Allogeneic Stem Cell Transplant chungchang hi a awlsam zawngin i zir dawn nia.

Doctor pakhatin chhungte emaw, a thian emaw hnenah ‘stem cell transplant’ chungchang a sawipui tawh pawh a ni mai thei. A nih loh leh leukemia ang chi damdawi lam dinhmun atan he enkawlna hi rawtna i dawng tawh pawh a ni thei. He hming i hriat hian tlem a hlauhthawn leh hlauhthawn hi thil pangngai tak a ni. Mahse hei hi mi tam tak nunna chhanhim thei tur enkawlna pawimawh tak a ni. Chuvangin vawiin hian he ‘Allogeneic Stem Cell Transplant’ hi eng nge a nih, engtin nge a tih tih leh a hlauhawmna te hi awlsam tak leh chiang takin sawi ila.

A awlsam zawngin, allogeneic stem cell transplant tih hi eng nge ni?

Hei hi hriatthiam a awlsam hle. Allogeneic stem cell transplant chu nangmah ngeiin i natna vei stem cells te chu lakchhuah a, donor hrisel, inmil tak atanga stem cells hmanga thlak a ni. Heng stem cells te hi kan ruhroa awm cell chi khat bik an ni a, thisen cell chi hrang hrang (red blood cells, white blood cells, platelets) ah an lo thang lian thei a ni.

Heng cell hrisel tak tak pekte hi i taksaah an luh chuan i ruhroah an kal a, thisen cell hrisel thar an siam tan thin. Hei hi damdawi chak tak a ni a, natna khirh tak tak thenkhat pawh a tidam vek thei a ni. Doctor-te chuan enkawlna dang a hlawhchham emaw, natna a lo awm leh tawh emaw chuan he enkawlna hi an hmang tlangpui.

He enkawlna hi eng dinhmunah nge hman a nih?

Allogeneic stem cell transplantation hi thisen leh immune system nena inzawm natna atan hman a ni ber.

Engtin nge enkawl hmain i inbuatsaih thin?

Hei hi enkawlna lian tak a nih avangin doctor-te chuan i taksa hriselna enfiah nan test eng emaw zat an kalpui ang a, chu chu enkawlna avanga side effects i tuar theih leh theih loh tur a ni.

Main test hrang hrang tih a ni

I medical team chuan test engemaw zat an ti ang a, chungte chu:

• Complete Blood Count (CBC): I thisen sen, thisen var leh platelet level te a enfiah thin.
• Echocardiogram: Thinlung hnathawh that dan en rawh.
• Electrocardiogram (EKG): Thinlung hnathawh rhythm a enfiah thin.
• Liver leh kidney function test neih a ni.
• Bone Marrow Biopsy: Cancer i neih chuan i ruhro sample te tak te la in test a ni. Hei hian natna inthlak danglamna leh enkawl hnua natna lo awm leh theihna tur tehna atan a pui a ni.

Transplant hmaa Conditioning tih a ni

Heng test i neih zawh hian damdawi inah dah i ni ang a, ‘conditioning’ tih enkawlna pek i ni ang. Hei hian chemotherapy chak tak leh/ emaw taksa pum pui radiation therapy hman a huam a ni . Hei hian tum pathum a nei a, chungte chu:

1. I taksaa cancer cell la awm zawng zawng tihchhiat .

2. I ruhroah stem cell thar lo thang lian tur hmun siam .

3. I immune system tihchak loh . Hei hian i taksain cell thar a beih (reject) theihna a ti tlem a ni.

Hetiang conditioning process hi kar khat emaw kar hnih emaw vel a ni tlangpui.

Stem cell transplant lai hian eng nge thleng?

Hei hi a pawi tak tak lo. I medical team chuan i rilru chunglam vein lian takah central venous catheter (CVC) an tih tube te tak te an dah ang. Stem cell thar te hi he tube hmang hian i taksaah pek a ni ang.

Hetiang hian minute 30 atanga 60 vel a awh thin. Hemi chhung hian medical team te chu i bulah ṭhuin i vital signs te chu an enfiah ang. Tin, side effect a awm leh awm loh pawh uluk takin an enfiah ang. Side effects hi a tlem hle a, a tlangpuiin a tlem hle. Entîr nân, tlêm tê i khur thei a, thawk harsa i nei thei a, khawsik i nei thei bawk.

He enkawlna avanga harsatna lian ber chu eng nge ni?

Allogeneic transplantation avanga harsatna lian ber leh pawi ber chu graft-versus-host disease (GVHD) a ni.

A awlsam zawngin, hei hi donor (graft) atanga immune cell hrisel thar lo chhuakte chuan i taksa (host) chhunga cell hrisel leh tissue te chu an rawn beih tan hun a ni. Sipai tharin i ram mipuite an beih ang mai a ni. Hetiang dinhmun hian vun, thin leh chaw ei dan a nghawng thei a ni. Mahse i lungkham a ngai lo, doctor ten he natna hi control leh enkawl nan damdawi mamawh an pe thei che a ni.

Enkawl hnuah eng nge thleng? A dam leh theih nan eng chen nge hun a duh?

Transplant hnuah kar engemaw zat damdawi inah i awm a ngai dawn a ni. Chumi chhung chuan medical team ten uluk takin an enkawl ang che. I taksain cell thar dah tharte a hnawl loh nan immunosuppressants i dawng chhunzawm zel ang. Cell tharte hian thisen cell thar an siam chhuah theih hma loh chuan thisen pek i mamawh thei bawk.

Cell tharte chu ruhroah an lut a, thisen cell thar an siam tan dan chu ‘engraftment’ an ti a. Hei hian ni 10 atanga ni 14 vel a daih thei. Mahse, i taksa hriselna (immune system) a lo dam leh theih nan thla engemaw zat atanga kum khat emaw a aia rei emaw a ngai thei. Hemi hun chhung hian hri kai laka inven a pawimawh hle.

A dam kim theih nan kum hnih emaw a aia rei emaw a ngai thei a, chuvangin hei hi dawhtheihna leh doctor thupek zawm ngai zinkawng a ni.

Doctor pan nghal ngai symptoms te chu engte nge ni?

Inenkawl zawha in lama i haw dawnin i taksa hi ngun takin i ngaihven tur a ni. A hnuaia symptoms te hi i neih chuan i medical team te ko nghal rawh .

Allogeneic leh autologous transplant te hi eng nge an danglamna?

An pahnih inthlauhna ber chu stem cells lo chhuahna a ni.

Allogeneic transplant hian nunna atana hlauhawm natna thenkhat a tidam thei a ni. Hei hi mi hriat lohte ngilneihna avanga tih theih a ni fo. Heng mite hi stem cell pe thinte an ni. A chang chuan thilpek petute hi chhungte an ni. Cell pek chhuah dawn hian hlauhawmna a awm a ni. Hetiang tih dan hlawkna leh hlauhawmna hriatthiam nan hun hmang rawh. I doctor chuan i thutluknaah i rintlak theih nan a hlauhawmna leh a hlawkna te tehna atan a pui thei che a ni.