Lung natna leh mipat hmeichhiatna lama harsatna nei tan damdawi pek thinte i zir dawn teh ang? (Phosphodiesterase tihkhawtlai thei) .

I chhungkuaa mi tu emaw, i pa emaw, i pa emaw, thinlung natna, thisen sang, emaw, mipa chak lohna damdawi ei lai i hmu tawh mai thei. Chutiang bawkin Doctor ten vun natna, thawkna lam natna, Asthma, etc. damdawi chi hrang hrang an pe thin a, heng natna tam tak enkawlna atana hman thin damdawi class pawimawh tak a awm tih i hria em? Chu damdawi class, Phosphodiesterase Inhibitors tih chu vawiinah hian he thuziak-ah hian kan sawi dawn a, awlsam tak leh zahawm takin.

A awlsam zawngin, heng Phosphodiesterase Inhibitor te hi engte nge ni?

Hei hi hming buaithlak tak angin a lang thei a, mahse a takah chuan a awlsam khawp mai. Hengte hi kan taksa chhunga thisen kalna kawngte ti hahdam leh tizau theitu, thisen kal awlsamna tur damdawi chi khat an ni. Thisen kal dan a that chuan thisen sang pawh a thunun thei a ni. Hei vang hian heng damdawi te hi natna chi hrang hrang enkawlna atan an hmang a, vun, ruh, thinlung leh lung lam harsatna atanga mipat hmeichhiatna lama harsatna thleng thlengin an hmang thin.

He damdawi hian taksa chhungah engtin nge hna a thawh?

Kan taksaah hian enzyme chi khat Phosphodiesterases (PDEs) tih a awm a. A awlsam zawngin, enzyme te hi kan taksaa chemical process ti chaktu tanpuitu te tak te ang an ni. Heng PDE enzyme te hi chi hrang hrang a awm a. Number leh then hran an ni. A specialty chu PDE enzyme chi hrang hrang hi taksa hmun hrang hrangah hmuh tur a awm a ni.

Phosphodiesterase Inhibitors (PDE Inhibitors) hian a chunga kan sawi tak PDE enzyme te hnathawh dan a tikhawlo a ni. Kawngkhar khar ang mai a ni. PDE Inhibitor thenkhat chuan enzyme chi khat chauh (selective) an target a, thenkhat erawh chuan PDE enzymes a tlangpuiin (nonselective) an nghawng thei thung.

He damdawi hmanga enkawl dan ber berte chu engte nge ni?

Heng damdawi te hi natna hrang hrang sawmhnih chuang enkawlna atana pawm a ni. Category lian thenkhat han thlir ila.

Lung leh circulatory system natna te

• Decompensated heart failure: Lung a chak lo a, a tul anga taksaah thisen a pump thei lo a nih chuan.
• Pulmonary hypertension: Lung chhunga thisen kalna kawng hrang hranga thisen sang sang.
• Ke leh ke ruh chhunga thisen kal tlem (Peripheral artery disease - PAD): Thisen tling tawk lo, a bik takin ke-ah.
• Operation hnua thisen zam ven dan: Operation hnua thisen zam hian natna hlauhawm tak tak, stroke, heart attack, leh pulmonary embolism te a thlen thei a ni. Anmahni chu veng rawh.
• Thrombocythemia: Platelet siam chhuah tam lutuk, thisen zam tura puitu.

Vun leh ruhkawr natna (inflammatory diseases) a awm

• Eczema (Atopic dermatitis): Vun natna, vun sen hring, itchy redness.
• Psoriasis: Immune system chak lutuk avanga vun natna (inflammatory condition) a ni.
• Psoriatic arthritis: Psoriasis natna vei avanga ruh natna (inflammation) a awm.

Mipa reproductive system nena inzawm natna

• Benign prostatic hyperplasia: Cancer ni lo avanga prostate gland a hring.
• Erectile dysfunction: Erection neih harsat.

Thluak lam natna

• Chronic obstructive pulmonary disorder (COPD): Thâwk harsatna thlentu natna chi khat.
• Neonatal apnea: Nausen piang hma, a bik takin kar 7 hmaa piangte zingah thawk harsatna a awm .

He damdawi hian eng hlawkna nge a neih?

Heng damdawi hman hian thatna engemaw zat a nei a.

• A awlsam zawng: Hengte hi oral pill, topical cream, leh IV injection ang chi te a ni. Damdawi thenkhat chu nitin ei a ngai a, thenkhat erawh chu a tul hunah chauh ei theih a ni thung.
• Targeted therapy hmanga enkawlna: 1.1.Kan sawi tawh ang khan PDE enzyme chi khat chauh enkawlna hi target theih a nih avangin duh loh zawng side effects te chu nasa takin a tlahniam thei a ni.
• Damdawi pakhat thatna engemaw zat: A chang chuan natna pahnih lo awm dun chu damdawi pakhat hmangin enkawl theih a ni. Entirnan, mi pakhat, prostate lian leh erectile dysfunction nei ve ve chu PDE-5 inhibitor tadalafil -ah pek theih a ni. Chutiang bawkin Apremilast hi psoriasis leh psoriatic arthritis pahnih enkawlna atan hman a ni.

Side effect leh risk te pawh i hrechiang ang u.

Damdawi dang ang bawkin hengte hian side effect a thlen thei a ni. Heng side effects te hi PDE inhibitor i ei chi hrang hrangah a innghat ber a ni.

A hnuaia tarlan te hi damdawi chi hrang hrang nena inzawm side effect awm thei thenkhat te an ni.

Engtikah nge he damdawi hi i ei loh tur?

He damdawi hi mi thenkhat tan chuan hlauhawm tak a ni thei. A hnuaia thil awmte hi i neih chuan he damdawi hi i ei hmain i doctor nen inbia ngei ngei tur a ni.

• PDE inhibitor eng pawh tan: Tun hmaa damdawi emaw thil emaw eng emaw avanga allergy na tak (hypersensitivity) i neih tawh chuan.
• Cilostazol (PDE-3): Lung lam natna chi hrang hrang i neih chuan hei hi a tha lo.
• PDE-5 inhibitors: Lung natna khirh tak i neih a, tun hnaia heart attack emaw stroke emaw i neih emaw, angina nghet lo i neih emaw chuan hengte hi i ei loh tur a ni.
• Nitrates i ei a nih chuan PDE-5 inhibitor i ei hian i thisen sang a ti hniam lutuk thei.
• PDE inhibitor thenkhat (e.g. Cilostazol) hi thisen chhuahna lama harsatna i neih chuan a tha lo.

Naupai laiin hman tur a ni

Naupai emaw, naupai tum emaw i nih chuan PDE inhibitor chi hrang hrang ei loh chu a finthlak mai thei. Hemi chungchangah hian doctor rawn rawh.

Engtikah nge Doctor i hmuh nghal tur?

He damdawi i hman lai hian natna lan chhuah dan danglam tak i neih chuan doctor hnenah hrilh a tha ber. Mahse, a hnuaia mite hi a lo awm a nih chuan damdawi in pakhat Emergency Department (ETU)-ah tihkhawtlai lohvin kal tur a ni.

• Lung natna lan chhuah dan: 1.1.Thil hrang hrang, rilru na, tightness, thawk harsa, thawk hah, luak chhuak, luak chhuak.
• Priapism: Erection na tak, darkar 4 aia rei mipat hmeichhiatna lama tihchak loh. Hei hi enkawl vat ngai dinhmun a ni.
• Sudden loss/decrease in vision or bearing: Hengte hi a chhiatna nghet tak a thlen hmain enkawl hmasak phawt tur a ni.

Heng damdawi te hi a pawimawh hle a, nunna chhanhimtu leh nunna quality tisangtu a ni. Mahse doctor rawtna leh a pek zat chauh ei tur a ni.