Stress a lo thlen hian taksa chhungah eng nge thleng tak tak? HPA axis (Hypothalamic-Pituitary-Adrenal Axis) chungchang hi awlsam takin i zir ang u!

Exam i neih dawn vang emaw, office-a hna lian tak pek i nih vang emaw, in lama harsatna i neih vang emaw pawh nise, pressure nasa tak i neih hun a awm thin? I rilru a na a, i thawk a hah a, lungkhamna mak tak mai i nei bawk. Hetiang hunah hian, "Ka stress a ni," kan ti thin. Mahse, he ‘stress’ hian a rawn thlen hian kan taksa chhungah eng nge thleng tak tak tih hi i ngaihtuah ngai em? Heng zawng zawng hnuaiah hian kan taksaah hian mak tak mai, automatic control system a awm a. Vawiin hian chu chu kan sawi dawn a ni.

A awlsam zawngin, HPA axis chu eng nge ni?

HPA Axis hi kan taksaa inbiakpawhna kawng pawimawh tak a ni. A dik tak chuan kan taksa peng lian pathum inzawmna a ni. Kan taksaa stress enkawltu system ber a ni. Kan taksa chhunga emergency management team angin han ngaihtuah teh. He team-ah hian hruaitu pathum an awm a. Thuchah an in thawn a, inrual takin hna an thawk bawk. He system hi HPA axis kan ti a.

Damdawi lam hawi chuan HPA axis hi neuroendocrine system a ni. Chu chu, kan nervous system atanga signal lo lutte chhanna atan hormone an tih chemical messengers thisenah chhuahtirtu system a ni tihna a ni. Heng hormone te hian kan taksa hian stress kan hmachhawn dan tur a hrilh a.

He pawl hruaitu pathumte hi tute nge ni?

Kan sawi tawh ang khan he system-ah hian taksa peng lian pathum a awm a. Heng pathumte hi he process zawng zawng hi kalpui tu an ni. Heng pathumte hi tute nge an nih a, eng hna nge an nih tih i lo en ang u.

Engtin nge heng pathumte hi an thawh dun?

Heng pathumte inrem dan hi a felfai hle. Chain reaction ang mai a ni. Entirna hmangin i hrethiam ang u.

Kawngpuiah i kal a, rang takin ui pakhatin a rawn zuang thla che ang tih han ngaihtuah teh. I hlauthawng hle mai. Second tlemte chhungin i taksa chhungah heng thilte hi a thleng thin:

1. Step hmasa ber: I thluak chuan i mit hmuh chu "Hei hi hlauhawm a ni!" Chutah chuan autonomic nervous system kaltlangin hypothalamus (main control room) ah message a thawn nghal a. Hypothalamus hian chemical message `CRH` (Corticotrophin-releasing hormone) tih chu a chhuah nghal a.

2. Step 2: He `CRH` message hi pituitary gland (manager) ah a kal nghal a ni. Chu thuchah a dawn chuan pituitary gland chuan hormone dang `ACTH` (Adrenocorticotropic hormone) tih chu thisenah a chhuah tir a. Hei hi "Kal rawh!"

3. Step 3: Thisen chhunga kal hormone `ACTH` hian adrenal glands (the acting unit) a thleng a . Chu thupek chu kan dawn chuan adrenal gland-te chuan kan stress hormone ber, cortisol tam tak an siam a, thisenah an chhuahtir a ni.

Mahse he system hi a on reng tur a ni lo. Ui a chhuah hnuah, chu chu hlauhawm a liam hnuah, he system hi a tawp mai tur a ni. Tin, mak tak maiin a thleng bawk. Thisen a cortisol level a san chuan thluak (hypothalamus leh pituitary gland) ah signal a thawn leh a, "Okay, tunah chuan buaina chu a chinfel tawh a, chu `CRH` leh `ACTH` message te chu thawn tawh suh," a ti. Hei hi negative feedback loop kan tih chu a ni . Hna thawh zawh hunah switch off ang mai a ni.

He system hi a thawk tha lo a ni thei em?

Ni e, a ti thei ngei ang. He delicately balanced system hi tihbuai theihna kawng lian pahnih a awm. Pakhat chu over-activity hmangin a ni a, pakhat chu under-activity hmangin a ni.

HPA Axis hnathawh that lohna

Ngaihtuah teh, i stress reng reng a ni. Ui zuang chhuak reng ang mai a ni. Office-a harsatna, in lama harsatna, sum leh pai lama harsatna... Hetiang hun rei tak, chronic stress i neih hian chu system chuan chawlh a nei lo. A on reng a ni. Tichuan cortisol level chu a sang reng a ni . Hei hian kan taksa tan a pawi hle.

Chu bâkah, zirchiangtute chuan hun rei tak chhûnga HPA axis dysfunction hian hriatrengna lama harsatna leh neurodegenerative diseases , Alzheimer’s disease -te a thlen thei niin an ngai bawk.

HPA Axis tihtawp a ni

Hei hi a lehlamah a ni. Chu chu, stress a chhan tur a nih pawhin system chu a thawk tha lo tihna a ni. Hei hi a chhan ber chu damdawi chi hrang hrang pawn lam atanga ei thin a ni.

Hetiang dinhmun hi a awm thei a, a bik takin corticosteroids (e.g., Prednisolone), asthma, COPD, arthritis, cancer, leh organ transplant hnua hman thin, hun rei tak ei hian a awm thei a ni.

Thil thleng chu hetiang hi a ni mai: heng damdawi te hi pawn lam atanga kan in pek hian kan taksa chuan, "Aw, cortisol siam kan ngai tawh lo, pawn lam atangin kan hmu thei ang," tiin a ngaihtuah thin. Tichuan kan adrenal glands (factory) te chu a lazy deuh a, cortisol siam chhuah a ti tlem ta a ni.

Chuvang chuan doctor pakhat chuan steroid damdawi ei kha bansan nghal lo turin a ti. I doctor thupek angin i ti tur a ni a, zawi zawiin a ei tur chu tihtlem la.

Chuti a nih chuan engtin nge he system hlu tak hi kan humhim ang?

HPA axis chungchanga zirchianna hi kalpui mek a ni a, mahse stress enkawl dan tha ber chu uluk taka enkawl hi a ni . Kan nunah hian stress kan paih bo vek thei lo. Mahse kan thunun theih loh nan kan thunun thei a ni. Ṭanpui tûra i tih theih thil awlsam ṭhenkhat chu hetiang hi a ni:

• Rilru ti thlamuang thei thil ti rawh: Nitin meditation, yoga, leh deep breathing exercise ang chi thilte ti thin ang che.
• I taksa enkawl \ha rawh: Chaw \ha tak tak ei la, nitin exercise la la, mut \ha rawh. Heng pathumte hi an pawimawh hle.
• Thil \ha ngaihtuah rawh: Nunna atana thil \hate ngaihtuah rawh. Engkim i thunun thei lo tih pawm rawh. I thlak danglam theih loh thil ngaihtuah hian i stress a tizual mai ang.
• "Ni lo" tih hi thiam rawh: I rilru hah lutuk hian mawhphurhna thar la suh.
• Khawtlang inzawmna vawng reng rawh:I rilru a thil awmte chu i ṭhian emaw, i chhungte emaw, i hnaih leh hrethiam tak takte nena sawi dun chu thlamuanna ropui tak a ni.

Heng thilte i tih hnua i stress control-na kawngah harsatna i la nei a nih chuan zak suh la, nangmah chauhin hrehawm tuar suh. Chumi chungchang chu i chhungkaw doctor nen sawiho rawh. He dinhmun hneh tura i mamawh kaihhruaina a pe thei ang che.