Uma othile emndenini wakho, mhlawumbe umama wakho othandekayo, ubaba, ugogo noma u-anti, ehlushwa yisifo i-Alzheimer's, siyazi ukuthi kungaba nzima kangakanani. Amazwi awakwazi ukuchaza usizi nokungabi namandla okuzizwa njengoba ulahlekelwa inkumbulo yakho kancane kancane futhi ukuthola kunzima ukwenza imisebenzi yansuku zonke. Nakuba kungekho ikhambi lesifo i-Alzheimer's, kunemithi engasiza ekulawuleni izimpawu futhi yenze impilo ibe lula kancane. Ngakho-ke, namuhla sikhuluma ngeklasi elikhethekile lemithi odokotela abavame ukuyincoma kulokhu.
Ake siqonde ukuthi lo muthi usebenza kanjani, akunjalo?
Ukuze siqonde lokhu, ake siqale sibheke ukuthi ubuchopho bethu busebenza kanjani. Amangqamuzana ezinzwa ebuchosheni bethu, abizwa ngokuthi ama-neurons, ayakhulumisana futhi ashintshana ngolwazi ngokusebenzisa izithunywa zamakhemikhali, njengomuntu othumela izincwadi.
Esinye isithunywa esibalulekile yi -acetylcholine . Isiza ngezinto eziningi ezibalulekile njengenkumbulo yethu, ukufunda, kanye nokunaka.
Kodwa-ke, lapho isifo i-Alzheimer's siqala, amangqamuzana ezinzwa akhiqiza lawa ma-messenger abizwa ngokuthi i-acetylcholine ayabhujiswa kancane kancane. Bese inani lala ma-messenger ebuchosheni liyancipha. Lawo asele ayaphuka ngokwemvelo uma eseqedile umsebenzi wawo.
Yilapho izidakamizwa ezibizwa ngokuthi i-Cholinesterase Inhibitors zingena khona. Lezi zidakamizwa zisebenza ngokunciphisa ijubane lokuqhekeka kwezithunywa ze-acetylcholine ezisele. Lokhu kusho ukuthi zigcinwa futhi zivunyelwe ukusebenza ebuchosheni isikhathi eside ngangokunokwenzeka. Lokhu kuphumela ekuthuthukisweni kwesikhashana kwenkumbulo kanye namakhono okucabanga.
Kalula nje, le mithi ayilaphi lesi sifo. Kunalokho, ilawula izimpawu futhi inikeze isiguli impumuzo yesikhashana.
Imithi evame ukusetshenziswa ye-Cholinesterase Inhibitor
Kunemithi eminingana ye-Cholinesterase Inhibitor evunyelwe ukwelapha isifo i-Alzheimer emhlabeni wonke naseSri Lanka. Udokotela wakho uzokhetha imithi efaneleke kakhulu ngokusekelwe kuhlobo lwesifo kanye nesimo sesiguli.
| Igama lomuthi (igama lomkhiqizo) | Izimo zokusetshenziswa | Imiphumela emibi evamile |
|---|---|---|
| I-Donepezil (i-Aricept) | Ezimweni ezincane, eziphakathi nendawo, nezinzima zesifo. Kuthathwa njengephilisi elilodwa kanye ngosuku. | Isicanucanu, ukuhlanza, ukuqunjelwa, ukuqaqamba kwemisipha, ukukhathala, nokulahlekelwa yisifiso sokudla. |
| I-Rivastigmine (i-Exelon) | Kwama-case amancane kuya kwaphakathi (amaphilisi). Iyatholakala futhi njenge-patch yesikhumba yamacala abucayi. | Isicanucanu, ukuhlanza, ukuqunjelwa, ukulahlekelwa yisifiso sokudla, kanye nobuhlungu besisu (lokhu akuvamile kakhulu uma usebenzisa i-patch). |
| I-Galantamine (i-Razadyne) | Ezimweni ezincane kuya kweziphakathi zalesi sifo, thatha kabili ngosuku noma njenge-capsule esebenza isikhathi eside kanye ngosuku. | Isicanucanu, ukuhlanza, ukuqunjelwa, ukulahlekelwa yisifiso sokudla, ikhanda elibuhlungu , isiyezi. |
| I-Donepezil + i-Memantine (i-Namzaric) | Ikhiqizwa ngokuhlanganiswa nomunye umuthi (i-NMDA agonist) ezimweni eziphakathi kuya kwezinzima zesifo. | Ikhanda elibuhlungu , ukudideka, isiyezi, ukuqunjelwa, isicanucanu, ukuhlanza. |
Kuthiwani uma ngiba nemiphumela emibi lapho ngiqala ukuthatha imithi?
Abanye abantu bangase babe nemiphumela emibi lapho beqala ukuthatha lo muthi. Kodwa ungakhathazeki. Esikhathini esiningi, le miphumela emibi izophela njengoba umzimba wakho ujwayela umuthi. Udokotela wakho uvame ukuqala ngomthamo ophansi kakhulu bese ekhulisa umthamo kancane kancane.
Uma unesicanucanu, ukuthatha umuthi nokudla kungasiza ekulawuleni lesi simo. Into ebaluleke kakhulu ukukhuluma nodokotela wakho nganoma yikuphi ukungakhululeki obhekene nakho. Uzokwazi ukukunikeza ikhambi elingcono kakhulu.
Lo muthi usebenza kangakanani ngempela?
Lokhu kuyinkinga kubantu abaningi. Uma ngikhuluma iqiniso, imiphumela yale mithi ingeyesikhashana. Ezinye iziguli zingabona ukwehla okukhulu kwezimpawu. Ziyakwazi ukucabanga ngokucacile, zikhumbule izinto, futhi zenze imisebenzi yansuku zonke kalula. Lesi simo ngezinye izikhathi singahlala iminyaka eminingana.
Kodwa kumelwe siqonde ukuthi lokhu kufana nokubeka iplasta okwesikhashana phezu kwethangi elivuzayo. Kuzovimba amanzi ukuthi angavuzi isikhashana, kodwa i-patch ngeke isebenze njengoba imbobo ethangini ikhula. Ngokufanayo, le mithi ayikwazi ukuvimba noma ukubuyisela emuva umonakalo ebuchosheni obangelwe yisifo i-Alzheimer's. Ngokuhamba kwesikhathi, njengoba lesi sifo siqhubeka, futhi ukukhiqizwa kwe-acetylcholine ebuchosheni kucishe kume ngokuphelele, le mithi nayo ayinawo umphumela.
Ingabe bakhona abantu okungafanele bathathe lo muthi?
Yebo. Lo muthi awufanele wonke umuntu. Izithibi ze-Cholinesterase zingehlisa izinga lokushaya kwenhliziyo kanye nomfutho wegazi. Ngakho-ke, odokotela bayaqaphela kakhulu lapho bewunikeza abantu abanezimo ezithile zempilo.
- Abantu abane-asthma
- Abantu abanezinkinga zesigqi senhliziyo
- Abantu abanesifo sezinso noma sesibindi
- Abantu abanezilonda zesisu
Uma othandekayo wakho enanoma yiziphi zalezi zimo, qiniseka ukuthi wazisa udokotela wakho ngakho.
Kubaluleke kakhulu: Tshela udokotela wakho nganoma yimiphi imithi , amavithamini, izithasiselo zokudla okunempilo, ngisho nemithi ye-Ayurvedic noma ye-Sinhala ethathwa ngumuntu omthandayo. Eminye imithi (isib. eminye imithi yomkhuhlane kanye neyokungezwani komzimba) ingasebenzisana nalezi Zithibi ze-Cholinesterase, okwenza yomibili le mithi ingasebenzi kahle noma ibangele imiphumela emibi eyingozi.
Umlayezo Wokuya Nawe Ekhaya
- Ama-cholinesterase inhibitors awayona ikhambi lesifo i-Alzheimer's. Alawula okwesikhashana izimpawu ezihlobene nenkumbulo nokucabanga.
- Lo muthi usebenza ngokwandisa amazinga esithunywa samakhemikhali esibizwa ngokuthi i-acetylcholine ebuchosheni.
- Imiphumela emibi efana nokucasuka nokuhlanza ingase ivele ekuqaleni komuthi, kodwa ivame ukuncipha ngokuhamba kwesikhathi.
- Ungalokothi uyeke ukuthatha imithi noma ushintshe umthamo ngaphandle kweseluleko sikadokotela wakho.
- Kubalulekile ukwazisa udokotela wakho ngayo yonke eminye imithi ethathwa ngumuntu omthandayo.
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