Kan thluak hi engtiang chiahin nge a buai tih i ngaihtuah ngai em? Colombo Town ang mai a ni a, a rualin thil sang tam tak a thleng thin. Thuchah a kal leh zel a, thutlukna siam a ni a, rilru natna thunun a ni... heng zawng zawng hi chemical messenger tenau network hmanga thleng a ni. Chuti a nih chuan, chutiang hmun buai takah chuan engkim a tlan chhuak vek a nih chuan eng nge thleng? Engkim a buai ta vek mai, a dik em? Kan thluaka chu buaina titawptu, engkim tiremtu, thununtu a awm a ni. Vawiin hian chu palai pawimawh tak, chu chu kan thluaka natural ‘brake’ chungchang kan sawi dawn a ni. Chu chu GABA a ni.
GABA hi eng nge ni tak tak?
A awlsam zawngin, GABA , gamma-aminobutyric acid tih tawi hi kan thluaka chemical messenger a ni. Damdawi lamah chuan hengte hi neurotransmitter kan ti a. Postmen ang bawkin thluaka nerve cell pakhat atanga thuchah dangah an keng tel a ni.
Mahse GABA-in thuchah a phurh hi a danglam deuh hlek a ni. "Hmanhmawh rawh, tlan rawh" tih message a ni lo. "Okay, okay, enough now. Tlem tal slow la, calm down" tih message a ni. Chu chu GABA hian kan central nervous system - chu chu thluak leh ruhro hnathawh chu tlem a tidanglam tihna a ni. Nerve cells te chu a tul lo taka tihchak loh nan a titawp thin.
Hei vang hian GABA hian kan rilru tihmuangtu leh stress, hlauhna leh lungkhamna ang chi thilte thunun kawngah hmun pawimawh tak a chang tih kan ring. Kan thluak natural tranquilizer ang mai a ni.
GABA hnathawh dan hi ngun zawkin han thlir ila.
Chu chu hrethiam tûr chuan i thluaka nerve cell-te chu an inbia ang tih han ngaihtuah teh. Mahse an inzawm lo. Cell pakhat leh a dang inkarah hian gap tlemte a awm a. Synapse kan ti a. Thuchah thawn a ngaih chuan cell pakhat a\angin neurotransmitter a chhuak a, chu gap chu a inbual a, a hnuaia cell-a receptor bik pakhatah a binding a ni.
Chabi leh lock ang mai a ni. Chabi zawng zawng hian lock tin a hawng thei vek lo. Tin, `Neurotransmitter` zawng zawng hi `Receptor` tin nen an inzawm thei lo bawk. GABA an tih `key` hian GABA receptor an tih `lock` te chauh a hawng thei a ni.
GABA chu a kal a, a `receptor`-ah a binding chuan, a hnuaia nerve cell-in thuchah a dawn chu "i activity tihtlem" tih hi a ni. Chu chu, chu cell-in cell dang atanga message a dawn theihna te, message thar a siam theihna te, cell dang hnena message a thawn theihna te chu a tlahniam tihna a ni. Chutiang chuan thluak hnathawh zawng zawng chu a reh ta a ni. Kawngpui buai takah traffic light a sen a nih ang bawkin car te chu an ding a, traffic chu tlem a control a ni.
GABA leh Glutamate - thluaka ‘On’ leh ‘Off’ switch pahnih te hi
Kan thluak a thawk tha tur chuan balance a pawimawh hle. GABA chungchang kan sawi hian a kalh zawng pawh kan sawi a ngai a, chu chu Glutamate .
GABA leh glutamate te hian ‘On’ leh ‘Off’ switch pahnih angin hna an thawk a.
- GABA hi thluaka 'off' switch ber a ni . Chu chu, activity titawptu leh i rilru ti hahdamtu neurotransmitter bulpui ber a ni.
- Glutamate hi thluaka 'On' switch ber a ni . Chu chu ‘neurotransmitter’ a ni a, chu chuan nerve cell te a tichak a, an hnathawhna a tipung a ni.
Car chhunga accelerator leh brake ang maiin han ngaihtuah teh. Car khalh thiam i duh chuan an pahnih hi dik tak leh a hun takah i hman a ngai a ni. Pakhat chauh neih hian a ti thei lovang. Accelerator chauh i neih chuan hmun tinah i crash vek ang. Brake chauh i neih chuan hma i sawn thei lo. Chutiang bawkin kan thluak hi hrisel leh tha taka a thawh theih nan GABA hian calming effects leh glutamate stimulating effects te inkarah hian balance nalh tak a awm a ngai a ni.
Mak tak maiin he calming agent GABA an tih hi stimulant pakhat, glutamate atanga siam a ni. Glutamate hi enzyme bik hnathawh avang hian GABA ah a inthlak thin.
GABA level a inthlau a nih chuan eng nge thleng ang?
Balance kan sawi tawh kha a bo a nih chuan, a bik takin GABA hnathawh a tlahniam chuan thluak ‘brake’ te chu a thawk tha lo ang. Tichuan thluak hnathawh chu a tul lovah a pung ang a, harsatna pakhat hnu pakhat a lo chhuak thei bawk. A hnuaia GABA activity tlahniam nena inzawm nia ngaih damdawi lam dinhmun thenkhat hi han en ila.
| Damdawi lam dinhmun | A sawifiahna awlsam tak |
|---|---|
| Lungkhamna leh Mood Disorder te | Rilru tihlum thei tur GABA a awm tawk loh chuan hlauhna tul lo, ngaihtuahna tibuaitu leh rilru hahdam lo tak tak a awm thei a ni. |
| Schizophrenia natna (Schizophrenia) natna a ni | Ngaihtuahna, rilru put hmang leh nungchang tichhe thei rilru natna khirh tak. GABA imbalance hian hei hi a thlen thei tih finfiahna engemaw zat a awm. |
| Autism Spectrum Disorder natna a ni | Khawtlang inlaichinna leh inbiakpawhna tichhe thei hmasawnna dinhmun. GABA system inthlak danglamnaah pawh a lang thei. |
| Lungngaihna | Hun rei tak chhung lungngaihna leh thil ngaihven loh. Hei hi GABA level hniam vang pawh a ni thei. |
| Epilepsy / Seizures natna a awm | Thluak chhunga electrical activity tihpun nghal, thunun theih loh. Hei hi a chhan ber chu GABA 'brake' process chak loh vang a ni. |
| Huntington-a Natna a ni | Thluak cell te tichhe zauh zauh thin, thlahtu natna. |
| Mutthilh tam lutuk (hypersomnia) a ni | Nitin mut tam lutuk emaw, hun rei tak mut emaw hi GABA system hnathawh tam lutuk vang a ni thei. |
GABA target thei damdawi a awm em?
Awle. Kan thluaka GABA hian hmun pawimawh tak a chan avangin damdawi siamtute chuan GABA system target tur damdawi engemaw zat an siam chhuak a ni. Heng damdawi te hian GABA natural calming effects tihchakna hmangin emaw, GABA angin hna an thawk a ni.
Pawimawh: A hnuaia damdawi te hi entirnan chauh a ni. Doctor thurawn leh rawtna tel lo chuan eng thil vang pawha hman loh tur leh hman tawh loh tur a ni. Chung zinga ṭhenkhat chu ruihhlo ngawlvei an ni thei a, side effect an nei thei bawk.
| Ruihhlo chi hrang hrang / hming | Eng atan nge hman a nih? (Entirna) |
|---|---|
| Benzodiazepines - e.g. Diazepam (Valium®), Alprazolam (Xanax®) te hi a tha hle a ni. | Lungkhamna tihziaawm nan, seizures control nan, zu in lohna symptoms control nan, leh taksa ruhte tih hahdam nan. |
| Barbiturates a awm bawk | Hengte hi sedative drug chi khat an ni bawk. Seizure leh anesthesia atan an hmang thin. |
| Valproic Acid hmanga siam a ni | Seizures control nan pek a ni a, mood stabilizer atan pawh pek a ni bawk. |
| Zolpidem (Zolpidem - Ambien®) tih a ni a, a man hi a to hle. | Mut theih lohna enkawlna atana hman thin mutna damdawi. |
| Propofol a ni | Surgery neih laiin general anesthesia atana hman thin damdawi chak tak. |
| Baclofen a ni | Muscle stiffness duh loh (spasticity) tihziaawmna atana pek damdawi. |
GABA supplement leh ei tur chungchangah thudik emaw dik lo emaw
Damdawi dawrah emaw online-ah emaw "GABA Supplements" hralh hi i hmu tawh ngei ang. Anni chuan chawlh hahdamna, mutthilh theihna leh lungkhamna tihziaawmna turin a pui che niin an sawi. Mahse buaina a awm.
Kan thluak hi hmun him tak a ni. Engmah chauh a luh tir lo va, thluak chhehvelah hian security system bik a awm a, chu chu Blood-Brain Barrier tih a ni. Castle vel moat ang mai a ni. He security system kaltlang hian thluak tana thil pawimawh tak tak chauh kal tlang phal a ni.
Researcher tam tak chuan pawn lam atanga kan ei thin GABA supplement te hian thisen leh thluak inkharkhip a paltlang theihna hi a hniam hle niin an ngai. Chuvangin, thluak an nghawng dan hi a la chiang lo. Mi thenkhat chuan heng supplement te hi an ei hian an rilru a hahdam zawk niin an sawi. Hei hi thluak thlenga GABA a thlen tak tak em tih leh, placebo effect a nih leh nih loh chungchangah scientific consensus a la awm lo.
Chuvangin, GABA supplement i ei hmain i doctor nen inbia hmasa phawt ang che. I dinhmun nena inmil leh remchan loh chungchanga thutlukna siamtu tha ber chu amah hi a ni.
Chaw ei tur ah GABA a awm em?
Ni e, GABA hi ei tur thenkhatah chuan a pianphungah a awm a, a bik takin ei tur hmin (fermented foods)-ah hian a awm a ni.
- Kimchi
- Miso
- Tempeh a ni
Hei bakah hian green, black, leh oolong tea te hian GABA a pai bawk. Tin, ei tur brown rice, soy, broccoli, spinach, tomato, leh cauliflower te hian kan taksaah GABA siam chhuah a tipung tih rinna a awm bawk.
Mahse supplement ang bawkin, heng ei tur atanga GABA hian thluak a thlen tak tak dan tur finfiahna chiang tak a la awm lo. Mahse ei leh in inthlau tak, hrisel tak ei hi taksa tan kawng engkimah a tha a ni.
Take-Home Thuchah a ni
- GABA hi kan thluaka chemical messenger ‘calming’ ber a ni. Kan thluaka ‘brake’ ang maiin a che thin.
- Thluak chakna tipungtu glutamate leh hnathawh tihtlemtu GABA inkara inthlauhna hi rilru hrisel tak neih nan a pawimawh hle.
- GABA level hniam hi damdawi lam thil hrang hrang, lungkhamna, lungngaihna, leh epilepsy te nen a inzawm thei a ni.
- Damdawi lama hman thin damdawi pawimawh tam tak chuan GABA system hi an target a ni. Hengte hi damdawi lam enkawlna hnuaiah chauh hman tur a ni.
- GABA supplement hi market-ah a thatzia chungchangah scientific evidence a la tling tawk lo a, thluaka a lut tak tak em tih pawh zawhna awm thei a ni.
- Lungkhamna, lungkhamna, emaw, mut theih lohna emaw i neih chuan, supplement emaw ei tur emaw chauh rinchhan ai chuan, doctor thiam tak zawh a, thurawn lak a pawimawh ber.
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