Tonsefe timamva chizungulire kapena kutopa nthawi ina tikadzuka pampando kapena pabedi. Nthawi zambiri, zimatha pakangopita masekondi ochepa. Koma ngati izi zikukuchitikirani kawirikawiri, kapena ngati mukumva ngati mukugwa ndikugwa, sizingakhale zachilendo. Lero tikambirana za vuto losowa lomwe limayambitsa zizindikirozi. Ndiko kulephera kwa Pure Autonomic, kapena PAF mwachidule.
Mwachidule, kodi Pure Autonomic Failure (PAF) ndi chiyani?
Taganizirani izi, pali njira zambiri m'thupi lathu zomwe zimachitika zokha popanda kulamulira kwathu. Mwachitsanzo, kupuma, kugunda kwa mtima, kugaya chakudya, kulamulira kutentha kwa thupi, ndi kulamulira kuthamanga kwa magazi. Zonsezi zimayendetsedwa ndi Autonomic Nervous System yathu. Zili ngati 'auto-pilot' system m'thupi lathu.
Kulephera Kodziletsa Kokha (PAF) ndi vuto la mitsempha lomwe limayamba pang'onopang'ono kufooketsa ntchito ya dongosolo la mitsempha lodzilamulira pakapita nthawi. Chinthu chachikulu chomwe chimachitika pankhaniyi ndichakuti mukayimirira mwadzidzidzi kuchokera pamalo omwe mumakhala kapena mukugona, kuthamanga kwa magazi kumatsika kwambiri . M'mawu azachipatala, timatcha izi kuti orthostatic hypotension . Koma si vuto lokhalo, PAF ingayambitse mavuto ena ambiri.
Matendawa nthawi zambiri amapezeka mwa akuluakulu azaka zapakati pa 40 ndi 60. Kale, matendawa ankatchedwanso Bradbury-Eggleston syndrome.
Kodi zizindikiro za matenda a PAF ndi ziti?
Monga tafotokozera kale, chizindikiro chodziwika bwino komanso chachikulu ndi chizungulire komanso kukomoka mukayimirira (orthostatic hypotension). Komabe, popeza dongosolo la mitsempha lodziyimira lokha limalamulira ziwalo zambiri m'thupi lathu, zizindikiro sizimangokhala chimodzi chokha.
Chofunika kwambiri ndichakuti zizindikirozi sizichitika mofanana kapena motsatizana kwa aliyense. Anthu ena angakumane ndi zizindikiro zina asanamve chizungulire akaimirira.
Tiyeni tiwone zizindikiro zina zomwe zingayambitsidwe ndi PAF.
| Dongosolo/njira yokhudzidwa | Zizindikiro zomwe zingatheke |
|---|---|
| Thukuta la thupi | Kawirikawiri thukuta limachepa (anhidrosis) kapena nthawi zina thukuta lopitirira muyeso (hyperhidrosis). |
| Maso | Kusawona bwino chifukwa cha ana osakwanira kukula. |
| Dongosolo la mkodzo | Kuvuta kutulutsa madzi m'chikhodzodzo chonse (kusunga mkodzo) kapena kulephera kulamulira kukodza (kusadziletsa kwa mkodzo). |
| Dongosolo la m'mimba | Kudzimbidwa kapena kusadziletsa kwa ndowe. |
| Zochita zogonana | Mavuto monga kulephera kugwira ntchito kwa erectile kapena anorgasmia. |
Kuphatikiza apo, pafupifupi theka la anthu omwe ali ndi PAF amathanso kukhala ndi vuto la kuchepa kwa magazi m'thupi.
Kodi chifukwa cha kupangidwa kwa PAF n'chiyani?
Chifukwa chachikulu cha izi chadziwika kuti ndi kuchulukana kosazolowereka kwa puloteni yotchedwa alpha-synuclein m'maselo athu amitsempha. Monga dothi lomwe limatseka chitoliro, puloteni iyi ikasonkhana m'maselo amitsempha, ntchito yawo imachepa.
Puloteni iyi imayikidwa m'mitsempha ya mitsempha (autonomic ganglia) mbali zonse za msana kapena pafupi ndi ziwalo. Pakapita nthawi, chiwerengero cha maselo a mitsempha awa chimachepa, ndipo ntchito ya dongosolo lodziyimira palokha imasokonekera. Koma chofunika kwambiri ndichakuti mu PAF, ubongo kapena msana sizimawonongeka . Chifukwa chake, sizimakhudza zinthu monga kukumbukira ndi luso loganiza.
Ofufuza akadalibe lingaliro lomveka bwino chifukwa chake puloteni iyi imayikidwa motere.
Ubale ndi matenda ena
Nayi mfundo yofunika kudziwa. Puloteni yomweyi, alpha-synuclein, ndi yomwe imadziunjikira muubongo m'matenda monga matenda a Parkinson, Multiple System Atrophy, ndi Lewy Body Dementia. Chifukwa chake, anthu ena omwe ali ndi PAF (osati onse) ali ndi mwayi wokhala ndi limodzi mwa matenda amenewa pakapita nthawi. Dokotala wanu adzakudziwitsani za izi.
Kodi mungazindikire bwanji matendawa?
Kuzindikira matenda a PAF ndi njira yovuta, chifukwa madokotala amachotsa kaye matenda ena omwe angayambitse zizindikiro zanu, makamaka kuchepa kwa kuthamanga kwa magazi mukayimirira.
Njira yodziwira matenda ingaphatikizepo:
- Kufunsa mafunso mosamala okhudza zizindikiro zanu ndi mbiri yanu yachipatala.
- Kuwunika thupi lonse ndi kuunika ubongo.
Pambuyo pake, mayeso angapo apadera angalimbikitsidwe kuti atsimikizire matendawa.
| Mayeso | Ingochitani izi... |
|---|---|
| Mayeso a Tebulo Lopendekeka | Mudzaikidwa pabedi lapadera kenako mwadzidzidzi mudzasunthidwa kuti muyime. Kuthamanga kwa magazi ndi kugunda kwa mtima wanu zidzayang'aniridwa. |
| Kuyesa thukuta (QSART) | Izi zikuyang'ana momwe mitsempha yomwe imalamulira thukuta imagwirira ntchito. Izi zimathandiza kuzindikira mavuto omwe ali ndi dongosolo la mitsempha lodziyimira palokha. |
| Mayeso ojambula zithunzi (monga MRI) | Zinthu monga MRI scan ya ubongo zimachitika kuti zitsimikizire kuti palibe matenda ena omwe angayambitse zizindikirozo. |
| Mayeso a Laboratory (Magazi ndi Mkodzo) | Kuchuluka kwa mankhwala otchedwa norepinephrine m'magazi ndi mkodzo kumayesedwa akagona pansi komanso akaimirira. Mu PAF, pakhoza kukhala kusintha kwapadera pa kuchuluka kumeneku. |
Zingakhale zovuta kwambiri kukhala ndi mayeso ambiri, koma pokhapokha ngati titazindikira matendawa molondola ndi pomwe tingapange njira yabwino kwambiri yothandizira.
Kodi mankhwala a PAF ndi otani?
Palibe mankhwala a izi pakadali pano. Koma musadandaule. Pali zinthu zambiri zomwe mungachite kuti muchepetse zizindikiro zanu ndikukhala moyo wabwinobwino. Dokotala wanu ndi gulu lachipatala adzagwira nanu ntchito kuti apange dongosolo la chithandizo lomwe likukhudzana ndi inu.
Kuchepetsa kuthamanga kwa magazi (kutsika kwa magazi mukamaimirira)
Vuto lalikulu ndi ili. Pali mankhwala osagwiritsa ntchito mankhwala komanso mankhwala ena.
- Samalani mukasintha malo: Mukadzuka kuchokera pamene mwagona kapena mutakhala, chitani pang'onopang'ono kwambiri . Musadzuke mwadzidzidzi.
- Madzi ndi mchere: Dokotala wanu angakulangizeni kumwa malita atatu a madzi patsiku. Angakuuzeninso kuti muwonjezere mchere pang'ono pa chakudya chanu.
- Kukonzekera bedi: Gonani mutu wa bedi uli pamwamba pafupifupi mainchesi 4-6. Mwanjira imeneyi, simudzamva kusiyana kwakukulu pa kuthamanga kwa magazi mukadzuka.
- Zovala Zothina: Kuvala masokisi apadera omangika (zovala zothina) zomwe zimafika m'chiuno kapena m'ntchafu zimathandiza kuchepetsa kusonkhana kwa magazi m'miyendo ndikusunga kuthamanga kwa magazi kukhala kokhazikika.
- Kuwonjezera pa izi, dokotalayo amalimbikitsanso mankhwala enaake omwe amawonjezera kuthamanga kwa magazi.
Mavuto okhudzana ndi kutsekula m'mimba komanso kukodza
- Pa kudzimbidwa: Mutha kudya zakudya zokhala ndi ulusi wambiri (masamba, zipatso, mpunga wa chimanga) ndikugwiritsa ntchito zofewetsa ndowe.
- Pa mavuto a mkodzo: Ngati mukuvutika kukodza, mungafunike kugwiritsa ntchito catheter. Ngati simungathe kulamulira mkodzo wanu, pali mankhwala apadera (monga Oxybutynin, Mirabegron).
Chiwerewere
Ngakhale pali mankhwala monga sildenafil kapena tadalafil a izi, mankhwalawa amatha kuwonjezera chiopsezo cha hypotension ya orthostatic. Chifukwa chake, muyenera kukambirana izi momasuka ndi dokotala wanu ndipo muzigwiritsa ntchito pokhapokha ngati akulangizidwa.
Kodi n’chiyani chidzachitikire munthu amene ali ndi matendawa mtsogolomu?
N'zovuta kupereka yankho limodzi lokha lokhudza tsogolo la munthu amene ali ndi matendawa, chifukwa amasiyana malinga ndi munthu.
PAF ndi matenda omwe amapitirira. Koma kwa anthu ambiri, zimachitika pang'onopang'ono, kwa zaka zambiri, ngakhale zaka makumi ambiri. Kafukufuku wina wasonyeza kuti nthawi yapakati yokhala ndi moyo pambuyo pozindikira kuti ali ndi PAF ndi pafupifupi zaka 12.5. Koma iyi ndi nthawi yapakati, ndipo imatha kusiyana kwambiri kutengera zizindikiro zanu ndi thanzi lanu. Choncho musamangoganizira kwambiri za ziwerengero zimenezo.
Ngati muli ndi PAF, ndikofunikira kukaonana ndi dokotala nthawi zonse kuti muwonetsetse kuti chithandizo chanu chikuyenda bwino komanso momwe matenda anu akupitira patsogolo. Ngati mukupeza zizindikiro za matenda a Parkinson (monga kunjenjemera, kuvutika kuyenda), muyenera kuuza dokotala wanu nthawi yomweyo.
Uthenga Wopita Nawo Kunyumba
- Kulephera Kodziyimira Payekha (PAF) ndi matenda osowa omwe amakhudza dongosolo la mitsempha lomwe limayendetsa machitidwe odziyimira pawokha m'thupi lathu.
- Chizindikiro chachikulu ndi chizungulire komanso kukomoka mukadzuka kuchokera pamene mutakhala kapena kugona chifukwa cha kuchepa kwa kuthamanga kwa magazi.
- Ngakhale kuti matendawa sangachiritsidwe kwathunthu, zizindikiro zake zimatha kulamulidwa bwino ndipo moyo wabwino ukhoza kusungidwa.
- Palibe njira yopewera izi, ndipo si vuto lanu kuti zachitika.
- Ndikofunikira kwambiri kulankhulana ndi dokotala nthawi zonse ndikutsatira ndondomeko yanu ya chithandizo molondola. Musaope kulankhula momasuka za mafunso ndi nkhawa zanu.
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