Ngatingodzidzai zvese nezveAromatase Inhibitors (AI) inoshandiswa pakurapa kenza.

Chiremba wako akakuudza here kana mumwe munhu wemumhuri mako kuti utange kutora mushonga unodzivirira aromatase? Zvakajairika kuti unzwe kutya uye kuda kuziva kana ukanzwa izvozvo. "Mushonga werudzii uyu?", "Sei ndichipihwa uyu?", "Chii chichaitika kwandiri?", "Pachava nemigumisiro yakaipa here?" Pamwe une mibvunzo yakawanda mupfungwa dzako. Saka usatya. Nhasi, tichataura nezvemushonga uyu unonzi aromatase inhibitor mumutauro uri nyore kwazvo waunogona kunzwisisa, sekunge uri kutaura neshamwari.

Chii chinonzi Aromatase Inhibitor (AI) muchidimbu?

Zvichitaurwa zviri nyore, Aromatase Inhibitor rudzi rwemishonga inoshandiswa pakurapa kenza. Inonyanya kushandiswa kurapa mhando yekenza yemazamu inonzi Estrogen Receptor-Positive (ER+) .

Zvino ungangove uchishamisika kuti, "Zvinorevei izvi `ER+`?" Zvinoreva chimwe chinhu chakadai. Mamwe masero ekenza yemazamu anobatsirwa kukura nekupararira nehormone inonzi estrogen mumuviri wedu. Kungofanana nemuti unoda mvura nefetereza kuti ukure, masero aya ekenza anoshandisa hormone estrogen se "chikafu" chawo. Saka, kenza dzinokurudzirwa nehormone iyi estrogen ndidzo dzatinodaidza kuti kenza dze`ER+`.

Zvinoitwa neAromatase Inhibitor kumisa masero ekenza kuti asawane "chikafu" ichocho. Izvi zvinoitwa ne: Muviri wedu une enzyme inonzi Aromatase . Iyi enzyme inoshandura mamwe mahormone mumuviri kuita estrogen. Saka mushonga uyu unovhara kushanda kweAromatase enzyme. Zvadaro kugadzirwa kweestrogen mumuviri kunoderera zvakanyanya. Kana estrogen yapera, masero ekenza anorasikirwa ne "chikafu" chaanoda kuti chikure, uye anofa zvishoma nezvishoma.

Kurapa uku kunonyanya kushanda kuvakadzi vane makore anopfuura makumi mashanu vakambosvika pakuguma kuenda kumwedzi , nekuti mushure mekuguma kuenda kumwedzi, estrogen mumuviri wemukadzi inonyanya kugadzirwa kuburikidza neiyi aromatase enzyme.

Muzviitiko zvipi kurapwa uku kunopiwa?

Pane mamiriro akati wandei apo vanachiremba vangakurudzira kurapwa neAromatase Inhibitor. Ngationei kuti chii.

• Mushure mekuvhiyiwa kwekenza yemazamu yeER+: Mushonga uyu unopihwa kudzivirira kenza kuti isadzoke, kureva kuti, kuderedza njodzi yekudzokororwa.
• Kana kenza yapararira kumasero emudumbu ari pedyo: Kurapa uku kunobatsira kudzora kupararira kwekenza.
• Kana kenza yapararira (metastatic) kune dzimwe nhengo mumuviri:Kenza yemazamu dzimwe nguva inogona kupararira kunhengo dziri kure dzakadai semapapu, mapfupa, uropi, kana chiropa. Kurapa uku kunoshandiswawo mumamiriro ezvinhu akadaro.
• Kana ukava nekenza yemazamu yeER+ usati waenda kumwedzi: Sezvo maovari achiri kugadzira estrogen pazera iri, uchafanira kutora mushonga wearomatase inhibitor pamwe chete nedzimwe nzira dzinomisa maovari kugadzira estrogen.
• Kana uine mukana wakawedzerwa wekuva nekenza yemazamu ye'ER+': Dzimwe ongororo dzakaratidza kuti mishonga iyi inoderedza njodzi yekenza yemazamu. Zvisinei, haisati yatenderwa zviri pamutemo kuti ishandiswe pachinangwa ichi.
• Kana murume akabatwa nekenza yemazamu inonzi `ER+`: Ehe, varume vanogonawo kubatwa nekenza yemazamu. Vanewo hormone inonzi estrogen yakaderera mumuviri wavo. Saka, pane dzimwe nguva apo varume vanogonawo kupiwa mushonga uyu.

Ndedzipi mhando dzeAromatase Inhibitors dzinonyanya kushandiswa?

Kune mhando dzakasiyana dzemishonga iyi dziri kutengeswa. Chiremba wako achakurudzira imwe yakakunakira. Idzi ndidzo mhando nhatu dzinonyanya kushandiswa.

Ndingashandisa sei mushonga uyu? Ndinofanira kuutora kwenguva yakareba sei?

Mishonga inodzivirira kurwara (aromatase inhibitors) imhando yemapiritsi aunotora zuva nezuva . Unogona kupihwa mushonga uyu paunotanga kurapwa. Kana, mune dzimwe nguva, chiremba wako anogona kutanga akupa imwe mishonga inonzi tamoxifen kwemakore mashoma ozobva achinja kuita mushonga unodzivirira kurwara (aromatase inhibitors).

Kazhinji, kurapwa uku kunoenderera mberi kwemakore angangoita mashanu . Pakupera kwemakore mashanu, kana usina zviratidzo zvekenza uye bvunzo dzisiri kuratidza kenza, unoonekwa sewapora.

Asi pane chimwe chinhu chakakosha chekurangarira. Dzimwe ongororo dzakaratidza kuti kenza yemazamu inogona kudzoka chero bedzi mushure memakore makumi maviri ekurapwa. Izvi zvinonzi kudzoka kwechirwere kunonoka . Saka zvakakosha kutaura nachiremba wako nezvenjodzi iyi, zvichienderana nemamiriro ako ezvinhu.

Ndezvipi zvakanakira uye njodzi dzekurapa uku?

Sekune chero kurapwa kupi zvako, kune zvakanakira uye njodzi dzemamwe matambudziko.

Chinhu chikuru chakanakira

Chinhu chikuru uye chinonyanya kukosha chekurapa uku mukana wekubvisa zvachose kenza yemazamu ye'ER+'. Zvidzidzo zvinoratidza kuti 95% yevanhu vanorapwa mushure mekuvhiyiwa havazovi nezviratidzo zvekenza zvachose mushure memakore mashanu. Uku kubudirira kwakanyanya.

Migumisiro inogona kuitika (njodzi)

Sezvatakambokurukura, mushonga uyu unoshanda nekuderedza huwandu hweestrogen mumuviri. Estrogen ihormone inokosha pahutano hwekubereka pamwe nehutano hwemapfupa nemoyo . Saka kana huwandu hweestrogen hukadzikira, panogona kuva nemigumisiro inokonzerwa nayo.

Ungaitei kana uchinetseka nemigumisiro yacho?

Migumisiro iyi, kunyanya kurwadziwa kwemajoini, inogona kuva yakanyanya zvekuti vamwe vanhu havakwanise kuita mabasa ezuva nezuva. Asi haufanirwe kutambura chinyararire . Kune mhinduro. Chinhu chakakosha kutaura pachena nachiremba wako nezvekusagadzikana kwauri kunzwa. Iye anogona kukubatsira.

Chiremba wako anogona kukurudzira zvinhu zvakaita se:

• Mishonga yekudzivirira kuzvimba: Mishonga isiri yesteroidal inorwisa kuzvimba (NSAIDs) yakaita seibuprofen inogona kupihwa kuderedza marwadzo. Zvisinei, iyi inofanira kutorwa chete kana yapihwa zano nachiremba.
• Kuchinja kushandisa imwe Aromatase Inhibitor: Dzimwe nguva migumisiro yeimwe mhando yeAI haiitike kune imwe mhando. Saka chiremba wako anogona kukuudza kuti uedze imwe piritsi yeAI.
• Kuchinja kuenda kuTamoxifen: Kana migumisiro yacho isingatsungiririki, panogona kuva nesarudzo yekuchinja kuenda kune imwe hormone therapy inonzi Tamoxifen.

Unofanira kufonera chiremba rini?

Iva nechokwadi chekutaura nachiremba wako muzviitiko zvinotevera:

• Kana migumisiro yacho yakanyanya kuipa kupfuura zvawaitarisira uye yakaoma kutsungirira.
• Kana mushonga wakapihwa nachiremba usingabatsire pamigumisiro yakaipa.
• Kana ukaona chero shanduko mumuviri wako dzaunofungidzira kuti dzinogona kunge dziri zviratidzo zvegomarara rinodzoka (semuenzaniso bundu idzva, kurwadziwa kusingawanzoitiki). (Bvunza chiremba wako kuti zviratidzo zvipi zvekutarisa).

Kurapa uku kwakakosha sei?

Kurapa neAromatase inhibitor kunoderedza zvakanyanya njodzi yekudzoka kwekenza yemazamu ine mahormone. Ongororo dzakawana kuti vakadzi vanotora aromatase inhibitor therapy mushure mekuvhiyiwa vane mukana wakaderera we40% wekufa nekenza yemazamu mushure memakore gumi, zvichienzaniswa nevaya vasingatore chero hormone therapy.

Imwe ongororo yakaratidza kuti kutora mushonga we 'Letrozole' kunogona kuderedza njodzi yekufa nekenza ne24 % kusvika 35% .

Nhamba idzi dzinoratidza kukosha kwekurapa uku mukuponesa hupenyu hwako. Ungangoda kurega kurapwa uku nekuda kwemigumisiro yacho. Asi usati waita izvozvo, zvakanaka kutaura nachiremba wako nezvematambudziko aya, woagadzirisa, uye woedza kupedzisa kurapwa uku kunoponesa hupenyu.