So wowɔ asiane mu sɛ wubenya Alzheimer yare? Sua APOE Gene Test no ho ade

So obi wɔ w’abusua mu, ebia nanabea anaa nana bi, anya Alzheimer yare? Sɛ ɛba saa a, ɛyɛ ade a ɛfata koraa sɛ wobɛnya ehu kakra wɔ w'adwene mu, "Oh, so me nso menya saa yareɛ yi?" Ɛno ne bere a saa APOE awosu mu abɔde mu nhwehwɛmu yi ba asɛm no mu. So ebetumi ahyɛ yɛn daakye ho nkɔm ankasa? Momma yɛnka biribiara ho asɛm tiawa na emu nna hɔ.

Dɛn ne saa APOE awosu mu abɔde mu nhwehwɛmu yi?

Sɛ yɛbɛka no tiawa a, APOE awosu mu abɔde mu nhwehwɛmu yɛ awosu mu nhwehwɛmu a ɛhwɛ awosu mu abɔde bi a wɔfrɛ no apolipoprotein E. Sɛ wowɔ awosu mu nkwaadɔm yi mu ahorow bi a, ebia asiane kɛse wom kakra sɛ wubenya Alzheimer yare sen afoforo .

Nanso ade a ɛho hia sen biara wɔ ha ne eyi. Esiane sɛ wowɔ asiane kɛse nti, ɛnkyerɛ sɛ akyinnye biara nni ho sɛ wobɛyare. Fa no sɛ mununkum tuntum wɔ wim. Ɛno kyerɛ sɛ osu betumi atɔ, nanso ɛnkyerɛ sɛ akyinnye biara nni ho sɛ osu bɛtɔ. Saa na ɛte. Ɛnyɛ yɛn awosu mu nkwaadɔm nko na ɛka yɛn akwahosan, na mmom nneɛma afoforo pii te sɛ nea yedi, sɛ yɛteɛteɛ yɛn apɔw mu, ne yɛn asetra kwan nso.

Enti, ɛho hia paa sɛ wo ne wo duruyɛfo kasa na ama woate nea efi sɔhwɛ yi mu ba no ase.

Okay, enti dɛn ne saa APOE gene yi?

Awosu mu abɔde a wɔfrɛ no APOE ka kyerɛ yɛn nipadua mu nkwammoaa sɛ wɔnyɛ protein soronko bi a wɔfrɛ no apolipoprotein E. Saa protein yi yɛ adwuma a ɛho hia yiye. Ɛne srade (srade) a ɛwɔ yɛn nipadua mu no bom na ɛde nneɛma te sɛ srade kɔ baabi a ɛsɛ sɛ ɛwɔ mogya no mu, te sɛ taksi. Yɛfrɛ eyi sɛ lipoprotein.

APOE awosu mu abɔde no mu nneɛma atitiriw abiɛsa na ɛwɔ yɛn nipadua mu.

Yɛn nyinaa nya saa awosu mu abɔde yi abien, biako fi yɛn maame hɔ na biako fi yɛn papa hɔ. Enti wobɛtumi anya saa ahodoɔ mmiɛnsa yi mu mmienu biara a wɔaka abom (e.g. e3/e3, e3/e4, e2/e4).

Awosu mu nkwaadɔm yi mu nea ɛwɔ he na ɛne Alzheimer yare no wɔ abusuabɔ?

Nea edi kan koraa no, wonnya nhuu awosu mu abɔde biara a ɛde Alzheimer yare ba tẽẽ . Nanso nhwehwɛmu ada no adi sɛ sɛ obi nya APOE-e4 awosu mu abɔde mu nkwaadɔm no biako mpo a, ɛma asiane a ɛwɔ hɔ sɛ obenya Alzheimer yare no yɛ kɛse.

• APOE-e4: Nnipa a wɔwɔ saa awosu mu nkwaadɔm a ɛyɛ soronko yi biako anaa abien no wɔ asiane kɛse sɛ wobenya Alzheimer yare a efi ase akyiri yi a ɛba bere a wɔadi mfe 65 akyi no.
• APOE-e2: Eyi yɛ asɛmpa kakra. Ebia saa awosu mu nkwaadɔm a ɛyɛ soronko yi bɛma ahobammɔ bi afi Alzheimer yare no ho. Sɛ obi a ɔwɔ saa awosu mu abɔde yi nya yare no mpo a, ɛtaa ba akyiri yi koraa sen obi a ɔwɔ APOE-e4.

Woyɛ dɛn yɛ sɔhwɛ yi? Hena na ɔyɛ?

Eyi nyɛ sɔhwɛ a wɔhyɛ wo ma woyɛ. Ɛyɛ biribi a w’ankasa wo pɛ mu na woyɛ. Sɛ Alzheimer yareɛ bi wɔ w’abusua mu a, ebia w’ani begye ho sɛ wubesua eyi ho ade. Sɛ ɛba saa a, wubetumi ne wo duruyɛfo akasa na woahu eyi ho nsɛm pii.

Sɔhwɛ no yɛ mmerɛw yiye:

1. DNA nhwɛsode a wubenya: Oduruyɛfo bi begye DNA nhwɛsode afi wo hɔ. Wobetumi ayɛ eyi denam mogya kakraa bi a wobɛfa anaasɛ wode aduru ketewaa bi a wɔde bɛbɔ w’ano anaa w’afono mu no so.

2. Wɔde kɔ aduruyɛdan mu: Wɔde saa nhwɛsode yi kɔ aduruyɛdan titiriw bi mu kɔsɔ hwɛ.

3. Nea efi mu ba a wode bɛma: Lab no hwehwɛ wo DNA mu na wɔsan de nea efi mu ba no kɔma wo duruyɛfo.

4. Nea ebefi mu aba no ho nkɔmmɔbɔ: Afei, wo duruyɛfo anaa awosu ho ɔfotufo bi ne wo bɛkasa na wakyerɛkyerɛ nea nea afi mu aba yi kyerɛ mu.

Mprempren awosu mu nhwehwɛmu a wɔyɛ wɔ fie wɔ aman bi mu. Nanso, sɛ wunya nea efi biako mu ba mpo a, ɛho da so ara hia sɛ wo ne w’abusua oduruyɛfo kasa na ama woate nsɛm pɔtee no ase.

Dɛn na yesua fi nea efi mu ba no mu?

Nea efii sɔhwɛ no mu bae no kyerɛ wo APOE awosu mu abɔde no mu nneɛma ahorow (alleles) a wowɔ.

Dɛn na APOE4 positive kyerɛ?

"APOE4 positive" kyerɛ sɛ anyɛ yiye koraa no wowɔ APOE-e4 gene no bi wɔ wo DNA mu.

Asiane bɛn na ɛwɔ mu sɛ wubenya Alzheimer yare sɛ wowɔ APOE4 a?

Wiase nnipa dodow 15% kosi 25% na wɔwɔ APOE-e4 awosu mu abɔde no biako. 2% ne 5% ntam wɔ abien no nyinaa. Sɛ obi nya biako mpo a, ebetumi ama asiane a ɛwɔ hɔ sɛ obenya Alzheimer yare no ayɛ kɛse.

Nanso, mesan ka bio sɛ, eyi nyɛ sɔhwɛ a ɛkyerɛ sɛ yare bi wɔ hɔ. Asiane a ɛwɔ mu no nkutoo na ɛka kyerɛ wo.

Sɛ nea efi mu ba no kyerɛ sɛ asiane no sõ a, ebia wo duruyɛfo bɛka akyerɛ wo sɛ yɛ nneɛma te sɛ:

• Apɔw-mu-teɛteɛ a wobɛyɛ daa: Apɔw-mu-teɛteɛ a ɛma wo ho fifiri anyɛ yiye koraa no nna kakraa bi dapɛn biara a wobɛyɛ.
• Da yiye: Anyɛ yiye koraa no, da nnɔnhwerew 7-8 da biara.
• Fekubɔ: bere a wo ne wo nnamfo ne abusuafo nya, de wo ho hyɛ fekubɔ dwumadi ahorow mu.
• Amemene no a wɔbɛsɔ ahwɛ: Nneɛma te sɛ ahodwiriwde ahorow a wobedi, nhoma akenkan, kasa foforo anaa sanku foforo a wosua.

So nea efi mu ba yi a wubehu no betumi aka adwene no?

Yiw, koraa. Sɛ yehu nea efi awosu mu nhwehwɛmu a ɛte sɛɛ mu ba a, ebetumi aka yɛn wɔ akwan pii so. Ebia wobɛte ehu nka, wo ho yeraw wo, anaa wo bo afuw. Ɛtɔ da bi a, ebia nea ebefi mu aba no remma wo mmuae a emu da hɔ a na wohwɛ kwan no.

Kae sɛ, ɛmfa ho sɛnea w’awosu te biara no, nneɛma pii wɔ hɔ a wubetumi ayɛ de atew asiane a ɛwɔ hɔ sɛ wubenya Alzheimer yare no so. Afotu a eye sen biara ma eyi ne sɛ wo ne wo duruyɛfo bɛkasa.