Ngaihtuah teh, mi pakhat chu ni engemaw zat chhung chu a dam lo hle a, a hriatrengna chu a fuzzy deuh a, a ruh chu a chang chuan a na a, a vun pawh a na tan bawk. Chuvangin hetiang thil ti tura doctor i pan a, test chi hrang hrang an tih hian heng zawng zawng bul chu taksa chhunga cancer inthup a ni tih an hrechhuak thin. Mak a ni lo maw? Cancer hi hmun khatah a awm a, mahse a nghawng avang hian taksa peng hrang hrangah hian symptoms inzawm lo tak tak ang maia lang a lang thin. Chu chu damdawi lamah Paraneoplastic Syndrome kan tih chu a ni.
A awlsam zawngin, Paraneoplastic Syndrome hi eng nge ni?
Hei hi hriatthiam a harsa deuhin a lang thei a, mahse a awlsam zawngin i dah ang u. I taksaah malignant tumor a lo awm chuan direct effect a awm thin. Entirnan, lung cancer i neih chuan khuh i nei thei. Colon cancer i neih chuan i ek chhungah thisen a awm thei. Hengte hi cancer symptoms direct a ni.
Mahse Paraneoplastic Syndrome hi thil danglam tak a ni. Heta thil thleng hi i taksa hian cancer chhanna atan symptom dang a siam khawm a ni. Chu chu, cancer-in direct-a a tih tur a ni lo va, cancer chu taksaah a awm avangin taksa chhunga system dangte chu a ‘response’ angin an kal lo.
Hei hi a thlen theih dan tlangpui pahnih a awm a, chungte chu:
1. Autoimmune Response: Kan taksa immune system hi ram humhimtu sipai angin han ngaihtuah teh. Cancer cells te hi hmêlma ram chhunga lut tawh an ni. Chuvangin kan sipaite (immune system) hian he hmelma (cancer) hi an do tan ta a ni. Chumi atân chuan ralthuam bik an siam a, chu chu antibodies . Mahse a chang chuan he indo lai hian kan sipaite hian tihsual an nei thin. Hmelma cell chauh ni lovin, kan taksa chhunga cell tha, hrisel tak takte pawh hmêlma anga ngaihin an bei ṭan a ni. Entîr nân, nervous system-a cell-te, vun cell-te, a nih loh leh ruhkawr chhûnga cell-te chu an bei thei a ni. Chutah chuan chu taksa peng hrang hrangte nena inzawm symptoms te chu a lo lang ta a ni.
2. Cancer cells hmanga hormone siam chhuah: Cancer chi thenkhat chuan kan taksain a siam chhuah pangngai loh, a nih loh leh a siam chhuah tlem lutuk thil tam lutuk, hormone ang chi a siam thei a ni. Heng hormone pangngai lote hi thisenah an pung khawm a, taksa pum puiah an fang kual a, taksa peng hrang hrangte hnathawh a tibuai a ni. Entirnan, heng hormone te hian thisen sang a tisang lutuk thei a, thisenah calcium level a tisang thei bawk.
A pawimawh ber chu a chang chuan cancer hmuhchhuah hma pawh hian he Paraneoplastic Syndrome nena inzawm symptoms hi a lang hmasa ber thin. Chuvangin heng symptoms te hi kan hriat chian a pawimawh hle.
Hetiang dinhmun hian taksa peng engte nge a nghawng?
Paraneoplastic syndromes hian taksa chhunga system zawng zawng deuhthaw a nghawng thei a ni. Mahse, heng system-ah hian an lang tam ber. Eng nge an nih a, anmahni nena inzawm eng dinhmun nge thleng thei tih hi han thlir ila.
| Taksa system a nghawng | Damdawi lam dinhmun awm thei (entirnan) . |
|---|---|
| Nervous system (thluak, ruhro, nerve) 1.1. | Cerebellar degeneration, Encephalitis, Lambert-Eaton myasthenic syndrome, Myasthenia gravis, Peripheral neuropathy, Stiff person syndrome te ang chi natna te hi a ni. |
| Endocrine system (hormone) te hi a tha hle. | Cushing syndrome, Hypercalcemia (thisen a calcium tihpun), leh Carcinoid syndrome te ang chi natna te. |
| Connective tissue (ruh, ruh, ruh) 1.1. | Dermatomyositis, Paraneoplastic polyarthritis (ruh natna), Hypertrophic osteoarthropathy te a awm bawk. |
| Thisen | Natna rei tak atanga thisen tlakchhamna, Paraneoplastic erythrocytosis, Paraneoplastic thrombocytosis te. |
| Vun | Acanthosis nigricans (kawng leh kawr hmuna vun thim leh thim), Dermatomyositis, Sweet syndrome, Paraneoplastic pemphigus. |
A lan chhuah dan tlangpui leh chiang tak takte chu engte nge ni?
Paraneoplastic syndrome-a hmuh hmasak ber symptoms langsar tak tak engemaw zat a awm. Hengte hi natna dangah pawh hmuh theih a nih avangin hengte hi hmuh ringawt pawha hlauhthawn hi thil tha a ni lo.
A lan chhuah dan tlangpui:
- Chhan awm lovin khawsik
- Chaw chakna
- Zanah thawk hah lutuk
- Thawhrimna tel lova taksa rihna tihtlem dan danglam tak
Heng natna lan chhuah dan tlangpui bakah hian kan sawi tawh ang khan taksa kalphung a nghawng dan azirin chhinchhiahna bik a lo awm thin.
| A nghawng system | Symptom bik hmuh tur awm thei |
|---|---|
| Nervous system a ni | Kal harsa, balance hloh, luak chhuak, double vision, hriatrengna hloh, dementia, taksa ruh chak lo, tawng harsa. |
| Endocrine system a ni | Thisen sang, sawifiah theih loha taksa rihna sang, thisen sugar level sang, hah lutuk. |
| Connective tissue a ni | Joint na, ruh hring, ruh na leh chak lohna. |
| Thisen | Thisen cell chi khat a tlahniam emaw, a pung emaw dan pangngai lo (e.g. thisen tlakchhamna, emaw thisen zam tamna). |
| Vun | Cancer ni lo vunah lump, vun sen, vun na lutuk, vun rawng inthlak danglam. |
He natna hi tute nge vei theihna chance sang zawk?
Paraneoplastic syndromes hi theoretically chuan cancer vei tan chuan a awm thei a ni. Mahse, cancer chi thenkhat nen chuan an awm tam zawk. Statistics atanga a lan dan chuan cancer vei 100 zinga 8 vel (8%) chuan he natna hi an vei a ni.
He natna nena inzawm cancer chi hrang hrangte chu:
- Lung cancer (hetiang chi nen hian hmuh tam ber) .
- Hnute cancer a ni
- Thisen kaihhnawih cancer (lymphoma, leukemia ang chi) .
- Ovarian cancer a ni
Engtin nge doctor hian hei hi a hmuh theih?
Heng symptoms nei doctor pan i kal hian a tih hmasak ber tur chu history uluk taka ziak a, physical exam tih hi a ni. Tichuan, an natna lan chhuah dan chu cancer emaw, damdawi lam thil dang emaw avanga lo awm a nih leh nih loh hriat nan test eng emaw zat an ti ang.
- Thisen test: Thisen test pangngai hian i natna lan chhuah chhan dang (e.g., infection, hormonal imbalances) a enfiah thei a ni. Tin, thisen test bik thenkhatah chuan paraneoplastic syndrome nena inzawm antibodies emaw tumor marker emaw an zawng thei bawk.
- Imaging: CT scan , MRI scan , ultrasound ang chi test hmangin taksa chhungah cancer natna hrik a awm leh awm loh hriat theih a ni.
- Neurological exam: I symptoms te hi nervous system nena inzawm nia rinhlelh a nih chuan i doctor chuan i chakna, i hriatrengna, i balance leh coordination te test nan thil chi hrang hrang a ti ang.
- Spinal tap/Lumbar Puncture: Hei hian cerebrospinal fluid, i spinal cord vel a tui tlemte lak a, he fluid-ah hian cell hrisel tak takte beitu antibodies pangngai lo a awm em tih enfiah a ngai a ni.
Engtin nge enkawl a nih?
Paraneoplastic syndrome enkawlna atana thil pawimawh leh bulpui ber chu a chhan zawng zawng thlentu cancer enkawl hi a ni. Cancer hi control emaw tihdam emaw a nih chuan paraneoplastic syndrome nena inzawm symptoms te chu a mah chauhin a reh fo thin.
Chutih rual chuan cancer enkawl lai hian a natna lanchhuahna lo awm tawhte thunun nan enkawlna pawh pek a ni bawk. Heng enkawlnate hian a tum ber chu immune system tihlum a ni a, chu chuan tihsualin cell hriselte a bei thin.
- Corticosteroids: Prednisolone ang chi damdawi. Hengte hian taksaa inflammation leh swelling tihziaawmna hmangin hna an thawk a ni.
- Immunosuppressants te chu: 1.1.Heng damdawi te hian immune system hnathawh a ti tlem a, cell hrisel te a beih loh nan a titawp bawk.
- Intravenous immunoglobulin (IVIG): Hei hian mi hrisel atanga lak antibodies awmna thil chu thisenah pek a ni. Heng antibody te hian taksa tichhe mek antibody tha lo te chu a tichhia a ni.
- Plasmapheresis: Hei hi thisen tihthianghlimna ang chiah a ni. I thisen chu lak a ni a, a liquid part (plasma) chu a inthen a, antibody tha lo tak tak te chu filter chhuakin, plasma thianghlim chu i taksaah dah leh a ni.
- Physical, occupational and speech therapy: Nervous system a nghawng a, kea kal, thusawi emaw, nitin hna thawh emaw a harsat chuan heng enkawlnate hian chu theihnate chu a siam thar leh thei a ni.
Engtikah nge doctor i hmuh ang?
He thuziaka kan sawi ang chi natna danglam bik i neih chuan, a bik takin a nasat emaw, kar hnih aia rei emaw a nih chuan doctor i pan ngei ngei tur a ni.
Heng symptoms nei zawng zawng hian cancer an nei vek lo tih hre reng ang che. Heng symptom tam tak hi cancer ang chi natna dang, natna dang vang pawh a ni thei. Chuvangin a chhe ber chu ngaihtuah suh la, hlauthawng rawh. Mahse, a chhan dik tak hriat a pawimawh. Chuvangin damdawi lam thurawn zawng ngei ang che.
Tun hmaa cancer enkawl tawh, kum nga kalta chhunga sawi ila, tunah chuan hetiang symptoms hi i nei a nih chuan test nawn leh a pawimawh hle. Hei hian cancer chu a lo kir leh tawh em tih hriat theih nan a pui thei a ni.
Cancer natna i vei hian hetiang symptoms inzawmkhawm i neih hian i rilru a buai tih hi thil pangngai a ni. Mahse he paraneoplastic syndrome enkawlna tha ber chu cancer enkawlna nen a inang tih hriat a pawimawh. Cancer enkawlna ruahmanna ngun taka zawm hian heng natna lan chhuah dante hi i enkawl theih nan kawng thui tak a zawh ang. Enkawlna tam tak a awm a, chu chuan hahdamna a pe thei che a ni. An chungchang hi i doctor nen zalen takin sawipui rawh.
Take-Home Thuchah a ni
- Paraneoplastic syndrome hi cancer in direct effect a ni lo va , cancer dona atana taksa immune system emaw hormone emaw indirect effect a ni zawk.
- A then phei chuan, he syndrome nena inzawm symptoms hi a lang hmasa ber , cancer hmuhchhuah hma pawhin.
- He natna enkawl dan ber chu a hnuaia cancer awm enkawl hi a ni.
- I natna lan chhuah dan danglam (e.g. i rihna tlahniam, taksa ruh chak lohna, vun inthlak danglam) chhan awm lova lo lang leh kar hnih aia rei i neih chuan rei lovah doctor pan tur a ni.
- Heng chhinchhiahnate hi damdawi lam thil dang tam tak avanga lo awm thei a nih avangin, hlauthawng lo va, damdawi lam enfiahna dik neih a pawimawh hle .
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