Chiremba wako akakunyorera mushonga we'Antimetabolite' here iwe kana mumwe munhu ari pedyo newe wekurapa chirwere chegomarara? Kana zvakadaro, ungangoda kuziva zvese nezverudzi urwu rwemushonga, zvakanakira nezvakaipira, uye mashandiro awo. Antimetabolites imhando yemishonga inoshandiswa mukurapa gomarara nekenza. Kutaura zvazviri, imhando yekare yemushonga unoshandiswa zvakanyanya mukurapa gomarara, sezvo wave uchishandiswa kubvira kuma1940.
Ndezvipi zvinhu izvi zvinorwisa metabolites? Zvinoshanda sei?
Zvichitaurwa zviri nyore, mishonga inorwisa metabolites imhando yemushonga unoparadza masero (cytotoxic) . Basa rawo harina kunyanya kuoma.
Fungidzira, sero riri mumuviri wedu, kunyanya sero rekenza, rinoda zvimwe zvezvinhu zvaro kuti rikure, rigovane, uye riwande. Zvinoitwa nemushonga uyu zvinoshanda se "chinhu chenhema" chinotaridzika sezvinhu izvozvo. Saka masero ekenza anonyengerwa uye panzvimbo pezvinhu chaizvo zvaanoda kuti akure, anodya zvinhu izvi zvenhema, mushonga wedu.
Ruzivo rwemajini esero, kureva kuti, purani yakazara yesero iroro, rwunowanikwa muzvinhu zvinonzi DNA neRNA . Kana mushonga uyu we antimetabolite ukapinda musero rekenza, sero iroro harigone kugadzira makopi eDNA yaro. Zvakafanana nekuisa cartridge isiriyo muprinta uye harigone kugadzira makopi.
Kana DNA isingakwanise kukopwa, sero iroro harigone kupatsanuka kuita masero matsva. Masero egomarara anomira kuwanda ofa.
Nekuti rudzi urwu rwemushonga runonyanya kunanga masero anokamura nekukurumidza , runoshanda zvikuru mukudzivirira kenza dziri kukura nekukurumidza.
Heano mamwe ema antimetabolites anoshandiswa zvakanyanya mukurapa kenza.
| Mamwe ma antimetabolites anoshandiswa zvakanyanya |
|---|
| 6-mercaptopurine |
| Fludarabine |
| 5-fluorouracil |
| Gemcitabine |
| Cytarabine |
| Pemetrexed |
| Methotrexate |
Mushonga uyu unoshandiswa kumhando dzipi dzegomarara?
Mishonga inorwisa metabolites inonyanya kushandiswa kurapa kenza dzeropa dzakadai seleukemia , kenza yemazamu , kenza yemazai , uye kenza yemudumbu .
Asi nekuda kwekuti mishonga iyi inogona kudzivirira kukura kwerudzi rwesero rinokamuka nekukurumidza, vanachiremba vanokurudzirawo kune mamwe marudzi akasiyana ekenza.
Ndingawana sei mushonga uyu?
Mashandisirwo emishonga inorwisa metabolite anogona kusiyana zvichienderana nemushonga uri kutaurwa nezvawo uye rudzi rwekenza iri kurapwa.
- Mapiritsi kana zvinwiwa: Mamwe maantimetabolites anowanikwa semapiritsi kana zvinwiwa zvinogona kunwiwa nemuromo zuva nezuva.
- Mutsinga (IV): Kune mamwe marudzi ejekiseni anopinzwa mutsinga. Idzi dzinowanzopihwa semvura ine saline kuburikidza netsinga. Kune vanhu vari kurapwa kwenguva refu, mishonga iyi dzimwe nguva inopinzwa kuburikidza nechubhu chaiyo (mediport) inoiswa mutsinga huru, yepakati.
- Makirimu: Mishonga inorwisa kenza yeganda inowanikwawo semafuta ekurapa. Aya anoiswa panzvimbo yeganda yakakanganiswa kamwe chete kana kaviri pazuva.
Ndezvipi zvakanakira uye njodzi dzekurapa uku?
Chinhu chikuru chinobatsira pakurapa kwerudzi urwu ndechekuti kunoparadza masero ekenza, kunomisa kukura kwekenza kana kuideredza. Izvi zvinobatsira murwere kuti apore uye ararame kwenguva refu.
Zvisinei, pane njodzi iripo. Mishonga iyi haishande zvakafanana kune wese munhu. Dzimwe nguva, kunyange vanachiremba vanonetseka nekutaura kuti mushonga uyu wakakodzera kenza ipi.
Chimwe chinhu chakakosha ndechekuti dzimwe nguva, kunyangwe zvichishanda zvakanaka pakutanga, nekufamba kwenguva, masero egomarara anojaira mushonga uyu. Tinoti uyu 'unodzivirira'. Zvadaro mushonga wacho hauchagoni kushanda.
Ndezvipi migumisiro yemishonga inoderedza metabolites?
Nekuti mishonga inodzivirira metabolites imhando yemishonga, kwete mushonga mumwe chete, migumisiro inogona kusiyana. Saka, kana wakanyorerwa mushonga chaiwo we antimetabolite, zvakakosha kutaura nachiremba wako nezvemigumisiro chaiyo inobatanidzwa nawo.
Asi kazhinji, kune mimwe migumisiro yakajairika inowanikwa nevakawanda vanorwisa metabolites.
| Mhedzisiro Yepadivi | Tsananguro |
|---|---|
| Matambudziko ekugaya chikafu | Kusvotwa, kurutsa, kushaya chido chekudya, manyoka, kana kuvimbiwa. |
| Kusagadzikana kwemuviri | Kuneta, kushaya simba, kurwadziwa kwetsandanyama, musoro, uye dzungu. |
| Kuchinja mumuromo nemiromo | Maronda kana kuzvimba mumuromo nemumiromo. |
| Mhedzisiro pachiropa | Ma enzymes echiropa akakwira (izvi zvinogona kuratidza kukuvara kwechiropa kana kuzvimba). |
| Ganda nebvudzi | Kupera kwebvudzi, mapundu paganda, ganda rakaoma uye rakatsemuka. |
| Kuchinja kwemaziso | Kuchinja kwekuona kana kunzwa chiedza. |
| Mhedzisiro pamasero eropa | Kuderera kwehuwandu hwemasero machena eropa, izvo zvinowedzera njodzi yekutapukirwa. |
Mharidzo Yekuenda Nayo Kumba
- Mishonga inorwisa mabhakitiriya (antimetabolites) imhando yemishonga inouraya kenza inonyengera masero ekenza kuti arege kukura.
- Izvi zvinonyanya kushandiswa pakurapa kenza dziri kukura nekukurumidza dzakadai sekenza yemudumbu, kenza yemazamu, kenza yemazamu, uye kenza yemudumbu.
- Kunyangwe mishonga iyi ine mukana wekuparadza masero egomarara, inewo njodzi dzakadai sekusakwanisa kushandisa mishonga uye migumisiro yakaipa.
- Nekuti migumisiro yemishonga inosiyana kubva pamushonga mumwe kuenda kune mumwe, zvakakosha kuti uzive nezvemushonga wauri kutora uye migumisiro yawo.
- Chinonyanya kukosha: Taura nachiremba wako usingazenguriri nezvemushonga wawakapihwa, migumisiro yawo, uye chero mibvunzo kana zvinokunetsa. Iye chete ndiye anogona kukupa mazano akakodzera uye akanyatsojeka.
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