Zonse zokhudza mayeso a ACTH Stimulation Test, omwe amayesa mahomoni a thupi lanu!

Nthawi zina zinthu zina m'thupi lathu zikapanda kugwira ntchito bwino, tingakhale ndi mavuto osiyanasiyana azaumoyo, sichoncho? Makamaka ngati pali kusalinganika kwa mahomoni m'thupi lathu, kungayambitse mavuto aakulu. Pankhaniyi, dokotala wanu angakulangizeni kuti muyesedwe mwapadera. Imeneyo ndi `ACTH Stimulation Test`. Tiyeni tikambirane izi mosavuta.

Kodi mayeso a ACTH (ACTH Stimulation Test) ndi chiyani?

Mwachidule, iyi ndi mayeso apadera omwe amaona momwe ma adrenal glands m'thupi lathu amayankhira ku mahomoni otchedwa ACTH. Nthawi zina izi zimatchedwanso Cosyntropin Stimulation Test (CST). Iyi ndi mayeso akuluakulu oti mudziwe ngati pali vuto lotchedwa adrenal insufficiency, lomwe ndi kuchepa kwa ntchito ya ma adrenal glands. Izi zitha kukhala zoyambirira, zachiwiri kapena zachitatu.

Kuyezetsa kumeneku kumaphatikizapo kubaya hormone ya ACTH yopangidwa (Synthetic ACTH - Cosyntropin) mu minofu yanu. Kenako, theka lililonse la ola kapena kuposerapo, magazi anu amatengedwa ndipo kuchuluka kwa hormone yotchedwa cortisol kumayesedwa. Izi ndikuwona momwe adrenal glands yanu ikugwira ntchito.

Kodi ACTH ndi Cortisol ndi chiyani?

`ACTH`, yomwe imatanthauza `Adrenocorticotropic Hormone`, ndi mahomoni opangidwa ndi `Pituitary Gland` muubongo mwathu. Amakhudza kwambiri momwe thupi lathu limayankhira kupsinjika. `ACTH` ikatulutsidwa, imalimbikitsa ma adrenal glands kuti apange `Cortisol`, yomwe imadziwikanso kuti `stress hormone` . Cortisol ndi mahomoni ofunikira omwe amakhudza pafupifupi chiwalo chilichonse ndi minofu m'thupi mwathu.

Mitundu ya Kulephera kwa Adrenal

Izi zitha kuchitika m'njira zitatu zazikulu:

1. Kulephera Kwambiri kwa Adrenal: Izi zimachitika pamene adrenal glands yanu yawonongeka ndipo simungathe kupanga cortisol bwino. Chifukwa chachikulu cha izi ndi matenda a Addison. Ndi matenda odziyimira pawokha.

2. Kulephera kwa Adrenal kwachiwiri: Izi zimachitika pamene pituitary gland yanu siimapanga ACTH yokwanira. Kenako adrenal glands sakukakamizidwa mokwanira kuti apange cortisol.

3. Kulephera kwa Adrenal: Izi zimachitika pamene hypothalamus muubongo siipanga hormone ya `CRH (Corticotropin-Releasing Hormone)` moyenera. `CRH` ndi yomwe imauza pituitary gland kuti ipange `ACTH`.

Kodi mayeso a ACTH amafunika liti?

Kuyezetsa kumeneku kungathandize kudziwa ngati ma adrenal glands ndi pituitary gland anu akugwira ntchito bwino popanga cortisol. Dokotala wanu akhoza kuyitanitsa mayesowa pazifukwa zotsatirazi:

• Ngati mayeso ena apeza kuti kuchuluka kwa cortisol m'magazi anu ndi kochepa.
• Ngati muli ndi zizindikiro za kulephera kwa adrenal (monga kutopa pafupipafupi, kuchepa thupi, kupweteka m'mimba, nseru, chizungulire, khungu lakuda ).
• Mukasiya kugwiritsa ntchito mankhwala a glucocorticoid, monga prednisone, kwa kanthawi, yang'anani ngati pituitary ndi adrenal glands anu abwerera mwakale.

Ndani akuchita mayeso awa?

Kawirikawiri, jakisoni wa ACTH amaperekedwa ndi namwino. Kutengedwa kwa magazi, ndiko kuti, chitsanzo cha magazi, kumachitika ndi katswiri wa matenda a phlebotomist, ndiko kuti, munthu amene waphunzitsidwa mwapadera pa cholingachi. Kenako zitsanzo zimenezi zimatumizidwa ku labu. Kumeneko, wasayansi wa ku labotale ya zamankhwala amayesa zitsanzo zimenezi.

Mayeso amenewa nthawi zambiri amachitikira kuchipatala kapena ku ofesi ya dokotala wa matenda a endocrinologist, dokotala amene amagwira ntchito zachipatala zokhudzana ndi matenda okhudzana ndi mahomoni. Izi zimaphatikizapo kubaya jakisoni wa mankhwala ndi kutenga magazi. Dokotala wa matenda a endocrinologist ndi dokotala amene amagwira ntchito zachipatala zokhudzana ndi matenda okhudzana ndi mahomoni.

Kodi ndikufunika kukonzekera chilichonse ndisanachite mayeso?

Inde, pali zinthu zina.

• Mungapemphedwe kuti muchepetse zochita zanu ndikudya zakudya zokhala ndi chakudya chambiri maola 12-24 mayeso asanachitike.
• Munganenenso kuti mudzasala kudya kwa maola pafupifupi asanu ndi limodzi. Izi zikutanthauza kuti simungadye kapena kumwa chilichonse kupatula madzi.
• Ngati mukumwa mankhwala ena omwe angakhudze mayeso a cortisol, mungapemphedwe kuti musiye kumwa mankhwalawo kwakanthawi.
• Popeza kuchuluka kwa cortisol kumasiyana tsiku lonse (komwe kumakhala kwakukulu kwambiri m'mawa), mayesowa ndi bwino kuchitidwa m'mawa kuti achepetse chiopsezo cha zotsatira zabodza.

Komabe, dokotala wanu adzakupatsani malangizo enieni a momwe mungakonzekerere mayesowa. Muyenera kutsatira malangizo amenewo molondola.

Kodi mayeso a ACTH amachitidwa bwanji?

Izi ndi njira zoyambira:

1. Choyamba, magazi amatengedwa kuchokera mumtsempha womwe uli m'dzanja lanu. Izi ziwunika kuchuluka kwa cortisol m'magazi anu. Mayeso ena angachitikenso.

2. Kenako, namwino adzalowetsa hormone yopangidwa yotchedwa `ACTH (Cosyntropin)` mu minofu yanu. `ACTH` yopangidwayi imagwira ntchito ngati `ACTH` yomwe thupi lathu limapanga, zomwe zimapangitsa kuti adrenal glands ipange cortisol.

3. Kenako, patatha mphindi 30 ndi mphindi 60 (nthawi zambiri), magazi amatengedwanso kuchokera m'mitsempha yanu ndipo milingo ya cortisol imayesedwa.

4. Zitsanzo za magazi izi zimatumizidwa ku labotale.

Kodi mumapeza chidziwitso chotani panthawi ya mayeso?

Nazi zinthu zina zomwe mungayembekezere mukatenga magazi anu:

• Mudzakhala pampando ndipo mtsempha wosavuta m'dzanja lanu udzapezeka. Nthawi zambiri, udzakhala mkati mwa mkono wanu, kumbuyo kwa chigongono chanu.
• Mtsempha ukapezeka, malowo amayeretsedwa ndi kutsukidwa ndi mankhwala ophera tizilombo.
• Kenako singano yaying'ono imalowetsedwa mu mtsempha ndipo magazi amatengedwa. Izi zingamveke ngati kubayidwa pang'ono.
• Mukayika singano, magazi pang'ono adzasonkhana mu chubu choyesera.
• Magazi okwanira atasonkhanitsidwa kuti ayezedwe, singano imachotsedwa ndipo chidutswa cha thonje kapena gauze chimayikidwa pamalopo ndikukanikizidwa kuti magazi asiye kutuluka.
• Kenako pulasitala imayikidwa pamalopo.

Mukalandira Cosyntropin, nthawi zambiri imabayidwa m'dzanja lanu lapamwamba, pamwamba pa phewa lanu. Mungamve kupweteka pang'ono kapena kutentha mukalandira jakisoni, koma ndi kwakanthawi.

Kodi chimachitika ndi chiyani pambuyo pa mayeso?

Magazi akatengedwa, amatumizidwa ku labu. Zotsatira zake zikaperekedwa, dokotala wanu adzakuuzani za magaziwo.

Kodi pali zoopsa zilizonse ndi mayesowa?

Kuyezetsa magazi ndi chinthu chofala kwambiri mu zamankhwala. Zoopsa zake n'zochepa kwambiri. Mungamve ngati muli ndi mabala kapena ululu pamalo pomwe magaziwo adatengedwa, koma zimenezo zimatha msanga. Palibe chodetsa nkhawa.

Zimatenga nthawi yayitali bwanji kuti mudziwe zotsatira zake?

Zingatenge mpaka sabata imodzi kuti zotsatira za mayeso a ACTH zibwerere, chifukwa zotsatira za labu zikabweranso, dokotala ayenera kuzifufuza mosamala ndikupeza yankho.

Kodi zotsatira zake ndi zotani?

Malipoti oyesa magazi, kuphatikizapo malipoti a cortisol ochokera ku mayeso a ACTH, nthawi zambiri amakhala ndi chidziwitso chonga ichi:

• Dzina la mayeso a magazi, kapena zomwe zinayesedwa m'magazi.
• Chiwerengero kapena muyeso wa zotsatira za mayeso anu a magazi.
• Umenewo ndiye muyeso wabwinobwino wa mayeso.
• Chidziwitso chokhudza ngati zotsatira zanu ndi zabwinobwino, zachilendo, zapamwamba, kapena zochepa.

Kodi zotsatira zapakati ziyenera kukhala zotani?

Muzochitika zabwinobwino, kuchuluka kwa cortisol m'magazi anu kuyenera kukwera mukamaliza kusonkhezera ACTH. Zotsatira zake zabwinobwino, kuchuluka kwa cortisol m'magazi anu kuyenera kupitirira 12.6 mcg/dL (ma microgram pa deciliter) mukamaliza kusonkhezera ACTH.

Kumbukirani, mitundu yanthawi zonse iyi imatha kusiyana kuchokera ku labu kupita ku labu, mayeso kupita ku mayeso, komanso munthu ndi munthu. Nthawi zonse yang'anani mitundu yanthawi zonse yomwe yaperekedwa pa lipoti lanu.

Pankhani ya mayeso a ACTH, dokotala wanu kapena katswiri wa matenda a endocrinologist ayenera kumvetsetsa bwino zotsatira zake musanazione. Ngati muli ndi mafunso okhudza zotsatira zake, onetsetsani kuti mwafunsa dokotala wanu.

Kodi zotsatira zosazolowereka zikutanthauza chiyani?

Dokotala wanu kapena katswiri wa matenda a endocrinologist adzafufuza mosamala zotsatira za mayeso anu a ACTH. Pali zinthu zambiri zomwe zingakhudze kulondola kwa mayesowo. Chifukwa chofala kwambiri cha zotsatira zabodza ndi kugwiritsa ntchito mankhwala a corticosteroid posachedwapa.

Zotsatira za mayeso a ACTH zosazolowereka nthawi zambiri zimasonyeza kusakwanira kwa adrenal koyambirira ndi kwachiwiri.

Kulephera Kwambiri kwa Adrenal

Ngati muli ndi vutoli, ma adrenal glands anu sangathe kupanga cortisol kapena sayankha bwino ku ACTH. Chifukwa chake, simungaone kuwonjezeka kwakukulu kapena kuwonjezeka kulikonse kwa milingo ya cortisol yanu mutayesa ACTH. Izi zili choncho chifukwa ACTH yopangidwayo sikhudza ma adrenal glands anu.

Kulephera kwa Adrenal kwachiwiri

Ngati pituitary gland sigwira ntchito mokwanira kwa nthawi yayitali (hypopituitarism), ndipo kupanga kwa ACTH kukuchepa, izi zimapangitsa kuti adrenal insufficiency yachiwiri isagwire ntchito. Zotsatira zake, maselo omwe nthawi zambiri amapanga ACTH sakukhudzidwa, ndipo adrenal glands imayamba kufooka, kutanthauza kuti, imayamba kufooka .

Chifukwa chake, ngati mwakhala ndi hypopituitarism komanso adrenal insufficiency kwa nthawi yayitali, simungaone kuwonjezeka kwakukulu kwa cortisol yanu mutatha mayeso a ACTH.

Komabe, ngati hypopituitarism ndi yochepa (kutanthauza kuti pituitary gland ikupangabe ACTH), kapena ngati vutoli langoyamba kumene, kuwonjezeka kwa cortisol, kutanthauza kuti mulingo "wabwinobwino", kungawonekere pambuyo pa mayeso a ACTH.

Uthenga Womaliza Wopita Nawo Kunyumba

Mayeso a ACTH Stimulation Test ndi mayeso ofunikira komanso odalirika kwambiri pozindikira kusakwanira kwa adrenal. Kuyembekezera zotsatira za mayeso ozindikira kungakhale kovuta pang'ono. Koma kumbukirani, mosasamala kanthu za zotsatira zake, gulu lanu lachipatala lilipo kuti likuthandizeni. Musaope kufunsa dokotala wanu za mayeso anu kapena zotsatira zake. Ndikofunikira kudziwa za thanzi lanu.

Kuyesa kwa ACTH , cortisol, adrenal glands, pituitary gland, mahomoni, adrenal insufficiency, mayeso azachipatala