Brentuximab Vedotin Vaccine: Nea Ɛsɛ sɛ Wuhu

So wo nnuruyɛfo asi gyinae sɛ wɔbɛma wo anaa obi a wunim no aduru a wɔfrɛ no Brentuximab Vedotin de asa kokoram tebea te sɛ lymphoma? Sɛ saa a, ɛnnɛ yɛbɛka saa aduru yi ho asɛm, sɛnea ɛyɛ adwuma, nea ebetumi afi mu aba, ne nneɛma a ɛsɛ sɛ wohwɛ yiye. Esiane sɛ eyi yɛ aduru a ɛyɛ den kakra nti, ɛho hia sɛ woma wo ho da hɔ wɔ saa nneɛma yi ho.

Aduru bɛn na Brentuximab Vedotin yɛ?

Sɛ yɛbɛka no tiawa a, Brentuximab Vedotin yɛ aduru titiriw bi a wɔde sa kokoram bi a wɔfrɛ no Lymphoma. Nea enti a ɛte saa ne sɛ protein soronko bi wɔ hɔ a ɛboa ma kokoram nkwammoaa nyin, kyekyɛ, na ɛdɔɔso. Ɛdenam saa protein no a ɛmma ɛnyɛ adwuma so no, saa aduru yi boa ma kokoram nkwammoaa no trɛw, anaasɛ anyɛ yiye koraa no, ɛma ɛyɛ brɛoo. Sɛ yɛbɛka no pɛpɛɛpɛ a, eyi yɛ aduru a wɔde ma kokoram nkwammoaa (targeted therapy). Ne din a agye din ne ADCETRIS . Ɛtɔ da bi a, wo duruyɛfoɔ nso bɛtumi de saa aduru yi adi dwuma ama tebea foforɔ. Enti sɛ wowɔ nsɛmmisa bi a, ɛbɛyɛ papa sɛ wubebisa wo duruyɛfo anaa nnuruyɛfo.

Nneɛma bɛn na ɛsɛ sɛ woka kyerɛ w’aduruyɛfo kuw no ansa na woanom saa aduru yi?

Ansa na wubefi saa aduru yi ase no, ɛsɛ sɛ woka nneɛma bi kyerɛ wo kuw a wɔhwɛ wo no pefee. Efisɛ saa nsɛm no bɛboa wɔn ma wɔasi gyinae sɛ ebia aduru yi fata wo ne ɔkwan a wɔbɛfa so de ama. Mfa biribiara nsie, ade ketewaa mpo. Sɛ wowɔ tebea horow yi bi a, hwɛ hu sɛ wobɛka akyerɛ wɔn:

• Asikreyare : Sɛ wowɔ asikreyare a.
• Asaabo mu yare : Sɛ ɔhaw anaa yare bi wɔ asaabo no mu a .
• mmerɛbo mu yare : Sɛ ɔhaw anaa yare bi wɔ mmerɛbo no mu a.
• Mogya mu nkwammoaa fitaa dodow a ɛba fam: Sɛ wɔadi kan ahu sɛ mogya mu nkwammoaa fitaa sua wɔ wo mogya mu a. Eyinom ne nkwammoaa a ɛko tia nyarewa wɔ yɛn nipadua mu.
• Ahurututu mu yare : Sɛ wowɔ ahurututu mu yare biara, sɛ nhwɛso no , ɛyɛ den sɛ wobɛhome .
• Ntini mu haw : Sɛ wo nsa ne wo nan ho ayɛ wo yaw, wo ho yɛ wo yaw, anaa ntini mu haw afoforo (te sɛ peripheral neuropathy).
• Allergies: Sɛ woanya aduru yi, Brentuximab Vedotin, aduru foforo biara a wode adi dwuma bere bi a atwam, aduan biara, nnuru biara a wɔde yɛ nneɛma, anaa nneɛma biara a wɔde siw ano.
• Nyinsɛn anaa mmɔden a worebɔ sɛ wubenyinsɛn: Sɛ mprempren woanyinsɛn anaa woreyɛ nhyehyɛe sɛ wobɛwo akokoaa nnansa yi ara a.
• Nufu a Woma: Sɛ worema wo ba no nufu a.

Sɛ wɔka saa nsɛm yi yiye a, nnuruyɛfo kuw no betumi asa wo yare dwoodwoo.

Mɛyɛ dɛn ama wo aduru yi?

Wɔde saa aduru yi ma wo sɛ nea wɔde gu ntini mu (wɔde fa ntini mu anaa wɔde fa IV mu). Mpɛn pii no, nnuruyɛfo a wɔatete wɔn wɔ ayaresabea anaa kokoram ayaresabea na wɔde eyi ma wo. Eyi kyerɛ sɛ wuntumi mfa nkɔ fie mfa nni dwuma.

So wobetumi de saa aduru yi ama mmofra nkumaa?

Yiw, wɔ nsɛm titiriw bi mu no, wobetumi de saa aduru yi ama mmofra a wɔadi mfe 2 pɛ . Nanso, ɛsɛ sɛ wodi ahwɛyiye soronko bi akyi. Sɛ wɔakyerɛw aduru yi ama wo ba a, wo ne wo duruyɛfo nka ho asɛm yiye na hwehwɛ mu nsɛm nyinaa.

Sɛ wonom nnuru pii a, dɛn na ɛba?

Sɛ wususuw sɛ woadi mfomso anom aduru yi pii a, frɛ beae a wɔhwɛ awuduru so anaa baabi a wɔhwɛ wɔn a wɔwɔ yare a egye ntɛmpɛ ntɛm ara.

Nea ɛho hia: Wɔakyerɛw saa aduru yi ama wo nkutoo. Mma nnkyɛ obi foforo biara esiane biribiara nti.

Na sɛ mepa nnuru dodow bi nso ɛ?

Wɔbɛma wo da ne bere pɔtee bi a wode bɛma saa vaccine yi. Ɛho hia paa sɛ wobɛkɔ akɔgye vaccine no wɔ saa nna no mu. Sɛ biribi nti woantumi ankɔ da a woahyɛ da ayɛ no a, frɛ w’akwahosan kuw no ntɛm ara na ma wɔnhu.

Nneɛma foforo bɛn na ebetumi ne aduru yi adi nkitaho?

Nnuru bi wɔ hɔ a ebetumi de ɔhaw aba bere a wɔde Brentuximab Vedotin ka ho no. Enti, ɛsɛ sɛ woka nnuru a wonom nyinaa ho asɛm kyerɛ wo duruyɛfo, a vitamin, nhabannuru, ne aduannuru a wɔde ma ka ho. Nnuru bi a ɛnsɛ sɛ wɔde ka aduru yi ho da no bi ne:

• Bleomycin a wɔde yɛ aduru

Afei nso, nneɛma afoforo bi wɔ hɔ a ebetumi ne aduru yi adi nkitaho:

• Ketoconazole a wɔde ma
• Rifampin na ɔkyerɛwee
• St. John's Wort - Eyi yɛ amammerɛ mu nhabannuru a nnipa binom de di dwuma.

Saa list yi nwie pɛyɛ. Enti, ka nnuru a wonom nyinaa ho asɛm kyerɛ wo duruyɛfo, ne sɛ wonom sigaret, wonom nsa, anaa wode nnuru foforo di dwuma a. Nneɛma bi betumi aka sɛnea aduru yi yɛ adwuma.

Dɛn na ɛsɛ sɛ wohwɛ yiye wɔ ho bere a worenom aduru yi?

Wo nnuruyɛfo bɛhwɛ wo tebea no yiye bere a worenom aduru yi no. Afei nso, ɛsɛ sɛ wohwɛ yiye wɔ nneɛma bi ho.

• Mogya mu nhwehwɛmu: Ɛho behia sɛ woyɛ mogya mu nhwehwɛmu daa (mogya mu adwuma) bere a worenom aduru yi. Eyi yɛ sɛnea ɛbɛyɛ a wobɛhwɛ sɛnea aduru no renya wo nipadua so nkɛntɛnso ne sɛ ebia nsunsuanso bɔne bi wɔ hɔ anaa.
• Asiane a ɛwɔ hɔ sɛ wubenya ɔyare mmoawa: Ebia asiane a ɛwɔ hɔ sɛ wubenya nyarewa, titiriw ɔyare mmoawa, bɛkɔ soro kakra bere a worenom aduru yi no. Enti, sɛ wunya atiridii ho sɛnkyerɛnne biara, te sɛ atiridiinini, atiridiinini, menewam yaw, anaa sɛnkyerɛnne afoforo a ɛte sɛ atiridii , nnyɛ wo ho aduru na hwehwɛ aduruyɛfo afotu ntɛm ara. Bɔ mmɔden sɛ wobɛkwati mmeae a nkurɔfo yare sɛnea wubetumi biara.
• Progressive Multifocal Leukoencephalopathy (PML): Ebia eyi bɛyɛ te sɛ nea ɛyɛ hu, nanso ɛho hia sɛ wuhu. Wɔ nnipa binom mu no, saa aduru yi betumi ama amemene mu yare a emu yɛ den aba (Progressive Multifocal Leukoencephalopathy - PML). Eyi ho yɛ na koraa, nanso ebetumi akum obi. Enti sɛ wowɔ sɛnkyerɛnne bi te sɛ w’ani a ɛsakra, adwene mu haw, kasa mu haw, anaa nantew anaa gyinabea mu haw a , ka kyerɛ w’aduruyɛfo kuw no ntɛm ara. Sɛ wuntumi nkɔ wɔn nkyɛn a, nya aduruyɛ mu mmoa foforo ntɛm ara.
• Asikre a ɛdɔɔso wɔ mogya mu: Ebia saa aduru yi bɛma asikre a ɛwɔ wo mogya mu no akɔ soro. Asiane yi yɛ kɛse wɔ nnipa a wɔwɔ asikreyare dedaw mu. Enti, bisa w’aduruyɛfo kuw no akwan a wobɛfa so ahwɛ asikre dodow a ɛwɔ wo mogya mu no so.
• Nyinsɛn ne nufu a wɔde ma:
• Nnyinsɛn bere a worenom aduru yi ne asram 6 bere a woagyae aduru no akyi. Eyi ho hia paa, efisɛ saa aduru yi betumi apira akokoaa a ɔwɔ awotwaa mu no kɛse.
• Enti, ɛho hia sɛ wɔde nnuru a ɛfata a wɔde siw nyinsɛn ano di dwuma wɔ saa bere yi mu. Wo ne wo duruyɛfo nkasa fa akwan a wɔfa so siw awo ano a ɛfata ma wo ne wo hokafo no ho.
• Sɛ wususuw sɛ ebia wo anaa wo hokafo anyinsɛn a, ka kyerɛ wo duruyɛfo ntɛm ara.
• Mma mma nufu bere a worenom aduru yi.
• Awo: Saa aduru yi betumi aka awo, a ɛkyerɛ sɛ obi ntumi nwo. Sɛ wowɔ eyi ho haw bi a, wo ne w’aduruyɛfo kuw no nkasa.

Dɛn ne aduru yi mu nsunsuanso bɔne a ebetumi afi mu aba?

Te sɛ aduru biara no, Brentuximab Vedotin betumi de nsunsuanso bɔne bi aba. Ebi yɛ aniberesɛm, ebi nso nyɛ aniberesɛm saa. Ade a ɛho hia sen biara ne sɛ sɛ wuhu biribi a ɛyɛ soronko a, wobɛka akyerɛ wo duruyɛfo ntɛm ara.

Nneɛma bɔne a ɛsɛ sɛ wɔbɔ ho amanneɛ kyerɛ oduruyɛfo ntɛm ara:

Sɛ wuhu saa sɛnkyerɛnne ahorow yi bi a, frɛ w’aduruyɛfo kuw no ntɛm ara sɛnea wubetumi:

• Nneɛma a ɛma obi ho yɛ no hyew: Honam ani akisikuru, ɛyaw, akisikuru, anim, anofafa, tɛkrɛma, ne menewa a ɛho ahonhon.
• Adwene a ɛyɛ basaa ne ɔhaw ahorow a ɛfa nneɛma a wɔyɛ no pɛpɛɛpɛ ho:Adwene a ɛyɛ basaa, sɛ obi ntumi nkari pɛ anaasɛ ontumi nyɛ adwuma yiye, adwene a ɛyɛ basaa, na ɛyɛ den sɛ ɔbɛkasa.
• Asikre dodow a ɛkɔ soro wɔ mogya mu (Hyperglycemia): Sɛ obi te nka sɛ sukɔm de no kɛse, ɛsɛ sɛ ɔtow nsu mpɛn pii, ɔte nka sɛ wabrɛ soronko, onhu ade yiye.
• Nsɛnkyerɛnne a ɛkyerɛ sɛ obi anya ɔyare no: atiridiinini, atiridiinini, ɔfe, menewam yaw, akuru a ɛnsa, ɛyaw anaa ɛyɛ den sɛ wobɛtow, ne ɔhaw a ɛba obiara so.
• Nsɛnkyerɛnne a ɛkyerɛ sɛ mmerɛbo apira: Ɛyaw wɔ yafunu no atifi nifa so, aduan ho akɔnnɔ a ɛyera, akisikuru, nsu a ɛyɛ kɔla a ɛyɛ hare, nsu a ɛyɛ kɔkɔɔ anaa bruu tuntum, honam ani ne aniwa a ɛyɛ kɔkɔɔ (jaundice), ne ɔbrɛ a ɛyɛ soronko.
• Mogya mu nkwammoaa kɔkɔɔ a ɛba fam ho sɛnkyerɛnne: ɔbrɛ a ɛyɛ soronko, adwenemhaw, tiyɛ, ɔhome a ɛyɛ den.
• Ahurututu mu opira ho sɛnkyerɛnne: ɛyɛ den sɛ ɔbɛhome, ɔfe, mogya a ɛwɔ ahurututu mu, koko mu yaw, atiridiinini.
• Ɛyaw, akisikuru, anaa nsa anaa anan a ɛyɛ mmerɛw: Eyi betumi ayɛ ntini a ɛwɔ akyi no mu yare ho sɛnkyerɛnne.
• Pancreatitis: Yafunu mu yaw a emu yɛ den (eyi betumi akɔ akyi, na ɛyaw no betumi ayɛ kɛse bere a woadi anaa bere a woatu awie no), atiridiinini, akisikuru, ne ɔfe.
• Sɛnea honam ani yɛ n’ade: Kɔkɔɔ, akisikuru, honam ani a ɛbɛpae, ne nneɛma a ɛtete saa betumi aba ano no mu.
• Nsɛnkyerɛnne a ɛkyerɛ sɛ mogya tu wɔ yafunu mu: nsu a mogya ayɛ no ma anaa tar, ne mogya a ɛfe a ɛte sɛ kɔfe a wɔayam anaa bruu.
• Yafunu mu yaw a emu yɛ den mpofirim: Yafunu mu yaw a emu yɛ den mpofirim, akisikuru a mogya wom, atiridiinini, akisikuru, ne ɔfe.
• Tumor Lysis Syndrome (TLS): Eyi ba bere a kokoram nkwammoaa no sɛe ntɛmntɛm dodo no. Nsɛnkyerɛnne no bi ne: akisikuru, ɔfe, akisikuru, nsu a ɛso tew, nsu a ɛyɛ tumm, ɔbrɛ a ɛyɛ soronko, adwene a ɛyɛ basaa, ntini a ɛwosow anaa ɛyaw, koma a ɛbɔ ntɛmntɛm anaasɛ ɛnyɛ daa, ne nkwaa mu yaw.
• Akuru anaa mogya a ɛyɛ soronko: Akuru a ɛyɛ mmerɛw, ɛyɛ den sɛ wubegyae mogya.

Nsunsuanso bɔne a mpɛn pii no enhia sɛ wɔde kɔ ayaresabea (nanso sɛ ɛkɔ so anaasɛ ɛhaw adwene a, ɛsɛ sɛ wɔbɔ ho amanneɛ kyerɛ oduruyɛfo):

Mpɛn pii no, saa nsunsuanso bɔne yi nyɛ aniberesɛm. Nanso, sɛ wɔkɔ so anaasɛ wɔhaw wo pii a, ka kyerɛ w’aduruyɛfo kuw no.

• Ɛwa
• Ayamtuo
• Ɔbrɛ
• Nkwaa mu yaw
• Abofono
• Yafunu mu yaw
• Ɔfe a wɔfe

Saa nsɛm a wɔahyehyɛ yi nka nsunsuanso bɔne a ebetumi aba nyinaa ho. Sɛ wuhu biribi a ɛyɛ soronko a, bisa wo duruyɛfo no ho asɛm. Wubetumi nso abɔ amanneɛ akyerɛ FDA (Food and Drug Administration) denam 1-800-FDA-1088 a wobɛfrɛ so.

Ɔkwan bɛn so na ɛsɛ sɛ mede saa aduru yi sie?

Esiane sɛ wɔde saa aduru yi ma wo wɔ ayaresabea anaa ayaresabea nti, ɛnsɛ sɛ wode kɔ fie na wode sie. Enti ɛnsɛ sɛ wohaw wo ho wɔ ho.

Nea etwa to no, nneɛma a ɛho hia sen biara a ɛsɛ sɛ wokae (Take-Home Message) .

Okay, enti yɛaka Brentuximab Vedotin ho asɛm pii. Sɛ yɛde rewie a, nneɛma a ɛho hia paa a ɛsɛ sɛ wokae ni:

• Eyi yɛ aduru titiriw bi a ɛhwɛ ma kokoram nkwammoaa nyin.
• Hwɛ hu sɛ wobɛka w’ayaresa tebea afoforo ne nnuru a wonom ho asɛm akyerɛ wo duruyɛfo.
• Bɔ wo ho ban fi nyarewa ho bere a worenom aduru no na hwɛ yiye wɔ sɛnkyerɛnne biara a ɛyɛ soronko ho.
• Di akwankyerɛ a ɛfa nyinsɛn ne nufu a wɔde ma ho no akyi yiye.
• Sɛ wowɔ nsɛmmisa anaa adwenem naayɛ bi a, nsuro sɛ wubebisa nnuruyɛfo kuw no. Wɔwɔ hɔ sɛ wɔbɛboa wo.

Saa ayaresa yi betumi ayɛ den, nanso ɛnyɛ wo nkutoo. Yɛpɛ sɛ mo ahoɔden! Brentuximab Vedotin, Lymphoma, Kokoram Ayaresa, Kokoram Nnuru, Nsunsuanso bɔne, ADCETRIS