Ebizimba bisobola okukula ku busimu bwo? Ka twogere ku Nerve Sheath Tumors mu bigambo ebyangu!

Obusimu obutambula mu mibiri gyaffe gyonna bulinga omukutu gwa waya ezitambuza obubaka bw’amasannyalaze. Zino ze zitwala amawulire okudda n’okudda okuva ku bwongo okutuuka ku mubiri gwonna, n’okuva mu mubiri okutuuka ku bwongo. Teebereza nti obutoffaali buno obw’obusimu, ebibinja byabwo, byonna bizingiddwa mu bitundu eby’enjawulo ebikuuma, ng’ekikuta ky’akaveera okwetooloola waya, okubukuuma n’okuyamba obubonero bw’amasannyalaze okutambula amangu. Mu bitundu bino ebikuuma mwe muva ebizimba bino ebiyitibwa nerve sheath ebizimba oluusi.

Ebizimba by’obusimu (nerve Sheath Tumors) bye biruwa?

Mu ngeri ennyangu, ebizimba bino bikola mu "sheaths" ezikuuma ezitwetoolodde obusimu bwaffe. "Ekiziba" kino oba ekibikka kikolebwa layers eziwerako:

• Obutoffaali bwa Schwann: Buno bwe butoffaali obuzinga ku axon, ekitundu ekiwanvu eky’obutoffaali bw’obusimu, ng’okuziyiza okwetooloola waya.
• Endoneurium: Kino kye kitundu ekiyunga ekyetoolodde buli fiber y’obusimu, okufaananako nnyo ekikuta ekyetoolodde waya emu ey’ekikomo mu waya.
• Perineurium: Kino kye kyetoolodde ebibumbe by’obusimu.

Enkola yaffe ey’obusimu esobola okwawulwamu ebitundu bibiri:

• Enkola y’obusimu obw’omu makkati: Kino kizingiramu obwongo bwaffe n’omugongo.
• Enkola y’obusimu obw’okumpi: Guno gwe mutimbagano gw’obusimu obuva ku bwongo n’omugongo okutuuka mu bitundu by’omubiri byonna.

Ebiseera ebisinga, obusimu buno obuyitibwa neurofibromas butondebwa mu nkola y’obusimu obw’okumpi .

Bika ki eby’entangawuuzi ebiriwo?

Waliwo ebika by’obusimu ebikulu ebiwerako. Ka tulabe kiki kye bali.

Ensigo za Schwannomas

Ebizimba bino bikula mu butoffaali bwa Schwann obwogeddwako emabegako. Ebitundu nga 60% ebya schwannomas bikula mu busimu obuyitibwa vestibular nerve mu kutu kwaffe okw’omunda . Obusimu buno buyamba omubiri gwaffe okukuuma bbalansi. Schwannomas endala oluusi zisobola okukula wansi w’olususu lwaffe, oba munda mu bitundu by’omubiri n’ebitundu by’omubiri. Ebifo ebisinga okulabibwa ebizimba bino bye bino:

• Mu mikono n’amagulu
• Mu mutwe
• Mu kikolo (kwe kugamba, ekitundu ekiri wakati w’ebibegabega n’ebisambi) .

Schwannomas kika kya kizimba ekitera okubikkibwako oluwuzi olugonvu olw'ebitundu by'omubiri, oba "encapsulated." Ebizimba bino bitera okuba nga tebirina kookolo (benign). Naye, si bulijjo nnyo, ekizimba ekimaze ebbanga eddene kiyinza okufuuka kookolo (malignant).

Obulwadde bw’obusimu obuyitibwa neurofibromas

Ekizimba eky’ekika kino kizingiramu ebika by’ebitundu ebiwerako ebiyitibwa Schwann cells, endoneurium, ne perineurium ebibikka obusimu. Bino bitera okulabika ng’ebizimba wansi w’olususu, naye oluusi bisobola okukula ku busimu obuli munda mu mubiri.

Okwawukanako ne schwannomas, neurofibromas tezikwatibwa. Zikula munda mu bitundu by’obusimu. Plexiform neurofibromas kika kya kizimba ekisaasaana ng’akatimba, nga kyetoolodde ebibumbe by’obusimu bingi era nga kisobola okusaasaana mu bitundu ebikyetoolodde.

Ebirungo ebisinga ebiyitibwa neurofibromas si bya kookolo. Kyokka, ebitundu nga 5% ku 10% ku bizimba bino bisobola okufuuka kookolo . Ziyitibwa ebizimba by’obusimu obuyitibwa malignant peripheral nerve sheath tumors (MPNST) . Abantu nga kitundu ku bantu abalina ebizimba bino eby’obulabe we bazuulibwa nga basaasaana dda mu bitundu by’omubiri ebirala.

Ekibala kino kya bulijjo kitya?

Ebizimba by’obusimu ebitali bya kookolo tebitera kubaawo.

• Obulwadde bwa Schwannomas businga kulabibwa mu bantu abali wakati w’emyaka 50 ne 60.
• Neurofibromas esinga kubeera mu bantu abali wakati w’emyaka 20 ne 40.
• Plexiform neurofibromas zitera okukula nga tezinnaweza myaka 5.

Malignant Peripheral Nerve Sheath Tumors kika kya kookolo ekitali kya bulijjo nnyo , nga buli mwaka kikwata omuntu omu yekka ku buli bukadde 10.

Lwaki ebizimba nga bino bikola? Biki ebivaako?

Enkyukakyuka mu buzaale zirina kinene kye zikola ku nkula y’obusimu buno obuyitibwa neurofibromas.

• Enkula ya Schwannomas ekwatagana n’enkyukakyuka mu ggiini eyitibwa NF2.
• Neurofibromas zikwatagana n’obuzaale obuyitibwa (NF1).

Ebiseera ebisinga, enkyukakyuka zino ez’obuzaale zibaawo buli luvannyuma lwa kiseera, nga tewali nsonga yonna eraga nti evaako . Kyokka, omuwendo omutono ogwa schwannomas ne neurofibromas guva ku mbeera y’obuzaale etali ya bulijjo eyitibwa neurofibromatosis , eyinza okutambulira mu maka.

Ebika by’obulwadde bwa Neurofibromatosis

Obulwadde buno bulina ebika bisatu ebikulu:

• Neurofibromatosis type 1 (NF1): Abantu abalina NF1 bafuna obulwadde bwa neurofibromas bungi. Era balina obulabe obweyongedde obw’okufuna obulwadde bwa plexiform neuromas n’ebizimba ebibi ebiyitibwa malignant peripheral nerve sheath tumors (MPNST). Embeera endala ezirabibwa mu bantu abalina NF1 mulimu obulwadde bwa macrocephaly , scoliosis, n’obulemu mu kuyiga .

• Obulwadde bw’obusimu obuyitibwa neurofibromatosis ekika kya 2 (NF2):Kumpi buli muntu alina NF2 afuna vestibular schwannomas mu matu gombi nga tannaweza myaka 30. Okugatta ku ekyo, ebika ebirala ebya schwannomas n’ebizimba nabyo bisobola okukula mu lususu lwe, amaaso, n’obusimu obw’omu makkati.

• Schwannomatosis: Mu mbeera eno, schwannomas eziwera zikula mu busimu obuyitibwa vestibular nerve (mu matu gombi) okusinga mu vestibular nerve.

Bubonero ki obulaga ebizimba bino?

Abantu abasinga abalina ebizimba bya neuromastoid tebafuna bulumi bwonna oba obubonero obulala . Wabula singa ekizimba kikula oba nga kinyigiriza obusimu, obubonero nga:

• Ekizimba oba ekizimba wansi w’olususu (kiyinza okuluma ng’onyigiddwa).
• Obunafu bw'ebinywa .
• Okuzirika .
• Obulumi, obulumi, oba obulumi obw’amaanyi .
• Okuwulira ng’owunya, ng’okukubwa amasannyalaze .

Okusinziira ku kifo ekizimba we kiri, obubonero obulala obw’enjawulo nabwo buyinza okubaawo. Wano waliwo ebyokulabirako ebitonotono:

• Sciatic nerve tumor: Obulumi obuva emabega okukka wansi ku kigere (sciatica).
• Ekizimba ku mukono: Obubonero obufaananako n’obw’obulwadde bwa Carpal Tunnel Syndrome.
• Ekizimba ky’obusimu obuyitibwa vestibular nerve tumor: Okubulwa okuwulira, okuwulira, okuwulira obubi, obuzibu mu bbalansi.

Ebiseera ebisinga, omuntu bw’aba n’obulwadde bw’obusimu obuyitibwa neurofibromatosis, kiba kizimba kimu. Wabula mu bantu abalina embeera eyogeddwako emabegako eya neurofibromatosis, ebizimba ebingi bisobola okulabibwa (ebiseera ebisinga ku lususu).

Omanya otya nti olina entangawuuzi zino?

Omusawo ajja kusooka kukukebera mu mubiri era akebere obulamu bwo okutwalira awamu. Kino kijja kuzingiramu okubuuza ku byafaayo byo eby’obujjanjabi, ebyafaayo by’obujjanjabi bw’amaka go, n’obubonero bwonna bw’oyinza okuba ng’olina.

Okwongera okunoonyereza ku kizimba ekyalabika edda oba ekiteeberezebwa okuba ekizimba, omusawo ayinza okukuwa amagezi okukebera bino wammanga:

• Okukebera ebifaananyi by’abasawo: Mu bino mulimu MRI scans, ultrasound scans, ne PET scans okulaba ekizimba obulungi.
• Biopsy: Akatundu akatono akaggibwa mu kizimba ne kakeberebwa mu microscope okuzuula ekika ky’obutoffaali obuliwo. Kino kye kiyinza okukutegeeza mu butuufu oba ekizimba kirimu kookolo oba nedda.

Bw’oba ​​olina ebizimba ebingi, omusawo ayinza n’okukuwa amagezi okukebera obuzaale okulaba oba olina embeera eziyitibwa (NF1), (NF2), ne Schwannomatosis.

Bujjanjabi ki obukolebwa ku kino?

Bw'oba tolina bubonero bwonna buva ku bulwadde bwa neuromastoid, omusawo ayinza okukuwa amagezi nti "tunula era olinde."Osobola okugenda n'enkola eyitibwa "okulondoola." Ekyo kitegeeza okukebera ekizimba emirundi mingi okulaba oba kigenda kyeyongera obunene oba kikyuka.

Ku bizimba ebirina obubonero, oba bw’oba ​​oyagala okuggyawo ekizimba olw’ensonga z’okwewunda, okulongoosa ebiseera ebisinga kye kyokka .

Ebiwuka ebimu ebiyitibwa neurofibromas naddala ebiyitibwa plexiform neurofibromas bizibu okubiggyawo ddala kubanga bikula munda mu busimu ne wakati wa layers z’ekibikka. Singa ekizimba tekisobola kuggyibwawo ddala oluvannyuma lw’okulongoosebwa, omusawo ajja kukulondoola nnyo, kubanga ekizimba kisobola okuddamu okukula.

Obujjanjabi bwa schwannomas mu mutwe

Schwannomas ezikolebwa mu mutwe, gamba nga vestibular schwannomas, zisobola okukosa obusimu obufuga emirimu emikulu mu mubiri gwaffe. Mu mbeera zino, abasawo bakozesa enkola eyitibwa stereotactic radiosurgery (e.g., Gamma Knife®) okuziyiza okwonooneka kw’obusimu.

Kino si kulongoosa kwa kinnansi okuzingiramu okusalako. Kizingiramu okusindika ekitangaala ky’obusannyalazo ekigendereddwamu obulungi ennyo okuyita mu lususu okusaanyaawo oba okukendeeza ekizimba.

Obujjanjabi bw’ebizimba by’obusimu obw’okumpi obulina kookolo

Ng’oggyeeko okulongoosa, obujjanjabi bwa kookolo nga radiation therapy ne chemotherapy nabwo busobola okukozesebwa okujjanjaba ebizimba eby’obusimu obuyitibwa malignant peripheral nerve sheath tumors.

Bizibu ki ebiyinza okuva mu kulongoosebwa?

Nga bwe kiri ku kulongoosa kwonna, waliwo ebizibu ebiwerako ebitera okuva mu kulongoosa kuno:

• Okuvaamu omusaayi
• Obulwadde bw’ebiwundu
• Obulumi
• Okufuna enkovu

Okugatta ku ekyo, okulongoosa obusimu kuleeta akabi k’obusimu okwonooneka n’okulemagana enkalakkalira . Ttiimu yo ey’abasawo ejja kukuyamba okuddukanya obulemu bwonna obw’ekiseera ekiwanvu obuyinza okuvaayo oluvannyuma lw’okulongoosebwa. Obujjanjabi obw’enjawulo (obujjanjabi obw’omubiri, obw’okujjanjaba emirimu, n’obujjanjabi obw’okwogera) buyinza okukuyamba okudda engulu.

Ebizimba bino bisobola okuziyizibwa okutondebwa?

Tewali ngeri emanyiddwa ey’okuziyiza ebizimba bino okutondebwawo. Kyokka omusawo ayinza okukuwa amagezi okukebera obuzaale singa oba:

• Singa omuntu yenna mu maka go alina ebyafaayo by’okulwala obulwadde bwa neurofibromas.
• Bw’oba ​​olina ebizimba by’obusimu ebingi (kino kiyinza okuba akabonero k’embeera ya neurofibromatosis).

Kiki kye tusaanidde okulowooza ku ntangawuuzi zino okugenda mu maaso? (Endowooza)

Ebiwuka ebisinga ebiyitibwa neurofibromas tebirina kookolo . Zisobola okuwona nga zilongooseddwa era tezitera kudda. Kyokka singa ekizimba kyo tekisobola kuggyibwawo ddala ng’olongooseddwa, ojja kwetaaga okweyongera okulabirirwa abasawo.

Abantu nga 3 ku buli 4 abafuna obujjanjabi bw'obulwadde bwa vestibular schwannoma basobola okukuuma okuwulira kwabwe .

Obulabe bw’ekizimba ky’obusimu okufuuka kookolo butono nnyo. Obulabe obusinga obungi buli ku bantu abalina embeera eno (NF1) abafuna obulwadde bwa Plexiform neurofibroma. Enteebereza y’ebizimba by’obusimu obuyitibwa malignant peripheral nerve sheath tumors (MPNST) si nnungi nnyo naddala singa ekizimba kiba kinene okusinga yinsi 2. Abantu abatakka wansi wa kitundu ku bantu abalina embeera eno bawangaala oluvannyuma lw’emyaka etaano nga bazuuliddwa.

Ddi lw’osaanidde okulaba omusawo?

Bw’olaba ekizimba wansi w’olususu lwo, oba n’ofuna obubonero bwonna bw’olowooza nti buyinza okuba obulwadde bw’obusimu obuyitibwa neurofibromatosis , laba omusawo mu bwangu . Ekirala, tegeeza omusawo wo oba waliwo omuntu yenna mu maka go abadde n’ebizimba eby’ekika kino.

Obubaka Obusembayo Okutwala Awaka

Jjukira nti ebizimba ebisinga obungi eby’obusimu (neuroendocrine tumors) tebirina bulabe, ebitali bya kookolo ebikula mpola . Bw’oba ​​tolina bubonero bwonna, omusawo ayinza okusalawo okukwetegereza kwokka. Singa ekizimba kyetaaga okuggyibwamu, ebiseera ebisinga okulongoosebwa kuba kwa buwanguzi nnyo. Tekitera kubaawo nnyo ebizibu (nga obutasobola kuggyawo ddala kizimba, okwonooneka kw’obusimu) oba ekizimba okufuuka kookolo. Omusawo ajja kukuyamba okukola enteekateeka y’obujjanjabi n’enteekateeka y’okukeberebwa mu biseera eby’omu maaso okukuyamba okuddukanya embeera yo. Kale totya kwogera na musawo wo ku kintu kyonna.

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