Ngati wina m'banja mwanu, mwina amayi anu okondedwa, abambo, agogo kapena azakhali, akudwala matenda a Alzheimer's, tikudziwa momwe zimakhalira zovuta. Mawu sangathe kufotokoza chisoni ndi kufooka komwe mumamva pamene mukutaya pang'onopang'ono kukumbukira kwanu ndikupeza zovuta kuchita ntchito za tsiku ndi tsiku. Ngakhale kuti palibe mankhwala a matenda a Alzheimer's, pali mankhwala omwe angathandize kuwongolera zizindikiro ndikupangitsa moyo kukhala wosavuta. Chifukwa chake, lero tikulankhula za gulu lapadera la mankhwala omwe madokotala nthawi zambiri amalangiza pa izi.
Tiyeni timvetse momwe mankhwalawa amagwirira ntchito, sichoncho?
Kuti timvetse izi, choyamba tiyeni tiwone momwe ubongo wathu umagwirira ntchito. Maselo amitsempha muubongo wathu, otchedwa ma neuron, amalankhulana ndipo amagawana chidziwitso kudzera mwa amithenga a mankhwala, mofanana ndi positi yotumiza makalata.
Mtumiki wofunika kwambiri ndi acetylcholine . Imathandiza pa zinthu zambiri zofunika monga kukumbukira, kuphunzira, ndi kusamala.
Komabe, matenda a Alzheimer akayamba, maselo amitsempha omwe amapanga ma acetylcholine amawonongeka pang'onopang'ono. Kenako chiwerengero cha ma acetylcholine muubongo chimachepa. Otsalawo amawonongeka mwachibadwa akamaliza ntchito yawo.
Apa ndi pomwe mankhwala otchedwa Cholinesterase Inhibitors amalowa. Mankhwalawa amagwira ntchito pochepetsa kusweka kwa acetylcholine messengers otsala. Izi zikutanthauza kuti amasungidwa ndikuloledwa kugwira ntchito muubongo kwa nthawi yayitali momwe angathere. Izi zimapangitsa kuti kukumbukira ndi kuganiza ziwonjezeke kwakanthawi.
Mwachidule, mankhwala amenewa sachiza matendawa. M'malo mwake, amaletsa zizindikiro ndi kupereka mpumulo kwakanthawi kwa wodwalayo.
Mankhwala oletsa Cholinesterase omwe amagwiritsidwa ntchito kwambiri
Pali mankhwala angapo a Cholinesterase Inhibitor omwe avomerezedwa kuchiza matenda a Alzheimer padziko lonse lapansi komanso ku Sri Lanka. Dokotala wanu adzasankha mankhwala oyenera kwambiri kutengera mtundu wa matendawa komanso momwe wodwalayo alili.
| Dzina la mankhwala (dzina la mtundu) | Mabokosi ogwiritsira ntchito | Zotsatira zoyipa zofala |
|---|---|---|
| Donepezil (Aricept) | Pa milandu yofatsa, yapakati, komanso yoopsa ya matendawa. Imwani piritsi limodzi kamodzi patsiku. | Kusanza, kusanza, kudzimbidwa, kupweteka kwa minofu, kutopa, kusowa chilakolako cha chakudya. |
| Rivastigmine (Exelon) | Kwa odwala ofooka mpaka ocheperako (mapiritsi). Amapezekanso ngati chigamba cha khungu kwa odwala okalamba. | Kusanza, kusanza, kudzimbidwa, kusowa chilakolako cha chakudya, komanso kupweteka m'mimba (izi sizimachitika kawirikawiri mukamagwiritsa ntchito chigamba). |
| Galantamine (Razadyne) | Pa milandu yofatsa mpaka yapakati ya matendawa, imwani kawiri patsiku kapena ngati kapisozi yogwira ntchito nthawi yayitali kamodzi patsiku. | Kusanza, kusanza, kudzimbidwa, kusowa chilakolako cha chakudya, mutu , chizungulire. |
| Donepezil + Memantine (Namzaric) | Imapangidwa pamodzi ndi mankhwala ena (NMDA agonist) pa milandu yapakati mpaka yoopsa ya matendawa. | Mutu , chisokonezo, chizungulire, kudzimbidwa, nseru, kusanza. |
Nanga bwanji ngati ndili ndi zotsatirapo zoyipa ndikayamba kumwa mankhwalawo?
Anthu ena angakumane ndi zotsatirapo zoyipa akangoyamba kumwa mankhwalawa. Koma musadandaule. Nthawi zambiri, zotsatirapo zoyipazi zimatha thupi lanu likayamba kuzolowera mankhwalawo. Dokotala wanu nthawi zambiri amakuyambitsani ndi mlingo wochepa kwambiri ndipo pang'onopang'ono amawonjezera mlingo.
Ngati muli ndi nseru, kumwa mankhwala pamodzi ndi chakudya kungathandize kuchepetsa vutoli. Chofunika kwambiri ndikulankhula ndi dokotala wanu za vuto lililonse lomwe mukukumana nalo. Iye adzatha kukupatsani yankho labwino kwambiri.
Kodi mankhwalawa ndi othandiza bwanji?
Vutoli ndi la anthu ambiri. Kunena zoona, zotsatira za mankhwala awa ndi zakanthawi kochepa. Odwala ena amatha kuona kuchepa kwakukulu kwa zizindikiro. Amatha kuganiza bwino pang'ono, kukumbukira zinthu, komanso kuchita ntchito za tsiku ndi tsiku mosavuta. Vutoli nthawi zina limatha kwa zaka zingapo.
Koma tiyenera kumvetsetsa kuti izi zili ngati kuyika pulasitala kwakanthawi pa thanki yotayikira madzi. Zidzaletsa madzi kutuluka kwa kanthawi, koma chigambacho sichidzagwira ntchito pamene dzenje lomwe lili mu thankiyo likukulirakulira. Mofananamo, mankhwala awa sangalepheretse kapena kubwezeretsa kuwonongeka kwa ubongo komwe kumachitika chifukwa cha matenda a Alzheimer's. Pakapita nthawi, pamene matendawa akupitirira, ndipo kupanga acetylcholine muubongo kumasiya pafupifupi kwathunthu, mankhwala awa nawonso alibe mphamvu.
Kodi pali anthu omwe sayenera kumwa mankhwalawa?
Inde. Mankhwalawa si oyenera aliyense. Mankhwala oletsa cholinesterase amatha kuchepetsa kugunda kwa mtima ndi kuthamanga kwa magazi. Chifukwa chake, madokotala amasamala kwambiri akamawapereka kwa anthu omwe ali ndi matenda enaake.
- Anthu omwe ali ndi mphumu
- Anthu omwe ali ndi vuto la mtima
- Anthu omwe ali ndi matenda a impso kapena chiwindi
- Anthu omwe ali ndi zilonda zam'mimba
Ngati wokondedwa wanu ali ndi vuto lililonse mwa izi, onetsetsani kuti mwadziwitsa dokotala wanu za izi.
Chofunika kwambiri: Uzani dokotala wanu za mankhwala aliwonse , mavitamini, zakudya zowonjezera, komanso mankhwala a Ayurvedic kapena Sinhala omwe wokondedwa wanu akumwa. Mankhwala ena (monga mankhwala a chimfine ndi ziwengo) amatha kuyanjana ndi Cholinesterase Inhibitors awa, zomwe zimapangitsa kuti mankhwalawa onse awiri asagwire ntchito bwino kapena kuyambitsa zotsatirapo zoopsa.
Uthenga Wopita Nawo Kunyumba
- Mankhwala oletsa cholinesterase si mankhwala a matenda a Alzheimer's. Amangoletsa kwakanthawi zizindikiro zokhudzana ndi kukumbukira ndi kuganiza.
- Mankhwalawa amagwira ntchito powonjezera kuchuluka kwa mankhwala otchedwa acetylcholine muubongo.
- Zotsatirapo monga nseru ndi kusanza zimatha kuchitika kumayambiriro kwa mankhwala, koma nthawi zambiri zimachepa pakapita nthawi.
- Musasiye kumwa mankhwala kapena kusintha mlingo popanda upangiri wa dokotala.
- Ndikofunikira kuuza dokotala wanu za mankhwala ena onse omwe wokondedwa wanu akumwa.
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