dɛn lɛk yu lip ɛn finga nel de tɔn blu, dat kin bi sayn fɔ se yu nɔ gɛt ɔksijɛn.
- I nɔ izi fɔ yu fɔ blo: If i nɔ izi fɔ yu fɔ blo, i kin tan lɛk se yu de blo.
- Chest pen ɔr fil fɔ tayt na yu chɛst: Dis kin bi sayn fɔ hat atak.
- At bit fast ɔ i nɔ de bit ɔltɛm.
- Fɔ fil se yu nɔ ebul fɔ waka ɔ yu gɛt layt, yu kin fɔdɔm.
- Pen we yu de pis: Dis kin bi sayn fɔ se yu gɛt infekshɔn.
- Di anklɛ, fut, ɛn an dɛn kin swel.
- Di sayn dɛm we de sho se yu gɛt gaut kin bɔku wantɛm wantɛm: Sɔntɛnde dis kin apin we yu fɔs bigin fɔ tek di mɛrɛsin, bɔt tɛl yu dɔktɔ .
- Blɔd ɔ brus we nɔ kɔmɔn: If yu jɔs gɛt brus ɔlsay na yu bɔdi.
- Fɔ fil wik ɔ taya we nɔ kɔmɔn.
Sayd ɛfɛkt dɛn we nɔ kin nid fɔ go to dɔktɔ kwik kwik wan (bɔt if dɛn kɔntinyu ɔ de mɔna yu, yu fɔ tɛl yu dɔktɔ ):
Ivin if dɛn tin ya nɔ siriɔs so, tɛl yu dɔktɔ if dɛn de mɔna yu.
- Mɔsul dɛn kin pen.
- Nɔs, fɔ vɔmit.
- Fɔ fil lɛk se yu bɛlɛ dɔn pwɛl, yu de fil ful (Upset stomach).
Mɛmba se dis list nɔ kin gɛt ɔl di bad tin dɛn we kin apin. If yu notis ɛnitin we nɔ kɔmɔn ɔ we difrɛn na yu bɔdi, nɔ shem fɔ aks yu dɔktɔ fɔ advays.
Usay yu kin kip dis mɛrɛsin? A kin kɛr am go na os?
Nɔ, dis mɛrɛsin we dɛn kɔl Pegloticase nɔto sɔntin we yu kin bay na famasi ɛn kɛr go na os. Dis naNa ɔspitul ɔ klinik we dɛn dɔn gri fɔ, na ɔspitul ɔ klinik we dɛn dɔn gri fɔ yuz, usay pɔsin we tren fɔ mɛn wɛlbɔdi biznɛs de gi yu. So yu nɔ nid fɔ wɔri bɔt aw fɔ kip ɔ protɛkt di mɛrɛsin.
Di tin we impɔtant pas ɔl fɔ mek yu mɛmba (Take-Home Message) .
Okay, so lɛ wi mɛmba yu bak di impɔtant tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt.
- Pegloticase na spɛshal injεkshɔn we dɛn kin gi fɔ krɛse gaut.
- Dɛn kin gi dis as injɛkshɔn na wan vein na ɔspitul ɔ klinik, ɔnda di klos we dɔktɔ de kia fɔ am .
- Bifo yu bigin fɔ trit yu, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl yu wɛlbɔdi infɔmeshɔn ɛn ɔl di ɔda mɛrɛsin dɛn we yu de tek .
- Tek tɛm bad bad wan bɔt di sayd ɛfɛkt dɛn we yu kin gɛt, mɔ di alɛji, we yu de tek di mɛrɛsin ɛn afta yu tek am.
- I rili impɔtant fɔ gɛt tritmɛnt di rayt tɛm ɛn fala wetin di dɔktɔ tɛl yu fɔ du.
Fɔ dɔn, if yu gɛt ɛni kwɛstyɔn, dawt, ɔ wɔri bɔt dis Pegloticase mɛrɛsin ɔ yu kɔndishɔn, duya nɔ fred fɔ aks yu dɔktɔ, fama, ɔ pɔsin we de kia fɔ yu wɛlbɔdi biznɛs. Fɔ no gud gud wan na di bɛst we fɔ mek yu gɛt wɛlbɔdi.
Wi op se dis infɔmeshɔn sheet dɔn ɛp yu fɔ ɔndastand dis mɛrɛsin. Bɔt mɛmba se dis nɔto kɔmplit diskripshɔn, na jɔs sɔmari. Sɔntɛm i nɔ go inklud ɔltin. So i impɔtant ɔltɛm fɔ tɔk to yu dɔktɔ.
` Pegloticase, Gout, Kronik Gaut, Enzyme, Sayd ifekt, Mεdisin, Tritmεnt
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