Peptide Receptor Radionuclide Therapy (PRRT) hi cancer cell-te beihpui thlakna atana hman tur a ni.

Cancer taksa peng khat atanga hmun danga a darh chuan enkawl chu thil harsa tak a ni tih i hria mai thei. Mahse tunlai damdawi lama hmasawnna avang hian cancer cell te chu missile ang maia target thei leh tichhe mai thei tur special treatment a awm ta a ni. Vawiin hian cancer chi khat `neuroendocrine tumors (NETs) an tih enkawlna atana hmanraw changkang tak kan sawi dawn a ni. Hei hi PRRT an ti a, chu chu `Peptide Receptor Radionuclide Therapy` tihna a ni.

A awlsam zawngin PRRT enkawlna chu eng nge ni?

PRRT hi cancer enkawlna tur targeted a ni. Cancer cell-ah radioactive substance direct-a thlen a, tihchhiat a huam a ni. Kan taksaa cell hriselte tichhe lovin cancer cell thlan chhuah hmanga tihhlum ang maiin han ngaihtuah teh.

Engtin nge hei hian hna a thawh? A mak khawp mai!

Hei hi hrethiam tur chuan entirnan tlem han la ila. Cancer cell tin hian an chung lamah receptor bik an nei a, chu chu kawngkaa keyhole ang mai a ni. Heng receptor chauh nena inmil protein bikte chu chabi ang maia an inzawm khawm chuan kawngkhar chu a inhawng a, chu chuan thilte chu cell chhungah a luh tir a ni.

Hei hi PRRT enkawlnain a tih chu a ni:

1. "Key" siam: Cancer cell chunglama receptor nena inmil chiah protein (peptide) chu laboratory-ah siam a ni.

2. "Bomb" attaching: Tichuan, radioactive element pakhat radionuclide an tih, cancer cell thattu tak tak chu engineered protein-ah hian a inzawm leh ta a ni.

3. Target thlenga zin: He damdawi hi taksaah a luh chuan protein hian kawng a zawng a, cancer cell-a receptor-te nen a inzawm khawm a ni.

4. Cancer cell tihchhiat: Chabiin kawngkhar a hawn ang maiin, protein chu receptor-ah a binding chuan radioactive drug chu cell chhungah a lut a. A chhunga a luh chuan a radioactivity a chhuah chuan cancer cell DNA a tichhe a, a chhung atang chuan cell chu a tichhia a ni.

Khawvelah hian eng ang PRRT nge hman a nih?

Tun thlenga khawvela PRRT damdawi pawmpui ber chu `lutetium Lu 177 dotatate (LUTATHERA®) a ni.` Hetah hian `dotatate`, synthetic protein chu radioactive element `lutetium-177`-ah a inzawm a ni.

He protein `dotatate` an tih hi kan taksaa hormone `somatostatin` nen a inang a ni. `NET` type cancer cell thenkhat chuan he `somatostatin` hormone hi receptor bik an nei a. He protein `dotatate` an tih hi chu receptor-ah chuan a kal a, a nghet hle. Chuvangin damdawi chu cancer cell chhungah a lut nghal a ni.

Hei bakah hian PRRT compound dang pawh zirchian mek a ni a, a then chu clinical trial neih mek a ni.

He PRRT enkawlna hi tute tan nge a tha?

Tunah hian PRRT enkawlna hi `gastroenteropancreatic NETs` an tih cancer te tan hman a ni ber a, chungte chu chaw ei kawng a cancer lo awm thin te an ni. Entir nan:

• Pancreas a ni
• Rectum (Rectum) a ni
• Intestine te leh lian te
• Pumpui

He enkawlna hi mi pakhat tan a tha em tih chu thil engemaw zatah a innghat a ni. A hnuaia table hi en rawh.

Engtin nge enkawl hmain i inbuatsaih thin?

NET cancer damdawi dang i ei tawh chuan i doctor chuan PRRT enkawl hmain a then chu rei lo te chhung chawlhsan turin a fuih thei che a ni.

• A tlangpuiin, long-acting somatostatin injection hi enkawl hma kar 4 tal chu tihtawp a ngai a ni.
• Short-acting somatostatin injection hi enkawl hma darkar 24 chhungin tihtawp a ni thei.
• Tin, he enkawlna chhung hian glucocorticosteroids ang chi steroid dose sang tak ei loh tur a ni.

Enkawlna neih apiangin kar khatah thisen test vawi tam tak i nei ang a, i taksa chu a inpeih tawh em tih i enfiah ang.

Enkawlna ni hian eng nge thleng?

PRRT enkawlna hi thla hnih danah thla 8 chhung session 4 chhung pek thin a ni tlangpui. Hei hi outpatient procedure a ni a, damdawi ina awm reng a ngai lo tihna a ni. Procedure zawng zawng hi darkar 5-6 vel a ni.

1. A hmasa berin i kut chhunga vein pakhatah intravenous (IV) cannula dah a ni ang.

2. Damdawi hi enkawl tan hma darkar khat velah nausen leh luak chhuak lo turin damdawi pek thin a ni.

3. Tichuan, i kal venhim nan IV hmangin darkar 4 vel amino acid solution pek i ni ang.

4. Amino acid solution an ei tan atanga minute 30 vel hnuah PRRT damdawi hi IV hran hmangin minute 30-45 chhung pek thin a ni.

5. Solution zawng zawng pek zawh hnuah IV cannula chu lakchhuah a ni.

Enkawl zawh ni khatah special scan an nei a, damdawi chu taksa pum puiah engtin nge a darh tih hriat a ni.

PRRT enkawlna hian eng hlawkna leh hlauhawmna nge a neih?

Eng nge a thatna?

PRRT hi enkawlna hlawhtling tak a ni. Mi tam takah chuan a dawngtuah chuan an tumor te chu a bo emaw, a lo thang tawh lo emaw a ni. Hei hian damlote chu an dam rei thei a , nunphung tha tak a nei thei bawk .

Risk leh side effect a awm thei

He enkawlna hian a nghawng nghal zung zung thei ber chu luak leh luak chhuak hi a ni a, mahse a tam zawk chu enkawl hmaa damdawi pek hmangin a thunun theih a ni.

Harsatna dang awm thei chu:

• Kidney emaw liver emaw lama harsatna nei.
• Thisen cell zat hniam. Hei hian thawk harsatna a thlen thei a, natna hrik kai theihna a tipung thei a, thisen chhuah emaw, hliam emaw a thlen thei bawk.
• Thisen cancer, myelodysplastic syndrome leh leukemia te vei theihna a awm tlem hle.

I doctor chuan thla 8 chhung enkawl chhung zawngin thisen test mumal takin a enkawl ang che. Harsatna a lo awm chuan i enkawlna chu thlak danglam emaw, tihtawp emaw a rel ang.

Thil awmdan hmanhmawh ber: Carcinoid Crisis

Hei hi thil awm lo mahse pawi tak, nunna atana hlauhawm thei a ni. Cancer cell atanga hormone lo chhuak nghal vang a ni. Enkawlna an dawn atanga darkar 48 chhungin natna lan chhuah dan a lang tlangpui.

Dam lehna leh nitin nun

Mi tam zawk chuan PRRT enkawlna hi an tuar tha hle a, an dam thuai thin.

Hnathawh lamah ka kir leh thei ang em?

PRRT hian radioactive material tlemte chauh a hmang a. He radioactive material hi i taksa atangin i zun leh ek ah i enkawl hnuah ni engemaw zat chhung chu a chhuak thin. I doctor chuan he hun chhung hian midang atanga metre khat tal inhlat turin a fuih ang che, a bik takin hmeichhe naupai leh naupang te te nen . Kut sil fo a pawimawh bawk.

Hemi hun chhung hian zin theih a ni em?

I enkawl hnu thla 3 thleng i taksaah radiation tlemte chauh a awm thei. Hei hi airport-a radiation screening hmanrua hmanga hriat theih a ni a, entirnan. I doctor chuan i enkawlna tur chipchiar taka tarlanna card bik a pe ang che. He card leh i treatment note copy hi i kalna apiangah i enkawl hnu thla 3 thleng i keng tel a pawimawh.