Bamemi-nsango ya sekele ya nzoto na biso: Toyekola makambo etali ba cytokines na ndenge ya pɛtɛɛ!

Osilá kokanisa ete ntango nzoto na biso ebɛli to ezoki, etumba moko monene esalemaka na kati mpo na kobika? Tozali na mampinga na biso moko ya mayele mingi mpo na kobundisa banguna lokola ba virus mpe bactérie oyo ewutaka libanda ya nzoto na biso. Tobengi yango système immunitaire. Donc il faut kozala na mutu oyo ako commander armée oyo, a échanger ba messages, pe akotinda bango exactement esika banguna bazali. Ba messagers secrets wana ezali ba cytokines oyo tozali kolobela lelo.

Ba cytokines ezali mpenza nini?

Na mokuse, ba cytokines ezali baproteini ya mikemike oyo etindaka bansango kati na baselile oyo ezali na ebongiseli na biso oyo ebundisaka maladi. Ezali lokola 'groupe WhatsApp' na kati ya nzoto na biso. Ntango likama lokola infection to kozoka eyei na nzoto, baselile oyo ebundisaka maladi ebimisaka bansango yango oyo babengaka ba cytokines. Ba messages oyo eyebisaka ba cellules immunitaires misusu, "Problème ezali awa, yaka noki!", "Oyo ezali lolenge ya monguna oyo tosengeli kobunda," mpe "Kosala ba soldats mingi."

Kanisá ete mikrobe moko ekɔti na nzoto na yo. Na ntango wana, baselile mosusu etindaka bansango yango ya ba cytokines, koyebisa baselile mosusu ete emibongisa mpo na kobundisa mikrobe yango. Yango elingi koloba ete soki bamemi-nsango wana ya mikemike ezalaki te, ebongiseli na biso ya kobundisa maladi elingaki kosala malamu te. Ba cytokines oyo esalisaka mpo na kobatela système immunitaire na biso na nzoto kolɔngɔnɔ, ata soki likama ezali te.

Ezali na mitindo minene ya ba cytokines yango?

Oui, kaka ndenge ezali na ba rangs différents na armée, ezali na ba types différents ya ba cytokines. Lolenge mokomoko ezali na mosala moko boye. Tótala mwa mitindo ya minene.

Longola yango, bapesaka bankombo ya ba cytokines mosusu engebene lolenge ya selile oyo ebimisaka yango:

• Lymphokines: Ebimisamaka na lolenge moko ya globules blancs oyo babengaka ba lymphocytes.
• Monokines: Ebimisamaka na lolenge moko ya globules blancs oyo babengaka monocytes.

Mosala monene ya ba cytokines: kopekisa kovimba

Ntango bato mingi bayokaka liloba ‘kovimba’, bakanisaka ete ezali likambo ya mabe, elembo ya bokono. Kasi kovimba ezali mpenza elembo ya ntina oyo emonisi ete ebongiseli na biso ya kobundisa maladi ezali kobundisa banguna to kobongisa misisa oyo ebebi. Kanisá soki okati mosapi na yo, ekozala motane, kovimba, mpe mwa molunge, boye te? Yango nde inflammation ezali.

Ba cytokines epesaka mingimingi bilembo ya makambo oyo elandi:

• Activation cellulaire: Koyebisa baselile esika esengeli kokende mpe nini esengeli kosala. Na ndakisa, kotambwisa baselile oyo ebundisaka maladi na esika oyo maladi ekɔti.
• Bokeseni ya baselile: Bayebisaka selile oyo ekɔmeli te ete “ekóma lolenge moko ya sipesiale ya globules blancs oyo ekoki kobundisa maladi yango.”
• Bokóli ya baselile: Elembo mpo na kosala baselile mingi, to baselile mingi. Na ndakisa, elembo yango epesami ntango esɛngaka ba globules blancs mingi mpo na kobundisa maladi moko monene.

Ba cytokines pro-inflammatoires na anti-inflammatoires

Yango ezali lokola accélérateur mpe frein ya motuka. Nyonso mibale ezali na ntina mingi mpo na kopekisa na bosikisiki eyano ya ebongiseli na biso ya nzoto oyo ebundisaka maladi.

• Ba cytokines pro-inflammatoires: Yango nde ba accélérateurs . Ntango mikrobe moko ekɔti, esalaka ete moto avimba mpe esalaka ete nzoto ebundisa maladi esala nokinoki. Wana nde bapesaka signal ya kobanda combat.
• Ba cytokines anti-inflammatoires: Yango nde frein . Nsima ya kolonga monguna, bapekisaka kobebisama mosusu ya misisa na biso moko oyo ezali malamu na ndenge bakitisaka kovimba mpe bazongisaka makambo nyonso na ndenge ya malamu.

Ndenge nini échange ya message oyo esalemaka?

Oyo ezali processus moko très intéressant. Tokokanisa yango na fungola mpe na libulu ya fungola.

Cytokine ezali lokola fungola . Na likoló ya selile oyo esengeli kozwa nsango, ezali na libulu ya fungola (récepteur) oyo ekokani na fungola yango. Ntango cytokine (fungola) ekei mpe ekangami na récepteur (libulu ya fungola) oyo ezali na selile yango, selile yango ezwa nsango yango. Na nsima, selile yango esalaka na kolanda nsango yango.

Ezali na ndenge misato ya kotinda bansango oyo:

1. Signalisation autocrine: Cellule moko etindaka message na yango moko.

2. Signalisation paracrine: Cellule moko etindaka ba messages na ba cellules oyo ezali pene.

3. Signalisation endocrine: Cellule moko etindaka ba messages na nzela ya makila na ba cellules oyo ezali mosika na yango.

Baselile nini ebimisaka ba cytokines mingi?

Mbala mingi, baselile oyo ezali na ebongiseli na biso ya kobundisa maladi ebimisaka ba cytokines. Kasi, ezali kaka baselile yango te. Lolenge mosusu ya baselile na nzoto na biso ekoki mpe kobimisa yango.

Baselile oyo ebundisaka maladi

• Ba macrophages oyo ezali
• Baselile ya dendritique
• Ba lymphocytes oyo babengi lymphocytes
• Ba monocytes oyo babengi monocytes
• Ba neutrophiles oyo babengi neutrophiles
• Basophiles oyo babengi basophiles
• Ba éosinophiles oyo ezali
• Ba mast cellules

Baselile mosusu

• Ba cellules endothéliales (ba cellules oyo ekangami na kati ya misisa ya makila) .
• Ba cellules épithéliales ezali ba cellules oyo ezipaka likolo ya binama na biso.
• Ba cellules na kati ya tissu connectif (Fibroblastes, Ba cellules stromales) .
• Baselile oyo ezali zingazinga ya misisa (ba cellules ya Schwann) .

Nini ekosalema soki bokatikati ya ba cytokines ebungaki?

Atako ba cytokines ezali na ntina mingi mpo na kolɔngɔnɔ ya nzoto na biso, lokola biloko mosusu nyonso, soki eleki mingi ezali malamu te. Tango mosusu, mpo na infection to na ba traitements mosusu, système immunitaire ekomaka koleka ndelo mpe ebandi kobimisa ba cytokines eleki ndelo oyo ekoki kozala na contrôle te.

Tobengaka maladi yango Syndrome de liberation des cytokines (CRS) to mopepe makasi ya ba cytokines . Ezali lokola système immunitaire na biso moko ezo kende berserk, ezo attaquer kaka ba ennemis na biso te mais pe ba cellules na biso moko ya santé. Yango ekoki komema na kovimba koleka ndelo, kobeba ya misisa, mpe bamaladi ndenge na ndenge.

Maladi oyo ekoki kouta na ba cytokines oyo eleki mingi :

• Maladi oyo ebundisaka maladi yango moko: Na likambo yango, ebongiseli ya nzoto oyo ebundisaka maladi ebundisaka na libunga baselile na yango moko oyo ezali malamu.
• Troubles métaboliques: Mikakatano na ndenge ya kobongola bilei na nguya.
• Kansere.
• Sepsis: Oyo ezali maladi moko ya makasi mpenza. Kovimba makasi na nzoto esalaka ete makila ekende mingi te na binama minene. Oyo ezali likambo ya mbalakaka ya monganga mpe ekoki koboma moto soki basalisi yango te.

Soki ozali na ntembe mpo na maladi yango, ezali na ntina mingi okende mbala moko epai ya monganga na yo mpo na kozwa toli .

Momekano ya panneau ya cytokines

Minganga bakoki koyeba soki nzoto na yo ezali na ba cytokines mingi to moke. Ekzamɛ ya makila babengaka yango panneau cytokines . Ezali komeka nivo ya ba cytokines na makila na yo oyo esalaka na kovimba. Na kotalela matomba oyo ezwami, monganga na yo akoki kopesa yo bankisi mpo na kopekisa kovimba soki ozali na yango mingi.