Ngezinye izikhathi, ngemva kokudla ukudla okubabayo, uthola umuzwa oshisayo esifubeni sakho, akunjalo? Noma uzizwa ungakhululekile sengathi i-asidi yesisu sakho inyukile futhi ikhuphukela emphinjeni wakho? Ama-H2 blockers awuhlobo lomuthi abantu abaningi abawusebenzisa ngezikhathi ezinjengalezi. Ngakho-ke namuhla, ake sixoxe ngokuthi ayini lawa ma-H2 blockers, ukuthi asebenza kanjani emizimbeni yethu, nokuthi yiziphi izinto ezibalulekile okudingeka sizazi lapho siwasebenzisa.
Ziyini lezi H2 Blockers?
Kalula nje, ama-H2 blockers (abizwa nangokuthi ama-H2 antagonists) uhlobo lomuthi olawula noma onciphisa ukukhiqizwa kwe-asidi esiswini sakho.
I-asidi yesisu ibalulekile ekugayeni ukudla esikudlayo. Kodwa uma le-asidi iningi kakhulu, ingalimaza ulwelwesi lomgudu wakho wokugaya ukudla. Lokhu kungaholela ezimpawini ezifana nobuhlungu besisu kanye nesilungulela. Kungaba yinto engakhululekile njengokuzisola ngokudla okokugcina okudlile.
Uma futhi uzizwa ungakhululekile ngenxa yokwanda kwe-asidi yesisu, ungase uthande ukucabanga ngokusebenzisa i-H2 blocker.
Yiziphi izimo ezisetshenziswa ama-H2 blockers?
Ama-H2 blocker asetshenziswa kakhulu ukwelapha izimo ezihlobene nokukhiqizwa kwe-asidi eningi esiswini. Kodwa-ke, kubalulekile ukukhumbula ukuthi le mithi ingalahlekelwa ukusebenza kwayo kancane kancane uma isetshenziswa njalo isikhathi eside.
Uma unesifo esingamahlalakhona, udokotela wakho angase ancome uhlobo lomuthi olubizwa ngokuthi i-Proton Pump Inhibitor (PPI) esikhundleni sama-H2 blockers. Nakuba ama-PPI ethatha isikhathi eside ukusebenza, angalawula ukukhiqizwa kwe-asidi ngempumelelo kakhulu kunama-H2 blockers. Angasetshenziswa futhi isikhathi eside.
Ezinye zezimo eziyinhloko ezelashwa ngama-H2 blockers zibalwe ngezansi.
| Isimo sezokwelapha | Incazelo elula |
|---|---|
| Izilonda zesisu | I-asidi eningi ekhiqizwayo ingalimaza ulwelwesi lwesisu futhi ibangele izilonda. Ukunciphisa i-asidi ngama-H2 blockers kunikeza lezo zilonda isikhathi nendawo ezidingayo ukuze zelapheke. |
| Izilonda ze-Duodenal | I-asidi yesisu ingahamba iye engxenyeni yokuqala yamathumbu amancane (i-duodenum) bese ibangela izilonda lapho. Lesi simo singelashwa nangama-H2 blockers, yize ama-PPI esebenza kahle kakhulu. |
| I-reflux ye-asidi | I-asidi yesisu ibuyela phezulu iye emhubheni nasemphinjeni, okubangela isilungulela. Lokhu kungabangela nesilungulela. I-H2 blocker iyisisombululo esihle salesi simo esingajwayelekile. Kodwa uma lokhu kwenzeka njalo (GERD), i-PPI ifaneleka kakhulu. |
| I-Zollinger-Ellison syndrome | Lesi yisimo esingavamile kakhulu. Amanye amathumba akheka kulesi simo abangela ukuthi isisu sikhiqize i-asidi eningi kakhulu. Nakuba ama-H2 blocker angasiza ekulawuleni lesi simo, odokotela bavame ukuncoma ama-PPI. |
Ama-blocker e-H2 asiza ekunciphiseni izimpawu ezilandelayo ezihambisana nalezi zimo:
- Ukungagayeki kahle kokudla
- Ubuhlungu besisu
- Ubuhlungu besifuba nomphimbo obuhlungu
- Isicanucanu nokuhlanza
- Isisu esimuncu
Lo muthi usebenza kanjani ngempela emzimbeni?
Kulula kakhulu. Elinye igama lama-H2 blockers yi-histamine-2 (H2) antagonists. Sifunde esikoleni ukuthi 'umphikisi' endabeni uyinto ephazamisa okuthile? Nokho, lokho okwenziwa yilaba baphikisi be-H2 ukuphazamisa inqubo yokukhiqiza i-asidi esiswini.
Cabanga ngale ndlela. Ngemva kokudla, imizimba yethu ikhipha ikhemikhali ebizwa ngokuthi i-H2. Le H2 iyahamba inamathele kuma-receptor e-H2 ezindongeni zesisu. Kufana nesihluthulelo esifakwa kukhiye. Lokhu kuhlanganiswa yilokho okutshela isisu ukuthi, "Kulungile, manje yenza i-asidi."
Uma uthatha i-H2 blocker, umuthi uyahamba ubophe kulawo ma-receptor e-H2 (izingidi) bese "uyawavimba". Ngaleyo ndlela, ama-H2 (izihluthulelo) awatholi ithuba lokuza abophe kuma-receptor. Lapho isignali yokwenza i-asidi iyeke, isisu sikhiqiza i-asidi encane.
Lokhu akuphazamisi inqubo yakho yokugaya ukudla. Kulawula nje inani le-asidi eyengeziwe ekhiqizwayo ebangela ubuhlungu nokungakhululeki.
Yimiphi imithi yokuvimbela i-H2 etholakalayo?
Kunezinhlobo eziningana zama-H2 blocker. Amanye angathengwa ngaphandle kwemithi kadokotela (OTC), kanti amanye adinga udokotela oqaphile.
| Igama lomuthi | Uhlobo oluvame ukubonakala | Ungayithola kanjani |
|---|---|---|
| I-Cimetidine | I-Tagamet® | Ukuthola imithi ngaphandle kwemvume kadokotela kanye nemithi kadokotela (OTC & Rx) |
| I-Famotidine | I-Pepcid® | Ukuthola imithi ngaphandle kwemvume kadokotela kanye nemithi kadokotela (OTC & Rx) |
| I-Nizatidine | I-Axid® | Kuphela ngomuthi kadokotela (i-Rx kuphela) |
Inothi Elikhethekile: Ungase ukhumbule i-H2 blocker i-Ranitidine (Zantac®) eyayithandwa kakhulu. Kodwa ngo-Ephreli 2020, izinhlangano ezifana ne-FDA (US Food and Drug Administration) zatshela abakhiqizi ukuthi basuse lo muthi emakethe. Isizathu sasiwukuthi ukuhlolwa kwabonisa ukuthi ngokuhamba kwesikhathi futhi lapho kugcinwa emazingeni okushisa aphezulu, amazinga ekhemikhali ebizwa ngokuthi i-nitrosodimethylamine, noma i-NDMA, okungenzeka ukuthi iyimbangela yomdlavuza, akhuphuka afinyelela emazingeni angaphephile.
Lo muthi kufanele usetshenziswe kanjani futhi nini?
Ama-H2 blocker angathathwa ngomlomo njengamaphilisi noma ama-capsule. Kukhona futhi impuphu engancibilikiswa oketshezini kubantu abanenkinga yokugwinya amaphilisi. Anganikezwa futhi ngemithambo yegazi (IV) ezigulini ezilaliswe esibhedlela futhi ezingakwazi ukuthatha imithi yomlomo.
Isikhathi esingcono kakhulu sokuthatha umuthi
- Ukuze kube nokungakhululeki ngezikhathi ezithile:Uma wazi ukuthi ukudla ukudla okubabayo noma okunamafutha kungabangela inkinga, thatha i-H2 blocker imizuzu engama-30 kuya kwengama-60 ngaphambi kokudla lokho kudla. Lokho kukunika isikhathi sokusebenza. Kulungile ukukuthatha ngemva kokuqala kwenkinga, kodwa kungathatha isikhathi esingafika ehoreni ukuthi izimpawu ziphele.
- Uma kwenzeka isimo esifana nokuphola kwenxeba: Udokotela wakho angase akuncome ukuthi uphuze kanye ngosuku ngaphambi kokulala, noma kanye ekuseni kanye kanye ebusuku, kuye ngemiyalelo kadokotela wakho.
Into ebaluleke kakhulu ukuthi uma udinga ukusebenzisa le mithi isikhathi esingaphezu kwamasonto amabili ngesikhathi, kufanele nakanjani ubone udokotela wakho. Akunconywa ukuqhubeka nokusebenzisa le mithi ngaphandle kokuthola imbangela eqondile yezimpawu zakho.
Uyini umehluko phakathi kwama-H2 Blockers, ama-Antacids nama-PPI?
Abantu abaningi bayadideka ngalezi zinhlobo ezintathu zemithi esetshenziselwa isilungulela. Ake sibheke umehluko omkhulu phakathi kwazo.
| Uhlobo lwesidakamizwa | Isikhathi esithathiwe ukusebenza | Ubude bomphumela | Ithuba elifanele kakhulu |
|---|---|---|---|
| Ama-antacid (isib. iDigene, iGelusil) | Ngokushesha kakhulu (imizuzu embalwa) | Kufushane kakhulu (amahora angu-1-2) | Uma kudingeka usizo olusheshayo. |
| Ama-H2 Blockers | Cishe ihora | Cishe amahora angu-4-10 | Ukuvimbela isilungulela ngezikhathi ezithile noma ngaphambi kokudla. |
| Ama-PPI (Ama-Proton Pump Inhibitors) | Izinsuku ezingu-1-4 ukuze kusebenze ngokugcwele | Isikhathi eside (amahora angu-24+) | Ngezimo ezifana ne-gastritis engapheli kanye ne-GERD. |
Ingabe ikhona imiphumela emibi?
Ama-H2 blocker ngokuvamile ayimithi ephephile kakhulu enemiphumela embalwa emibi . Ngisho noma imiphumela emibi ivele, imvamisa iba mincane.
- Ubuhlungu besisu
- Ubuhlungu bemisipha
- Ukuqunjelwa
- Uhudo
- Umlomo owomile
- Ukukhathala
- Ikhanda elibuhlungu
Akuvamile kakhulu ukuthi abantu abasemaqenjini asengozini enkulu (ikakhulukazi labo abaneminyaka engaphezu kwengu-50 ubudala, labo abanezinkinga zezinso noma zesibindi) bangase babe nezimpawu ezihlobene nesimiso sezinzwa, njengokulahlekelwa yinkumbulo noma ubunzima bokukhuluma. Kodwa-ke, lokhu akuvamile kakhulu . Lezi zimpawu zivame ukuphela zingakapheli izinsuku ezimbalwa ngemva kokuyeka umuthi.
Ukusebenzisana nezinye izidakamizwa
Amanye ama-H2 blocker angathinta indlela eminye imithi oyithathayo esebenza ngayo. Isibonelo, i-H2 blocker cimetidine inganciphisa ukusebenza kweminye imithi yokucindezeleka (ama-SSRI) kanye ne-warfarin (`(warfarin)`).
Ngakho-ke, ngaphambi kokuthi uqale i-H2 blocker entsha, kubaluleke kakhulu ukwazisa udokotela wakho ngayo yonke eminye imithi osuvele uyisebenzisa.
Ingabe lezi zifanele omama abakhulelwe nabancelisayo?
Kusadingeka ucwaningo olwengeziwe mayelana nokuphepha kokusebenzisa ama-H2 blockers ngesikhathi sokukhulelwa, kodwa kuyaziwa ukuthi le mithi idlulela enganeni ngobisi lwebele.
Ngakho-ke, uma ukhulelwe, uhlela ukukhulelwa, noma ungumama oncelisayo, qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokuthatha noma yimuphi wale mithi.
Umlayezo Wokuya Nawe Ekhaya
- Ama-H2 blocker awuhlobo lomuthi onciphisa i-asidi yesisu. Alungele ukuhlinzeka impumuzo yesikhashana ekushiseni kwesisu kanye nobuhlungu besifuba ngezikhathi ezithile.
- Nakuba lezi zisebenza ngokushesha kune-PPI, azifanele ukusetshenziswa isikhathi eside, nsuku zonke.
- Uma udinga ukusebenzisa ama-H2 blockers isikhathi esingaphezu kwamasonto amabili ngesikhathi, kungasho ukuthi unenye inkinga eyisisekelo. Ngokuqinisekile bonana nodokotela.
- Tshela udokotela wakho nganoma yimiphi eminye imithi oyithathayo (ngisho namavithamini).
- Uma ukhulelwe noma uncelisa, ungayisebenzisi le mithi ngaphandle kweseluleko sikadokotela.
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