Na nɔmal tin fɔ fil smɔl frayd ɛn fred we yu ɔ pɔsin we yu lɛk bigin fɔ trit kansa. Dat frayd kin pasmak, mɔr lɛk wae yu yɛri di wɔd ‘kimotɛrapi’. Bɔt nɔ fred atɔl. Fɔ mek dis tritmɛnt prɔses go bifo, wi fɔ no gud gud wan bɔt dis mɛrɛsin fɔs. Dɔn wi kin ebul fɔ bia dis waka fayn fayn wan. Tide wi de tɔk bɔt wan pan dɛn kayn mɛrɛsin ya we de agens kansa, we nem Thioguanine (6-TG).
Us kayn mɛrɛsin na Thioguanine (6-TG)?
Fɔ tɔk am simpul wan, Thioguanine na wan mɛrɛsin we de fɛt kansa . Dɔktɔ dɛn kɔl am ‘kimotɛrapi’ drɔg. Di men wok we i de du na fɔ stɔp di kansa sɛl dɛn we de sheb kwik kwik wan na di bɔdi fɔ gro ɛn pwɛl dɛn.
Dɛn kin yuz dis mɛrɛsin spɛshal wan fɔ mɛn sɔm kayn lukimiya , we na kansa na di blɔd sɛl. Sɔntɛnde, yu dɔktɔ kin gi yu dis mɛrɛsin bak fɔ ɔda sik dɛn. So if yu gɛt ɛni kwɛstyɔn bɔt wetin mek dɛn gi yu dis mɛrɛsin, i go fayn fɔ aks yu dɔktɔ.
Tin dɛm wae yu fɔ tɛl yu dɔktɔ bifo yu bigin fɔ tek mɛrɛsin
Bifo yu bigin fɔ trit Thioguanine, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt yu kɔmplit wɛlbɔdi istri. Bikɔs wi nid fɔ rili tek tɛm we wi de yuz dis mɛrɛsin wit sɔm wɛlbɔdi prɔblɛm dɛn. If yu gɛt ɛni wan pan dɛn tin ya, mek shɔ se yu tɛl wi bɔt am.
| Wɛlbɔdi kɔndishɔn/fakt | Wetin mek yu fɔ tɛl di dɔktɔ? |
|---|---|
| Infεkshכn dεm we de naw (especially di wan dεm we vayral lεk chikinpoks εn hεpi) . | Bikɔs dis mɛrɛsin de ridyus di bɔdi in immunity, di infɛkshɔn dɛn we dɔn de kin wɔs. |
| Liva sik | Bikɔs na di liva de prosɛs dis mɛrɛsin, i kin gɛt sayd ɛfɛkt pan liva sik. |
| di bכdi sεl dεm we de dכn (wayt bכdi sεl dεm, rεd blɔd sεl dεm, pletlεt dεm) . | Tioguanine kin ridyus di blɔd sɛl dɛn we dɛn de mek, we kin denja if yu blɔd sɛl dɛn dɔn ɔlrɛdi smɔl. |
| TPMT dɛfisiɛns (Thiopurine methyltransferase dɛfisiɛns) . | Dis na wan sik we pɔsin kin gɛt we i kam pan jɛnɛtiks. Pipul dεm wae nכ gεt dis εnzym kin gεt bכku Thioguanine na dεn bכdi, we kin mek di sayd ifekt dεm bכku. |
| Alɛji dɛn we pɔsin kin gɛt | I impɔtant fɔ tɛl yu dɔktɔ if yu gɛt ɛni alɛji to Thioguanine ɔ ɔda mɛrɛsin ɔ it. |
| Fɔ tray fɔ gɛt bɛlɛ, fɔ gɛt bɛlɛ, ɔ fɔ gi pikin in bɛlɛ | Dis mεdikeshכn kin mek di pikin we de bכn bכku bad bad wan , so i impɔtant fכ tכk bכt am. |
Aw a fɔ yuz di mɛrɛsin?
Di we aw dɛn kin yuz dis mɛrɛsin rili simpul, bɔt i rili impɔtant.
- Swɛla di pil wit wan glas wata , lɛk aw dɛn tɛl yu fɔ du am.
- Tek yu mɛrɛsin ɛvride, jɔs lɛk aw yu dɔktɔ tɛl yu, di tɛm we dɛn tɛl yu. Nɔ skip di apɔntinmɛnt dɛn.
- Nɔ stɔp fɔ tek di mɛrɛsin ɔ chenj di doz fɔ ɛni rizin if yu dɔktɔ nɔ advays yu.
- If yu de gi pikin dɛn dis mɛrɛsin, tɔk to yu dɔktɔ we de mɛn pikin dɛn bɔt am ɛn fala dɛn instrɔkshɔn.
Atɛnshɔn: If yu tink se yu dɔn tek mɔ mɛrɛsin pas aw dɛn tɛl yu fɔ tek, nɔ de te. Wantɛm wantɛm, kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital ɔ go na di Imejɛnsi Dipatmɛnt (ETU) na di ɔspitul we de nia yu.
Wetin fɔ du if yu mis wan doz fɔ mɛrɛsin?
If yu mis wan doz, nɔ wɔri. Skip di doz we yu mis ɛn tek di nɛks doz na di tɛm we dɛn dɔn sɛtul. Nɔ ɛva tek tu dos wan tɛm.Dat min se nɔ tek dɛbul doz fɔ mek yu fɔgɛt wan. If yu vɔmit afta yu dɔn tek di mɛrɛsin, aks yu dɔktɔ fɔ advays bɔt wetin fɔ du nɛks.
Ɔda mɛrɛsin dɛm wae kin miks wit dis mɛrɛsin
I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, lɛk di mɛrɛsin dɛn we yu de tek, di mɛrɛsin dɛn we yu nɔ de bay, vaytamɛn dɛn, ɛbul mɛrɛsin dɛn, ɛn ivin sɔpɔtmɛnt dɛn. Sɔm mɛrɛsin kin intarakt wit Thioguanine ɛn inkrisayz di sayd ɛfɛkt ɔ chenj aw i de wok fayn.
Tek tɛm mɔ wit dɛn mɛrɛsin ya:
- Busulfan (wan ɔda mɛrɛsin we de mek pɔsin nɔ gɛt kansa) .
- Mεdikeshכn dεm we de mek bכdi nכ kכlכt (e.g. Warfarin) .
- Mεdisin dεm fכ inkrεs di bכdi sεl dεm (e.g. filgrastim) .
- Drug dɛn lɛk Mɛsalamin, Ɔlsalazin, Sɔlfasalazin, Balsalazayd
- Vaksin dɛn we gɛt ɛni kayn
Speshal wɔnin: Nɔ tek mɛrɛsin fɔ mek yu nɔ fil pen lɛk aspirin, asetaminofɛn, ɛn ibuprofen we yu nɔ go to yu dɔktɔ. Dɛn mɛrɛsin ya kin stɔp di sayn dɛm lɛk fiva. I impɔtant fɔ no fiva kwik, we kin bi sayn fɔ di sik kwik kwik wan, we yu de tek Thioguanine.
Tin dɛn we yu fɔ tink bɔt we yu de du tritmɛnt
Bikɔs kemotɛrapi kin afɛkt di kansa sɛl dɛn ɛn di wɛlbɔdi sɛl dɛn, i nɔmal fɔ mek yu fil fayn ɛn yu taya. Bɔt nɔ stɔp di tritmɛnt te yu dɔktɔ tɛl yu fɔ du am bikɔs ɔf dɛn tin ya we nɔ fayn.
- Protɛkt yusɛf frɔm infɛkshɔn: Dis mɛrɛsin de mek yu nɔ ebul fɔ fɛt di sik, so yu kin sik mɔ. So, nɔ fɔ go na say dɛn we pipul dɛn kin bɔku ɛn fɔ de nia sik pipul dɛn (di wan dɛn we gɛt fiva ɔ kol) as yu ebul. If yu gɛt sɔm sayn dɛn lɛk fiva, kol, trot we de at, ɔ bɔdi we de at , nɔ fɔ tek mɛrɛsin fɔ yusɛf ɛn tɛl yu dɔktɔ wantɛm wantɛm.
- Tek tɛm we yu de blɔd: Di risk fɔ mek yu blɔd go bɔku. So, brus yu tit jisnɔ. Nɔ yuz brɔsh dɛn we at fɔ yuz. Chek fɔ ɛni brus ɔ smɔl smɔl rɛd spat na di skin. If yu si ɛnitin lɛk dat, tɛl yu dɔktɔ.
- Nɔ gɛt bɛlɛ: Dis rili impɔtant. Nɔ gɛt bɛlɛ ɔltogɛda we yu de tek dis mɛrɛsin. Dɔn bak, nɔ fɔ gi pikin in bɛlɛ we yu de tek dis mɛrɛsin. Aks yu dɔktɔ fɔ no mɔ bɔt dis.
Wetin na di bad bad tin dɛn we kin apin to pɔsin?
Lɛk ɛni mɛrɛsin, Thioguanine kin mek yu gɛt sayd ɛfɛkt. Bɔt nɔto ɔlman kin gɛt dɛn. Sɔm kin rili kɔmɔn, ɛn sɔm kin rili rare. De impɔtant tin na fɔ no wetin na de sayd ɛfɛkt ɛn wetin fɔ du if dɛn apin.
| Thioguanine (6-TG) sayd ɛfɛkt dɛn | |
|---|---|
| 🚨 Sayd ɛfɛkt dɛn we nid fɔ go to dɔktɔ wantɛm wantɛm | |
| Di sayn dɛn we de sho se pɔsin gɛt alɛji | Skin rash, it, swel na di fes, lip, tong, i nɔ izi fɔ blo. |
| Sayn dɛn we de sho se pɔsin gɛt di sik | Fiva, kol, kɔf, trot we de at, pen we yu de pis. |
| Di sayn dɛn we de sho se pɔsin de blɔd | Brus we yu nɔ ɛksplen na di skin, pɔynt rɛd spat dɛn ɔnda di skin, blak stɔl, ɛn blɔd na di urine. |
| Di sayn dɛn we de sho se pɔsin nɔ gɛt bɛtɛ blɔd | Taya we nɔ kɔmɔn, taya, diziz, blu yay. |
| Liva prɔblɛm dɛn | Pen na di ɔp rayt say na di bɛlɛ, yu yay ɔ yu skin de yɔlɔ (jaundice). |
| Ɔda siriɔs sayn dɛn | Mɔt sos, di anklɛ, fut ɔ bɛlɛ we de swel, we yu gɛt wet wantɛm wantɛm. |
| 🙂 Sayd ɛfɛkt dɛm we dɛn fɔ ripɔt to di dɔktɔ if dɛn kɔntinyu fɔ de | |
| Prɔblɛm dɛn we de na di dijestiv sistɛm | Dayarɛa, nɔ kin want fɔ it, nɔs, vɔmit. |
Aw fɔ kip mɛrɛsin fayn fayn wan?
- Kip am na say we sef we pikin dɛn nɔ go ebul fɔ rich.
- Stɔr am na dray ples we di rum tɛmpracha (bitwin 15 ɛn 25 digri sɛlshiɔs).
- Protɛkt frɔm mɔstɔ. So kip di mɛrɛsin bɔtul tayt tayt wan.
- Trowe ɛni mɛrɛsin we dɔn pas di de we i fɔ dɔn.
Mɛsej we dɛn kin kɛr go na os
- Thioguanine na wan kemotɛrapi mɛrɛsin we dɛn kin yuz fɔ mɛn kansa lɛk lukimiya.
- Ɔltɛm tek yu mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu fɔ tek, di rayt tɛm.
- Tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn, vaytamɛn dɛn, ɛn tradishɔnal mɛrɛsin dɛn we yu de tek.
- If yu notis sayn dɛn we de sho se yu gɛt di sik ɔ yu de blɔd, lɛk fiva, brus, ɔ brus, tɛl yu dɔktɔ wantɛm wantɛm.
- Nɔ gɛt bɛlɛ ɛn gi pikin in bɛlɛ kpatakpata we yu de tek dis mɛrɛsin.
- Nɔ ɛva stɔp di tritmɛnt ɔ chenj di doz if yu nɔ gɛt dɔktɔ advays.
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