Depression i la nei reng em? NMDA enkawl dan chungchang han sawi ila

Depression nasa tak i nei bawk em, a nih loh leh damdawi lama kan sawi angin Major Depressive Disorder (MDD) i nei em? Doctor-in a pek damdawi pakhat emaw pahnih emaw i hman hnuah pawh hmasawnna leh inthlak danglamna i la nei lo em ni? "Tunah enge ka tih ang?" Lungngaihna nasa tak nen i ngaihtuah mai thei. Hetiang hunah hian mahni chauha awm leh tanpui theih loh anga inhriat hi thil pangngai tak a ni. Mahse, hlau suh. Nangmah chauh i ni lo. Science a lo thang chho zel a, beiseina thar a lo piang bawk. Vawiin hian chutiang beiseina thar kan sawi a ni.

A hmasain, antidepressant hman tlanglawn tak tak, an pek thinte kha tlem han hriat nawn tir ila.

Depression enkawlna i tan tawh a nih chuan i doctor chuan damdawi chi khat ‘traditional antidepressant’ an tih chu a rawn pe hmasa mai thei. Chungte chu chi hrang hrang lian tak tak a awm a. Heng damdawi te hian thluaka chemical messenger, neurotransmitters , an tih te hnathawh dan inthlauhna hmangin hna an thawk a, chu chuan kan rilru leh rilru put hmang a nghawng a ni. Chung zingah chuan serotonin , norepinephrine leh dopamine te pawh an tel .

Mahse heng damdawi te hi harsatna tlemte a awm. Pakhat chu hna thawh tan nan hun engemaw chen an hmang thin. A tlangpuiin result hmuh theih nan kar li atanga kar riat vel i nghah a ngai thin. A dang pakhat chu heng damdawi te hian mi zawng zawng tan hna a thawk dan inang lo tih hi a ni. Zirna hrang hrangah chuan hmangtu pathum zinga pahnih vel chuan an dam kim lo tih a tarlang .

I hriatthiam awlsam zawk nan hetiang table-a damdawi hman tlanglawn tak tak thenkhat hi han en ila.

Heng damdawi pakhat emaw a aia tam emaw i ei tawh a, i la dam lo a nih chuan lungngai suh. I sualna a ni lo. Hetiang hun lai hian doctor-te chuan enkawlna thar, hmasawn zawk an ngaihtuah thin.

Chuti a nih chuan heng NMDA enkawlna tharte hi engte nge ni?

A awlsam zawngin sawi ila, hei hi depression enkawlna kawng danglam tak a ni. Damdawi hmasa ang lo takin he enkawlna hian thluaka receptor N-methyl-D-aspartate (NMDA) tih chu a target a ni.

Hetiang hian han ngaihtuah teh. Major depression nei tan chuan thluak hmun pawimawh thenkhat chu a thawk tlem deuh thei a, ‘muthilh’ (underactive) ang chi te pawh a ni thei. NMDA enkawlnain an tih chu neurotransmitter chak tak dang glutamate , tih chu a thunun a, chu thluak cell ‘muthilh’ (neurons) te inzawmna chu a tichak bawk. Chu chu thluak cell inkara thuchah inthlengna chu an ti chak nghal tihna a ni.

Hei hi a thatna lian ber chu speed a ni. Damdawi pangngai chuan kar tam tak a daih thei a, mahse NMDA enkawlna thenkhat chuan darkar engemaw zat chhungin damlo tan hahdamna nasa tak leh inthlak danglamna nasa tak a pe tan thei a ni .

NMDA target-a enkawlnate chu engte nge ni? Risk a awm em?

Ketamine hi NMDA receptor target-a treatment-resistant depression enkawlna atana hman thin damdawi pawimawh tak a ni.

Hei hi damlo hnenah vein (intravenous emaw IV) hmangin saline nen pek thin a ni. Mahse hetah hian hriat reng tur thil a awm ngei ang.

Hei hi doctor-in depression enkawlna atana a rawt hmasak ber a ni hauh lo.

Hengte hi depression na tak nei, duhthlan tur dang zawng zawng hmang tawh, hlawhtlinna nei lo tan chauh hman a ni. Tin, he enkawlna hi damdawi inah tih a ni ngei ang, specialist doctor leh trained staff te enkawlna hnuaiah tih a ni ngei ang. Hei hi damdawi dawr atanga lei leh in lama hruai theih a ni lo.

Engvangin nge chutiang chu i tih? A chhan chu damdawi zawng zawng ang bawkin side effect awm thei a awm avangin. Enkawlna i neih chhung hian thisen sang a inthlak danglam thei a, luak chhuak, luak chhuak, a chang chuan thil tak tak atanga inthen tlem i nei thei bawk. Heng zawng zawng enkawl tur hian medical supervision hi a pawimawh hle.

Engtin nge he enkawlna atan hian ka tling em tih ka hriat theih ang?

Hei hi zawhna pawimawh ber a ni. Chumi chhanna chu i enkawltu doctor chauhvin a hre thei ang. NMDA therapy ang chi enkawlna sang tak dawng tura candidate tha tak i nih leh nih loh chu thil engemaw zatah a innghat ang:

• Eng ang antidepressant nge i hman tawh?
• Eng chen nge an hman a, a dose dik takah an hman?
• Engtin nge i taksain anmahni a chhân lêt?
• Tuna i lungngaihna lan chhuah dan nasat dan.
• I hriselna dinhmun pum pui (natna dang, damdawi dang i ei mek, etc.).

Chuvangin, i rilrua thil awm zawng zawng chu i doctor nen zalen taka sawipui hi a tha ber a ni. "Doctor, thla tam tak chhung chu he damdawi hi ka ei tawh a, mahse danglamna ka la hmu lo," tih emaw, "He thil hi ka hneh theihna tur kawng dang a awm lo em ni?" I rilru put hmang leh i thil tawn i sawi tam poh leh i doctor tan i tana enkawlna tha ber thlan a awlsam zawk ang.