Breast cancer, emaw osteoporosis emaw i hre tawh ngei ang. Vawiin hian heng natna pahnih enkawlna atana hman tur damdawi chi khat bik kan sawi dawn a ni. Anni hi Selective Estrogen Receptor Modulators an ti a, a tawi zawngin SERM an ti bawk. A hming hi scientific deuhin a lang thei a, mahse an hnathawh dan erawh a awlsam khawp mai. SERM hi eng nge a nih leh kan taksa a nghawng dan hi han thlir ila.
A awlsam zawngin, heng SERM te hi engte nge ni?
SERMs hi damdawi chi khat a ni a, kan taksaa hormone estrogen hnathawh dan control emaw tidanglam emaw a ni. Estrogen hi key angin ngaihtuah rawh. Kan taksa cell te hian he key nena inmil receptor an nei a. Estrogen hian heng receptor te hi a binding chuan chu cell te chuan message thenkhat an dawng thin. Entirnan, "thang" turin thuchah.
SERM hian hna ropui tak an thawk a ni. Taksa hmun thenkhata keyhole chhunga estrogen lut tur an block thin . Tin, taksa peng dangah chuan heng damdawi te hian estrogen angin hna an thawk bawk . Chu chu damdawi pakhat hian thil pahnih a ti tihna a ni a, a hmun a zirin. Mi pakhatin hun khatah humhimtu anga a che a, hun dangah chuan tanpuitu anga a che ang mai a ni.
He pawla damdawi hman tam ber pahnih chu tamoxifen leh raloxifene te an ni .
Engtin nge heng SERM te hian hna an thawh?
Kan sawi tawh ang khan hengte hian hmun hrang hrangah hna an thawk dan a inang lo. Chu chu tlem han sawifiah leh ila.
1. Hnute cancer chungchangah: Hnute cancer chi hrang hrang, hormone estrogen in a thang chakna tura puitu a awm a. Heng hormone receptor (HR) positive emaw estrogen receptor (ER) positive hnute cancer kan ti a. Heng cancer cell chi hrang hrangte hian an chung lamah estrogen inzawmna hmun an nei a. Estrogen hian heng hmunte hi a binding chuan cancer cell te hian "inthen darh la, lo thanglian lehzual turin" tih thuchah an dawng a ni. SERMs hian estrogen a tih hmain heng site te hi block in hna a thawk thin. Chabi dik lo chu keyhole-a dah ang mai a ni. Tichuan estrogen dik tak chu key-ah a thleng thei lo va, a bind thei lo. Hei hian cancer cell-te chu thuchah chu an lo thang lian thei lo.
2. Ruh hriselna: A lehlamah chuan estrogen hi hormone a ni a, kan ruh chakna tur a pawimawh hle. A bik takin menopause hnuah hmeichhiate estrogen level a tlahniam a, chu chuan ruh hloh, a nih loh leh osteoporosis . Hetih lai hian SERMs hian estrogen-in a tih ang bawkin ruh cell-ah hna a thawk a ni . Chu chu ruh lam pan chuan, "Chak takin awm rawh, calcium hloh suh," tih thuchah an pe tihna a ni.
I hrethiam em? He damdawi tho hian hnute chhunga estrogen hnathawh a titawp a, chutih rualin ruh chhunga estrogen angin hna a thawk a, ruh a venghim bawk. Hei hi heng damdawi te specialty a ni.
Eng dinhmunah nge SERM hi hman a nih?
Doctor-te chuan he damdawi hi thil engemaw zatah an rawt ber a ni.
Hnute cancer tan chuan
- Hmeichhia ER-positive hnute cancer vei theihna sang zawkte tan: Chhungkaw zinga mi tu emaw chuan he cancer hi a vei tawh a nih chuan, emaw, genetic test-a an genetic mutations an neih thu an hriat chian chuan cancer vei theihna tur a tipung a nih chuan, cancer a lo awm hmain he damdawi hi pek an ni.
- Hnute cancer avanga surgery nei tawhte tan: Surgery zawhah heng damdawi te hi cancer lo let leh (recurrence) venna atan pek thin a ni. Tin, hnute hrisel dang ah cancer a lo awm loh nan an pui bawk.
- DCIS (Ductal Carcinoma in Situ) tan chuan: Hei hi hnute cancer hmasa ber a ni. Hetiang dinhmun hi a darh zel loh nan SERMs hman a ni.
- Taksa peng dang a darh tawh hnute cancer tan (Metastatic Breast Cancer): He damdawi hi cancer control nana pek a ni.
- Mipa hnute cancer tan: Ni e, mipa pawhin hnute cancer an vei thei. Tamoxifen hi ER-positive cancer tan pawh hman a ni.
Osteoporosis tan chuan
Damdawi raloxifene an tih hi menopause hnua ruh hloh control nan leh ruh tliak hlauhawmna tihziaawmna atan hman a ni.
He enkawlna hi engtiang chiahin nge a hlawhtlin?
Ni e, hengte hi enkawlna tha tak tak an ni. Zirna atanga kan hmuh chhuah thenkhat hi han thlir ila:
- Hmeichhe risk sang tak, premenopausal (menopause paltlang lo) te hnena tamoxifen pek hian hnute cancer vei theihna chu 40% velin a tihtlem thei a ni
- Mi pakhatin a hnute pakhat cancer avanga operation nei tawhin tamoxifen a ei chuan a hnute dang cancer vei theihna chu 50% in a tlahniam a ni .
- Tamoxifen hian hnute cancer hmasa ber nei tan chuan a lo lang leh theihna tur 30% atanga 50% in a tihziaawm thei a ni.
- Zirna hrang hrangah chuan raloxifene damdawi hian postmenopausal hmeichhia, osteoporosis vei te chu an ruh (spinal fracture) a ti tlem tih hmuhchhuah a ni.
He damdawi ei hian eng side effect nge a neih theih?
Damdawi dang ang bawkin SERM hian side effect a nei thei a ni. Mahse, mi zawng zawng hian heng side effects zawng zawng hi kan nei vek lo.Chu chu hriat reng a pawimawh. Tin, heng damdawi te hlawkna hian a nghawng tha lo aiin a tam zawk fo bawk. I enkawltu doctor chuan heng zawng zawng hi a hrilhfiah vek ang che.
A hnuaia table-ah hian he damdawi hian side effect a neih tlangpui leh a awm loh dan kan thliar hrang a ni.
| Damdawi chi hrang hrang | Side effects a awm thei |
|---|---|
| Tamoxifen - hmeichhia tan | |
| Side effect awm fo thin |
|
| Rare mahse side effect na tak tak awm thei |
|
| Raloxifene - hmeichhia tan | |
| Side effect awm fo thin |
|
| Tamoxifen - mipa tan | |
| Side effects a awm thei |
|
A pawimawh ber chu i harsatna i tawh apiang doctor nen inbiakna neih hi a ni. Side effect thenkhat enkawl dan awlsam tak tak a awm.
Side effect avanga lungawi lohna hi tihziaawm theih a ni em?
Ni e, i ti thei ngei ang. Hrisel lohna tihziaawmna tur thil tlemte a awm a, a bik takin menopause ang chi symptoms (hot flashes, insomnia, vaginal dryness) te hi a ni.
- Hot flashes tihziaawmna: Caffeine (coffee, tea) leh ei tur rimtui tak takte tihtlem. Mi thenkhat chuan phytoestrogens awmna ei tur, soybean, chickpeas, leh lentils te ei hian hahdamna an hmu thin.
- Mut lama harsatna nei tan: Nitin exercise hian mut that nan a pui thin.
- Vaginal dryness atan: Hei atan hian vaginal moisturizer bik hman theih a awm. Hengte hi i doctor hnenah i zawt thei ang.
Engtikah nge damdawi lam thurawn i lak nghal ang?
A side effect tlangpui chu a na zual zel nia i hriat chuan i doctor hnenah hriattir rawh. Mahse, SERM-ah hian thil pawi tak tak, a awm tam lo hle. A hnuaia symptoms te hi i neih chuan tihkhawtlai suh. Damdawi in hnai ber emergency room (ETU) ah kal nghal rawh.
- Taksa emaw hmai emaw sir khatah rilru hah emaw, chak lohna emaw.
- Thusawi harsa, tawngkam slurring.
- Lu na tak, na tak a ni.
- Thâwk harsa nghal.
- A chhan hriat loha awm, rilru, kut, ke emaw, hmuiah emaw natna nasa tak.
Hengte hi stroke emaw pulmonary embolism emaw chhinchhiahna a ni thei a, chuvangin hengte hi i fimkhur hle tur a ni.
Take-Home Thuchah a ni
- SERMs hi damdawi chi khat bik a ni a, taksaa hormone estrogen hnathawh dan a tidanglam a ni.
- Hengte hi hnute cancer chi thenkhat venna leh enkawl nan leh ruh hloh control nan hlawhtling takin an hmang thin.
- Heta specialty chu damdawi tho hian taksa peng khatah estrogen hnathawh a tikhawlo a, hmun dangah chuan estrogen angin a thawk thung.
- Damdawi zawng zawng ang bawkin side effect a awm thei. Mahse, mi zawng zawngin an hmu vek lo. I harsatna i tawh apiang chu i doctor nen sawiho rawh.
- Stroke emaw thisen zam emaw ang chi symptom na tak tak te chu fimkhur rawh. Heng symptoms zinga pakhat tal i neih chuan damdawi in Emergency Department (ETU) ah kal nghal rawh.
- Breast cancer vei theihna i neih emaw, osteoporosis i neih emaw chuan i doctor nen he SERM treatment hi i tan a tha em tih sawi la, a hlawkna leh a hlauhawmna i hriatthiam ngei ngei tur a ni.
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