Uruhare mu kurwanya kanseri: Reka twige ku binini bya Vemurafenib

Uyu munsi tugiye kuvuga ku muti wihariye uhabwa umuntu urwanya kanseri. Wowe cyangwa undi muntu uzi ushobora kuba warahawe uyu muti, witwa Vemurafenib , na muganga wawe. Rero, uyu munsi turaganira birambuye ku bwoko bw'umuti, uburyo ukoreshwa neza, n'icyo tugomba kwitondera cyane.

Uyu muti witwa Vemurafenib ni uwuhe?

Muri make, Vemurafenib ni umuti wibasira poroteyine zimwe na zimwe ziri mu turemangingo twa kanseri ukazibuza gukura. Mu by'ukuri, ukora nk'umuti wibasira . Ukoreshwa cyane cyane mu kuvura ubwoko bwa kanseri y'uruhu yitwa melanoma . Ukoreshwa kandi mu kuvura indwara idakunze kugaragara yitwa Erdheim-Chester disease .

Wibuke ko abaganga bashobora gukoresha uyu muti ku zindi ndwara, bityo niba ufite ikibazo icyo ari cyo cyose, ni byiza kubaza muganga wawe cyangwa umufarumasiye.

Izina ry'ikirango rizwi cyane kuri uyu muti ni Zelboraf .

Ni ibihe bintu ngomba kubwira muganga mbere yo gutangira uyu muti?

Mbere yo gutangira gufata Vemurafenib, ni ngombwa cyane kubwira muganga wawe amateka y'ubuzima bwawe. Ni ngombwa cyane cyane kubwira muganga wawe niba ufite imwe muri izi ndwara zikurikira:

• Niba ufite indwara z'amaso cyangwa ibibazo byo kutabona neza
• Niba ufite indwara y'umutima
• Niba wigeze kugira umutima utari umeze neza mbere
• Niba warigeze gusanga ufite urugero ruke rwa kalisiyumu, manyeziyumu, cyangwa potasiyumu mu maraso
• Niba ufite indwara y'impyiko
• Niba ufite indwara y'umwijima
• Niba uherutse kuvurwa cyangwa uri gukora ubuvuzi bushingiye ku maraso
• Niba warigeze kugira ikibazo cy'ubwivumbure cyangwa se Vemurafenib idasanzwe, indi miti, ibiryo, amarangi, cyangwa imiti irinda ubushyuhe.
• Niba urimo kugerageza gutwita cyangwa utwite ubu (ibi ni ingenzi cyane)
• Niba uri umubyeyi wonsa (ibi nabyo ni ingenzi)

Mu kukubwira ibi bintu neza gusa, ni bwo muganga azabasha gufata icyemezo niba uyu muti ukubereye cyangwa utakubereye, ndetse n'uburyo bwo kwirinda ugomba gufata.

Ni gute neza neza nkoresha uyu muti?

Uyu muti uza mu buryo bw'ibinini. Ugomba kuwunywa unyoye ikirahure cy'amazi. Kurikiza amabwiriza ari ku rupapuro rwa muganga wawe cyangwa umufarumasiye wahawe.

• Ntukavune ibi binini, ubijanjagure cyangwa ngo ubiheke. Mira ibinini byose.
• Ushobora kubifata uri mu biryo cyangwa utabirya. Ariko, niba wumva igifu kikurya nabi, ni byiza kubifata uri mu biryo.
• Fata umuti ku gihe gikwiye, gusa ku rugero rwanditswe na muganga wawe. Ntugafate umuti urenze urugero rwanditswe.
• Igikuru ni uko utareka gufata uyu muti mu buryo butunguranye utabanje kugirwa inama na muganga.
• Akenshi, iyi miti ifatwa amasaha 12 hagati. Ibyo bivuze ko iyo uyifashe mu gitondo, ugomba gufata indi dose nijoro.

Iyo ubonye umuti wawe, farumasi izaguha agatabo k'ubuyobozi bwihariye (MedGuide) . Soma aka gatabo witonze igihe cyose ubonye umuti mushya. Karimo amakuru menshi y'ingenzi kuri wewe.

Niba uha abana uyu muti, ugomba kubibwira muganga w’abana kandi ukabyitondera cyane.

Wakora iki niba ufashe imiti myinshi?

Niba utekereza ko wafashe uyu muti urenze urugero mu buryo butari bwo, hamagara ikigo gishinzwe kurwanya uburozi cyangwa icyumba cy’ubutabazi kiri hafi yawe ako kanya.

Uyu muti wanditswe kuri wewe gusa. Ntuwusangire n'undi muntu uwo ari we wese.

Wakora iki niba wabuze dose y'umuti?

Niba wabuze dose, fata vuba uko wibuka. Ariko, niba hasigaye amasaha 4 ngo dose yawe ikurikira igere, jya usimbuka dose yabuze. Ahubwo fata dose yawe ikurikira ku gihe cyagenwe. Ntukigere ufata dose ebyiri.

Ni ibihe bintu bindi bishobora kugira ingaruka kuri uyu muti?

Iki ni ikintu cy'ingenzi cyane. Vemurafenib ishobora kugira ingaruka ku yindi miti ufata. Ibi nibibaho, ingaruka mbi zishobora kwiyongera cyangwa imikorere y'imiti ikagabanuka.

Ntugafate Vemurafenib hamwe n'imiti ikurikira:

• Cisapride
• Dronedarone
• Fluconazole
• Pimozide
• Posaconazole
• Saquinavir
• Thioridazine

Byongeye kandi, imiti ikurikira ishobora kugira ingaruka kuri Vemurafenib:

• Imiti igabanya ubukana bwa virusi itera SIDA cyangwa SIDA
• Ibintu birimo kafeyine (baza muganga wawe ibi)
• Amwe mu ma antibiyotike, urugero: clarithromycin, erythromycin, telithromycin
• Imiti imwe n'imwe ivura indwara z'ibihumyo, urugero: itraconazole, ketoconazole, voriconazole
• Imiti imwe n'imwe ivura indwara z'umutima
• Imiti imwe n'imwe ikoreshwa mu kuvura indwara nk'ibicurane (gupfa), urugero: carbamazepine, phenobarbital, phenytoin
• Imiti imwe n'imwe irinda cyangwa ivura kubyimba kw'amaraso, urugero: warfarin
• Dextromethorphan
• Digoxin
• Nefazodone
• Midazolam
• Indi miti ishobora gutera umutima kudakora neza, ni ukuvuga kongera igihe cyo gutera umutima mu gihe cya QT , urugero: dofetilide, ziprasidone
• Rifabutin
• Rifampine
• Rifapentine
• Inyongeramusaruro y'ibimera byitwa St. John's wort (Hypericum perforatum)
• Tizanidine

Uru rutonde ntirukubiyemo imiti yose ikoreshwa. Kubwibyo, bwira muganga wawe imiti yose (yanditswe na muganga n'iyishyurwa ku giciro cya muganga), ibikomoka ku bimera, vitamine, n'inyongeramusaruro ufata. Menya neza ko wabibwiye muganga wawe niba unywa itabi, unywa inzoga, cyangwa ukoresha ibiyobyabwenge bitemewe n'amategeko. Ibi bishobora no kugira ingaruka ku miti yawe.

Ni ibihe bintu ugomba kwitondera cyane cyane mu gihe ufata uyu muti?

Ni ngombwa cyane kwita ku buzima bwawe igihe ufata Vemurafenib.

• Jyana na muganga wawe buri gihe: Komeza kujya kwisuzumisha nk'uko muganga wawe abikubwira. Ushobora kandi gukenera gukora isuzuma ry'amaraso mu gihe ufata uyu muti.
• Indwara zikomeye z'uruhu: Uyu muti rimwe na rimwe ushobora gutera ingaruka zikomeye z'uruhu. Ibi bishobora kubaho ibyumweru cyangwa amezi nyuma yo gutangira gufata umuti. Bibwire muganga wawe ako kanya niba ugize ibisebe birimo ibimenyetso nk'umuriro cyangwa ubukonje. Ibisebe bishobora guhinduka umutuku cyangwa umuhengeri, hanyuma uduheri n'uruhu bigashibuka. Cyangwa ushobora kugira ibisebe bitukura bivanze no kubyimba mu maso cyangwa ku minwa, cyangwa kubyimba imitsi mu ijosi cyangwa mu kwaha. Niba ubonye ikintu nk'iki , bibwire muganga wawe ako kanya.
• Vuga ku byago bya kanseri: Uramutse ufashe uyu muti, ushobora kuba ufite ibyago byinshi byo kurwara izindi kanseri. Vugana na muganga wawe kuri ibi.
• Impinduka mu kureba: Niba ubonye impinduka mu kureba kwawe, nko kutabona neza cyangwa kubona ibintu mu buryo butandukanye n’uko bisanzwe, ugomba guhita ubimenyesha muganga wawe.
• Kumva izuba riva: Iki nacyo ni ikibazo gikomeye cyane. Iyo ufashe Vemurafenib, uruhu rwawe ruhita rworohera izuba cyane. Ibi bivuze ko no kumara igihe gito uri ku zuba bishobora gutuma uruhu rwawe rushya, rugahinduka umutuku, ndetse rukazana uduheri.
• Kubwibyo, irinde izuba uko bishoboka kose.
• Niba ugomba kujya ku zuba,Ambara imyenda ipfuka uruhu rwawe neza, wambare ingofero nini, kandi ukoreshe amavuta meza yo kwisiga akingira izuba yatanzwe na muganga wawe.
• Ntugakoreshe amatara y'izuba cyangwa utubati two gusiga ibara ry'uruhu.
• Gutwita no konsa:
• Ntugatwite urimo gufata uyu muti kandi mu gihe cy'ibyumweru 2 nyuma yo guhagarika uyu muti.
• Niba uteganya gutwita cyangwa utekereza ko utwite, bwira muganga wawe ako kanya. Uyu muti ushobora kwangiza umwana uri mu nda. Baza muganga wawe cyangwa umufarumasiye wawe amakuru arambuye.
• Ntugahe umwana wawe ibere mu gihe ufata uyu muti kandi mu byumweru 2 nyuma yo guhagarika uyu muti.

Ni izihe ngaruka mbi zishobora kubaho?

Kimwe n'indi miti yose, Vemurafenib ishobora gutera ingaruka zimwe na zimwe. Zimwe ni zikomeye, izindi si zikomeye cyane.

Ingaruka mbi zigomba kumenyeshwa muganga wawe cyangwa umuganga wawe vuba bishoboka:

Niba ubonye kimwe muri ibi bimenyetso, bwira muganga wawe bidatinze:

• Indwara zo kugira ubwivumbure: uduheri ku ruhu, kuribwa cyangwa uduheri, kubyimba mu maso, iminwa cyangwa ururimi
• Guhumeka bigoranye
• Impinduka mu cyerekezo
• Inkari z'ibara ryijimye
• Kubabara amaso cyangwa kubyimba
• Umutima utera vuba cyangwa utari umeze neza
• Kunanirwa, isereri, no kugwa
• Indwara rusange cyangwa ibimenyetso bisa n'ibicurane
• Intebe z'amabara yoroheje
• Gukunda kurya
• Hagaragara ibiheri bishya; igisebe cy'uruhu cyangwa ikibyimba gitukura kiva amaraso cyangwa kidakira; impinduka mu bunini cyangwa ibara ry'ibiheri cyangwa ikizinga
• Ububabare, ibinya cyangwa kubura ibyiyumvo mu maguru
• Ibibyimba, umuriro, no kubyimba ikibuno
• Gutukura k'uruhu, uduheri, gukurura uruhu (harimo no gukurura uruhu mu kanwa)
• Kubabara mu gice cyo hejuru cy'iburyo cy'inda
• Guterwa n'izuba cyangwa gutwikwa n'izuba
• Uruhu rwo mu biganza no mu birenge binini
• Intoki zigonze imbere kandi zikomeye
• Kumva ufite intege nke cyangwa umunaniro udasanzwe
• Kuruka
• Ibara ry'umuhondo ry'amaso cyangwa uruhu

Ingaruka mbi ubusanzwe zidasaba ubuvuzi (bwira muganga wawe niba zikomeje cyangwa zigutera ikibazo):

• Impinduka mu buryohe
• Kubura ubushake bwo kurya
• Impiswi (kubabara mu gifu)
• Kuzungera
• Uruhu rwumye
• Gutakaza umusatsi
• Umutwe
• Ububabare bw'ingingo
• Kubabara imitsi
• Isesemi (kumva urwaye)
• Kubyimba utuguru, ibirenge, amaboko
• Umunaniro

Uru rutonde ntirugaragaza ingaruka mbi zose zishobora kubaho. Niba ubonye izindi bimenyetso bidasanzwe, gana muganga wawe. Niba ubyifuza, ushobora kandi gutanga raporo ku kigo gishinzwe ibiribwa n'imiti (FDA) uhamagara kuri 1-800-FDA-1088.

Ni gute nabika ibi binini?

• Bika ahantu abana batagera. Ibi ni ingenzi cyane.
• Bika ku bushyuhe bw'icyumba (hagati ya dogere selisiyusi 20 na 25 / dogere selisiyusi 68 na 77).
• Bika umuti mu icupa ry'umwimerere wajemo, ufunze neza.
• Tara imiti yarengeje igihe utayikoresheje.

Hanyuma, ibintu ugomba kwibuka (Ubutumwa bwo kujyana mu rugo)

Vemurafenib ni umuti ugira uruhare runini mu kuvura kanseri. Hari ibintu bike ugomba kumenya mu gihe uwukoresha.

• Kurikiza amabwiriza ya muganga neza. Kora byose uko akubwira, harimo igihe cyo gufata umuti, ingano yawo, n'uburyo bwo kureka kuwufata.
• Bwira muganga wawe indi miti yose ufata n'izindi ndwara zose ufite. Ibi bizagufasha kwirinda ingaruka mbi.
• Niba ubonye ibimenyetso bishya, cyane cyane impinduka z'uruhu cyangwa impinduka mu iyerekwa, bwira muganga wawe vuba.
• Witondere izuba. Ntukibagirwe ibi.
• Niba utwite, uteganya gutwita, cyangwa wonsa, banza ubibwire muganga wawe mbere yo gufata uyu muti.

Iyi nkuru ni incamake rusange gusa. Niba ufite ibindi bibazo kuri uyu muti, nyamuneka ntutindiganye kubaza muganga wawe, umufarumasiye, cyangwa undi muvuzi. Bazagufasha.

Tukwifurije ibyiza byose mu rugendo rwawe rw'ubuzima!

Vemurafenib , Zelboraf, umuti wa kanseri, kanseri y'uruhu, melanoma, ingaruka mbi, umuti, kuvura kanseri