Ngaihtuah teh, i taksaa cell tin hian nangmah DNA an nei vek niin kan ngai vek a ni lawm ni? Chu chu genetics chungchanga kan hriat bulpui ber chu a ni. Mahse, a tlem hle a, mi taksaah hian DNA chi hnihna nei cell a nei thei a, chu chu anmahni ta ni lo, chu chu a danglam vek a ni. A mak deuhin a ri a ni lawm ni? Damdawi lamah chuan he dinhmun mak tak hi ‘Chimerism’ kan ti thin. Lungngai suh, natna a ni lo. Eng nge a nih tak tak i en ang u.
‘Chimerism’ chu eng nge ni?
A awlsam zawngin, chimerism chu mi pakhat taksa chhunga cell set hnih awm, genetically different individual pahnih atanga lo chhuak a ni. Chumi awmzia chu i taksaa cell thenkhat chuan DNA chi khat an nei thei a, cell thenkhat erawh chuan DNA chi danglam tak an nei thei tihna a ni.
Hei hi a thlen theih dan ber pakhat chu twin births te hi a ni. Nu pakhatin a pum chhungah fapa mal a keng tih han mitthla teh. Naupai kar hmasa lamah chuan embryo pakhat chu a lo thanglian thei lo va, eng emaw chhan vangin a bo thei bawk. Hei hi Vanishing Twin Syndrome an ti a. Chutiang a nih chuan embryo bo atanga cell lo chhuak chu embryo dang hrisel taka lo thanglian mek chuan a la lut ta a ni. Chuvangin, naute hian a dam chhung zawngin a cell leh unau bo atanga cell te chu a nei vek ang.
Hetianga cell inzawmkhawm chi hrang hrangte hi a inang lo hle. A tam zawkah chuan he danglamna hi thisenah hmuh tur a awm. ‘Blood chimerism’ an ti a. Hei hi a chhan chu bone marrow-a thisen cell lo awmte hi an chak a, awlsam takin placenta kaltlangin an kal thei a ni. Research atanga a lan dan chuan twins pangngai zinga 8% vel chuan he natna hi an nei thei a ni. Triplet zingah hian he probability hi 21%-ah a pung a ni.
Chimerism awm chhante chu engte nge ni?
Kan sawi tawh ang khan mi thenkhat chu he natna hi neiin an piang chhuak thin. Mahse, mi pakhatin a dam chhungin chimerism a nei thei a ni. Hei hi chhan lian tak pahnih a awm a. A hnuaia mi ang hian han then darh ila.
| Chhan | A thlen dan sawifiahna |
|---|---|
| Congenital Chimerism tih a ni | Hei hi a hmaa kan sawi tawh ‘Vanishing Twin Syndrome’ kha a ni. Embryo pakhat chu nausen pum chhungah a bo a, a cell te chu embryo dangin a hip lut a, chu chuan dam chhung zawng taksaah cell chi hnih a awm reng a ni. |
| Chimerism (Chimerism) a nei a | Hei hi nunna chhanhim thei damdawi anga tih a ni. Entîr nân, taksa peng hrang hrang thlak (organ transplant) hi han ngaihtuah teh . Miin mi hrisel dang atanga kal a dawn chuan kal thar chuan a petu DNA nen hna a thawk a ni. Chumi hnuah chuan a dawngtu chuan anmahni DNA leh a petu DNA an nei vek a ni. Chutiang bawkin bone marrow transplant pawh hi a ni . Hetiang a nih chuan donor hrisel tak ruhro (bone marrow) chu natna vei ruhro aiah a thlak a ni. Tichuan thisen cell thar zawng zawng chu a petu DNA atang hian siam vek a ni. Hei hian mi thisen chi pawh a tidanglam thei a ni. |
Hei hi chhinchhiahna a awm em?
Thu lawmawm tak chu chimerism vei tam zawk hian symptom an nei lo. Mi tam tak chuan an dam chhung zawngin he natna hi an nei tih hre lovin an kal thin. Test bik a awm loh avangin diagnosis hmuh a harsa hle.
Mahse, a chang chuan hei hian ngaihtuah phak loh harsatna a thlen thei a, a bik takin DNA test-naah chuan.
Ngaihtuah teh, pa pakhatin DNA test a neih chuan naupang pa a nih leh nih loh finfiah a ni. Mahse a rah chhuah chu naupang pa a ni lo tih a lo chhuak ta a ni. A fa ngei a ni tih hi 100% in a ring tlat a ni. Heta thil thleng thei chu pa hian chimerism a vei a nih chuan DNA chu a thisen emaw, a hmui emaw-ah ni lovin, a reproductive cells (sperm)-ah a awm zawk a ni. Nau pum chhunga bo tawh unaupa DNA a ni. Tichuan genetically chuan naupang chu a unaupa pakhat, chu chu a farnu emaw, a farnu emaw fa ang maiin a inzawm tlat a ni.
Nu chungah pawh hetiang thil hi a thleng thei bawk. Chuvangin, a tam zawkah chuan hetiang DNA test-naah hian random mismatch avanga chimerism hi hmuhchhuah a ni.
Hetiang dinhmun hian harsatna lian tak a thlen thei em?
Chimerism hi natna leh hlauhawm tak a ni lo va, i hriat loh chuan harsatna engemaw zat a thlen thei a ni.
- Dan lama harsatna: A hmaa kan sawi tawh ang khan paternity test result dik lo chuan naupang enkawlna chungchangah dan lama harsatna lian tak a thlen thei a ni. Khawvel hmun hrang hrangah hetiang thil thleng hi eng emaw zat report a awm tawh a ni.
- Rilru lama harsatna nei:Mi thenkhat chuan midang taksa peng an neih thu an hriat chuan psychological shock leh identity issues tlem an nei thei.
- Medical significance: Organ transplant hmaa tissue matching neih laiin he dinhmun hi hriat a pawimawh mai thei.
Mahse nute hian ‘vanishing twin syndrome’ hi an ngaihtuah a ngai lo. Naupai thla thum hmasa berah a lo thleng a nih chuan nu emaw, naute hrisel emaw a tichhe lovang. Nu chuan thisen chhuah tlem tih loh chu symptom dang a hmu lo mai thei.
Take-Home Thuchah a ni
- Chimerism chu thil nung pakhata DNA chi hnih awm hi a ni. Hei hi nausen pum chhunga twin atanga cell te lakluh emaw, organ/bone marrow transplant hmanga emaw a thleng fo thin.
- Hei hi dinhmun hlauhawm tak a ni lo. Chimerism vei tam zawk chuan symptom an nei lo.
- Buaina ber chu DNA test-ah a lo chhuak a, a bik takin paternity test ang chi thilah a awm a, chutah chuan result a inmil lo thei a ni.
- DNA test result-a sawifiah theih loh harsatna i neih chuan chimerism awm theih dan tur chu i doctor nen sawiho rawh.
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