Yu dɔn ɛva fil lɛk se yu trot de lɔk ɛn yu gɛt prɔblɛm fɔ swɛla it? Sɔntɛm yu ɔ pɔsin we yu sabi gɛt wan sik we dɛn kɔl Eosinophilic Esophagitis. I kin bi se na lɔng nem, bɔt i kin rili afɛkt yu ɛvride layf. Bɔt gud nyus de! Dupixent na di nyu mɛrɛsin we dɛn dɔn gri fɔ mɛn dis sik. Lɛ wi tɔk bɔt am simpul wan ɛn klia wan tide.
Fɔ tɔk am simpul wan, wetin na Eosinophilic Esophagitis?
Dis na krεse sik wae de afekt wi imyun sistεm. Tink bɔt am, difrɛn kayn sɛl dɛn de na wi bɔdi we de protɛkt wi frɔm sik dɛn, nɔto so? Wan pan dɛn kayn wayt blɔd sɛl dɛn de na in dɛn kɔl eosinophil . Pan ɔl we dɛn kin ɛp wi, pan pɔsin we gɛt Eosinophilic Esophagitis, dɛn sɛl ya kin gɛda pasmak ɛn mek inflamɛns na di esophagus , di tiub we wi kin swɛla it tru.
dis inflameshn de mek di εsophagus swel εn sכmtεm. Wetin kin apin da tɛm de? I kin at fɔ mek it pas dɔŋ na di bɛlɛ. Dis...
- I kin at fɔ swɛla it.
- Fɔd kin stɔp na di trot.
- Chest pen ɔ bɔn kin apin.
- Vɔmit kin apin.
Bɔrku tɛm dis sik kin gɛt fɔ du wit alɛji to sɔm it dɛm.
Aw Dupixent de woke fɔ dis sik?
Bɔku tɛm, dɔktɔ dɛn kin gi dɛn mɛrɛsin fɔs we de ridyus di asid na di bɛlɛ (Proton Pump Inhibitors). Fɔ ɛgzampul, yu kin dɔn yɛri bɔt mɛrɛsin lɛk ``omeprazole'' ɛn ``lansoprazole''. Sɔntɛnde, dɛn kin gi yu bak stɛroyd (kɔtikosterɔyd) fɔ ridyus di inflamɛns.
Bɔt Dupixent de wok na wan kɔmplit difrɛn we.
Dupixent na vaysin we de afɛkt wi imyun sistɛm dairekt wan ɛn kɔntrol di inflamɛns we de mek wi gɛt di sik.
Di aktif ingridiɛnt we de insay Dupixent na dupilumab . Fɔ tɔk am simpul wan, i de wok bay we i de blok di wok we tu protin dɛn we dɛn kɔl intalyukin-4 ɛn intalyukin-13, we na signal frɔm wi imyun sistɛm fɔ mek wi gɛt inflamɛns. we dεn blכk dεn signal dεm ya, di nכmba fכ di eosinofil dεm we de kכmכt na di εsophagus de dכn, we de ridyus di swεla εn inflameshn. Dis kin mek bak i nɔ kin izi fɔ swɛla.
Wetin di risach we dɛn bin du bɔt dis mɛrɛsin sho?
Dɛn dɔn du tu big klinik stɔdi fɔ si aw dis mɛrɛsin wok ɛn sef. Ɔl di wan dɛn we tek pat pan dɛn stɔdi ya na pipul dɛn we bin dɔn yuz wan prɔton pɔmp inhibito fɔ lɛk tu mɔnt bifo bɔt dɛn sik nɔ bin dɔn bɛtɛ.
- Fɔs stɔdi: Di wan dɛn we tek pat bin ol 12 ia ɔ pas dat.
- Sɛkɔn risach: Yɔŋ pikin dɛn we ol bitwin 1-11 ia bin tek pat.
Insay dɛn stɔdi ya, dɛn bin gi wan grup di Dupixent vaysin. Dɛn bin gi di ɔda grup wan ples we dɛn kɔl plasɛbo. Wi kin kɔl dis plesibo . Bɔt dɛn nɔ bin tɛl ɛnibɔdi if dɛn de gɛt di rial drɔg ɔ di plasɛbo.
Aw di tin dɛn we kin apin kin bi?
We yu luk bak afta 4-6 mɔnt, di rizɔlt kin rili ɛnkɔrej.
1. Eosinophil count: mכr dan 60% pan di wan dεm we tek Dupixent bin sכmtεm ridyus di eosinophil sεl kכnt na dεn εsophagus, we rich rεmishכn. Dis bin bi fɔ lɛk 5% nɔmɔ pan di wan dɛn we bin de tek plasɛbo.
2. I nɔ izi fɔ swɛla: Insay wan stɔdi we dɛn du pan pipul dɛn we dɔn pas 12 ia, di wan dɛn we tek Dupixent nɔ bin gɛt bɛtɛ prɔblɛm fɔ swɛla pas di wan dɛn we tek plasɛbo.
Aw a go yuz dis mɛrɛsin?
Dupixent na wan wata we de kɔmɔt na di wata. Dɛn kin gi am as injɛkshɔn we dɛn kin put ɔnda di bɔdi . Yu dɔktɔ go disayd if yu fɔ gi am wan tɛm insay di wik ɔ ɛvri tu wik, i go dipen pan yu ej ɛn wet. Dɛn kin gi am na di shɔl, bɛlɛ, ɔ ɔp an.
Dis mɛrɛsin gɛt tu kayn we dɛn:
- Pen we dɛn dɔn ful-ɔp bifo tɛm: Dis na tin we rili izi fɔ yuz. Yu nɔ nid fɔ wɔri bɔt sirinj.
- Sirinj we dɛn dɔn ful-ɔp bifo tɛm: Dɛn kin yuz dis fɔ yɔŋ pikin dɛn.
Di tin we impɔtant pas ɔl na dat bifo yu yuz am fɔ di fɔs tɛm, yu dɔktɔ ɔ nɔs we tren go sho yu di rayt we aw fɔ injɛkt am. I rili impɔtant bak fɔ rid ɛn ɔndastand di instrɔkshɔn liflet we de kam wit di mɛrɛsin.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Lɛk ɛni mɛrɛsin, Dupixent kin mek smɔl smɔl sayd ɛfɛkt dɛn. Bɔt nɔ wɔri, bɔku pan dɛn na pɔsin we pɔsin kin ebul fɔ kɔntrol.
| Kɔmɔn sayd ɛfɛkt dɛn | Aw fɔ manej |
|---|---|
| Skin riakshɔn na di say we dɛn injɛkshɔn(Rɛd, pen, swel, brus) | Di bɛst we fɔ du dis na fɔ rɔta di say dɛn we dɛn de injɛkshɔn . Fɔ ɛgzampul, if yu injekt na yu rayt shɔl wan tɛm, injɛkt na yu lɛft shɔl di nɛks tɛm. Nɔ injekt na say dɛn we wund, brus, ɔ wund. |
| Infεkshכn dεm we de na di say dεm we yu de blo (kol, trot we de at) . | Fɔ fala di bɛst we fɔ protɛkt yusɛf frɔm infɛkshɔn. Wash yu an ɔltɛm. Stay away frɔm pipul dɛn we sik. Gɛt yu ɛni ia flu shot kwik kwik wan. |
Dis na de men sayd effekt wae yu kin si. Bɔt if yu fil ɛni ɔda tin ɔ yu nɔ fil fayn, mek shɔ se yu tɛl yu dɔktɔ .
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn?
Yɛs, so dis tin rili impɔtant.
- Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek: Bifo yu bigin fɔ yuz Dupixent, yu fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn, ɛbul mɛrɛsin, ɛn sɔpɔtmɛnt dɛn). Dis impɔtant mɔ if yu de tek mɛrɛsin fɔ asma.
- Tek tɛm wit vaysin: Dɛn nɔ kin advays sɔm layf vaysin dɛn we yu de tek dis mɛrɛsin. So if yu fɔ gɛt di vaysin, tɔk to yu dɔktɔ bɔt am bifo yu bigin di mɛrɛsin.
Nɔ ɛva stɔp fɔ tek di mɛrɛsin we yu nɔ go to yu dɔktɔ, ilɛksɛf di mɛrɛsin dɔn bigin fɔ wok ɛn yu sik dɔn bɛtɛ. If yu du dat, dat kin mek yu sik dɛn wɔs bak.
Mɛsej we dɛn kin kɛr go na os
- Eosinophilic Esophagitis na wan sik we de te we gɛt fɔ du wit di imyun sistɛm we de mek i nɔ izi fɔ swɛla.
- Dupixent na nyu injɛkshɔn we dɛn dɔn gri fɔ yuz fɔ mɛn dis sik.
- Dis kin blok di imyun signal dɛm wae kin mek pɔrsin gɛt inflamɛns, we na di rut kɔz fɔ di sik, ɛn kɔntrol di sayn dɛm.
- Smɔl sayd ɛfɛkt dɛn lɛk fɔ rɛd ɛn swel na di say we dɛn injɛkshɔn kin apin, bɔt dɛn kin ebul fɔ kɔntrol dɛn.
- I impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek ɛn ɛni vaysin we yu dɔn sɛtul fɔ gɛt.
- Nɔ ɛva stɔp di tritmɛnt ɔ chenj di doz if yu nɔ gɛt dɔktɔ advays.
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