Doctor chuan i lungngaihna emaw, lungkhamna awm reng emaw atan damdawi chi khat SNRI tih a pe che em? I thiante zinga pakhat hian he damdawi hi a hmang ve mai thei. He hming i hriat hian hlauhna tlem i nei tawh mai thei. I rilruah zawhna tam tak i nei ngei ang, "He damdawi hi eng nge ni? Hengte hi taksa tan a tha em?" Chuvangin vawiin hian he damdawi chi hrang hrang SNRI tih hi awlsam takin sawi ila, i thianpa nen in inbia ang maiin.
A awlsam zawngin, heng SNRI te hi engte nge ni?
SNRI awmzia kimchang chu Serotonin leh Norepinephrine Reuptake Inhibitors tih a ni . Okay, a hming hi a buaithlak deuhin a ri a ni lawm ni? I ti chhe vek ang u, awlsam takin i hrethiam ang u.
Kan thluak chhungah hian chemical messenger bik a awm a, chu chuan thil tam tak a thunun a, chung zingah chuan kan rilru put hmang te, kan ngaihtuahna te, kan mutna te, leh kan ei duhna te pawh a tel a ni. Hengte hi ``Neurotransmitters'' kan ti a ni.Postman ang bawkin heng palai te hian thluak hmun khat atanga hmun dangah thuchah an keng tel thin.
Heng messenger zinga pahnih chu serotonin leh norepinephrine te an ni .
- Serotonin hi kan mood, mut leh ei leh in lama kan ei dan ang chi thil atan a pawimawh hle. Serotonin level a san chuan hlim leh hahdam takin kan awm thin.
- Norepinephrine hian kan ngaihtuahna fim tak, chakna leh active taka awm reng turin min pui thin.
Thil thleng tlangpui chu heng palaite hian an thuchah an thlen hnuah thluak cell-te chuan an la lut leh a, hei hi ``Reuptake'' an ti a, postman-in lehkha a thawn hnua post office-a a kir leh ang bawkin.
Mahse, depression emaw anxiety ang chi natna nei te tan chuan heng serotonin leh norepinephrine messenger te hnathawh hi thluak ah hian a tlahniam deuh thei a ni.
Hei hi SNRI damdawi a lo lutna hmun a ni a, heng damdawi te hian an tih chu chu messenger te reuptake chu hun eng emaw chen atan a block a ni. Postman hnenah "rei tal nghak la, message tlemte rawn thawn leh rawh" tih ang mai a ni. Tichuan heng palai tha (serotonin leh norepinephrine) te hi thluaka an awm rei zawk a, an hna tha tak tak an thawk thin. Hei hian kan rilru a titha tan a, lungkhamna a ti tlem a, kan chakna a tipung bawk.
A awlsam zawngin sawi ila, SNRIs hi damdawi chi khat a ni a, kan thluaka "hlimna leh chakna" control tu natural chemicals level te chu a inthlau hle.
SNRI damdawi hi eng dinhmunah nge hman a nih?
Heng damdawi te hi rilru lam hriselna lam thila pek chhuah ni mahse, doctor-te chuan taksa lam thil dang engemaw zat atan pawh an pe ve bawk. Eng nge an nih i han thlir teh ang.
| Damlohna | A sawifiahna awlsam tak |
|---|---|
| Hun remchang ber berte | |
| Major Depressive Disorder a ni a, a rilru a hah hle | Hun rei tak lungngaihna, eng thil pawh ngaihven lohna, nun borehna ang chi symptoms te tihziaawm nan. |
| Generalized Anxiety Disorder a ni a, a rilru a hah hle | Chhan bik nei lova rilrua lo lang reng hlauhna, lungkhamna leh rilru hahna te thunun turin. |
| Khawtlang nun lungkhamna (Social Anxiety Disorder) a ni | Midang hmaa thusawi leh perform hlauh lutuk leh zak lutuk tihziaawmna turin. |
| Panic Disorder a ni | Sudden, control theih loh panic attack lo awm tur ven nan. |
| Natna rei tak (Chronic Pain) a awm | Diabetes kaihhnawih neuropathy leh fibromyalgia ang chi natna avanga natna rei tak awm thei tihziaawmna tur. |
| Thil dang (Off-label hman) . | |
| Obsessive-Compulsive Disorder (OCD) tih a ni a, a rilru a buai em em a, a rilru a hah em em bawk. | Ngaihtuahna duh loh lo thleng fo leh chu chu chhanna atana thil thenkhat sawi nawn fo thin chu thunun turin. |
| Menopause natna lan chhuah dan | Menopause nena lo awm hot flashes ang chi symptoms control nan. |
| Migraine natna (Migraine) a awm | Migraine laka invenna damdawi atan. |
"Off-label use" tih awmzia chu i ngaihtuah mai thei. Doctor chuan a damdawi lam hriatna leh tawnhriat a\angin, a pawmpuina natna bulpui bakah, natna dang atan damdawi a rawt tihna a ni. Hei hi thil tih dan tlanglawn tak a ni.
Sri Lanka rama SNRI chi hrang hrang awm tam berte chu engte nge ni?
SNRI damdawi chi hrang hrang a awm a. I doctor chuan i dinhmun, kum leh hriselna dinhmun dangte a zirin i tan damdawi tha ber a thlang ang.
- Venlafaxine (brand hming Effexor® ang chi) .
- Duloxetine (brand hming Cymbalta® ang chi) .
- Desvenlafaxine (brand hming Pristiq®) tih a ni.
- Milnacipran (brand hming Savella®) a ni.
- Levomilnacipran (brand hming Fetzima® ang chi) .
Damdawi i dawnah hian a chunga kan sawi zinga pakhat a awm thei.
He damdawi hman hian eng side effect nge a neih theih?
Damdawi zawng zawng ang bawkin he damdawi hian side effect tenau te a nei thei bawk. Mahse mi tam zawk tan chuan hengte hi thil pawi tak a ni lo. Damdawi ei atanga kar hmasa berah an awm tlangpui a, i taksain damdawi a insiamrem angin an bo leh thin.
| Side effect a awm thei | Hrilhfiahna |
|---|---|
| Digestive system lama harsatna awm thei | Luak chhuak, luak chhuak, pum na, chaw ei kham, emaw, luak chhuak emaw. |
| Luak chhuak (vertigo) . | Luak chhuak, a bik takin ding emaw, dinhmun thlak emaw hian. |
| Kawng a vawt | Kawngkhar chhungah chil a chhuak tih hriatna. Hei hi tui tlem in tam zawkin a thunun theih a ni. |
| Thaw hah lutuk | Thawmhnaw a pung thei a, a bik takin zan lamah. |
| Mut harsatna a awm | Mi thenkhat chuan mut theih lohna an nei thei. Mi dangte chuan mutthilh lutukin an inhria thei bawk. |
| Mipat hmeichhiatna lama harsatna a awm | Mipat hmeichhiatna lama duhna tlahniam leh ejaculating harsatna ang chi thil a awm thei. Hemi chungchang hi i doctor nen sawi dun hi zak suh. |
A pawimawh ber chu, hetiang side effect hi i tawk a, chu chu tuar theih loh khawpa tam a nih chuan, nangmah chauhin damdawi ei kha bansan ngai suh. I doctor nen thurawn dil turin inbia ngei ang che.
Risk situation bik ngaihven tur
SNRI hi a tlangpuiin damdawi him tak ni mahse, hlauhawmna lian tak tak thenkhat hriat a tha a, mahse a awm tlem hle.
1. Serotonin Syndrome natna a ni
Hei hi fimkhur tur pawimawh ber a ni. SNRI leh damdawi dang serotonin level tichhe thei te hi ei dun a nih chuan thluaka serotonin level chu a tul lovah a sang thei a ni. Hei hi medical emergency pawi tak a ni .
- A lan chhuah dan: Sawifiah loha buaina, thinlung na rang, khawsik sang, taksa ruh khauh emaw, hrual emaw, leh thawk hah lutuk.
- Tih tur: Nangmah emaw, i hriat miin emaw heng natna lanchhuahna hi a lo neih thut chuan doctor pan nghal emaw, damdawi in hnai ber Emergency Department (ETU)-ah emaw kal rawh.
2. Damdawi ei tawh loh huna natna lan chhuah dan (Antidepressant Discontinuation Syndrome) .
He damdawi hi rei tak i ei a, i chawlhsan nghal chuan i taksain a chhanna angin harsatna a tawk thei a ni.
- Ziarang:Luak chhuak, lu na, luak chhuak, taksa na (khawsik i neih lai ang chi), leh lungkhamna nasa tak.
- Invenna: Doctor rawn hmasa lovin damdawi ei kha bansan ngai suh. I chawlhsan a ngai a nih chuan i doctor chuan thla khat emaw thla hnih emaw chhungin a dose chu a tihtlem zauh zauh ang a, i taksa chu a insiamrem tir ang a, chutah chuan him taka tihtawp dan tur a entir ang che.
3. Mahni intihhlum tumna
Hei hi thupui sensitive tak a ni a, mahse sawi chhuah ngai tak a ni. Zirna hrang hrangah chuan he damdawi hman kar hmasa berah hian mahni intihhlum duhna a pung thei tih hmuhchhuah a ni a, a bik takin thalai kum 25 hnuai lam tan chuan a tlem hle.
- Pawimawh: Heng ngaihtuahnate hi i neih chuan khawngaihin nangmah chauhin tuar suh. Hei hi i sualna a ni lo va, damdawi ei avanga side effect a ni thei bawk. I doctor hnenah hrilh nghal rawh. Chhungkaw member emaw, i thian emaw i rintlak hnenah hrilh rawh. Ṭanpuina dil hian chakna a pe a ni.
SNRI ei huna ngaihtuah tur dang
Zu in a in thin
SNRI ang chi antidepressant ei lai hian zu in loh a tha ber. Zu hi central nervous system depressant a ni bawk. Chuvangin damdawi hman thatna a tibuai thei a ni. Zu hian a chang chuan depression symptoms a ti na zual thei.
Damdawi dang
SNRI i ei a nih chuan i doctor hnenah damdawi dang i ei zawng zawng (painkiller, khuh damdawi, vitamin, herbal remedies thlengin) hrilh la. Damdawi thenkhat chu SNRI nen an inzawm thei a ni.
- Natna tihdamna damdawi NSAID (e.g. Ibuprofen, Diclofenac) te hi a ni.
- Thisen zam venna damdawi (e.g. Aspirin, Clopidogrel) .
- Triptan hi migraine damdawi a ni.
- Thlai chi hrang hrang, St. John’s Wort ang chi te
Naupai leh nau hnute pek
Naupai i tum a, nau i pai tawh a, nau i hnute i pe a nih chuan he damdawi hman chungchangah hian i doctor nen inbiakna neihpui ngei tur a ni. SNRI thenkhat chuan nausen pum chhunga awm chu a nghawng thei a ni. Tin, damdawi tihtawp thut chuan nu tan pawh a pawi thei hle bawk. I doctor chuan nang leh i naute tan eng nge him ber tih ngaihtuah turin a pui thei che a ni.
Damdawi hian eng chen nge hna a thawh theih?
Hei hi mi tam takin an zawh thin a ni. SNRIs hi Panadol ang maia hnathawk nghal thei damdawi a ni lo. Thluak chemical process te hi a balance theih nan hun engemaw chen a ngai a ni.
- Mi tam zawk chuan kar 4 atanga kar 6 chhungin symptoms ah hmasawnna (progress) engemaw zat an hmu ang .
- Mi thenkhatin damdawi hlawkna kimchang an hmuh theih nan kar 9 leh kar 12 (thla 2-3) vel a ngai thei.
Chuvangin, kar hmasa lamah danglamna lian tham i hriat loh vang mai maia damdawi ei kha bansan suh.Dawhthei takin awm rawh. Chumi hun hnuah pawh danglamna i la nei lo a nih chuan i doctor nen inbia leh rawh. A dose chu a siamrem thei a, damdawi dang hmangin a thlak thei bawk.
Take-Home Thuchah a ni
- SNRIs hi damdawi tha tak a ni a, i thluaka natural chemical messengers te hnathawh dan inthlauhna siamin depression, anxiety leh natna thenkhat control theitu a ni.
- He damdawi hian hna a thawk nghal lo. Dawhthei takin i result hmuh theih nan kar engemaw zat i nghah a ngai a ni.
- Damdawi zawng zawng ang bawkin, side effect tenau te pawh a awm thei. Hun kal zelah an reh tlangpui. Tuar theih loh khawpa harsatna i neih chuan doctor hnenah hrilh rawh.
- Engtik lai pawhin, eng chhan pawh nise, doctor rawn hmasa lovin he damdawi hi ei nghal vat suh. Chutianga tih chuan natna lan chhuahna duhawm lo tak tak a thlen thei a ni.
- Damdawi dang i ei zawng zawng te, zu i in a nih leh nih loh te, naupai i nih chuan i doctor hriattir a pawimawh hle.
- I damdawi ei chungchangah zawhna, ngaihtuahna, rinhlelhna i neih chuan i doctor nen zalen takin sawipui rawh. Amah hi i advisor tha ber leh rintlak ber a ni.
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