I hriatrengnaah eng thil nge thleng? Alzheimer natna chungchang hi han sawi ila

A chang chuan thil i theihnghilh thin em? I chabi awmna hmun, mi hming emaw, i tih tur emaw... theihnghilh tenau te hi mi zawng zawng tan chuan thil pangngai a ni. Mahse mi thenkhat tan chuan he theihnghilh hian nasa takin a nghawng thei a ni. Vawiin hian natna pakhat, hriatrengna nasa taka tichhe thei leh thluak tibuaitu chungchang kan sawi dawn a ni. Chu chu Alzheimer natna a ni.

Alzheimer natna hi eng nge ni?

A awlsam zawngin sawi ila, Alzheimer’s hi dementia chi khat a ni a, chu chuan hriatrengna a hloh a, hriatna a tichhe thei a ni. A dik tak chuan neurodegenerative disease a ni. Chumi awmzia chu hun kal zelah kan thluaka cell te chu a chhe vek a, a chhe vek tihna a ni. A tawpah chuan Alzheimer natna vei chuan thluak hnathawh pawimawh tak tak, hriatrengna leh tawng thiamna te chu a hloh thei a ni.

Khawvel puma mi maktaduai 24 velin he natna hi an vei tih han ngaihtuah teh. Kum 65 chunglam mi sawm zinga pakhatin he natna hi a vei thei a ni. Tin, kum 85 chunglam mi pathum zinga pakhat velin Alzheimer natna an vei nia sawi a ni bawk.

Heng symptoms te control tur hian enkawlna awm mahse Alzheimer natna hi damdawi a la awm lo. Nangmah emaw, i hnaih ber emaw pawhin heng symptoms te hi an nei nia i rinhlelh chuan doctor pan vat a, thurawn la turin a tha ber.

Alzheimer’s natna lan chhuah dan chu engte nge ni?

Alzheimer natna hian mi zawng zawng a nghawng dan inang vek lo a, mahse a tlangpuiin, i theihna:

• Hriatrengna
• Thil ngaihtuah thiam
• Thusawi thiam (language) .
• Nungchang leh mize
• A chhehvel boruak (space) hriatthiamna .

Vawi tam tak chu hriatrengna hloh emaw, Alzheimer natna dang nei emaw chuan anmahni rilru leh taksa lama inthlak danglamna hriat harsa an ti thei. Heng symptoms te hi a chang chuan i hmangaih te tan chuan a langsar zawk thin.

Heng symptoms te hi hun kal zelah a na zual sauh sauh a (progressive decline). Nangmah emaw, i hriat miin emaw heng dementia ang chi natna hi i neih chuan doctor pan nghal tur a ni.

Hriatrengna hloh

Alzheimer natna lan chhuahna ber leh langsar ber chu hriatrengna hloh hi a ni. Hei hian tun hnaia thil thleng (short-term memory) emaw, hun rei tak kaltaa thil thleng (long-term memory) emaw hriatreng a harsat phah thei a ni.

Heng thilte hi hriat reng harsa i ti mai thei:

• Hmêl, hmingte
• Thudik thenkhat
• I awmna hmun (in ang hmun hriat lar tak pawh ni se) .

Alzheimer’s natna avanga hriatrengna lama harsatna kan neih hi kan phone kan dahna hmuna kan theihnghilh fo thin thil tenawm tak tak emaw, kawngkhar kan khar em tih ngaihtuah thin emaw aiin a na zawk hle.

Logical taka ngaihtuah harsa

Alzheimer’s vei chu a buai angin a lang fo thei a, thutlukna siam nan hun danglam tak a hmang thei bawk. Hei hian a hnuaia thil tih hi a ti harsa thei che a ni:

• Eng nge i tih leh tur tih chu rel rawh.
• Recipe angin chhum rawh
• Ruahmanna siam rawh.

Ṭawng kaihhnawih thil

Alzheimer natna hian tawng thiamna, lehkha chhiar, leh tawng (aphasia) hriatthiam a ti harsa thei che a ni. I ti thei ang:

• A hma aia thu sawi leh inbiak pawhna a tlem zawk
• Miin tawng engemaw zat a thiam chuan tawng a thlak danglam ang a, a buaithlak hle ang.
• Naupan laia tawng hman tam ber chu thlak leh a ni ang
• Thu dik lo a hmang thin

Nungchang leh mize inthlak danglamna

Alzheimer natna vei mi pakhat rilru put hmang emaw, mize emaw a inthlak danglam tih i hmu mai thei. Anni chuan:

• I rinhlelh hle thei (kum tam tak chhunga i hriat tawhte pawh).
• Mood swings a awm fo thei (a tlangpui aia nasa zawk pawh a ni thei) .
• I rilru hahdam lohna, paranoia, a nih loh leh hallucinations i nei fo thei.
• Nangmah leh i hmangaihte chungah rinna i hloh mai thei.

Mi zawng zawng hian ni chhia leh hun harsa kan nei vek a. Mahse Alzheimer’s natna avanga rilru leh mize inthlak danglamna hi thinrimna emaw thinrimna emaw a lo chhuah dan pangngai aiin a nasa zawk a, a lo thleng nghal mai thin .

A chhehvel boruak hriatna tlahniam

I taksa nena thil a inhnaih zia hriatthiam harsa i ti mai thei a, a nih loh leh i taksa chu a hma aiin i thunun thei lo niin i inhria thei bawk. Hei hian a huam thei ang:

• Furniture-ah a tlakbuak
• Thil pakhat pick up a harsa khawp mai.
• Kekawr hrui khih emaw keyboard-a type emaw ang chi kut chetna tha tak tak siam harsa

Doctor-te chuan Alzheimer natna hi stage hrang hrangah an thliar hrang a. Heng stage te hian dementia i hnaih zia te, i Alzheimer natna a nasat zia te, a lo zual chak zia te a hrilh che a ni.

Alzheimer natna thlentu te chu engte nge ni?

Alzheimer natna thlentu ber chu thluaka protein chi hnih awm dan pangngai lo a awm vang a ni. A bik takin protein chi hnih amyloid leh tau an tih.

Kan thluak hian nerve cell, a nih loh leh neuron maktaduai tam tak a nei tih i hria a ni . Heng neurons te hi ngaihtuahna, zir, hriatreng leh ruahmanna siam tura min puitu an ni. Chu amyloid protein ka sawi tak chu thluak cell chhungah a inzawm khawm a , plaque ah a inzawm khawm a . Tau protein chu a inzawm khawm a , tangles ah a awm . Heng plaques leh tangles te hian neurons te chu a thawk tha thei lo. An kal tlanga electrical leh chemical signal kalte chu an tibuai a ni.

Amyloid leh tau protein te thluaka an lo punkhawm chuan zawi zawiin neurons te an that thin. Hei hian chhiatna nghet tak thlentu leh Alzheimer natna lanchhuahna a thlen thin a ni. Nerve cell thihna hi thluak hmun khatah a intan a, zawi zawiin hmun dangah a darh leh thin. Alzheimer’s hi kan hriatrengna thununtu thluak hmun - hippocampus -ah a intan fo thin.

Mithiamte chuan Alzheimer natna hi an la zirchiang mek a, heng protein deposit awm chhan dik tak hi an la zirchiang mek a ni. Zirchiangtute chuan heng protein deposit te hi symptoms a lan tan hma rei takah a intan niin an ngai. Kum 10 atang khan inthlak danglamna i hriat hmain a intan tawh mai thei.

Alzheimer natna hi thlahtute atanga lo chhuak a ni em?

Ni e, Alzheimer natna hi genetic a ni thei.

I nu leh pa emaw, i unau emaw zinga pakhatin he natna hi a neih chuan Alzheimer’s vei theihna chance chu 10% atanga 30% vel a ni. I unau pahnih emaw a aia tam emaw hian he natna hi an vei a nih chuan Alzheimer’s vei theihna i neih theihna chu mi pangngai aiin a let thum velin a sang zawk a ni.

APOE e4 gene nei te hi Alzheimer’s vei theihna a sang hle. Tin, chu gene nei mite chuan Alzheimer’s hi kum hmasa zawk (a lo awm tan tirh kum) ah an vei tam zawk bawk. Mahse APOE e4 gene nei zawng zawng hian Alzheimer’s an vei vek dawn lo. Risk tipungtu pakhat chauh a ni.

Alzheimer natna vei theihna tur risk factors te chu engte nge ni?

Mi thenkhatin Alzheimer’s an vei a, thenkhatin an vei loh chhan hi zirchiangtute chuan an la hre chiang lo a, mahse heng thilte hi risk factor a ni thei:

• Mihring dum emaw Latino emaw hnam chhuak nih
• Environmental factors (i chenna hmun, hnathawhna hmun, emaw i tlawh fona hmun emaw chungchanga thil engemaw) .
• Genetic inthlak danglamna
• Lu hliam na tak (Traumatic brain injury) .
• Meizial zuk
• I kum (Alzheimer natna hian kum 65 chunglam a vei tlangpui) .
• I hriselna dinhmun zawng zawng

Hriselna lama harsatna thenkhat chuan Alzheimer’s vei theihna a tipung thei bawk. Entir nan:

• Lung leh thisen zam natna
• Zunthlum
• Down syndrome hi Trisomy 21 avanga lo awm a ni
• Thisen sang a sang
• Cholesterol sang tak a ni
• Thau lutuk

Alzheimer natna hian eng harsatna nge a thlen?

Alzheimer natnain harsatna lian ber chu thluak a tihchhiat vang a ni. Hei hian i ngaihtuahna te, i taksa hman thiamna te, leh i mizia te chu a tidanglam reng thei a ni. Natna a zual zel chuan harsatna chi hrang hrang i nei thei a ni. Ṭhenkhat chu nunna atana hlauhawm tak an ni thei.

Hetiang ang harsatna hi a awm thei a ni:

• Taksa hriselna zawng zawng a tlahniam
• Infection (entir nan, pneumonia emaw vun natna emaw) .
• Seizures a awm thin
• Thâwk harsa
• Chaw ei harsat

I taksa thunun theihna i hloh thei a, chu chuan:

• Bedsores te pawh a awm
• Dehydration emaw ei leh in tha lo emaw
• Tlu, ruh tliak leh accident dangte
• Urinary incontinence leh bowel incontinence te a awm bawk
• Ha hring, ha hring, leh ha lama harsatna dangte

Engtin nge Alzheimer natna hi hriat chhuah a nih?

Doctor-te chuan Alzheimer natna hi an hriat theih nan kawng hrang hrang an hmang a. A hmasa ber atan chuan tuna i hriselna leh i damdawi lam chanchin sawi hi a ni.

I doctor chuan nang leh i chhungte a biak ang che. Zawhna an zawt ang che a, i hriselna leh nitin hnathawh dan an zir ang che. Alzheimer natna vei theihna tur risk factors i nei tih i hriat chuan i doctor hnenah hrilh rawh.

I doctor chuan i chhungte hnenah i hriat loh tur symptom emaw, inthlak danglamna emaw an hmuh leh hriat loh a zawt ang. Hengte hi an zawt mai thei:

• I hna pangngai i thawh theihna
• I rilru put hmang, nungchang leh mize inthlak danglamna
• Tuna damdawi hman mekte
• Damdawi lam chanchin
• Hriselna dinhmun zawng zawng

Doctor chuan taksa exam kimchang leh neurological exam pawh a pe ang che. Tin, hriatrengna lama harsatna leh symptom dang thlen thei dinhmun dang pawh an paih chhuak dawn bawk.

Doctor hian test eng emaw zat a hmang bawk ang a, chungte chu:

• Thisen test a ni
• Thluak MRI (Thluak MRI) 1.1.
• Thil hriatna (cognitive test) te
• CT scan a ni
• PET hmanga scan a ni
• Psychiatric leh rilru lam hriselna endikna neih a ni
• Zun test a ni

Heng test te hian i doctor chu amyloid proteins chhinchhiahna zawng turin a pui a, i thluak a tichhe em tih a enfiah bawk.

I doctor chuan nang leh i chhungte nen thawk hovin i tan a tha tur treatment plan a siam ang. Hun rei lote chhunga i hriselna leh hun rei tak chhunga i dinhmun tur atana thil tum dik tak siam turin an pui ang che.

Alzheimer natna enkawl dan tur chu engte nge ni?

I doctor chuan dementia natna zual zel tur tihziaawmna tur damdawi a rawn rawt thei ang. Alzheimer natna hi damdawi a la awm lo a, mahse enkawlna hian a natna lan chhuah dan a thunun thei a, natna a zual zel pawh a tikhawlo thei bawk.

A hma thei ang bera enkawl tan hi i dam chhung zawnga i thluak hriselna humhimna tha ber a ni. Mahse, tunah hian Alzheimer natna titawp thei leh tidanglam thei tur damdawi a la awm lo.

Alzheimer natna lan chhuah dan tur control thei damdawi chi hrang hrang a awm a. I doctor chuan i mamawh ang zela hengte hi a inzawm khawm ang. I mamawh mai thei:

Cholinesterase tihkhawtlai a ni

Heng damdawi te hian Alzheimer natna avanga thluak chhiatna ti chaktu enzyme pakhat chu a block a ni. Hriatrengna lama harsatna ṭhenkhat an siam ṭha thei a, nungchang inthlak danglamna pawh an ti tlem thei bawk. I doctor chuan hetiang damdawi hi a pe thei ang:

• Donepezil chuan a rawn ti a
• Galantamine a ni
• Rivastigmine a ni

Clinical trial neih a ni

Scientist-te chuan Alzheimer’s natna leh a enkawl theih dan tur an zirchiang reng a ni. I doctor hnenah clinical trial i tanpui thei tur a awm em tih zawt rawh. Clinical trial chu natna emaw, dinhmun bik emawa tel tura inpete telna test emaw research study emaw a ni. Heng trial te hian enkawlna thar, mipuiin an la hman theih lohte enchhin theihna hun remchang a pe thei che a ni.

I natna hi a hmaa hriat chhuah a nih chuan clinical trial-a tel theihna hun remchang i nei tam zawk mai thei.

Lecanemab emaw Donanemab emaw a ni thei

Lecanemab leh Donanemab hi thisen kalna (IV) damdawi a ni. Damdawi chi hnih an ni a , chu chu monoclonal antibodies an ti a . Heng damdawi te hian i taksa immune system a target thei a, amyloid proteins a tichhia thei bawk. Amyloid thenkhat chu thluak a tihchhiat hmain an paih chhuak thei a, Alzheimer natna a zual zel chu a tikhawtlai thei a ni.

Lecanemab hian amyloid fiber te chu an inzawm khawm hmain a target thin. Donanemab hian amyloid proteins te chu a target a, chu chu a inzawm khawm tawh a, plaque a siam ta a ni.

Damdawi dang zawng zawng ang bawkin heng damdawi te hian Alzheimer natna hi a tidam kim lo va, amyloid-in a tihchhiat tawh chu a tidanglam thei lo bawk.

NMDA receptor dotu a ni

Alzheimer’s i vei chuan i taksa hian chemical glutamate tih chu a siam tam lutuk a ni. Hei hian thluak cell a tichhia a ni. NMDA antagonists hian thluaka glutamate nena inzawm N-methyl-D-aspartate (NMDA) receptor te chu block emaw fill emaw hmangin hna an thawk a ni. Hei hian Alzheimer natna a zual zelna a tikhawlo thei a ni.

Memantine hi NMDA antagonist hman tlanglawn tak a ni. I doctor chuan i hriselna dinhmun leh Alzheimer natna stage a zirin damdawi dang a rawn rawt thei bawk.

Symptom-management damdawi te

I doctor chuan i natna lan chhuah dan a lo chhuah dan tur control-na tur damdawi emaw, enkawlna dang emaw a rawn rawt ang che. I mamawh mai thei:

• Antidepressants: Heng damdawi te hian lungkhamna, hahdam lohna, rilru natna, leh lungngaihna te a tidam thei a ni.
• Antipsychotics/neuroleptics damdawi te chu:Heng damdawi te hian paranoia, hallucinations, leh agitation ang chi thil te a tidam thei a ni.
• Antiseizure damdawi: Heng damdawi te hian a chang chuan mood swing te pawh a tidam thei bawk.

Engtin nge dam chhung chu?

Alzheimer natna hian mi zawng zawng a nghawng dan inang vek lo. Kum 65 chunglam Alzheimer’s vei tam zawk chu he natna hi an vei tih hmuhchhuah a nih atanga kum li atanga kum riat chhungin an thi thin. Mahse mi thenkhat chu kum sawm tam tak chhung an dam a, a bik takin kum 65 an tlin hmaa natna hmuhchhuah an nih chuan.

Alzheimer’s disease (AD) natna vei chungchang hi i doctor nen sawiho rawh. Anni chuan thiltum leh beisei tûr dik tak siam tûrin an ṭanpui thei che a ni. Hospice care chu nang leh i chhungte tan engtikah nge duhthlan tur tha tak a nih theih ang tih thutlukna siam turin an pui thei bawk che a ni.

Support i mamawh chuan mental health counselor nen inbia ang che . Alzheimer natna vei leh an chhungte hian extra stress leh anxiety an neih hi a awm fo thin a, a bik takin an natna an hmuhchhuah hnuah. Heng rilru put hmangte hi a tak tak leh dik tak a ni. Mental health professional chuan i ngaihtuahna leh rilru put hmang hriatthiamna leh i hmachhawn theih nan a pui thei che a ni.

Alzheimer natna hi ven theih a ni em?

Alzheimer natna hlauhawmna thenkhat, i kum leh i genetics ang chi te hi i thlak danglam thei lo va, i thunun thei lo bawk. Mahse thil dang i enkawl thei a, i risk pawh i tihtlem thei bawk. Hriselna pum pui tha tak neih hian i thluak chu hriatna tlahniam atanga venhimna kawngah a pui thei a ni. Heng thilte hi i lo enchhin thei ang:

• Ei leh in hrisel zawm: Ei leh in tha tak, chi hrang hrang ei hian i thluak leh hriselna zawng zawng a ti tha thei a ni. I doctor chuan ei leh in tur ruahmanna bik a rawt thei a, chu chu Mediterranean diet emaw DASH diet emaw a ni thei.
• Taksa tihchak tawk: Exercise leh taksa tihchakna hian thluaka thisen leh oxygen a tipung a. Hei hian i thluak cell te hriselna a ti tha thei a ni. Active reng tur chuan athlete lian tak i nih a ngai lo. Kea kal, huan enkawl, cycle khalh emaw, i taksa tichak thei hobby eng pawh hi active taka awm theihna kawng tha tak a ni.
• Rilru lama thawkrim reng rawh: Board game khel la, lehkhabu chhiar la, crossword puzzle ti la, musical instrument tum la, a nih loh leh thil thar zir leh hmang turin i thluak tichaktu hobby dang ti rawh.
• Khawtlang nunah awm reng rawh: I hmangaih tak takte emaw, i khawtlang mite emaw nen inbiakna neihpui fo ang che. Sakhaw inkhawm, exercise class, lehkhabu club, khawtlang tlawmngaihna ang chi group activities-a tel hian i thluak chu a thawkrim reng thei a ni.

I chhungkuaa mi tu emaw Alzheimer’s vei, i ngaihtuah a nih chuan i doctor nen genetic testing chungchang sawipui rawh. Alzheimer’s vei theihna tipung thei gene emaw genetic change emaw an enfiah thei a ni.

Engtikah nge doctor i hmuh ang?

Nangmah emaw, i hmangaih tu emaw hian hriatrengna emaw, ngaihtuahna emaw lama harsatna i neih chuan Doctor pan rawh. An harsatna chu Alzheimer’s vang nge, natna dang vang nge tih an hre thei a ni.

Alzheimer’s disease (AD) i vei tih hriat a nih veleh doctor pan a ngai ang a, regular check-up i nei ang. I doctor chuan natna kal zel dan a enfiah ang a, a tul angin i enkawlna chu a siamrem ang.

I doctor hnenah zawhna thenkhat i zawt thei bawk a, chungte chu:

• Ka chhungte leh kei hian eng symptom emaw, inthlak danglamna emaw nge kan ngaihven tur?
• Alzheimer natna hi engtiang chiahin nge a lo zual zel dawn tih sawi lawk theih dan a awm em?
• Eng enkawlna nge ka tan a tha ber?
• Clinical trial atan ka tling em?

Alzheimer natna (AD) hi a hlauhawm tak zet a ni. A châng chuan hun a ding reng ang maiin a lang thei a, a nih loh leh a kal chak lutuk ang maiin a lang thei bawk. Alzheimer natna ang natna neia nun dan dik lo a awm lo.

A tawp berah chuan a pawimawh ber

Alzheimer natna hi natna khirh tak a ni. Mahse, nangmah chauh i ni lo tih hre reng ang che. Alzheimer’s i vei emaw, Alzheimer’s vei i enkawl emaw pawh nise, i doctor-te chuan an pui reng che a ni. Enkawlna leh clinical trial atana rawtna siam turin an pui thei che a, i zawhnate an chhang thei che a, resources nen an inzawm tir thei che a, beisei tur i hriatthiam theih nan an pui thei bawk che a ni. Symptoms hriat hmasak a pawimawh a, damdawi lam pan a pawimawh. Tin, chhungte leh thiante puihna pawh he zinkawngah hian a hlu hle bawk. I rilru hriselna pawh ngaihtuah tel theihnghilh suh.

Alzheimer ’s, Alzheimer’s, Dementia, Hriatrengna hloh, Thluak hriselna, Tar, Thluak lam natna