I kal lai pawhin i balance i hloh a, i mit i tihchet harsat em? PSP (Progressive Supranuclear Palsy) a ni thei!

I kal apiangin i balance hloh a, i tlu thin tih i hmu em? A nih loh leh, hnuai lam hawi i tum hian i mit thunun harsa i ti em? I hriat mi pakhatin he harsatna hi a nei tih i hmu tawh mai thei. Hengte hi PSP, a nih loh leh Progressive Supranuclear Palsy tih hming pu, vawiin a kan sawi tur, a lan chhuah hmasak ber thenkhat a ni thei. Lungngai suh, hemi chungchang hi chipchiar takin kan sawi dawn a ni.

PSP (Progressive Supranuclear Palsy) tih hi eng nge ni? A awlsam zawngin i hrethiam ang u!

Okay, tunah chuan he natna hming sei deuh PSP (Progressive Supranuclear Palsy) tih hi eng nge a nih kan en ang. A awlsam zawngin sawi ila, kan thluak hmun thenkhat tichhe thei, progressive neurological disease a ni. I kal dan te, i ngaihtuahna te, i ei dan te, i mit i tihchet dan te a nghawng thei a ni. Hming dang a nei bawk a, chung zingah chuan Steele-Richardson-Olszewski syndrome pawh a tel.

Tunah en teh, a hminga thumal thenkhat i hriatthiam chuan a awlsam khawp mai.

• "Progressive" tih awmzia chu ka sawi tawh ang khan heng symptoms te hi hun kal zelah a na zual zauh zauh tihna a ni. A chhan chu thluak cell (neurodegenerative condition) a chak lo zauh zauh vang a ni.
• "Supranuclear" leh "Palsy" tih thumalte hi mit chetna tichhe thei dinhmun sawina atan hman a ni. "Supranuclear" tih hian chhiatna chu thluaka mit chetna control tu nuclei chung lamah a awm tihna a ni. "Palsy" tih awmzia chu taksa ruh chak lo emaw, hman harsa emaw tihna a ni.

PSP hi Parkinson natna nen hian a inthlau thei hle tih hre reng ang che, a bik takin natna hmasa berah chuan. Doctor-te chuan hei hi "atypical parkinsonian syndrome" emaw "Parkinson-plus disorder" emaw an ti a ni. Hei hian Parkinson natna ang chi symptom nei mahse, a danglam, a buaithlak zawk tihna a ni. Mahse, Parkinson natna aiin PSP hi a kal chak zawk tih hre reng ang che.

He natna hi kum 60 chunglam zingah a tam ber a, kum 40 hnuai lam tan chuan a vei hi a tlem hle.

PSP (Progressive Supranuclear Palsy) chi hrang hrangte chu engte nge ni?

PSP hi chi li, a nih loh leh phenotype lian tak tak pali a awm a. Heng chi zawng zawng hian symptom inang an nei vek a, mahse danglamna fiah lo tak tak a awm. A chi hnih hman tlanglawn ber chu:

1. Richardson natna a ni

2. Parkinson natna ang chi (PD ang chi - PSP-P) .

Heng chi hnih hian PSP vei zinga 75% vel an entir a ni.

Richardson syndrome vei chuan a hnuaia symptom tam tak hi a nei thei a ni:

• Kal leh balance lama harsatna.
• Thusawi dan pangngai lo (thusawi thiam lo, aw inthlak danglam).
• Hriatrengna leh ngaihtuahna lama harsatna.
• Mit che vel control harsat (a bik takin hnuai lam en hian).
• Mitmeng zau tak nen hmalam hawi nghal mai ang maia hmel lan dan.

Parkinson’s disease-like variant (PSP-P) vei te hian Richardson syndrome ang chiah chiah an nei a, mahse Parkinson’s disease nen an inang zawk thung. A lan chhuah dan ber chu tremor (involuntary muscle contraction avanga shaking) a ni. Balance lama harsatna leh nungchang inthlak danglamna aiin tremors hi a langsar zawk. PSP-P hian PSP chi dang aiin antiparkinsonian damdawi a dawng tam zawk a ni.

A dang pahnih hmuh tur awm lo chu:

• Corticobasal natna (corticobasal) natna a ni.
• Pure akinesia leh gait freezing (kea kal laiin che leh freezing harsa).

PSP (Progressive Supranuclear Palsy) hi natna tlanglawn tak a ni em?

Ni lo, PSP hi a awm lo hle. Mi sang za zinga panga vel chauhvin he natna hi an vei nia chhut a ni. Mi sang za zinga pakhat chauh hi kum tin he natna vei hmuhchhuah thar an ni. Chuvangin hei hi a tlem zia chu i hmu thei ang.

PSP (Progressive Supranuclear Palsy) natna lan chhuahna chu engte nge ni?

PSP natna lan chhuah dan hi mi hrang hrangah a inang lo thei. Zawi zawiin an tan tlangpui a, kum tam tak chhung chu zawi zawiin an na zual zel bawk.

A lan chhuah hmasak ber berte chu:

• Kea kal emaw, stairs chhoh emawa balance hloh. Hei hian tlu fo a thlen thei a, a bik takin hnunglam hawiin.
• Mit hmanga hnuai lam en harsa.
• Mitmeng zau tak nen hmalam hawi nghal mai ang maia hmel lan dan.

Symptom dang hmuh theihte chu:

• Ei leh in ei harsa.
• Muscle stiffness hian taksa chelh (mobility) a ti harsa hle.
• Thusawi harsa. Aw chu a slow a, a slurred thei bawk. Thumal lam thiam pawh a harsa thei bawk.
• Mood inthlak danglamna: lungngaihna, ngaihsak lohna, thinrimna.
• Mihring nihna a inthlak danglam thin.
• Nungchang inthlak danglamna: ngaihtuahna fim lo taka thil tih, thil dik leh dik lo thlang thei lo.
• Dementia (hriatrengna leh finna tlahniam zauh zauh).
• Mu thei lo.
• REM sleep behavior disorder (RBD) (mumang neih laiin au leh ke ruh tliak).
• Eng êng tak laka hriatna (photophobia).

PSP (Progressive Supranuclear Palsy) hi eng thilin nge a thlen?

Scientist te hian PSP hi eng nge a thlen tih chiang takin an la hre lo. Engpawhnise,Hemi kawngah hian protein pakhat "tau" an tih chu a inrawlh tih hmuhchhuah a ni. Tau hi kan thluak hriselna atana pawimawh tak protein a ni. He protein hian thluak cell (neurons) awm dan pangngai a venghim a ni.

PSP i neih chuan i thluaka heng tau protein te hi an inzawm khawm a, aggregate an siam thin. Chumi hnuah chuan heng tau protein clump te hian thluak cell te chu a tichhia a ni. Zirchiangtute chuan hei hi a chhan awm thei engemaw zat an rawt a:

• Random genetic mutations a awm thin.
• Hri kai theih hriat loh.
• Kan chhehvel (thli, tui, ei tur)-a awm, thluak hmun sensitive thenkhat zawi zawiin tichhe thei chemical hriat loh.

PSP hian mi zawng zawng a nghawng dan inang vek lo. Natna stage hrang hrangah thluak hmun hrang hrang a nghawng a, degree hrang hrangah a nghawng a ni. A tawpah chuan PSP hi thluak hmun tam zawkah a darh ta a ni. A tir lamah chuan he natna hian basal ganglia leh brainstem a nghawng tam ber.

I thluak bul hian hna pawimawh tam tak a thawk a, chu chu ei leh in leh dinhmun (posture) te hi a ni. Basal ganglia hian posture vawng reng turin a pui bawk a, i mit a ti che thei bawk a, ngaihtuahna a siam thei bawk a, i emotion te pawh a control thei bawk.

PSP (Progressive Supranuclear Palsy) hi thlahtute atanga lo chhuak a ni em?

Ni lo, PSP hi a tlem hle. PSP i neih chuan i chhungkaw member dangte, i unaute leh i fate pawhin an vei theihna chance a tlem hle. Chuvangin ngaihtuahawm tur a awm lo.

PSP (Progressive Supranuclear Palsy) vei theihna tur risk factors te chu engte nge ni?

PSP vei theihna tur risk factor ber chu kum a ni. Kum 60 aia upa i nih chuan PSP vei theihna i nei sang hle. He natna hi hmeichhia aiin mipaah ​​a tam zawk deuh.

PSP (Progressive Supranuclear Palsy) hian eng harsatna nge a thlen?

PSP a kal zel chuan damlote chuan an hmui, an hmui leh an lei chhunga ruh awmte chu an thunun thei lo tlangpui.

Thlarau ruh (throat muscle control) hloh hian ei leh in ei a ti harsa thei hle. Hei hian ei tur a tlakbuak loh nan leh rilru natna a thlen loh nan feeding tube a mamawh phah thei a ni.

PSP vei tam tak chuan bowel leh bladder function lamah harsatna an nei bawk. Entir nan:

• Ek khal.
• Zun harsatna.
• Zanah zun fo thin.
• Duh loh vanga chaw ei (bowel incontinence).
• Zun chhuah loh (Urinary incontinence) a awm.

Engtin nge PSP (Progressive Supranuclear Palsy) hi hmuhchhuah a nih?

PSP hi doctor-te tan chuan dik taka hmuhchhuah a harsa thei hle. Ka sawi tawh ang khan Parkinson natna nen hian a inthlau thei hle a, a bik takin a tir lamah chuan.Tunah hian PSP hriat theihna tur test bik a la awm lo. Doctor-te chuan i natna lan chhuah dan leh i thluak thlalakna imaging test hmangin an hre tlangpui.

I doctor chuan PSP i vei nia a rinhlelh chuan i thluak MRI (magnetic resonance imaging) scan turin a ti mai thei . Hei hian i natna lan chhuahna thlentu tur dinhmun dang, Parkinson natna emaw stroke emaw te chu a paih chhuak thei a ni. Tin, MRI-ah hian midbrain-ah shrinkage a awm a nih chuan PSP i neih theihna a tipung bawk.

He natna hi dik taka hriat theih nan chuan Parkinson natna leh chetna lama harsatna nei neurologist i hmuh a ngai mai thei.

PSP chhinchhiahna tam tak awm mah se, natna nemnghettu ber chu mit sang leh hnuai lama sawn harsat hi a ni. A lan chhuah dan tlangpui dangte chu tlu fo leh ei harsat te hi a ni.

PSP (Progressive Supranuclear Palsy) enkawl dan tur chu engte nge ni?

Vanduaithlak takin tun dinhmunah PSP hi damdawi leh enkawlna a la awm lo. Mahse, i natna lan chhuah dan control thei tur leh i nunphung tichangtlung thei tur enkawlna engemaw zat a awm.

Enkawlna kawng hrang hrangte chu:

• Damdawi ei tur.
• Movement therapies te pawh a awm bawk.
• Mit enkawl dan tur.
• Percutaneous endoscopic gastrostomy (PEG) - pum chhunga tube dah hmanga chaw pek.
• Palliative care hmanga enkawl a ni.

PSP atana clinical trial i tel theihna tur pawh a awm thei a, hengte hi i medical team te zawt rawh.

Damdawi ei tur

Antiparkinsonian damdawi hian a chang chuan PSP symptoms control nan a pui thei bawk. Balance lama harsatna, taksa ruh nghet lo, che slow, leh khur ang chi symptoms te chu rei lo te chhung atan an ti reh thei a ni. Mahse, mi zawng zawng tan hna inang an thawk lo. PSP damdawi hman tlanglawn ber berte chu:

• Levodopa (e.g. Atamet®, Rytary®, Sinemet®) te hi a tha hle a ni.
• Levodopa hi anticholinergic agents hmanga siam a ni.
• Amantadine (e.g. Symmetrel®) hmanga siam a ni.

Clinical depression enkawlna atan antidepressant damdawi hman a ni. Doctor-te chuan PSP avanga rilru lam harsatna i tawhte i hmachhawn theih nan hengte hi an pe thei che a ni. Antidepressant damdawi pek chhuah tam berte chu:

• Fluoxetine (e.g. Prozac®) hmanga siam a ni.
• Amitriptyline (e.g. Elavil®) hmanga siam a ni.
• Imipramine (e.g. Tofranil®) tih a ni.

Psychotherapy (talk therapy) pawh hi rilru lam harsatna leh natna nena khawsakna kawng tha tak a ni.

Movement therapies te pawh a awm bawk

Heng enkawlnate hian PSP natna lan chhuah dan thenkhat a tiziaawm thei a ni:

• Physical therapy: Physical therapy hian natna, rilru hahna, leh kal kual harsa te ang chi thilte a enkawl thei a ni.
• Occupational therapy: Occupational therapist chu nitin hna i thawh theihna tipungtu che a ni. Ding dan te, thut dan te, che vel dan te, hmanraw chi hrang hrang hmanga i hna him taka thawk tur te an zirtir thei che a ni.
• Speech therapy: Speech therapist te hian thusawi leh ei leh in lama harsatna an hneh theih nan an pui thin.

Mit enkawl dan tur

Heng enkawlnate hian mit lama harsatna hrang hrangah a pui thei a ni:

• Botox® (botulinum toxin) injection: I mitmeng control harsa i tih chuan Botox injection hian i mitmeng chhunga thau te chu hun eng emaw chen a ti hahdam thei a ni.
• Eye drops leh artificial tears: Hengte hian mit lubrication tlahniam avanga i mit a vawt chuan i mit a ti hnim thei a ni.
• Special glasses: Prism lens nei special glasses hian i line of sight hnuaia thil awmte chu a hmu thei a ni.
• Wraparound glasses: Eng êng tak laka i sensitive a nih chuan, sunglass ang maia mit khuh thei glasses dum bun hian hahdamna a pe thei a ni.

Percutaneous Endoscopic Gastrostomy (PEG) hmanga tih a ni.

PSP a nasat chuan ei leh in tur engmah i ei theih lohna hmunah i thleng thei a ni. Hei hian ei leh in i ei thei dawn lo tihna a ni. Chutiang hmun i thlen hmain i doctor chuan percutaneous endoscopic gastrostomy (PEG) tih a rawt thei ang.

A awlsam zawngin PEG hi surgeon-in i pum kaltlangin i pum chhungah tube a luhtir thin a ni. I ei leh in, damdawi leh tui te chu he tube hmang hian i taksaah a lut a.

Palliative care hmanga enkawl a ni

Palliative care hi enkawlna bik a ni a, PSP ang chi natna khirh tak nei te tan symptom relief, comfort, leh support a pe a ni. Damlo chauh ni lovin, an enkawltu leh chhungte pawh a thlawp a ni.

He enkawlna hi i PSP enkawlna atana i doctor-te hnen atanga enkawlna i dawn bakah a ni. Palliative care hian nuam zawka nun leh natna khirh tak i hmachhawn theihna tura i mamawh damdawi lam, khawtlang leh rilru lam puihna a pe a ni.

PSP (Progressive Supranuclear Palsy) hi eng nge a nih? (Prognosis) tih a ni.

PSP atana prognosis hi a tlangpuiin a tha lo hle. Hun kal zelah symptoms a zual zel a, tunah hian PSP tihdanglam emaw tihtawp theihna tur damdawi a la awm lo. Mahse, i natna hriatchhuah thuai a, enkawl dan tur ruahmanna i siam tan chuan i nunphung a tha zawk thei a ni.

PSP vei tam tak chuan a tawpah chuan wheelchair an mamawh ta a ni. Natna an vei atanga kum thum atanga kum li chhungin part-time emaw full-time emaw enkawlna an mamawh thei a ni. Mahse, hei hi mi hrang hrangah a inang lo. Hun a kal zel a, PSP atanga harsatna lo thlengte chu nunna atana hlauhawm tak a ni thei.

PSP (Progressive Supranuclear Palsy) vei dam rei zawng chu engzat nge ni ang?

PSP vei te hi an hmuhchhuah atanga kum ruk atanga kum kua vel an dam tlangpui a, mahse hei hi a danglam thei.

PSP symptoms hian pneumonia vei theihna a tipung a, chu chuan thihna a thlen thei a ni. PSP vei zinga thihna thlentu ber chu aspiration pneumonia a ni. Hei hi ei leh in tur thlipui hmanga lung chhunga a luh palh a, a chhan chu rilru ruhte a chak lo va, a inzawm tha lo a ni.

PSP vei te pawh an tluk theihna a sang hle. Tlu hian ruh a tikehsawm thei a, lu hliam a thlen thei bawk. Tlu, hliam na tak tuar pawh hi PSP vei zingah thihna thlentu a ni fo.

PSP (Progressive Supranuclear Palsy) hi ven theih a ni em?

A chhan chu zirchiangtute chuan PSP thlentu dik tak an la hriat loh avangin tun dinhmunah chuan ven dan tur a awm lo.

Engtikah nge Doctor ka hmuh ang?

I natna lan chhuah dan enfiah nan leh i enkawlna ruahmanna chu a tha em tih enfiah nan i medical team te i hmuh fo a ngai ang.

I rilru tibuaitu symptom i neih chuan doctor ko nghal rawh.

PSP (Progressive Supranuclear Palsy) i vei tih hriat chu hmachhawn harsa tak a ni thei. I medical team chuan personalized symptom management plan siam turin an pui ang che. A pawimawh ber chu i mamawh tanpuina i hmuh theih nan leh i hriselna lam ngaihtuah reng hi a ni. I medical team te chu nangmah leh i chhungte tanpui turin an awm reng tih hre reng ang che.

A tawp berah chuan hriat reng tur pawimawh ber berte

PSP hi thil buaithlak leh hmuh tur awm lo tak a ni. Mahse, hriat chian a pawimawh a, a natna lan chhuah dan hriat hmasak a pawimawh a, damdawi lam thurawn leh enkawlna mumal tak zawn a pawimawh.

• A lan chhuah hmasak berte hriatchhuah: Kal harsa, balance hloh, leh hnuai lam en harsa tih ang chi thilte chu en reng rawh.
• Damdawi lam thurawn zawng rawh: Ringhlel i neih chuan neurologist pan la, enfiah rawh.
• Enkawl chhunzawm zel: Natna hi tihdam theih ni lo mah se, a natna lan chhuah dan control leh nunphung tihchangtlunna tur enkawlna a awm.
• I rilru hriselna ngaihtuah rawh: Hetiang dinhmun nena kan nun hian rilru chak taka awm reng a pawimawh. A tul chuan counseling zawng rawh.
• Support services chungchangah fimkhur rawh: Physical therapy, occupational therapy, speech therapy, leh palliative care te pawhin a pui thei che a ni.

He thu hi in tan a tangkai ngei ka beisei. Nangmah emaw, i hmangaih tak emaw hian he harsatna hi i tawk a nih chuan nangmah chauhin hrehawm tuar suh. Damdawi lam ṭanpuina dik tak leh i hmangaih tak takte enkawlna i neih chuan he harsatna hi i hmachhawn thei a ni.

` PSP, Progressive Supranuclear Palsy, Thluak natna, Thluak lam natna, Parkinson’s, Incheina lama harsatna, Balance