Kodi munayamba mwakhala ndi bala laling'ono, ndipo linauma m'masiku ochepa, ndipo linachira bwino ngati kuti palibe chomwe chachitika? Muyenera kuti munatero, sichoncho? Panthawiyo, timangoganiza kuti balalo lachira. Koma sitiganizirapo za zinthu zodabwitsa zomwe zimachitika m'thupi lathu kuti lichiritse bala limenelo. Lero, tikambirana za njira yachilendo yomwe imachitika nthawi zonse m'thupi lathu, yomwe ndi yofunika kwambiri kuti tipulumuke, ndipo nthawi zina imatipangitsa kuseka. Timatcha izi angiogenesis.
Mwachidule, kodi angiogenesis ndi chiyani?
Zosavuta kwambiri. Angiogenesis ndi njira yogwiritsira ntchito mitsempha yamagazi yomwe ili kale m'thupi lathu popanga mitsempha yatsopano yamagazi (capillaries). Izi zimayamba tisanabadwe, m'mimba mwa amayi athu, ndipo zimapitirira kwa nthawi yonse yomwe tili ndi moyo.
Tsopano mwina mukudabwa kuti mitsempha yaing'ono yamagazi iyi, yotchedwa capillaries, imagwira ntchito yanji. Ndipotu, mitsempha yaing'ono yamagazi iyi imagwira ntchito yofunika kwambiri m'thupi lathu. Imagwira ntchito ngati 'ntchito yotumizira' yomwe imanyamula magazi, zakudya, ndi mpweya womwe ziwalo ndi minofu yathu zimafunikira.
Tangoganizani kuti kwinakwake m'thupi lathu, minofu sikupeza mpweya wokwanira. Tikutcha vutoli hypoxia. Pamene mpweya wochepa, maselo omwe ali m'derali amanjenjemera ndikuyamba kutulutsa zizindikiro za mankhwala akunena kuti, "Tithandizeni! Palibe mpweya wokwanira pano!" Zili ngati kutumiza uthenga wa 'SOS'. Uthenga wa 'SOS' uwu ukangolandiridwa, maselo omwe amapanga khoma lamkati la mitsempha yathu yamagazi, otchedwa maselo a endothelial, amayamba kugwira ntchito ndikuyamba kupanga mitsempha yatsopano yamagazi. Ichi ndi chiyambi cha njira ya angiogenesis.
Kodi mitsempha yatsopano yamagazi iyi imapangidwira bwanji? Pali njira ziwiri zazikulu!
Thupi lathu limagwiritsa ntchito njira ziwiri zazikulu zopangira mitsempha yatsopano yamagazi. Tiyeni tiwone tsatanetsatane uwu kuti timvetse kusiyana pakati pa ziwirizi.
| Dzina la njira | Momwe zimachitikira | Mwachidule... |
|---|---|---|
| Kumera kwa Angiogenesis | Mphukira yatsopano imamera kuchokera mu mtsempha wamagazi womwe ulipo. Mphukira iyi imakula pang'onopang'ono kupita ku chizindikiro cha mankhwala (monga mankhwala otchedwa VEGF) ochokera kudera lopanda mpweya. Pamapeto pake, imakhala mtsempha watsopano wamagazi. | Zili ngati nthambi yatsopano yomwe yatuluka pamtengo. Yatsopano imatuluka pa yakale ndikukula. |
| Angiogenesis ya Intussusceptive | Mphukira zatsopano sizimamera apa. M'malo mwake, mtsempha umodzi wamagazi umagawanika pakati, n’kukhala mitsempha iwiri yamagazi. Maselo a endothelial amabwera mkati mwa mtsempha wamagazi ndikupanga mizere, n’kuugawa pawiri. | Zili ngati kumanga misewu iwiri poika ngalande pakati pa msewu. Msewu wokhawo womwe ulipo umagawidwa m'magawo awiri. |
Kodi izi ndi zofanana ndi Vasculogenesis?
Ayi. Ngakhale kuti mawu awiriwa angamveke ofanana, pali kusiyana kochepa koma kofunikira. Onsewa akuphatikizapo kupangidwa kwa mitsempha yatsopano yamagazi. Koma kusiyana kuli mu mtundu wa maselo omwe amayambitsa mitsemphayi.
- Angiogenesis: Apa ndi pomwe mitsempha yatsopano yamagazi imapangidwira kuchokera ku mitsempha yamagazi yomwe ilipo kale, yokhwima mokwanira.
- Kuchuluka kwa magazi m'mitsempha: Apa ndi pomwe mitsempha yatsopano yamagazi imapangidwa kuchokera ku mtundu wapadera wa selo lotchedwa angioblast. Awa ndi maselo osakhwima omwe sanakule mokwanira kukhala maselo omwe ali m'makoma a mitsempha yamagazi.
Mwachidule, angiogenesis ili ngati kumanga chipinda chatsopano m'nyumba yakale. Vasculogenesis ili ngati kumanga nyumba kuyambira pachiyambi ndi maziko atsopano ndi njerwa zatsopano.
Kotero, kodi angiogenesis iyi ndi chinthu chabwino kapena choipa?
Uwu ndi lupanga lakuthwa konsekonse. Kaya uwu ndi wabwino kapena woipa zimadalira amene akudyetsedwa ndi mitsempha yatsopano ya magazi.
Kodi angiogenesis imayenda bwanji bwino?
Mu thupi lathanzi, njirayi ndi yofunika kwambiri kuti tipulumuke.
- Mabala amachira: Mukadula dzanja lanu, mitsempha yatsopano yamagazi imapangidwa mozungulira balalo, ndikulipatsa mpweya ndi michere yomwe imafunika. Ichi ndichifukwa chake mabala amachira mwachangu.
- Pa nthawi ya mimba: Mwana amene akukula m'mimba mwa mayi amalandira zakudya zonse ndi mpweya womwe amafunikira kudzera mu placenta. placenta iyi imafuna mitsempha yatsopano yamagazi kuti igwire ntchito bwino.
- Pa nthawi yochita masewera olimbitsa thupi: Tikamachita masewera olimbitsa thupi, minofu yathu imafunikira mpweya wambiri. Izi zimathandiza kukwaniritsa zosowazo.
- Panthawi ya msambo mwa akazi: Izi ndizofunikiranso kuti makoma a chiberekero amangenso.
Nthawi zina ngati izi, angiogenesis imakhala ngati ngwazi yomwe imathandiza kupulumutsa miyoyo yathu ndikutisunga athanzi.
Mbali yamdima ya njirayi - momwe mungathandizire khansa
Njira imeneyi yokha ingakhalenso mdani wathu. Izi zikutanthauza kuti, ikathandiza maselo a khansa kukula.
Tonsefe tikudziwa kuti khansa ndi pamene maselo m'thupi mwathu amayamba kugawikana mosalamulirika, ngati misala. Maselo ogawikanawa amasonkhana pamodzi kuti apange zotupa. Monga minofu ina yonse m'thupi mwathu, zotupazi zimafunikira chakudya, madzi, ndi magazi kuti zikhale ndi moyo, zikule, ndikufalikira m'thupi lonse.
Zimene zikuchitika apa ndi zanzeru kwambiri. Maselo a khansa, monga minofu yathanzi, amayamba kutulutsa zizindikiro za 'SOS' (monga VEGF). Zizindikirozi zimati, "Sitikupeza magazi okwanira, tumizani mitsempha yatsopano yamagazi kuno mwachangu!"
Tikalandira chizindikiro ichi, njira ya angiogenesis ya thupi lathu imayamba ndipo imayamba kukulitsa mitsempha yatsopano yamagazi kupita ku chotupacho. Mwa kuyankhula kwina, khansa 'imabisa' njira yachilengedwe m'thupi lathu.
Mitsempha yatsopano yamagazi iyi imapatsa chotupacho mpweya ndi michere nthawi zonse. Zotsatira zake, chotupacho chimakula mofulumira komanso mwachangu. Choopsa kwambiri ndichakuti maselo a khansa amatha kuyenda m'mitsempha yatsopanoyi yamagazi ndikuyamba kufalikira ku ziwalo zina za thupi.
Ndicho chifukwa chake timanena kuti njira yotchedwa angiogenesis ikhoza kukhala yoopsa mu khansa. Zili ngati kudyetsa mdani wathu, kumudyetsa.
Kodi izi sizingathetsedwe? Tiyeni tikambirane za Angiogenesis Inhibitors
Asayansi atangomvetsa bwino za matenda a khansa amenewa, anayamba kufunafuna njira yothetsera vutoli. Chimodzi mwa zotsatira za kafukufukuyu chinali gulu la mankhwala otchedwa Angiogenesis Inhibitors .
Chinthu chachikulu chomwe mankhwala awa amachita ndikuletsa magazi kupita ku khansa. Zili ngati kupha mdani ndi njala.
Mankhwalawa amagwira ntchito m'njira zingapo. Njira imodzi yayikulu ndikuletsa kulumikizana pakati pa chizindikiro cha 'SOS' cha khansa ndi mitsempha yamagazi yomwe imalandira. Monga momwe static imalepheretsa kuyimba kwa foni, mankhwala awa amaletsa uthenga wa khansa kufika m'mitsempha yamagazi. Izi zimaletsa mitsempha yatsopano yamagazi kupanga, kusowa zakudya zomwe khansa imafuna, ndikuchepetsa kukula kwake.
Masiku ano, mankhwala angapo oletsa angiogenesis avomerezedwa ndi mabungwe monga US Food and Drug Administration (FDA) pochiza khansa. Akhala gawo lofunika kwambiri pochiza khansa.
Ngati inu kapena munthu amene mumamudziwa ali ndi khansa ndipo ali ndi mafunso okhudza chithandizochi, munthu woyenera komanso woyenera kulankhula naye ndi dokotala wanu . Ndikofunikira kwambiri kufunsa upangiri kwa dokotala amene amadziwa bwino vuto lanu, m'malo modalira intaneti kapena magwero ena.
Angiogenesis ndi njira yooneka ndi maso yomwe sitingathe kuiona, koma ndi chitsanzo chabwino cha momwe matupi athu amagwirira ntchito modabwitsa. Kudziwa izi zokhudza matupi athu, matenda, ndi mankhwala kungatithandize kupanga zisankho zabwino zokhudza thanzi lathu.
Uthenga Wopita Nawo Kunyumba
- Angiogenesis ndi njira yachilengedwe yopangira mitsempha yatsopano yamagazi kuchokera ku mitsempha yamagazi yomwe ilipo m'thupi lathu.
- Njira imeneyi ndi yofunika kwambiri kuti thupi lizigwira ntchito bwino nthawi zina monga kuchira kwa mabala ndi mimba.
- Komabe, njira imeneyi ingakhale yoopsa chifukwa imapatsa maselo a khansa zakudya ndi mpweya, zomwe zimathandiza kukula ndi kufalikira m'thupi lonse.
- Mankhwala oletsa angiogenesis ndi gulu latsopano la mankhwala omwe amachiritsa khansa mwa kuletsa magazi kupita ku zotupa.
- Kudziwa momwe thupi lanu limagwirira ntchito kungakuthandizeni kumvetsetsa bwino thanzi lanu. Ngati muli ndi nkhawa iliyonse yokhudza matenda kapena chithandizo chilichonse, lankhulani ndi dokotala wanu.
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