Mutongi wepachivande anodzora BP yedu: Zvese nezveRenin!

Wakambozvibvunza here kuti zvinhu zvingani zvinoshamisa zvinoitika mumiviri yedu? Dzimwe nguva, tisingatombozvizivi, kune nzira dzakawanda dzinoshamisa dzinochengetedza miviri yedu ine hutano. Semuenzaniso, iyo inobatsira kudzora BP yedu inonzi Renin. Nhasi, ngatitaurei nezveRenin chii, mashandiro ayo, uye kukosha kwayo kuhutano hwedu.

Chii chinonzi Renin? Zvichitaurwa zviri nyore...

Zvakanaka, ngationei kuti renin iyi chii. Zvichitaurwa zviri nyore, renin ienzyme inogadzirwa nemasero akakosha ari muitsvo dzako. Usatya enzyme, ipuroteni inobatsira kukurumidzisa maitiro akasiyana-siyana emakemikari mumiviri yedu.

Murume uyu anonzi renin haashande ari ega. Iye chikamu chechinhu chikuru chinonzi renin-angiotensin-aldosterone system (RAAS). Zvakafanana nechain reaction. Chinangwa chikuru chehurongwa uhu ndechekuchengetedza BP yako ichidzorwa. Zvikuru, renin inodzora hormone inonzi aldosterone, inogadzirwa nema adrenal glands edu (ma glands madiki ari pamusoro peitsvo).

Saka, Renin iyi inoshanda sei?

Zvino hechino chikamu chakakosha. Basa guru raRenin nderekudzora BP. Izvi zvinoitwa pamwe chete nemamwe mahormone maviri akakosha anonzi angiotensin nealdosterone. Pamwe chete, matatu aya anobatsira kuchengetedza huwandu hwesodium (munyu) nepotassium mumuviri wako.

Fungidzira izvi zvichiitika:

1. Kutanga, renin inoshandura angiotensinogen (inotanga angiotensin) inogadzirwa nechiropa chako kuita angiotensin I ( angiotensin, hormone inotetepa tsinga dzeropa).

2. Zvadaro, iyi angiotensin I inoshanduka kuita angiotensin II .

3. Iye zvino iyi angiotensin II ndiyo inonyanya kushanda. Inoderedza tsinga dzeropa uye inobatsirawo kuburitsa hormone inonzi aldosterone.

4. Chekupedzisira, aldosterone iyi inobatsira itsvo dzako kuchengetedza mvura nemunyu (sodium) mumuviri wako. Izvi zvinowedzera huwandu hwemvura mumuviri wako. Izvi ndizvo zvinowedzera BP yako.

Zvichitaurwa zviri nyore, kana BP yadzikira, murume anonzi renin anouya, anounganidza vamwe vanhu vashoma, anovhara mitsipa yeropa, anochengeta mvura mumuviri, uye anodzosera BP pakare.

Renin inoburitswa sei? Panguva ipi?

Zvakanaka, ikozvino une mubvunzo: renin iyi inongogadzirwa mumuviri here, kana kuti inoburitswa panguva dzakatarwa? Renin inoburitswa muropa rako kana BP yako yaderera zvakanyanya, kana kuti paunorasikirwa nemunyu (sodium) yakakwana kubva mumuviri wako.

Zvikurukuru, zvinhu zvinotevera zvinokanganisa kuburitswa kwe renin:

• Mabaroreceptors (aya mareceptor anonzwa kumanikidzwa) ari mutsinga dzeropa rako anonzwa kuderera kweropa.
• Kana itsvo dzako dzikaona munyu wakaderera (sodium) mumuviri wako.
• Beta 1 adrenergic receptors, iyo inodzora kurova kwemoyo wako, inonzwa mashandiro mutsinga dzako dzetsinga (izvi zvinoitika kana tichinetseka kana kutya).

Ko renin chete inowedzera BP here?

Kwete, kwete chaizvo. Renin chete haikanganisi BP yako. Asi, sezvaambotaura, inoshanda pamwe chete neangiotensin nealdosterone. Angiotensin inotetepa tsinga dzeropa, uye aldosterone inobatsira itsvo dzako kuchengetedza mvura nemunyu. Izvi ndizvo zvinoita kuti muviri wako uchengetedze mvura yakawanda uye kukwidza BP yako.

Renin inogadzirwa kupi?

Pamwe wava kutoziva izvi. Renin inogadzirwa muitsvo dzako. Kana systolic blood pressure yako (nhamba yepamusoro pakuyera BP) yadzikira, kana kuti itsvo dzako padzinonzwa kuti muviri wako hauna mvura yakakwana, dzinoburitsa renin muropa rako.

Renin inogadzirwa nei? (Izvi zvine chekuita nesainzi, asi zvakakosha kuziva.)

Iyi inyaya yakadzama, asi muchidimbu, renin ine maamino acid anosvika 340. Maamino acids akafanana nezvidimbu zvidiki zvemapuroteni. Izvi zvinoungana kuti zvigadzire enzyme renin. Zvakafanana nezvidhinha zvakawanda zvinoungana kuti zvigadzire madziro.

Ndezvipi zvirwere zvinogona kukonzerwa nekugadzirwa kwe renin?

Dzimwe nguva huwandu hwe renin mumuviri hunogona kuwedzera. Zvinhu zvakaita seizvi zvinogona kukonzera izvi:

• Kuderera kweropa (Hypotension) .
• Kana wakarasikirwa neropa rakawanda (semuenzaniso netsaona).
• Kana itsvo dzako dzisisina kuyerera zvakanaka .
• Kudzikira kwehuwandu hwemuviri (semuenzaniso, kupera mvura mumuviri nekuda kwekurutsa kana dumbu rakavhiringidzika).
• Kuwedzera kwebasa retsinga dzinobatsira tsinga (Sympathetic nerve activation) (muchiitiko ichi, kurova kwemoyo, kufema, BP inowedzera, uye madenderedzwa matema mumaziso anokura).

Pane bvunzo dzekuongorora huwandu hwe renin here?

Ehe, zvechokwadi. Chiremba wako anogona kuita bvunzo yekushanda kwe renin uye bvunzo yemazinga e aldosterone. Izvi zvinomuudza kuti adrenal glands yako iri kugadzira aldosterone yakawanda sei.

Kana uine BP yakakwira, kunyanya kana isingadzoreki nemishonga yaunowanzo nwa, chiremba wako anogona kukuraira bvunzo iyi.Ungave uine chirwere chinonzi primary aldosteronism (PA) (chinonziwo Conn's syndrome) . Mumamiriro ezvinhu aya, aldosterone yakawandisa inogadzirwa, izvo zvinokonzera BP yakakwira. Kuongororwa kwe renin kunogona kubatsira kuona kana PA iriyo chikonzero cheBP yako yakakwira.

Renin inoyerwa sei?

Renin inowanzo kuyerwa nechinhu chinonzi plasma renin activity (PRA) . Izvi zvinoyera kuti renin iri kugadzira angiotensin I zvakanaka sei (inotanga angiotensin II). Inogonawo kuyerwa serenin yakananga .

Zvinorevei kana huwandu hwe renin yako hwakakwira?

Kana huwandu hwe renin yako hwakakwira, zvinogona kunge zvichikonzerwa ne:

• Chirwere cheAddison (apo adrenal glands yako isingaburitse mahormone akakwana) - kunyanya kana mvura yemuviri yakaderera.
• Kushaya mvura mumuviri (kushaya mvura mumuviri).
• Kuderera kwepotassium muropa (hypokalemia) .
• Kubuda ropa rakawanda (ropa rakawanda rinoyerera mukati kana kunze kwenhengo yemuviri).
• Matumbu eitsvo anogadzira renin .
• Kukwira kweropa muitsvo (BP yakakwira inokonzerwa nekutetepa kwetsinga dzeropa dzinoenda kuitsvo).
• Hypertension yakaipa (iyi iBP yakakwira inouya kamwe kamwe, pasina yambiro ).
• Hypertension yepamusoro (iyi iBP yakakwira isiri mhedzisiro yeimwe chirwere).
• Kukundikana kwemoyo kana kuti cirrhosis yechiropa (kana huwandu hweropa rinoshanda mumuviri huchiderera nekuda kwezvirwere izvi).

Ko kana huwandu hwe renin hwakaderera?

Kunewo zvikonzero zvinoita kuti huwandu hwe renin huve hwakaderera. Semuenzaniso:

• Kurwara kweganda (Primary aldosteronism) (PA)
• Kana uri kushandisa mishonga yesteroid inokonzera kuchengetedza munyu mumuviri.
• Hypertension inokonzerwa nemunyu (vamwe vanhu vane BP yakakwira kunyangwe vakadya munyu wakawandisa, idambudziko iri).

Ndingachengetedza sei huwandu hwe renin yangu huine hutano?

Kana huwandu hwe renin yako hwakakwira zvakanyanya kana kuti hwakaderera, chiremba wako ndiye achaona chikonzero chacho uye achagadzira hurongwa hwekurapa. Havangonyoreri mishonga yekuderedza kana kukwidza renin yako.

Semuenzaniso, kana uine renin yakakwira uye BP yakakwira, chiremba wako anogona kukupa mishonga inoderedza BP yakadai se beta-blockers ne clonidine .

Pakupedzisira, zvekurangarira (Mharidzo Yekuenda Kumba)

Saka, renin haisi enzyme chete. Inhengo inokosha kwazvo ye renin-angiotensin-aldosterone system (RAAS). Inobatsira zvikuru mukuderedza BP.

Panogona kuva nezvikonzero zvakasiyana-siyana zvinoita kuti huwandu hwe renin mumuviri wako husave hwakajairwa. Saka kana usina chokwadi, chinhu chakanakisa chekuita ndechekuona chiremba, kutsvaga chikonzero chaicho, uye kuwana kurapwa kwakakodzera. Usangotevedzera manzwiro ako emudumbu, nekuti zvinhu izvi zvakaoma.

Chiremba wako anogona kukubatsira chaizvo. Ramba uine hutano hwakanaka!

Renin , Kumanikidzwa kweRopa, Itsvo, Aldosterone, Angiotensin, Kumanikidzwa kweRopa Kwakakwira, Kumanikidzwa kweRopa Kwakaderera, Renin, Kumanikidzwa kweRopa, Itsvo, Aldosterone, Angiotensin, RAAS