LDH yo eri etya? (LDH - Lactate Dehydrogenase Test) Ka tumanye ku kino mu ngeri ennyangu!

Leero tugenda kwogera ku kukeberebwa okuyinza okutubuulira ebintu bingi ebikulu ebikwata ku bulamu bw'omubiri gwaffe. Oyinza okuba nga wali owulidde ku kigezo kya `LDH`. Oboolyawo omusawo akusaba n’okukeberebwa kuno. Kale, ka tulabe `LDH` eno kye ki era ky'oyinza okuyiga okuva mu kugezesebwa kuno mu ngeri ennyangu ennyo.

Lactate dehydrogenase (LDH) kye ki?

Kale, ka tusooke tulabe `Lactate Dehydrogenase` kye ki. Era tukiyita `(LDH)` mu bufunze. Mu ngeri ennyangu, eno enzyme nkulu nnyo mu mubiri gwaffe. Enziyiza (Enzyme) kika kya puloteyina eyanguya era eyamba enkola y’eddagala mu mubiri gwaffe. Kilowoozeeko ng’obuyambi obutonotono obwanguyiza omubiri gwaffe.

Enziyiza eno eya `LDH` eyamba nnyo mu kussa kwaffe okw'obutoffaali . Kwe kugamba, `LDH` eno eyamba ku nkola enkulu ennyo ey’okutwala glucose (mu ngeri ennyangu, ssukaali) mu mmere gye tulya n’okufulumya amaanyi obutoffaali bw’omubiri gwaffe ge bwetaaga. Kino kiringa okuyamba okukola amafuta mu butoffaali obukola ng’obuuma obutono obw’amasannyalaze mu mubiri gwaffe.

Obadde okimanyi nti enzyme eno `LDH` eri kumpi mu buli tissue mu mubiri gwaffe? Naye kisinga kubeera mu binywa, ekibumba, ensigo, n’obutoffaali obumyufu . Obutoffaali obupya bwe butondebwa mu mubiri gwaffe, obutoffaali obukadde oba "obufu" buggyibwawo. Kino kya bulijjo. Obutoffaali obukadde bwe buggyibwamu, `LDH` ezimu okuva mu bitundu ebyo zigattibwa mu musaayi gwaffe oba mu mazzi amalala ag’omubiri. N’olwekyo, kya bulijjo okuba ne `LDH` ezimu mu sampuli y’omusaayi oba sampuli endala ey’amazzi g’omubiri.

Kale, ekigezo kino ekya LDH (lactate dehydrogenase) kye ki?

Okay, kati olina ekirowoozo ekitono ku `LDH` kye ki. Okukebera `LDH` kupima obungi bwa `LDH` mu musaayi gwo oba mu mazzi amalala ag'omubiri. Kino okusinga kikolebwa kukebera oba waliwo okwonooneka kwonna ku bitundu by’omubiri gwo .

Nga bwe twayogeddeko emabegako, kya bulijjo okuba n'omuwendo gwa `LDH` mu musaayi gwo. Naye singa ekitundu kyonna mu mubiri gwo kyonoonese oba nga kifunye obuvune , `LDH` esukkiridde okuva mu kitundu ekyo ekyonoonese ejja kufulumizibwa mu musaayi gwo oba mu mazzi amalala ag’omubiri. Kale, singa `LDH` level yo esinga ku ya bulijjo, kiyinza okutegeeza nti ebitundu ebimu mu mubiri gwo byonoonese obulwadde obutawona , obulwadde obw'amaanyi , oba obuvune .

Naye ekintu kimu eky’okujjukira kiri nti kizibu okumanya ddala ebitundu by’omubiri ebyonooneddwa okukebera kwa `LDH` kwokka. Kubanga `LDH` eri mu bifo bingi mu mubiri gwaffe. N’olwekyo, abasawo batera okulagira okukeberebwa okulala okuwerako wamu n’okukeberebwa kwa `LDH` okuzuula obulungi obulwadde buno.

Ekigezo kino ekya `LDH` era kiyitibwa amannya amalala agawerako:

• Okugezesebwa kwa `LD`
• Ekirungo kya lactic dehydrogenase
• Asidi wa lactic dehydrogenase

Ddi lwe nneetaaga okukeberebwa LDH?

Abasawo bakozesa okukebera kwa LDH okuzuula n’okulondoola embeera z’obulamu ez’enjawulo. Ensonga enkulu lwaki okukebera kuno kukolebwa ze zino:

• Kebera oba ebitundu by'omubiri gwo byonoonese .
• Londoola endwadde nga okukendeera kw’omusaayi , endwadde z’ebitundu by’omunda (e.g. ekibumba, ensigo), n’embeera ezonoona ebitundu by’omubiri, gamba nga yinfekisoni ezimu .
• Kebera obuzibu bw'ebika bya kookolo ebimu .
• Laba oba obujjanjabi bwa kookolo abamu (e.g. chemotherapy) buba buwanguzi oba nedda.

Okuva okukebera kwa `LDH` bwe kukolebwa mu mbeera nnyingi ez'enjawulo, bw'oba osabiddwa okukeberebwa kuno, kirungi okubuuza omusawo wo lwaki okeberebwa.

Ani akola okukebera kuno okwa LDH?

Mu bujjuvu, okukebera omusaayi okuzuula LDH kukolebwa omukugu mu by’omusaayi (phlebotomist) atendekeddwa okuggya omusaayi . Kyokka omukugu yenna mu by’obulamu eyatendekebwa okusena omusaayi asobola okukikola. Oluvannyuma omusaayi gusindikibwa mu laboratory. Eyo, omukugu mu laboratory y’ebyobujjanjabi yeetegereza sampuli era n’akozesa ebyuma eby’enjawulo (analyzers) okupima omutindo gwa LDH.

Oluusi abasawo beetaaga okupima emiwendo gya LDH mu mazzi amalala g’omubiri, so si musaayi gwokka. Ng’ekyokulabirako, amazzi go ag’omu bwongo (CSF), amazzi g’omu bwongo , oba amazzi g’omu lubuto . Mu mbeera zino, omusawo atendekeddwa mu ngeri ey’enjawulo ajja kutwala sampuli.

Nneetegeke ntya okukeberebwa LDH?

Ebiseera ebisinga, teweetaaga kuteekateeka kintu kyonna kya njawulo ku kukeberebwa musaayi gwa LDH.

Kyokka singa sampuli eggyibwa mu mazzi amalala ag’omubiri, nga bwe kyayogeddwako emabegako, kiyinza okwetaagisa okuteekateeka okumu. Omusawo wo ajja kukunnyonnyola kino mu kiseera ekyo.

Kiki ekibaawo mu kiseera ky’okukeberebwa LDH?

Bw’owaayo omusaayi, kino kye kitera okubaawo:

• Ojja kutuula mu ntebe. Olwo omukozi w’ebyobulamu ajja kunoonya omusuwa mu mukono gwo ogwangu okuggyamu omusaayi. Ebiseera ebisinga, omusaayi guggyibwa munda mu nkokola yo.
• Omusuwa bwe guzuulibwa, ekitundu ekyo kiyonjebwa bulungi ne basiigako eddagala eritta obuwuka.
• Oluvannyuma, empiso entono eteekebwa mu musuwa ne bagiggyamu omusaayi omutono. Mu kiseera kino, oyinza okuwulira ng’olumwa katono, ng’enseenene eluma .
• Oluvannyuma lw’okuyingiza empiso, omusaayi omutono gukuŋŋaanyizibwa mu ttanka y’okukebera.
• Oluvannyuma lw’okuggyibwako omusaayi, empiso eggyibwamu ne bateeka akatundu ka ppamba oba gaasi mu kifo ne bamussaako puleesa entono okukomya omusaayi.
• Oluvannyuma pulasita bagisiiga mu kifo ekyo. Ekyo kye kiri.

Enkola eno yonna etera okutwala eddakiika ezitakka wansi wa ttaano . Omulimu gwa mangu nnyo.

Nga bwe twayogeddeko emabegako, oluusi amazzi amalala ag’omubiri gayinza okwetaagisa okupima `LDH`. Emisango egyo mulimu:

• Amazzi g’omu bwongo (CSF) .
• Amazzi g’omu kibumba (Pleural Fluid).
• Amazzi g’omu lubuto

Bw’oba ​​olina okukeberebwa ekika kino, tofaayo. Omusawo ajja kukunnyonnyola mu bujjuvu engeri okukebera gye kukolebwamu ne by’olina okumanya.

Kiki ekibaawo oluvannyuma lw’okukeberebwa LDH?

Oluvannyuma lw’okuggyibwako omusaayi gwo oba amazzi amalala ag’omubiri, gajja kusindikibwa mu laboratory okukeberebwa. Ebyava mu kukeberebwa bwe bimala okuyingira, omusawo wo ajja kuteesa naawe ebyava mu kukeberebwa.

Waliwo akabi konna akali mu kukeberebwa LDH?

Okuwaayo omusaayi nkola ya bulijjo nnyo mu kunoonyereza ku by’obujjanjabi. Tekitwala bulabe bungi . Wayinza okubaawo ebiwundu n’okulumwa omusaayi we gwaggyibwa. Naye ekyo kijja kuggwaawo mangu.

Kintwalira bbanga ki okumanya ebyava mu kukeberebwa kwa LDH?

Ebiseera ebisinga, ebyava mu kukeberebwa kwo okwa LDH birina okuba nga bifunibwa mu lunaku lumu oba bbiri , naye oluusi kiyinza okutwala ekiseera ekiwanvuko katono.

Bw’oba ​​okoze okukebera kuno mu ddwaaliro oba mu kisenge ky’abalwadde ab’amangu, oyinza okufuna ebyavaamu mu ssaawa ntono .

Biki ebiva mu kukeberebwa kwa LDH?

Lipoota y'okukebera omusaayi, kwe kugamba, lipoota y'okukebera `LDH`, etera okubaamu amawulire gano wammanga:

• Erinnya ly’okukebera omusaayi, oba ebyo ebyapimibwa mu musaayi gwo.
• Omuwendo (i.e., ennamba) y’ebyava mu kukebera omusaayi gwo.
• Range eyabulijjo ey’okugezesebwa okwo.
• Amawulire agalaga oba ebyavaamu byo bya bulijjo, si bya bulijjo oba bya waggulu oba wansi.

Miwendo ki egya bulijjo egya LDH (lactate dehydrogenase)?

Ekigero ekya bulijjo ekya `LDH` kiyinza okwawukana katono okuva ku laboratory emu okudda ku ndala. Bw’ofuna lipoota yo ey’okukebera omusaayi, ejja kulaga bulungi ekika ekya bulijjo ekya `LDH` kye kiri eri laboratory eyo.

Naye okutwaliza awamu, emiwendo egya bulijjo egy’okukebera LDH giri bwe giti:

• Ku basajja : Yuniti 135 – 225 buli liita (U/L).
• Ku bakyala : Yuniti buli liita (U/L) 135 – 214.

Okutwalira awamu emiwendo gya LDH egya wakati mu baana abato giba waggulu okusinga mu bantu abakulu.

Bw’oba ​​olina ekibuuzo kyonna ku bivudde mu kunoonyereza kwo, kakasa nti obuuza omusawo wo.

Kitegeeza ki singa LDH level yange eba waggulu?

Singa LDH yo eba waggulu okusinga eya bulijjo, kisinga kutegeeza nti waliwo okwonooneka kw’ebitundu ebimu mu mubiri gwo.Kitegeeza nti waliwo ekibaddewo. Okwonoonebwa okwo kuyinza okuva ku bulwadde obw’ekiseera ekiwanvu (obutawona), embeera ey’amangu (acute), oba yinfekisoni.

Ezimu ku mbeera z’obujjanjabi eziyinza okuvaako emiwendo gya LDH okulinnya ze zino:

• Okukendeera kw’omusaayi
• Obulwadde bw’ekibumba
• Obulwadde bw’amawuggwe
• Obulwadde bw’ekibumba
• Obuvune mu binywa
• Obulwadde bw’ebinywa
• Okumenya amagumba
• Omutima okulwala
• Obulwadde bw’olubuto
• Yinfekisoni ezimu , gamba ng’okuzimba omutwe , obulwadde bw’obwongo , obulwadde bwa mononucleosis (mono ), ne siriimu .
• Ebika bya kookolo ebimu , okugeza, metastatic melanoma , multiple myeloma, lymphoma , kookolo w’ensigo , ne leukemia .

Ate era, okubeera n’omutindo gwa LDH ogusinga ku gwa bulijjo kiyinza okutegeeza nti obujjanjabi bwa kookolo tebukola bulungi .

Wadde ng’okukebera kwa LDH kuyinza okulaga oba ebitundu by’omubiri gwo byonoonese oba olina obulwadde, tekisobola kukubuulira ddala wa byonooneddwa . Ate era, singa obutoffaali obumyufu bumenyekamenyeka mu kiseera ky’omusaayi (hemolysis), omuwendo gwa LDH oluusi guyinza okuba waggulu mu bukyamu . Kale singa ebyava mu kunoonyereza kwo biraga nti LDH yo eri waggulu, kirabika omusawo wo ajja kwetaaga okwongera okukeberebwa okusobola okuzuula obulungi obulwadde buno.

Nsaana okweraliikirira singa LDH level yange eba waggulu?

Ne bwe kiba nti ebyava mu kukeberebwa kwa LDH biraga nti LDH yo eri waggulu, tekitegeeza nti olina obulwadde obw’amaanyi . Tofaayo.

Waliwo ensonga endala eziwerako eziyinza okuvaako emiwendo gya LDH okulinnya:

• Okukola dduyiro n'amaanyi .
• Eddagala erimu okugeza aspirin , eddagala eribudamya , ebiragalalagala ne procainamide .

Ate era, wayinza okuba nga waaliwo ensobi mu kiseera ky’okukung’aanya sampuli, okutambuza, oba okugezesebwa.

Omusawo bw’aba asalawo ku bivudde mu kunoonyereza kwo, ajja kulowooza ku bintu bingi, gamba ng’eddagala ly’omira mu kiseera kino, ebyafaayo by’obulamu bwo, n’obubonero bw’olaba.Era ajja kukubuulira oba weetaaga okwongera okukeberebwa oba nedda.

Bw’oba ​​olina ekibuuzo kyonna ku bivudde mu kunoonyereza kwo, totya kwogera na musawo wo.

Kitegeeza ki singa LDH level yange eba wansi?

Si kya bulijjo nnyo ebyava mu kukeberebwa kwa `LDH` okuba wansi okusinga ebya bulijjo .

Okubeera n’omutindo gwa LDH omutono bwe gutyo kiyinza okulaga embeera y’obuzaale etali ya bulijjo ennyo eyitibwa obutaba na Lactate Dehydrogenase A - Glycogen Storage Disease XI, oba obutaba na Lactate Dehydrogenase B.

Ate era, abantu abanywa ennyo vitamiini C bayinza okuba n’ebyava mu kukeberebwa kwa LDH okutono mu bukyamu .

Bibuuzo ki bye nnina okubuuza omusawo wange?

Bw’oba ​​okebereddwa LDH, kiyinza okukuyamba okubuuza omusawo ebibuuzo nga bino:

• Olowooza kiki ekiyinza okuba nga kye kivuddeko omutindo gwange ogwa waggulu ogwa `LDH`?
• Nneetaaga okwongera okwekebejja okuzuula ekituufu ekivaako emiwendo gyange egya LDH egy’amaanyi?
• (Bw’oba ​​oli mulwadde wa kookolo) Omutendera gwange ogwa `LDH` gugamba ki ku buzibu n’okuteebereza kwa kookolo wange?
• (Bw’oba ​​ojjanjabibwa obulwadde) Omutendera gwange ogwa `LDH` gugamba ki ku ngeri embeera yange gy’ekwatamu obujjanjabi?

Ekintu ekisinga obukulu okukuuma mu birowoozo (Take-Home Message)

Kya bulijjo okuwulira ng’otya katono n’okweraliikirira ng’olaba ebyava mu kukeberebwa ebitali bya bulijjo. Naye jjukira, olw’okuba nti `LDH` (lactate dehydrogenase) level yo eri waggulu tekitegeeza nti olina obulwadde obw’amaanyi era weetaaga obujjanjabi.

Omusawo wo ajja kukubuulira ddala oba olina okwongera okwekebejja okuzuula ekivaako omutindo guno ogutali gwa bulijjo oba nedda. Totya oba okulonzalonza okubuuza omusawo ebibuuzo . Baliwo okukuyamba. Yogera nabo ku kintu kyonna ky’olina ku bulamu bwo.

` LDH, lactate dehydrogenase, enzyme, okwonooneka kw’ebitundu by’omubiri, okukebera omusaayi, obulamu, okuzuula obulwadde