Alzheimer’s vei theihna i nei em? APOE Gene Test chungchang hi zir rawh

I chhungkuaah hian tu emaw, pi emaw, pi emaw pawh ni thei, Alzheimer natna vei an awm em? Chutiang a lo thlen chuan i rilruah hlauhna tlem tal i neih chu thil pangngai tak a ni a, "Aw, he natna hi kei pawhin ka vei dawn em ni?" Chutih lai chuan he APOE gene test hi a langsar hle. Kan hmalam hun tur a sawi lawk thei tak tak em? Engkim hi awlsam tak leh chiang takin sawi ila.

He APOE gene test hi eng nge ni?

A awlsam zawngin, APOE gene test hi genetic test a ni a, apolipoprotein E an tih gene genotype a en a, he gene chi hrang hrang i neih chuan midang aiin Alzheimer natna vei theihna chance i nei sang zawk mai thei

Mahse hetah hian a pawimawh ber chu hei hi a ni. Risk sang zawk i neih vang mai mai chuan i damlo ngei ang tihna a ni lo. Vanah chhum dum a awm tih han mitthla teh. Chumi awmzia chu ruah sur theihna a awm tihna a ni a, mahse ruah a sur ngei dawn tihna erawh a ni lo. Chutiang chu a ni. Kan hriselna hi kan genes chauh ni lovin, thil dang tam tak, kan ei leh in, exercise kan tih leh kan nun dan te hian a nghawng a ni.

Chuvang chuan he test result hi hrethiam turin doctor nen inbiak a pawimawh hle.

Okay, chuti a nih chuan he APOE gene hi eng nge ni?

Gene APOE hian kan taksa cell te chu apolipoprotein E an tih protein bik siam turin a hrilh a, he protein hian hna pawimawh tak a thawk a ni. Kan taksaa thau (lipids) te nen a inzawm khawm a, cholesterol ang chi thil te chu thisena an mamawhna hmunah, taxi ang maiin a phur a ni. Hei hi lipoprotein kan ti a.

Kan taksaah hian APOE gene hi chi hrang hrang, a nih loh leh alleles lian pathum a awm a.

He gene hi copy pahnih kan rochun vek a, pakhat chu kan nu hnen atangin leh pakhat chu kan pa hnen atangin. Chuvangin heng variant pathum zinga pahnih (e.g. e3/e3, e3/e4, e2/e4) te hi combination i nei thei ang.

Heng gene zingah hian eng gene nge Alzheimer natna nena inzawm?

A hmasa berah chuan Alzheimer natna thlentu direct-a gene engmah hmuhchhuah a la ni lo . Mahse, zirchianna chuan APOE-e4 gene variant copy khat pawh neih hian Alzheimer’s vei theihna a tipung tih hmuhchhuah a ni.

• APOE-e4: He gene variant copy pakhat emaw pahnih emaw nei te hian late-onset Alzheimer’s disease an vei theihna a sang hle a, kum 65 an tlin hnuah a lo awm thin.
• APOE-e2: Hei hi thu lawmawm deuh a ni. He gene variant hian Alzheimer natna laka venhimna engemaw chen a pe thei a ni. He gene nei hian natna hi a nei ve tho a nih pawhin APOE-e4 vei aiin a tlai zawk tlangpui.

Engtin nge he test hi i tih thin? Tuin nge tih?

Hei hi i tih luih luih test a ni lo. Mahni duhthlanna anga tih a ni. I chhungkuaah Alzheimer natna vei tawh a nih chuan hemi chungchang hi hriat i duh mai thei. Chutiang a nih chuan i doctor nen inbiain hemi chungchang hi i hrechiang thei ang.

Test hi a awlsam hle mai:

1. DNA sample lak: Doctor pakhatin DNA sample a laksak ang che. Hei hi thisen tlemte lak emaw, i hmui chhung emaw, i hmui chhung emaw chu swab tlemte hmanga swab emaw hmanga tih theih a ni.

2. Laboratory-a thawn: He sample hi special laboratory-ah test turin thawn a ni.

3. Results pek chhuah: Lab hian i DNA a test a, result chu i doctor hnenah a thawn let leh thin.

4. Results sawiho: Tichuan, i doctor emaw, genetic counselor emaw chuan a sawipui ang che a, heng result awmzia hi a hrilhfiah ang che.

Tunah chuan ram thenkhatah chuan in lama genetic test neih theih a ni tawh. Mahse, pakhat atanga result i hmu a nih pawhin, a chipchiar tak hriat chian nan i chhungkaw doctor nen inbiakna neih a pawimawh hle.

A rah chhuah atang hian eng nge kan zir chhuah?

Test result hian APOE gene eng variant (alleles) nge i neih tih a hrilh che a ni.

APOE4 positive tih hian eng nge a awmzia?

"APOE4 positive" tih hian i DNA-ah APOE-e4 gene copy pakhat tal i nei tihna a ni.

APOE4 i neih chuan Alzheimer’s vei theihna chance eng nge ni?

Khawvel mihring 15% leh 25% inkar hian APOE-e4 gene copy khat an nei a. 2% leh 5% inkar chuan copy pahnih an nei vek. Copy pakhat pawh neih hian Alzheimer’s vei theihna a tipung thei a ni.

Mahse, ka sawi nawn leh ang, hei hi natna a awm leh awm loh finfiahna test a ni lo. Risk chungchang chauh a hrilh che a ni.

Results atanga risk a sang tih a lan chuan i doctor chuan hetiang thil hi ti turin a hrilh thei che a ni:

• Exercise neih fo: Kar khatah ni engemaw zat tal thawk hah tir thei exercise tih.
• Mut tha rawh: Ni khatah darkar 7-8 tal mut thin ang che.
• Khawtlang nun: thiante leh chhungte nena hun hman te, khawtlang nunah inhmang te.
• Thluak chakna: Puzzle chinfel te, lehkhabu chhiar te, tawng thar emaw musical instrument thar zir te.

Heng result hriat hian rilru a nghawng thei em?

Ni e, a dik tak zet. Hetianga genetic test result kan hriat hian kawng tam takah min nghawng thei a ni. I hlauthawng a, i lungkham a, i thinrim a ni thei. A châng chuan, a rah chhuah chuan i beisei ang chhânna chiang tak a pe lo thei che a ni.

I genes chu eng pawh ni se, Alzheimer natna i vei theihna tur tihtlem nan thil tam tak i tih theih a awm tih hre reng ang che. Chumi atana thurawn tha ber chu doctor nen inbiakna neih hi a ni.