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Let's learn more about the Prochlorperazine pill for nausea. (Prochlorperazine)

Let's learn more about the Prochlorperazine pill for nausea. (Prochlorperazine)

Has your doctor prescribed you a medicine called Prochlorperazine for nausea or vomiting? Or has anyone in your family been given this medicine? Sometimes this medicine is also used for mental illnesses. So today, let's talk simply and precisely about what this medicine is, what it does, and what things to be careful about when using it.

What really happens with this medicine?

Simply put, Prochlorperazine is a drug that is mainly used to control nausea and vomiting. What this drug does is block the signals that our brain sends to cause nausea. It's like closing the door to nausea.

This medicine is also used to treat some mental illnesses, especially schizophrenia . It works by balancing the levels of a chemical called dopamine in the brain. This dopamine is something that helps control our mood, behavior, and thoughts. So when it is balanced, it is easier to control the illness.

The most important thing is that the doctor may prescribe this medicine for other medical conditions as well. Therefore, the best thing to do is to listen to what the doctor says and use the medicine as prescribed.

Things you need to tell your doctor before taking medicine

Before your doctor prescribes this medication, you should definitely and honestly tell him or her about any medical conditions you have. Hiding these things puts you at risk.

  • Brain and nerve problems: If you have dementia, a brain tumor, seizures, or Parkinson's disease.
  • Heart disease: If you have heart disease, an irregular heartbeat, or low blood pressure.
  • Liver diseases: If you have any liver disease.
  • Blood problems: If you have a condition that causes a decrease in white blood cells, platelets, or red blood cells.
  • Respiratory system diseases: If you have lung diseases like asthma.
  • Other physical problems: Diabetes, glaucoma, intestinal obstruction, difficulty swallowing, difficulty urinating, or prostate disease.
  • Personal habits and allergies: If you are a regular drinker, have an allergy to Prochlorperazine or any other medicine, food, or dye.
  • Pregnancy and breastfeeding: If you are pregnant, trying to get pregnant, or are breastfeeding.

If anything on this list applies to you, don't be afraid to discuss it with your doctor.

How should I use the medicine?

The way this medicine is used is also very important.

  • Take this pill with a glass of water .
  • Take only the prescribed dose, at the time your doctor prescribes. Never take more than prescribed.
  • The most important thing is that it is not a good idea to stop taking this medicine suddenly. Doing so can cause nausea, vomiting, and dizziness. So if you need to stop taking the medicine, ask your doctor for advice on how to do it.
  • If given to children: This medicine can be given to children over 2 years of age in some special cases. But it should only be done under the supervision of a pediatrician. Special care should be taken with this.

What to do if you overdose or miss a dose?

If you think you have taken too much of this medicine, do not delay. Immediately call the National Poisons Information Centre at the Colombo National Hospital . Or go to the Emergency Treatment Unit (ETU) of the nearest hospital.

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take double doses for any reason.

Other medications that may interact with this medicine (Medication Interactions)

Prochlorperazine is a medication that can interact with some medications, so it is very important to tell your doctor about all other medications you are taking.

Type of medicine
Do not take Prochlorperazine with this medicine.
Cisapride, Dofetilide, Dronedarone, Metoclopramide, Pimozide, Saquinavir, Thioridazine
Problems can also occur with these medications (inform your doctor).

  • Alcohol
  • Medicines for allergies, coughs, and colds (Antihistamines)
  • Medication for anxiety or sleep
  • Medications for depression (e.g. Amitriptyline, Fluoxetine)
  • Blood pressure medication
  • Medications such as Levodopa for Parkinson's disease
  • Blood thinners such as Warfarin
  • Antiepileptic drugs (e.g. Phenobarbital, Phenytoin)
  • Medicines used for anesthesia and muscle relaxation during surgery
  • Painkillers (especially opioids)

This list is not complete. Also tell your doctor about any vitamins or herbal products you are taking.

Things to keep in mind when taking medication

  • Driving and operating machinery: This medicine may affect your concentration and decision-making speed. Therefore , avoid driving or operating heavy machinery until you know how this medicine affects you.
  • Dizziness: To reduce the risk of dizziness, get up slowly when getting up from a sitting position or out of bed. Drinking alcohol can make this condition worse.
  • Body temperature: This is very important. This medication may make it difficult for your body to regulate heat and cold.
  • In cold weather: Stay indoors as much as possible. If you go out, dress warmly.
  • In hot weather: Limit sun exposure. Avoid excessive exercise. Wear loose, light clothing. Drink plenty of water.
  • Blood sugar: This medication may increase blood sugar levels. People with diabetes should be especially careful with this.
  • Sun sensitivity: Your skin may become very sensitive to the sun while taking this medicine. So protect yourself from the sun. Use an umbrella and apply sunscreen.
  • Dry mouth: You may experience a dry mouth. Chewing sugar-free gum, sucking on sugar-free candy, and drinking plenty of water can help.

What are the possible side effects?

Like any medicine, Prochlorperazine can cause side effects. Some are serious, while others are common.

Side effects and symptoms
Serious side effects that require immediate medical attention

  • Allergic reactions: skin rash, itching, swelling of the face, lips, tongue or throat.
  • Neuroleptic Malignant Syndrome (NMS): High fever, muscle stiffness, excessive sweating, fast or irregular heartbeat, and confusion. This is a very serious emergency.
  • High Prolactin levels: A milky fluid discharge from the breasts, irregular menstrual cycles in women, changes in sexual desire.
  • Symptoms of infection: fever, chills, cough, sore throat.
  • Low blood pressure: dizziness, fainting, blurred vision.
  • Extrapyramidal Symptoms (EPS): Uncontrolled movements of body parts (especially the face and mouth), muscle stiffness, tremors, loss of balance when walking, restlessness.

Side effects that are usually not serious, but should be reported to the doctor if they persist

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth

Take-Home Message

  • Prochlorperazine should only be used on the advice of a doctor. Do not take more than the prescribed dose.
  • Before taking the medicine, tell your doctor about any other illnesses you have and any other medications you are taking.
  • Do not stop taking the medication suddenly without consulting your doctor.
  • If you experience any serious side effects, such as high fever, muscle stiffness, or uncontrollable movements , seek medical advice immediately.
  • Avoid drinking alcohol completely while taking this medication. Be very careful when driving.
  • If you suspect an overdose, call the National Poisons Information Centre immediately or go to the nearest hospital Emergency Department (ETU).

Prochlorperazine, Compazine, nausea, vomiting, mental health, side effects, medication, Sri Lanka
⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.

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Let's learn more about the Prochlorperazine pill for nausea. (Prochlorperazine)
MedicationsMay 23, 2026

Let's learn more about the Prochlorperazine pill for nausea. (Prochlorperazine)

Has your doctor prescribed you a medicine called Prochlorperazine for nausea or vomiting? Or has anyone in your family been given this medicine? Sometimes this medicine is also used for mental illnesses. So today, let's talk simply and precisely about what this medicine is, what it does, and what things to be careful about when using it.

What really happens with this medicine?

Simply put, Prochlorperazine is a drug that is mainly used to control nausea and vomiting. What this drug does is block the signals that our brain sends to cause nausea. It's like closing the door to nausea.

This medicine is also used to treat some mental illnesses, especially schizophrenia . It works by balancing the levels of a chemical called dopamine in the brain. This dopamine is something that helps control our mood, behavior, and thoughts. So when it is balanced, it is easier to control the illness.

The most important thing is that the doctor may prescribe this medicine for other medical conditions as well. Therefore, the best thing to do is to listen to what the doctor says and use the medicine as prescribed.

Things you need to tell your doctor before taking medicine

Before your doctor prescribes this medication, you should definitely and honestly tell him or her about any medical conditions you have. Hiding these things puts you at risk.

  • Brain and nerve problems: If you have dementia, a brain tumor, seizures, or Parkinson's disease.
  • Heart disease: If you have heart disease, an irregular heartbeat, or low blood pressure.
  • Liver diseases: If you have any liver disease.
  • Blood problems: If you have a condition that causes a decrease in white blood cells, platelets, or red blood cells.
  • Respiratory system diseases: If you have lung diseases like asthma.
  • Other physical problems: Diabetes, glaucoma, intestinal obstruction, difficulty swallowing, difficulty urinating, or prostate disease.
  • Personal habits and allergies: If you are a regular drinker, have an allergy to Prochlorperazine or any other medicine, food, or dye.
  • Pregnancy and breastfeeding: If you are pregnant, trying to get pregnant, or are breastfeeding.

If anything on this list applies to you, don't be afraid to discuss it with your doctor.

How should I use the medicine?

The way this medicine is used is also very important.

  • Take this pill with a glass of water .
  • Take only the prescribed dose, at the time your doctor prescribes. Never take more than prescribed.
  • The most important thing is that it is not a good idea to stop taking this medicine suddenly. Doing so can cause nausea, vomiting, and dizziness. So if you need to stop taking the medicine, ask your doctor for advice on how to do it.
  • If given to children: This medicine can be given to children over 2 years of age in some special cases. But it should only be done under the supervision of a pediatrician. Special care should be taken with this.

What to do if you overdose or miss a dose?

If you think you have taken too much of this medicine, do not delay. Immediately call the National Poisons Information Centre at the Colombo National Hospital . Or go to the Emergency Treatment Unit (ETU) of the nearest hospital.

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take double doses for any reason.

Other medications that may interact with this medicine (Medication Interactions)

Prochlorperazine is a medication that can interact with some medications, so it is very important to tell your doctor about all other medications you are taking.

Type of medicine
Do not take Prochlorperazine with this medicine.
Cisapride, Dofetilide, Dronedarone, Metoclopramide, Pimozide, Saquinavir, Thioridazine
Problems can also occur with these medications (inform your doctor).

  • Alcohol
  • Medicines for allergies, coughs, and colds (Antihistamines)
  • Medication for anxiety or sleep
  • Medications for depression (e.g. Amitriptyline, Fluoxetine)
  • Blood pressure medication
  • Medications such as Levodopa for Parkinson's disease
  • Blood thinners such as Warfarin
  • Antiepileptic drugs (e.g. Phenobarbital, Phenytoin)
  • Medicines used for anesthesia and muscle relaxation during surgery
  • Painkillers (especially opioids)

This list is not complete. Also tell your doctor about any vitamins or herbal products you are taking.

Things to keep in mind when taking medication

  • Driving and operating machinery: This medicine may affect your concentration and decision-making speed. Therefore , avoid driving or operating heavy machinery until you know how this medicine affects you.
  • Dizziness: To reduce the risk of dizziness, get up slowly when getting up from a sitting position or out of bed. Drinking alcohol can make this condition worse.
  • Body temperature: This is very important. This medication may make it difficult for your body to regulate heat and cold.
  • In cold weather: Stay indoors as much as possible. If you go out, dress warmly.
  • In hot weather: Limit sun exposure. Avoid excessive exercise. Wear loose, light clothing. Drink plenty of water.
  • Blood sugar: This medication may increase blood sugar levels. People with diabetes should be especially careful with this.
  • Sun sensitivity: Your skin may become very sensitive to the sun while taking this medicine. So protect yourself from the sun. Use an umbrella and apply sunscreen.
  • Dry mouth: You may experience a dry mouth. Chewing sugar-free gum, sucking on sugar-free candy, and drinking plenty of water can help.

What are the possible side effects?

Like any medicine, Prochlorperazine can cause side effects. Some are serious, while others are common.

Side effects and symptoms
Serious side effects that require immediate medical attention

  • Allergic reactions: skin rash, itching, swelling of the face, lips, tongue or throat.
  • Neuroleptic Malignant Syndrome (NMS): High fever, muscle stiffness, excessive sweating, fast or irregular heartbeat, and confusion. This is a very serious emergency.
  • High Prolactin levels: A milky fluid discharge from the breasts, irregular menstrual cycles in women, changes in sexual desire.
  • Symptoms of infection: fever, chills, cough, sore throat.
  • Low blood pressure: dizziness, fainting, blurred vision.
  • Extrapyramidal Symptoms (EPS): Uncontrolled movements of body parts (especially the face and mouth), muscle stiffness, tremors, loss of balance when walking, restlessness.

Side effects that are usually not serious, but should be reported to the doctor if they persist

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth

Take-Home Message

  • Prochlorperazine should only be used on the advice of a doctor. Do not take more than the prescribed dose.
  • Before taking the medicine, tell your doctor about any other illnesses you have and any other medications you are taking.
  • Do not stop taking the medication suddenly without consulting your doctor.
  • If you experience any serious side effects, such as high fever, muscle stiffness, or uncontrollable movements , seek medical advice immediately.
  • Avoid drinking alcohol completely while taking this medication. Be very careful when driving.
  • If you suspect an overdose, call the National Poisons Information Centre immediately or go to the nearest hospital Emergency Department (ETU).

Prochlorperazine, Compazine, nausea, vomiting, mental health, side effects, medication, Sri Lanka
⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.

💬 Comments (0)

No comments have been posted yet. Add your comment here for the first time.

Add your comment

Please calculate: 5 + 8 =