Yu gɛt siriɔs asma? Yu stil gɛt atak ɔltɛm pan ɔl we yu de yuz yu inhala ɛn ɔda mɛrɛsin dɛn? Yu taya fɔ nɔ slip fayn na nɛt ɛn nɔ ebul fɔ du ivin di smɔl smɔl wok dɛn? Na di wan dɛn nɔmɔ we gɛt am no aw i nɔ kin izi fɔ liv wit dis kayn asma we at fɔ kɔntrol ɛn we rili bad. Bɔt nɔ fred, we di sayɛns we dɛn de du fɔ mɛn pipul dɛn dɔn go bifo, nyu tritmɛnt dɛn dɔn kam fɔ ɛp yu naw. Tide, wi go tɔk bɔt wan pan dɛn kayn nyu ɛn advans tritmɛnt dɛn de. Dat na Tezspire.
Aw dis mɛrɛsin we dɛn kɔl Tezspire kin rili wok?
Okay, lɛ wi ɔndastand fɔs insay simpul wɔd wetin kin apin to wi bɔdi we wi gɛt asma. Asma na wan sik wae de mek wi aywe, ɔr windpaip kin inflam, swel, ɛn fil. We sɔntin we gɛt alɛji (fɔ ɛgzampul, dɔst, smok) kam insay di bɔdi, dɛn aywe ya kin smɔl ɛn i kin at fɔ blo.
Bɔrku tɛm, wi kin yuse tu men kayn mɛrɛsin fɔ trit asma. Wan na di mɛrɛsin dɛn we dɛn kin yuz fɔ kɔntrol . Dɛn kin yuse dɛn tin ya ɛvride fɔ kɔntrol asma ɛn fɔ mek i nɔ gɛt atak. Di ɔda kayn na di mɛrɛsin dɛn we dɛn kin yuz fɔ sev pipul dɛn . Dɛn kin yuse dɛn tin ya fɔ ridyus di sik kwik kwik wan we asma atak apin.
Tezspire na ad-on mɛrɛsin to di kɔntrol mɛrɛsin we yu dɔn ɔlrɛdi de tek. I de ɛp fɔ mek yu nɔ gɛt asma atak, nɔto ‘rɛskɔ’ mɛrɛsin fɔ tek we yu gɛt wan.
Fɔ tɔk am simpul wan, Tezspire na mɛrɛsin we dɛn mek wit wan patikyula kayn prɔtin. fכ bi prεsis, dεn kכl dis (monoclonal antibody) . wi bכdi gεt wan kεmikכl we dεn kכl (Thymic Stromal Lymphopoietin - TSLP) . dis TSLP na di men tin we de kכntribyut fכ swεla (inflameshכn) εn sεnsitiviti we nכ nid na di aywe dεm. Tezspire mɛrɛsin de blok di akshɔn fɔ da kemikal we dɛn kɔl TSLP. We dɛn blok TSLP, di swel ɛn smɔl we di aywe dɛn kin smɔl kin ridyus ɛn dɛn kin kɔntrol di asma simptom dɛn bɛtɛ.
Aw yu kam fɔ no aw dis mɛrɛsin de wok?
Bifo ɛni nyu mɛrɛsin kam na di makit, dɛn kin du big big klinik stɔdi fɔ no if i nɔ bad fɔ yuz am na mɔtalman ɛn if i rili wok. Tu big stɔdi dɛn dɔn du wit Tezspire.
Di wan dɛn we tek pat pan dis stɔdi na pipul dɛn we ol 12 ia ɔ pas dat we gɛt siriɔs asma . Dat min se, di wan dɛn we bin gɛt asma atak bɔku tɛm we bin nid fɔ tek stɛroyd pils ɔ fɔ go na ɔspitul.
Di risach bin men wan mɛzhɔ sɔm tin dɛn:
- Asthma Exacerbations: Wi bin luk aw di frɛkuɛns we asma atak kin go dɔŋ afta wi tek di mɛrɛsin.
- di lכng fכnshכn : Na spεshal tεst de mכsu di כmכnt כf briz we yu kin fכs fכ blo insay wan sεkכnd. dis dεn kכl am Fכs εkspiratכri Vכlyum insay 1 sεkכnd - FEV1 .
- Simptom control: Yuz wan spɛshal kwɛshɔn (`Asthma Control Questionnaire 6` ɔ ACQ-6 ), dɛn bin asɛs di pasɛnt dɛn bak fɔ si aw dɛn bin de kɔntrol dɛn simptom dɛn fayn fayn wan.
Dɛn stɔdi ya bin gɛt pipul dɛn we kɔmɔt na difrɛn trayb ɛn bakgrɔn, bɔt dɛn nɔ bin tek di wan dɛn we de smok ɛn di wan dɛn we gɛt ɔda sik dɛn we de mek dɛn blo.
Wetin na di tin dɛn we dɛn dɔn du we dɛn du dis risach?
Di patisipan dɛm na di stɔdi kɔntinyu fɔ tek dɛn ɔspitul asma kɔntrol mɛrɛsin dɛm (e.g. inhaled corticosteroids ). Dɛn bin gi wan grup di Tezspire vaysin, ɛn di ɔda grup bin gi wan plesibo . Plɛsɛbo na sɔntin we tan lɛk mɛrɛsin bɔt nɔ rili gɛt ɛni aktif mɛrɛsin. Dɛn kin yuz am fɔ no di tin dɛn we di rial mɛrɛsin kin du kɔrɛkt wan.
Di tin dɛn we kin apin we 52 wiks dɔn, dat na wan ia, kin rili ɛnkɔrej wi.
- We yu kɔmpia am wit di plasɛbo grup, di wan dɛn we bin gɛt Tezspire bin gɛt 56% to 72% ridɔkshɔn pan asma exacerbations (atak).
- כlso, di lכng fכnshכn , dat na FEV1, inkrεs bay lεk 0.13 lita pan di wan dεm we tek Tezspire.
- Akɔdin to di ACQ-6 kwɛshɔn, 86% pan di wan dɛn we tek Tezspire bin ripɔt se dɛn simptom dɛn dɔn impɔtant, we yu kɔmpia am wit 77% na di plasɛbo grup.
Dɛn rizɔlt ya sho klia wan se Tezspire na tritmɛnt we rili fayn fɔ kɔntrol siriɔs asma. Bɔt mɛmba se di tin dɛn we dɛn dɔn du we dɛn dɔn du risach nɔto di sem fɔ ɔlman. Yu rizulyt kin difrɛn.
Aw fɔ gɛt Tezspire? Aw fɔ yuz am?
If yu at fɔ kɔntrol yu asma ɛn yu intres pan Tezspire, yu kin tɔk to yu famili dɔktɔ ɔr pɔrmɔnolɔg bɔt am. If yu dɔktɔ disayd se dis mɛrɛsin fayn fɔ yu sik, i go mek di arenjmɛnt we nid fɔ mek yu gɛt am.
Tezspire na injεkshכn we dεn kin gi yu εvri 4 wik.. Bɔku tɛm, dɛn kin gi dis na dɔktɔ in ɔfis, klinik, ɔ ɔspitul. Sɔntɛnde, yu dɔktɔ kin disayd se i nɔ bad ɛn i fayn fɔ mek yu gi yusɛf di vaysin na os. If na so i bi, yu dɔktɔ ɔ nɔs we tren go tich yu aw fɔ gi di vaysin fayn fayn wan.
Impɔtant: Nɔ ɛva stɔp fɔ tek ɛni asma mɛrɛsin we yu de tek naw, mɔ di stɛroyd, if yu dɔktɔ nɔ advays yu. Tezspire na jɔs wan ad-ɔn mɛrɛsin.
Sayd ɛfɛkt ɛn tin dɛn we yu fɔ no bɔt
Lɛk ɛni mɛrɛsin, Tezspire kin mek smɔl smɔl ɛn sɔm tɛm dɛn kin gɛt siriɔs sayd ɛfɛkt. I impɔtant fɔ no bɔt dɛn tin ya.
| Sayd ɛfɛkt/risk | Diskripshɔn ɛn akshɔn dɛn we dɛn fɔ tek |
|---|---|
| Kɔmɔn sayd ɛfɛkt dɛn | Trot kin at, jɔyn pen, ɛn bak pen. Bɔku tɛm, dɛn tin ya nɔ kin siriɔs. Bɔt if yu de wɔri, tɛl yu dɔktɔ. |
| Riakshכn dεm na di sayt we dεn de injεkshכn | Rɛd, swel, ɔ pen kin apin na di say we dɛn injekt am. Dis kin smɔl if yu pul di injɛkshɔn na frij wan awa bifo di injɛkshɔn ɛn injɛkt am na difrɛn ples ɛvri tɛm. |
| Siriɔs Alɛji Riakshɔn dɛn | Sɔm kayn sik lɛk wae yu nɔr kin ebul fɔ blo fayn, yu fes/lip kin swel, yu at kin bit kwik kwik wan, ɛn yu kin gɛt rash. Dis na imejensi! Stɔp fɔ tek di mɛrɛsin wantɛm wantɛm ɛn go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) . |
| Posisibul fɔ gɛt infɛkshɔn | Dis kin afɛkt di bɔdi in imyun sistɛm, we kin mek i nɔ ebul fɔ fɛt sɔm infɛkshɔn dɛn, mɔ di parasayt ɛlminth infɛkshɔn dɛn . If yu gɛt dis kayn infekshɔn, yu fɔ trit am bifo yu bigin Tezspire. |
| Vaksin dɛn we dɛn kin yuz | Nɔ gɛt layf attenuated vaccines we yu de tek dis mɛrɛsin. Aks yu dɔktɔ bɔt us vaysin yu fɔ gɛt bifo yu bigin Tezspire. |
| Risk fɔ gɛt at sik | Insay wan stɔdi, pipul dɛn we de tek Tezspire bin gɛt smɔl ay risk fɔ gɛt tin dɛn we kin apin to dɛn at ɛn blɔd, lɛk at atak ɛn strok, we yu kɔmpia dɛn to di wan dɛn we de tek plasɛbo. Tɔk to yu dɔktɔ bɔt dis if yu de pan denja fɔ gɛt at sik. |
| Bεlε εn we i de gi pikin in bεlε | Nɔto inof data de yet bɔt di sef fɔ yuz Tezspire we yu gɛt bɛlɛ ɔ we yu de gi pikin in bɛlɛ. If yu de plan fɔ gɛt bɛlɛ, yu gɛt bɛlɛ, ɔ yu de gi pikin in bɛlɛ, tɛl yu dɔktɔ wantɛm wantɛm. |
Mɛmba se Tezspire nɔto ‘rescue’ mɛrɛsin fɔ yuz we yu gɛt asma atak. Na mɛrɛsin wae de ɛp fɔ kɔntrol yu asma fɔ lɔng tɛm.
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn?
Akɔdin to di infɔmeshɔn we de naw, dɛn nɔ ripɔt se Tezspire kin mek pɔsin gɛt siriɔs intarakshɔn wit ɔda drɔgs. Bɔt i bɛtɛ fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn, vaytamɛn dɛn, ɛn sɔpɔtmɛnt dɛn we yu de tek. Aks yu dɔktɔ ɔltɛm bifo yu bigin fɔ tek ɛni nyu mɛrɛsin.
If yu sɔspɛkt se yu dɔn gɛt sayd ɛfɛkt frɔm dis mɛrɛsin, ivin if yu nɔ shɔ 100% se na bikɔs ɔf Tezspire, yu kin ripɔt am to di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital . Dis infɔmeshɔn go rili impɔtant fɔ gɛda mɔ infɔmeshɔn bɔt dis mɛrɛsin tumara bambay.
Mɛsej we dɛn kin kɛr go na os
- Tezspire na ad-ɔn tritmɛnt fɔ siriɔs asma pan big pipul dɛm wae dɔn pas 12 ia wae nɔr de kɔntrol bay di tritmɛnt dɛm wae de naw.
- Dis na vaysin we dɛn kin gi ɛvri 4 wik ɛn i kin ɛp fɔ mek pɔsin nɔ gɛt asma atak, nɔto ‘rɛskɔ’ mɛrɛsin we dɛn kin yuz we i gɛt imejensi.
- Bifo yu bigin dis tritmɛnt, tek tɛm tɔk to yu dɔktɔ bɔt di bɛnifit ɛn bad tin dɛn we i gɛt.
- Nɔ stɔp ɛni asma mɛrɛsin we yu de tek naw if yu nɔ gɛt dɔktɔ advays.
- If yu gɛt siriɔs alɛji lɛk fɔ blo ɛn yu fes de swel, go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
- Tɛl yu dɔktɔ bɔt ɛni sayd ɛfɛkt ɔ ɛni prɔblɛm we yu gɛt.
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