Ɛyɛ ade a ɛfata sɛ obiara bɛte ehu ne ahodwiriw kɛse nka bere a ɔte nsɛmfua "colorectal cancer" no. Nanso, esiane nkɔso a aba wɔ nnuruyɛ mu nnɛ nti, ayaresa foforo pii wɔ hɔ a edi mu a ebetumi aboa yɛn ma yɛagyina nyarewa a ɛtete saa ano. Ɛnnɛ, yɛrebɛka "targeted therapy" kwan a ɛyɛ soronko wɔ atetesɛm mu nnuruyɛ ho na ɛde n'ani si kokoram nkwammoaa so titiriw na ɛtow hyɛ so.
Sɛ yɛbɛka no tiawa a, dɛn ne saa Monoclonal Antibodies yi?
Ansa na yɛbɛte eyi ase no, momma yɛnhwɛ ahobammɔ nhyehyɛe a ɛyɛ nwonwa a yɛn nipadua wɔ no. Sɛ mmoawa bi te sɛ ɔyare mmoawa anaa mmoawa bi hyɛn yɛn nipadua mu a, yɛn nipadua mu tumi a ɛko tia nyarewa no yɛ protein soronko bi a etumi hu saa ntuafo yi, bata wɔn ho, na ɛsɛe wɔn. Yɛfrɛ eyinom "bodyguards," anaasɛ antibodies sɛ yɛbɛka no pɛpɛɛpɛ a.
Afei, saa ``Monoclonal Antibodies`` yi yɛ antibodies a wɔayɛ wɔ lab mu a wɔde mfiridwuma soronko di dwuma. Wɔyɛ eyinom sɛnea ɛbɛyɛ a wɔbɛtow ahyɛ botae pɔtee biako pɛ so. Sɛ yɛbɛka no pɛpɛɛpɛ a, wɔayɛ no sɛnea ɛbɛyɛ a wobehu protein pɔtee bi a ɛwɔ kokoram nkwammoaa bi ani, abata ho, na wɔasɛe saa kokoram nkwammoaa no .
Eyi te sɛ commando a wɔatete no titiriw a obetumi ahu ɔtamfo wɔ baabi a nnipa ahyɛ hɔ ma na watow ahyɛ saa ɔtamfo no nkutoo so a ɔrempira obi foforo biara. Enti, sɛ́ anka ɛbɛsɛe nkwammoaa pa a ɛwɔ nipadua no mu te sɛ nnuru a wɔde sa yare daa no, wobetumi ahwɛ kwan sɛ saa ayaresa kwan yi rennya nsunsuanso bɔne pii efisɛ ɛyɛ pɔtee.
Nnuru a ɛma mogya ntini nyin wɔ kokoram mu (Angiogenesis Inhibitors) .
Kokoram nyɛ biribi a enyin ara kwa. Ɛte sɛ afifide. Ehia aduannuru na ama atumi atra ase, anyin, na anyin. Nea ɛbɛyɛ na kokoram nkwammoaa no anya saa aduan yi no, enyin mogya ntini foforo twa wɔn ho hyia. Yɛfrɛ saa adeyɛ yi ``angiogenesis.`` Enti, sɛ yegyae mogya ntini a ɛde saa "aduan ne anonne" yi ma kokoram no a, yebetumi agyae kokoram no nyin, ɛnte saa? Ɛno ne nea yɛfrɛ no nnubɔne kuw a ɛyɛ saa no.
Sɛnea Bevacizumab (Avastin) yɛ adwuma ni:
Bevacizumab (aduru din: Avastin) yɛ aduru titiriw a ɛwɔ saa adesuakuw yi mu. Kokoram nkwammoaa de sɛnkyerɛnne bi kɔma a ɛka kyerɛ wɔn sɛ "wɔnkyekye mogya ntini." Wɔfrɛ saa sɛnkyerɛnne yi vascular endothelial growth factor, anaa VEGF. Nea Avastin yɛ ne sɛ esiw saa sɛnkyerɛnne no kwan sɛ ɛnkɔ beae a wɔde wɔn ani asi so no. Sɛ yɛbɛka no tiawa a, esiw "krataa a wɔde kyekye mogya ntini" a kokoram no de mena no mu na ɛsɛe no.
Eyi mma kokoram no ntumi nyɛ mogya ntini foforo, na ɛma kokoram no nyin brɛoo. Wɔapene saa aduru yi so ama kokoram a ɛwɔ akyi berɛmo mu a atrɛw (a akɔ mmeae afoforo) akɔ nipadua no afã afoforo. Ɛwom sɛ entumi nsa kokoram no koraa de, nanso nhwehwɛmu ahorow ada no adi sɛ sɛ wɔde Avastin ka nnuru a wɔde sa yare ho a, ebetumi ama ayarefo nkwa nna akyɛ bɛyɛ asram 5 .
`Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, ne `ziv-aflibercept (Zaltrap)` yɛ nnuru foforo a ɛsan nso de wɔn ani si `VEGF` so no bi.
Ɔkwan bɛn so na wɔde ma Avastin? Dɛn ne nneɛma bɔne a efi mu ba?
Avastin yɛ aduru a wɔde fa ntini mu (IV). Wɔtaa de ma adapɛn abien kosi abiɛsa biara ka nnuru a wɔde sa yare ho.
Ɛho hia yiye sɛ wuhu nneɛma bɔne a ebetumi afi aduru yi mu aba.
| Nsunsuanso bɔne no su | Nkyerɛmu |
|---|---|
| Nneɛma bɔne a ɛtaa ba |
|
| Nsunsuanso bɔne a anibere wom |
|
Nnuru a ɛka kokoram nkwammoaa nyin tẽẽ
Cetuximab (Erbitux) ne panitumumab (Vectibix) yɛ nnuru afoforo abien a ɛko tia nyarewa a ɛyɛ monoclonal. Ɛsono sɛnea eyinom yɛ adwuma. Wɔde wɔn ani si protein bi a wɔfrɛ no epidermal growth factor receptor (EGFR) a ɛwɔ kokoram nkwammoaa no ani so.
Susuw `EGFR` yi ho sɛ `On` switch a ɛka kyerɛ kokoram nkwammoaa sɛ `ɔnkyekyɛ ntɛmntɛm na ennyin kɛse.` Nea nnuru `Erbitux` ne `Vectibix` yɛ ne sɛ wɔtra saa switch yi so na `siw` ano. Afei, abɔde mu sɛnkyerɛnne a ɛkyerɛ sɛ nkwammoaa no nnyin no ntumi nsɔ switch no. Wɔ saa kwan yi so no, wɔhwɛ ma kokoram nkwammoaa nyin.
Henanom na wɔde saa aduru yi ma?
Wɔapene Erbitux ne Vectibix nyinaa so sɛ wɔmfa nsa kokoram a ɛtrɛw kɔ nipadua no afã afoforo no.
Wɔde Erbitux aduru no ma pɛnkoro dapɛn biara, ɛno nkutoo anaasɛ wɔde nnuru a wɔde sa yare a wɔfrɛ no irinotecan (Camptosar) ka ho. Wɔde Vectibix vaccine no ma adapɛn abien biara a wɔde ka nnuru afoforo a wɔde sa yare ho.
Ɛho hia yiye sɛ ansa na wode saa aduru yi bɛma no, wɔyɛ awosu mu nsakrae ho nhwehwɛmu titiriw bi wɔ wo kokoram nkwammoaa no so de hwɛ sɛ saa aduru yi bɛyɛ adwuma ama saa kokoram no anaa. Eyinom mfata kokoram nyinaa. Enti, akyinnye biara nni ho sɛ wɔayɛ sɔhwɛ yi.
Dɛn ne Erbitux ne Vectibix ho nsunsuanso bɔne?
Saa nnuru yi nso wɔ nsunsuanso bɔne pɔtee bi.
| Nsunsuanso bɔne a ɛtaa ba a efi Erbitux ne Vectibix mu ba | |
|---|---|
| Honam ani haw ahorow | Akisikuru a ɛte sɛ akisikuru, honam ani akisikuru, ne honam ani a ɛyɛ mmerɛw. Nanso nea ɛyɛ nwonwa ne sɛ, ɛtɔ mmere bi a saa honam ani nneyɛe yi kyerɛ sɛ aduru no reyɛ adwuma yiye atia kokoram. |
| Nneɛma afoforo a ɛde ba |
|
Nkrasɛm a Wɔde Kɔ Fie
- Monoclonal Antibodies yɛ aduru a ɛkɔ akyiri a ɛde n’ani si kokoram nkwammoaa so pɔtee na ɛtow hyɛ wɔn so. Ɛsono wɔn wɔ nnuru a wɔde sa yare daa no ho.
- Nnuru bi twa mogya a ɛkɔ kokoram no mu no mu, na afoforo nso siw nsɛnkyerɛnne nhyehyɛe a ɛma kokoram nkwammoaa nyin no kwan.
- Nnuru yi nyinaa wɔ n’ankasa nsunsuanso bɔne. Wo ne wo duruyɛfo nsusuw eyinom ho pefee ansa na woafi ayaresa ase.
- Saa ayaresa ahorow yi mfata obiara. Wo duruyɛfo no begyina kokoram ko a wowɔ, baabi a atrɛw akodu, ne nea afi awosu mu nhwehwɛmu titiriw bi mu aba so asi ayaresa a eye ma wo ho gyinae.
- Sɛ wo anaa w’abusua mu obi wɔ kokoram a, mma wo ho nnyɛ wo hu. Wo ne wo kokoram ho ɔyaresafo nkasa mfa ayaresa ahorow a ɛwɔ hɔ nyinaa ho, mfaso ne nea enye, na fa akokoduru gyina ayaresa no ano.
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