Yu go mɔs no se fɔ trit kansa we i de skata frɔm wan pat na yu bɔdi to ɔda pat, rili tranga. Bɔt bikɔs ɔf di tin dɛn we dɔn apin na mɛrɛsin tide, spɛshal tritmɛnt dɛn de we kin ambɔg di kansa sɛl dɛn lɛk mishɔl ɛn jɔs pwɛl dɛn. Tide, wi de tɔk bɔt wan rili advans tritmɛnt we dɛn kin yuz fɔ trit wan kayn kansa we dɛn kɔl `neuroendocrine tumors (NETs). dis dεn kכl am PRRT, we tinap fכ `Pεptid Risεptor Radionuclide Therapy`.
Fɔ tɔk am simpul wan, wetin na PRRT tritmɛnt?
PRRT na wan tritmɛnt we dɛn kin yuz fɔ mɛn kansa. I min fɔ kɛr wan redioaktiv tin go dairekt insay di kansa sɛl dɛn ɛn pwɛl dɛn. Tink bɔt am lɛk fɔ pik di kansa sɛl dɛn we wi nɔ go ambɔg di wɛlbɔdi sɛl dɛn na wi bɔdi.
Aw dis kin wok? I rili wɔndaful!
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Ɛvri kansa sɛl gɛt spɛshal riseptɔ dɛn na in fes, lɛk kihol na domɔt. we spεshal protin dεm we de mach כnli dεn rεsεpכta dεm ya kam togεda lεk ki, di domɔt de opin fכ mek tin dεm go insay di sεl.
Dis na wetin PRRT tritmɛnt de du:
1. fכ mek di "ki": dεn de mek wan protin (pεptida) we de εksakכt fכ mach di rεsεpכta dεm we de na di sεf fכ di kεnsar sεl dεm na di labכtכri.
2. fכ atak di "bכm": afta dat, wan redioaktiv εlimεnt we dεn kכl raydionyuklayd, we de rili kil di kεnsar sεl, de atak di protin we dεn εnjinia.
3. Travul to di target: we dεn introdכks dis dכg insay di bכdi, di protin de fכn in we εn tay di rεsεpכta dεm na di kεnsar sεl dεm.
. We i dɔn go insay, di redioaktiv we i de pul kin pwɛl di kansa sɛl in DNA, ɛn i kin pwɛl di sɛl frɔm insay.
Di big bɛnifit fɔ dis we na dat i de tɔch di kansa sɛl dɛn nɔmɔ, so di damej we de pan di wɛlbɔdi sɛl dɛn we de rawnd am nɔ bɔku.
Us kayn PRRT dɛn de yuz na di wɔl?
di men PRRT dכg we dεn apruv na di wכl te naw na `lutetium Lu 177 dotatate (LUTATHERA®).` insay dis, `dotatate`, we na sεntetik protin, de atak di redioaktiv εlimεnt `lutetium-177`.
dis protin we dεn kכl `dotatate` de sכm kayn we lεk di כmon `somatostatin` na wi bכdi. sכm `NET` tכp kεnsar sεl dεm gεt spεsifi k rεsεpכta dεm fכ dis `somatostatin` כmon. dis protin we dεn kכl `dotatate` de go to dεn rεsεpכta dεm de εn i de stik tayt. So, di mɛrɛsin kin go rayt insay di kansa sɛl.
Apat frɔm dat, dɛn de du risach bɔt ɔda PRRT kɔmpawnd dɛn, sɔm pan dɛn dɔn ɔlrɛdi de na klinik trial.
Udat dis PRRT tritmɛnt fayn fɔ?
naw, dεn de yuz PRRT tritmεnt fכ kεnsar dεm we dεn kכl `gastroenteropancreatic NETs`, we na kεnsar dεm we de divεlכp na di dijestiv trakt. Fɔ ɛgzampul:
- Pankrias we de na di bɔdi
- Rɛktum na di rɛktɔm
- Smɔl ɛn big intestinal dɛn
- Bɛlɛ
If dis tritmɛnt fayn fɔ pɔsin, i kin dipen pan bɔku tin dɛn. Si di tebul we de dɔŋ ya.
| Pozishɔn | Tɔk bɔt |
|---|---|
| Nɔ fit fɔ mek dɛn du ɔpreshɔn | If di kansa dɔn skata ( metastasized ) to bɔku say dɛn na di bɔdi, i nɔ kin izi fɔ mɛn am wit ɔpreshɔn nɔmɔ. Fɔ bɔku pipul dɛn we dɛn dɔn no se gɛt NET kansa, di kansa dɔn ɔlrɛdi skata. |
| Fɔ nɔr de du ɔda tritmɛnt | If ɔpreshɔn nɔ pɔsibul, dɛn kin gi ɔmon tɛrapi. Bɔt pan sɔm pipul dɛn, di tumbu dɛn kin kɔntinyu fɔ gro we dɛn nɔ ebul fɔ kɔntrol pan ɔl we dɛn de trit dɛn ya. |
| Prεsεns כf Somatostatin rεsεpכta dεm na di kεnsar sεl dεm | Dis na di tin we impɔtant pas ɔl. fכ di PRRT dכg fכ wok, di kεnsar sεl dεm fכ gεt dεn spεshal rεsεpכta dεm de. Yu dɔktɔ go du spɛshal skan, lɛk ɔktriotayd skan, fɔ no if dɛn riseptɔ ya de. |
Aw yu kin pripia bifo yu gɛt tritmɛnt?
If yu dɔn ɔlrɛdi de tek ɔda mɛrɛsin fɔ NET kansa, yu dɔktɔ kin advays yu fɔ stɔp sɔm pan dɛn fɔ sɔm tɛm bifo yu gɛt PRRT tritmɛnt.
- Tipikli, somatostatin injεkshכn dεm we de wok fכ lכng tεm f כ stכp at le 4 wik bifo tritmεnt.
- Sɔntɛm dɛn dɔn stɔp di somatostatin injɛkshɔn dɛn we de wok fɔ shɔt tɛm 24 awa bifo dɛn trit dɛn.
- Dɔn bak, yu fɔ avɔyd fɔ tek ay doz stɛroyd lɛk glukokɔtikosterɔyd we yu de du dis tritmɛnt.
Wan wik bifo ɛni tritmɛnt, yu go du bɔku blɔd tɛst fɔ si if yu bɔdi dɔn rɛdi fɔ am.
Wetin kin apin di de we dɛn de trit am?
Dɛn kin gi PRRT tritmɛnt ɛvri tu mɔnt fɔ 4 sɛshɔn fɔ 8 mɔnt. Dis na ɔutpatient prosidur, we min se yu nɔ nid fɔ de na ɔspitul. di ol prosidכs de tek lεk 5-6 awa.
1. Fɔs, dɛn go put wan kanula we dɛn kin put insay yu bɛlɛ (IV) insay wan vein na yu an.
2. Dɛn kin gi am mɛrɛsin fɔ mek i nɔ gɛt nɔs ɛn vɔmit wan awa bifo di tritmɛnt bigin.
3. afta dat, dεn go gi yu wan amino asid sכlushכn tru wan IV fכ lεk 4 awa fכ protεkt yu kidni dεm.
4. lεk 30 minit afta dεn stat di amino asid sכlushכn, dεn de gi di PRRT mεdikeshכn tru wan sεparat IV fכ 30-45 minit.
5. afta dεn dכn gi כl di sכlushכn dεm, dεn kin pul di IV kanula.
Di de afta di tritmɛnt, dɛn kin du spɛshal skan fɔ si aw di mɛrɛsin dɔn skata ɔlsay na di bɔdi.
Wetin na di bɛnifit ɛn risk dɛm fɔ PRRT tritmɛnt?
Wetin na di bɛnifit dɛn we wi kin gɛt?
PRRT na tritmɛnt we kin rili wok fayn. Na bɔrku pipul dɛm wae gɛt am, dɛn tumbu kin dɔn ɔr kin stɔp fɔ gro. Dis kin mek di wan dɛn we sik kin liv lɔng ɛn gɛt gud kwaliti layf .
Bɔt wan tin we wi fɔ mɛmba na dat PRRT nɔto mɛrɛsin fɔ kansa. Fɔ bɔku pipul dɛn, di kansa kin kam bak afta sɔm tɛm.
Risk ɛn sayd ɛfɛkt dɛn
Vɔmit ɛn nɔs na di sayd ɛfɛkt dɛm we kin apin kwik kwik wan pan dis tritmɛnt, bɔt dɛn kin kɔntrol dɛn mɔ bay mɛrɛsin we dɛn gi bifo di tritmɛnt.
Ɔda prɔblɛm dɛn we kin apin na:
- Kidni ɔ liva prɔblɛm.
- Di blɔd sɛl dɛn nɔ bɔku. Dis kin mek i nɔ izi fɔ blo, i kin mek i gɛt infɛkshɔn mɔ ɛn mɔ, ɛn i kin mek i gɛt blɔd ɔ i kin gɛt brus.
- Risk de fɔ mek yu gɛt blɔd kansa lɛk maylodysplastic syndrome ɛn lukimiya.
Yu dɔktɔ go de wach yu wit blɔd tɛst ɔltɛm ɔl di 8 mɔnt we yu de trit yu. If ɛni prɔblɛm kam, i go disayd fɔ chenj ɔ stɔp yu tritmɛnt.
Di tin we kin apin kwik kwik wan: Carcinoid Crisis
Dis na wan sik wae nɔr kin bɔrku bɔt wae kin siriɔs, wae kin mek pɔrsin in layf de pan denja. Na we di ɔmon dɛn we de kɔmɔt na di kansa sɛl dɛn kin kɔmɔt wantɛm wantɛm. Bɔrku tɛm, di sayn dɛm kin apia insay 48 awa afta dɛn dɔn gɛt tritmɛnt.
If yu gɛt ɛni wan pan dɛn sik ya, go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
* I nɔ izi fɔ blo
* Di skin de rɛd ɔ bɔn na yu fes ɔ yu nɛk (we de flash) .
* Lɔw blɔd prɛshɔn (Hypotension) .
* Palpitations (fast at bit) .
* I kin gɛt siriɔs dayarɛa
Fɔ wɛl ɛn fɔ liv ɛvride
Bɔrku pipul dɛn kin telɛ PRRT tritmɛnt fayn fayn wan ɛn dɛn kin wɛl kwik kwik wan.
A go ebul fɔ go bak na wokples?
PRRT de yuz wan rili smɔl redioaktiv matirial. Dis redioaktiv tin de kɔmɔt na yu bɔdi insay yu urine ɛn stɔl fɔ sɔm dez afta yu dɔn trit am. Yu dɔktɔ go advays yu fɔ de at le wan mita fa frɔm ɔda pipul dɛn insay dis tɛm, mɔ di uman dɛn we gɛt bɛlɛ ɛn yɔŋ pikin dɛn . I impɔtant bak fɔ was yu an ɔltɛm.
Yu tink se i pɔsibul fɔ travul insay dis tɛm?
Na smɔl smɔl raytin kin de na yu bɔdi fɔ te 3 mɔnt afta yu dɔn trit yu. Dɛn kin no dis bay di tin dɛn we dɛn kin yuz fɔ chɛk di raytin na di aypɔt dɛn, fɔ ɛgzampul. Yu dɔktɔ go gi yu wan spɛshal kad we go tɔk bɔt di tritmɛnt we yu dɔn gɛt. I impɔtant fɔ kip dis kad ɛn wan kɔpi fɔ yu tritmɛnt not wit yu ɛnisay we yu go fɔ te 3 mɔnt afta yu tritmɛnt.
Mɛsej we dɛn kin kɛr go na os
- PRRT na wan advans tritmɛnt we de tɔch di kansa sɛl dɛn nɔmɔ ɛn i de yuz redyushɔn fɔ pwɛl dɛn.
- Dɛn kin yuz am mɔ fɔ nyuroɛndokrin tɔŋ (NET) we dɔn skata ɔlsay na di bɔdi ɛn we nɔ de ansa ɔpreshɔn ɔ ɔda tritmɛnt.
- Pan ɔl we dis nɔto tritmɛnt we de mɛn kansa ɔltogɛda, i kin rili ɛp fɔ kɔntrol di sik ɛn fɔ mek pɔsin liv bɛtɛ layf ɛn fɔ mek i liv fayn layf.
- I rili impɔtant fɔ fala di dɔktɔ in instrɔkshɔn fɔ protɛkt yusɛf frɔm redyushɔn fɔ sɔm dez afta yu dɔn trit yu.
- If yu gɛt sɔm sayn dɛm fɔ Carcinoid Crisis , lɛk fɔ mek yu nɔ ebul fɔ blo fayn, yu skin de flash, ɛn yu at de bit kwik kwik wan, go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm .
- If ɛni prɔblɛm ɔ sayd ɛfɛkt kam bɔt tritmɛnt, tɔk to yu dɔktɔ bɔt am.
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